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Total 791 results found since Jan 2013.

Role Of Glp-1 Analogs In The Management Of Diabetes And Its Secondary Complication
Mini Rev Med Chem. 2021 Apr 21. doi: 10.2174/1389557521666210422114909. Online ahead of print.ABSTRACTThe cardiovascular complications of type 2 diabetes mellitus (T2DM) include myocardial infarction, heart failure, peripheral vascular disease and, stroke and retinopathy, nephropathy and neuropathy are microvascular complications. While the newer therapies like glitazones or even dipeptidyl-peptidase-IV (DPP-IV) inhibitors increase the risk of therapy, the Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs), were reported as suitable alternates. The GLP-1RAs reduce the major adverse cardiovascular events (MACE), have anti...
Source: Mini Reviews in Medicinal Chemistry - April 23, 2021 Category: Chemistry Authors: Ponnurengam Malliappan Sivakumar B Premkumar Prabhawathi Veluchamy Pranav Kumar Prabhakar Source Type: research

Sphingosine 1-phosphate and its receptors in ischemia
Clin Chim Acta. 2021 Jun 18:S0009-8981(21)00221-7. doi: 10.1016/j.cca.2021.06.020. Online ahead of print.ABSTRACTSphingosine 1-phosphate (S1P), a metabolite of sphingolipids, is mainly derived from red blood cells (RBCs), platelets and endothelial cells (ECs). It plays important roles in regulating cell survival, vascular integrity and inflammatory responses through its receptors. S1P receptors (S1PRs), including 5 subtypes (S1PR1-5), are G protein-coupled receptors and have been proved to mediate various and complex roles of S1P in atherosclerosis, myocardial infarction (MI) and ischemic stroke by regulating endothelial f...
Source: International Journal of Clinical Chemistry - June 21, 2021 Category: Chemistry Authors: Shishu Lu Meihua She Qun Zeng Guanghui Yi Jiawei Zhang Source Type: research

Health risk and disease burden attributable to long-term global fine-mode particles
This study investigates global spatiotemporal variations in PM2.5 using the newly developed satellite-derived PM2.5 dataset from 1998 to 2018. An integrated exposure-response (IER) model was employed to examine the characteristics of PM2.5-related deaths caused by chronic obstructive pulmonary disease (COPD), ischemic heart disease (IHD), lung cancer (LC), and stroke in adults (age≥25), as well as lower respiratory infection (LRI) in children (age≤5). The results showed that high annual PM2.5 concentrations were observed mainly in East Asia and South Asia. Over the 19-year period, PM2.5 concentrations constantly decrea...
Source: Chemosphere - October 4, 2021 Category: Chemistry Authors: Xingchuan Yang Yuan Wang Chuanfeng Zhao Hao Fan Yikun Yang Yulei Chi Lixing Shen Xing Yan Source Type: research

Molecules, Vol. 26, Pages 7059: A Dynamic Model and Parameter Identification of High Viscosity Magnetorheological Fluid-Based Energy Absorber with Radial Flow Mode
rong Liao The excellent suspension stability of the high-viscosity linear polysiloxane magnetorheological fluid (HVLP MRF) makes it a great controlled medium for magnetorheological energy absorbers (MREAs). In our previous work, the Herschel–Bulkley flow model (HB model) was used to describe the shear-thinning rheological behavior and establish the dynamic model of an HVLP MRF-based MREA with radial flow mode. However, as the established model was implicit, the MREA response time increased and the buffer effect was degraded. To improve the time response characteristics, an explicit dynamic model based on ...
Source: Molecules - November 22, 2021 Category: Chemistry Authors: Benyuan Fu Xianming Zhang Zhuqiang Li Ruizhi Shu Changrong Liao Tags: Article Source Type: research

Plasma ADAM-10 levels and functional outcome of acute primary basal ganglia hemorrhage
CONCLUSIONS: Rising plasma ADAM-10 levels are independently related to increasing severity and poor long-term functional outcome after hemorrhagic stroke, substantializing serum ADAM-10 as a useful prognostic biomarker of ICH.PMID:34852263 | DOI:10.1016/j.cca.2021.11.026
Source: International Journal of Clinical Chemistry - December 1, 2021 Category: Chemistry Authors: Ma-Jing Feng Wei Wang Xue-Feng Zhang Fang-Fang Che Jie Yang Wei-Bin Ning Wei Gao Jiang Chen Source Type: research

Molecules, Vol. 26, Pages 7466: The Antioxidant Phytochemical Schisandrin a Promotes Neural Cell Proliferation and Differentiation after Ischemic Brain Injury
In conclusion, our findings suggest that SCH enhanced NPCs proliferation and differentiation possible by Cdc42 to regulated cytoskeletal rearrangement and polarization of cells, which provides new hope for the late recovery of stroke.
Source: Molecules - December 9, 2021 Category: Chemistry Authors: Wentian Zong Mostafa Gouda Enli Cai Wang Ruofeng Xu Weijie Yuming Wu Paulo E. S. Munekata Jos é M. Lorenzo Tags: Article Source Type: research

A strategy based on gene sequencing and molecular docking for analysis and prediction of bioactive peptides in Shuxuetong injection
Biophys Chem. 2021 Dec 24;282:106749. doi: 10.1016/j.bpc.2021.106749. Online ahead of print.ABSTRACTPeptides are a class of protein fragments with relatively high biological activity and intense specificity, which play crucial role in the treatment of Shuxuetong injection (SXT). However, the extraordinary complexity of Chinese medicinal formulates and the lack of systematic identification methods are primary challenges for study of pharmacodynamic peptides. In addition, infinitesimal peptides contents further hinder the identification and structural characterization of polypeptide by traditional means. In this paper, we de...
Source: Biophysical Chemistry - December 31, 2021 Category: Chemistry Authors: Xinyi Jiao Yanchao Xing Haitao Wang Xin Jin Tingting Zhang Xingru Peng Rui Li Liuyi Liang Rui Liu Lifeng Han Zheng Li Source Type: research