Stroke RSS Page 10

Filtered By:
Specialty: Chemistry

This page shows you your search results in order of relevance. This is page number 10.

Order by Relevance | Date

Total 791 results found since Jan 2013.

Design, synthesis and biological evaluation of indoline derivatives as multifunctional agents for the treatment of ischemic stroke
AbstractIn this work, a series of indoline derivatives as multifunctional neuroprotective agents for battling ischemic stroke were designed, synthesized, and biologically evaluated. In antioxidant assay, all compounds showed significant protective effects against H2O2-induced death of RAW 264.7 cells. In oxygen glucose deprivation/reperfusion (OGD/R)-induced neuronal damage, some compounds significantly elevated the cell survival rate. Among them,7i,7j and7r exerted comparable neuroprotective effects to ifenprodil, and exhibited binding affinity toN-methyl-D-aspartic acid receptors 2B (NMDA-GluN2B). At the concentrations o...
Source: Medicinal Chemistry Research - April 13, 2022 Category: Chemistry Source Type: research

Molecules, Vol. 27, Pages 4181: Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights
Sun Wu Ischemic stroke (IS) is a leading cause of death and disability worldwide. Currently, the main therapeutic strategy involves the use of intravenous thrombolysis to restore cerebral blood flow to prevent the transition of the penumbra to the infarct core. However, due to various limitations and complications, including the narrow time window in which this approach is effective, less than 10% of patients benefit from such therapy. Thus, there is an urgent need for alternative therapeutic strategies, with neuroprotection against the ischemic cascade response after IS being one of the most promising options. I...
Source: Molecules - June 29, 2022 Category: Chemistry Authors: Liu Lin Wang Pan Sun Wu Tags: Review Source Type: research

Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment
In conclusion, 5j has the potential for the treatment of stroke as an anti-inflammatory and neuroprotective agent.PMID:35931005 | DOI:10.1016/j.ejmech.2022.114597
Source: European Journal of Medicinal Chemistry - August 5, 2022 Category: Chemistry Authors: Hongwei Wang Enjing Cui Jiaming Li Xiaodong Ma Xueyang Jiang Shuaishuai Du Shihu Qian Le Du Source Type: research

Anti-ischemic effect of monoterpene citronellol on experimental stroke models mediated by proinflammatroy cytokines
Conclusion Our results confirm citronellol is an effective anti-ischemic drug with antioxidant, anti-inflammatory properties.PMID:36372917 | DOI:10.2174/1386207326666221110092715
Source: Combinatorial Chemistry and High Throughput Screening - November 14, 2022 Category: Chemistry Authors: Xiao Liu Chunji Zhu Yong Yin Source Type: research

Molecules, Vol. 27, Pages 7963: A New Therapeutic Trend: Natural Medicine for Ameliorating Ischemic Stroke via PI3K/Akt Signaling Pathway
Wei Lan Ischemic stroke (IS) is an acute cerebrovascular disease caused by sudden arterial occlusion, which is characterized by a high morbidity, mortality, and disability rate. It is one of the most important causes of nervous system morbidity and mortality in the world. In recent years, the search for new medicine for the treatment of IS has become an attractive research focus. Due to the extremely limited time window of traditional medicine treatment, some side effects may occur, and accompanied by the occurrence of adverse reactions, the frequency of exploration with natural medicine is significantly increased. P...
Source: Molecules - November 17, 2022 Category: Chemistry Authors: Xian Liu Xinyu Xiao Xue Han Lan Yao Wei Lan Tags: Review Source Type: research

Molecules, Vol. 28, Pages 380: Theoretical and Experimental Investigation of the Antioxidation Mechanism of Loureirin C by Radical Scavenging for Treatment of Stroke
e Hou Recent pharmacological studies have shown that dragon&rsquo;s blood has an anti-cerebral ischemia effect. Loureirin C (LC), a kind of dihydrochalcone compound in dragon&rsquo;s blood, is believed to be play an important role in the treatment of ischemia stroke, but fewer studies for LC have been done. In this paper, we report the first experimental and theoretical studies on the antioxidation mechanism of LC by radical scavenging. The experimental studies show that LC has almost no effect on cell viability under 15 &mu;M for the SH-SY5Y cells without any treatments. For the SH-SY5Y cells w...
Source: Molecules - January 2, 2023 Category: Chemistry Authors: Ye-Shu Liu Guo-Ying Zhang Yue Hou Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2297: Inhibition of TLR4 Alleviates Heat Stroke-Induced Cardiomyocyte Injury by Down-Regulating Inflammation and Ferroptosis
In conclusion, this study illustrated that inhibition of the TLR4/NF-&kappa;B signaling pathway can regulate the inflammatory response and ferroptosis induced by HS, which provides new information and a theoretical basis for the basic research and clinical treatment of cardiovascular injuries caused by HS.
Source: Molecules - March 1, 2023 Category: Chemistry Authors: Dandan Chen Yao Geng Ziwei Deng Peiling Li Shujing Xue Tao Xu Guanghua Li Tags: Article Source Type: research

Microfluidic device with reconfigurable spatial temporal gradients reveals plastic astrocyte response to stroke and reperfusion
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00276D, PaperCatherine Reed-McBain, Rithvik V Turaga, Seth Zima, Sara Abizanda Campo, Jeremiah Riendeau, Emmanuel Contreras Guzman, Terry Juang, Duane S. Juang, David Hampton, Melissa Skala, Jose M Ayuso As a leading cause of mortality and morbidity, stroke constitutes a significant global health burden. Ischemic stroke accounts for 80% of cases and occurs due to an arterial thrombus, which... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - July 8, 2023 Category: Chemistry Authors: Catherine Reed-McBain Source Type: research

Graphene Oxide Nanosheets Hamper Glutamate Mediated Excitotoxicity and Protect Neuronal Survival In An In vitro Stroke Model
Chemistry. 2023 Sep 14:e202301762. doi: 10.1002/chem.202301762. Online ahead of print.ABSTRACTSmall graphene oxide (s-GO) nanosheets reversibly downregulate central nervous system (CNS) excitatory synapses, with potential developments as future therapeutic tools to treat neuro-disorders characterized by altered glutamatergic transmission. Excitotoxicity, namely cell death triggered by exceeding ambient glutamate fueling over-activation of excitatory synapses, is a pathogenic mechanism shared by several neural diseases, from ischemic stroke to neurodegenerative disorders. Here we exposed CNS cultures to oxygen-glucose depri...
Source: Chemistry - September 14, 2023 Category: Chemistry Authors: Lorenza Tortella Irene Santini Neus Lozano Kostas Kostarelos Giada Cellot Laura Ballerini Source Type: research

Critical Appraisal of Ischemic Stroke Pathophysiology: Road to Cerebral Resuscitation?
PMID: 24372203 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Rajanikant GK Tags: Curr Med Chem Source Type: research

The Role of Two Ectonucleotide Pyrophosphatase/Phosphodiesterases in Bone Mineralization and Stroke♦ Papers of the Week
♦ See referenced article, J. Biol. Chem. 2014, 289, 3294–3306 Purinergic signals and their metabolites are potent regulators of bone mineralization and platelet aggregation. Some members of the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family metabolize these signals. Although NPPs share homologous catalytic domains, it is not well understood how these enzymes discriminate among substrates. In this Paper of the Week, a group led by Yale University's Demetrios Braddock describes the high-resolution structure of NPP4, which is involved in platelet aggregation, and compares it in structure-function studies wi...
Source: Journal of Biological Chemistry - February 7, 2014 Category: Chemistry Tags: Enzymology Source Type: research

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20