Ordered surface crack patterns in situ formed under confinement on fluidic microchannel boundaries in polydimethylsiloxane
We present ordered surface crack patterns discovered in microfluidic channels/chambers in polydimethylsiloxane (PDMS). Cracks are formed in situ under confinement due to compression applied following oxygen plasma step in soft... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 22, 2021 Category: Chemistry Authors: Yang Bu Source Type: research

An automated and portable antimicrobial susceptibility testing system for urinary tract infections
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01315C, PaperKuo-Wei Hsu, Wen-Bin Lee, Huey-Ling You, Mel S. Lee, Gwo-Bin Lee Urinary tract infections (UTIs) are bacterial infections that 1) commonly affect females, 2) can pose high risks to impair kidney function, 3) are often treated with broad-spectrum antibiotics, and 4)... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 22, 2021 Category: Chemistry Authors: Kuo-Wei Hsu Source Type: research

Rapid nitrate determination with a portable lab-on-chip device based on double microstructured assisted reactors
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01057J, PaperFang Wang, Jiaomeng Zhu, Xuejia Hu, Longfei Chen, Yun Feng Zuo, Yi Yang, Fenghua Jiang, Chengjun Sun, Weihong Zhao, Xiaotian Han Determining the nitrate levels is critical for water quality monitoring, and traditional methods are limited by high toxicity and low detection efficiency. Here, rapid nitrate determination was realized using a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 22, 2021 Category: Chemistry Authors: Fang Wang Source Type: research

Cardiovascular microphysiological systems (CVMPS) for safety studies – a pharma perspective
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC01040E, Tutorial ReviewAmy Pointon, Jonathan Maher, Myrtle Davis, Thomas Baker, Joseph Cichocki, Diane Ramsden, Christopher Hale, Kyle L. Kolaja, Paul Levesque, Radhakrishna Sura, David M. Stresser, Gary Gintant The integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 20, 2021 Category: Chemistry Authors: Amy Pointon Source Type: research

High-Throughput Functional Profiling of Single Adherent Cells via Hydrogel Drop-Screen
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01294G, PaperMing Wang, Mui Hoon Nai, Ruby Yun-Ju Huang, Hwa Liang Leo, Chwee Teck Lim, Chia Hung Chen Single-adherent-cell phenotyping on extracellular matrix (ECM) is essential to determine cellular biological functions, such as morphological adaptations and biomolecule secretions, correlated to medical treatments and metastasis, yet there is no... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 20, 2021 Category: Chemistry Authors: Ming Wang Source Type: research

Microfluidic studies of hydrostatic pressure-enhanced doxorubicin resistance in human breast cancer cells
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01103G, PaperMenglin Shang, Su Bin Lim, Kuan Jiang, Yoon-Sim Yap, Bee Luan Khoo, Jongyoon Han, Chwee Teck Lim Acquired multidrug resistance in tumors is a big challenge in cancer therapy. As an important physical stimulus in the tumor microenvironment, elevated interstitial fluid pressure has been reported to inhibit... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 20, 2021 Category: Chemistry Authors: Menglin Shang Source Type: research

Exploring early time points of vimentin assembly in flow by fluorescence fluctuation spectroscopy
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Eleonora Perego, Sarah K öster Despite the importance for cellular processes, the dynamics of molecular assembly, especially on fast time scales, is not yet fully understood. To this end, we present a multi-layer microfluidic device... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 19, 2021 Category: Chemistry Authors: Eleonora Perego Source Type: research

Programmable multilayer printing of a mechanically-tunable 3D hydrogel co-culture system for high-throughput investigation of complex cellular behavior
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC01230K, PaperJisu Hong, Yoonkyung Shin, Jiseok Lee, Chaenyung Cha Programmable multilayer printing is utilized to develop a 3D hydrogel co-culture system, consisting of a microgel array and hydrogel overlay with independently controlled mechanical properties and concurrent generation of mechanical gradients. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 18, 2021 Category: Chemistry Authors: Jisu Hong Source Type: research

Optimization of Aptamer Selection on an Automated Microfluidic System with Cancer Tissues
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01333A, PaperCheng-Sheng Lin, Yi-Cheng Tsai, Keng-Fu Hsu, Gwo-Bin Lee Cancer is among the world ’s most deadly inflictions, and early diagnosis is critical. Aptamers have shown utility as cancer probes since they can be screened rapidly in vitro against cancer... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 18, 2021 Category: Chemistry Authors: Cheng-Sheng Lin Source Type: research

Origami Paper-based Sample Preconcentration using Sequentially Driven Ion Concentration Polarization
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01032D, PaperJunwoo Lee, Yong Kyoung Yoo, Dohwan Lee, Cheonjung Kim, Kang Hyeon Kim , Seungmin Lee, Seungmin Kwak, Ji Yoon Kang, Hyungseok Kim, Dae Sung Yoon, Don Hur, Jeonghoon Lee Ion concentration polarization (ICP) is one of the preconcentration technique which can acquire high preconcentration factor. Still, the main hurdles of ICP are its instability and low efficiency in physiological... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 18, 2021 Category: Chemistry Authors: Junwoo Lee Source Type: research

Healthy and Diseased In vitro Models of Vascular Systems
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC00464B, Critical ReviewVahid Hosseini, Anna Mallone, Fatemeh Nasrollahi, Serge Ostrovidov, Rohollah Nasiri, Mahboobeh Mahmoodi, Reyhaneh Haghniaz, Avijit Baidya, Mehdi Salek, Mohammad Ali Darabi, Amir Shamloo, Mehmet Remzi Dokmeci, Samad Ahadian, Ali Khademhosseini, Gorka Orive Irregular hemodynamics affects the progression of various vascular diseases, such atherosclerosis or aneurysms. Despite the extensive hemodynamics studies on animal models, the inter-species differences between humans and animals hamper the... The content of this RSS Feed (c) The Royal Society of ...
Source: RSC - Lab Chip latest articles - January 18, 2021 Category: Chemistry Authors: Vahid Hosseini Source Type: research

Motile cells as probes for characterizing acoustofluidic devices
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01025A, PaperMinji Kim, Philip V Bayly, J. Mark Meacham Acoustic microfluidics has emerged as a versatile solution for particle manipulation in medicine and biology. However, current technologies are largely confined to specialized research laboratories. The translation of acoustofluidics from... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 16, 2021 Category: Chemistry Authors: Minji Kim Source Type: research

A fully integrated biomimetic microfluidic device for evaluation of sperm response to thermotaxis and chemotaxis
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00845A, PaperYimo Yan, Boxuan Zhang, Qiqi Fu, Jian Wu, Ran Liu We developed a fully integrated biomimetic microfluidic system for screening sperm for their characteristics when exposed to temperature and chemical gradients. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 16, 2021 Category: Chemistry Authors: Yimo Yan Source Type: research

Cardiovascular Microphysiological Systems (CVMPS) for Safety Studies - A Pharma Perspective
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01040E, Tutorial ReviewAmy Pointon, Jonathan Maher, Myrtle Davis, Thomas K Baker, Josesph Cichocki, Diane Ramsden, Christopher Hale, Kyle Kolaja, Paul Levesque, Radhakrishna Sura, David M Stresser, Gary A Gintant The integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body. Progress has been made in... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 16, 2021 Category: Chemistry Authors: Amy Pointon Source Type: research

Vascularized organoids on a chip: Strategies for engineering organoids with functional vasculature
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Shun Zhang, Zhengpeng Wan, Roger D. Kamm Human organoids, self-organized and differentiated from homogenous pluripotent stem cells (PSC), replicate the key structural and functional characteristics of theirin vivo counterparts. Despite the rapid advancement of organoid technology... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 16, 2021 Category: Chemistry Authors: Shun Zhang Source Type: research

Role of glucose in the repair of cell membrane damage during squeeze distortion of erythrocytes in microfluidic capillaries
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00411A, PaperYuanyuan Chen, Yunfan Pan, Yuzhen Feng, Donghai Li, Jia Man, Lin Feng, Deyuan Zhang, Huawei Chen, Haosheng Chen Glucose helps erythrocytes maintain their biconcave morphology and deformability as they pass through small capillaries with a repetitive high squeeze effect. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 12, 2021 Category: Chemistry Authors: Yuanyuan Chen Source Type: research

Collective dynamics of neuronal activities in various modular networks
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01106A, PaperMyung Uk Park, Yonghee Bae, Kyo-Seok Lee, Jun Ho Song, Sun-Mi Lee, Kyung-Hwa Yoo Modularity is a key feature of structural and functional brain networks. However, the association between the structure and function of modular brain networks has not been revealed. We constructed three... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 12, 2021 Category: Chemistry Authors: Myung Uk Park Source Type: research

Sequential capillarity-assisted particle assembly in a microfluidic channel
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Roberto Pioli, Miguel Angel Fernandez-Rodriguez, Fabio Grillo, Laura Alvarez, Roman Stocker, Lucio Isa, Eleonora Secchi Exploiting capillarity, a new microfluidic platform enables the placement of multiple colloidal particles into complex patterns within a microchannel, as required in a variety of applications, including electronics, sensing, and plasmonics. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab...
Source: RSC - Lab Chip latest articles - January 11, 2021 Category: Chemistry Authors: Roberto Pioli Source Type: research

Distributed colorimetric interferometer for mapping the pressure distribution in a complex microfluidics network
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC00960A, PaperXiongfeng Zhu, Tianxing Man, Marvin Xing Haw Tan, Pei-Shan Chung, Michael A. Teitell, Pei Yu Chiou We demonstrate a novel platform for mapping the pressure distribution of complex microfluidics networks with high spatial resolution. Our approach utilizes colorimetric interferometers enabled by lossy optical resonant cavities embedded... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 11, 2021 Category: Chemistry Authors: Xiongfeng Zhu Source Type: research

A portable sperm cell purification instrument based on continuous flow acoustophoretic separation of sperm cells for on-site forensic sample pretreatment
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01198C, PaperKai Sun, Han Wang, Lei Wang, Ying Lu, Ran Liu, Peng Liu, Jing Cheng Obtaining purified male sperm specimen from the original forensic sample mixtures is a critical procedure in identifying criminal suspect in the forensic analysis of sexual assult crimes. Differential extraction (DE)... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 7, 2021 Category: Chemistry Authors: Kai Sun Source Type: research

Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01061H, CommunicationChungha Lee, Seunggyu Kim, Herve Hugonnet, Moosung Lee, Weisun Park, Jessie Sungyun Jeon, YongKeun Park Label-free, three-dimensional (3D) quantitative observations of on-chip vasculogenesis were achieved using optical diffraction tomography. Exploiting 3D refractive index maps as an intrinsic imaging contrast, the vascular structures, multicellular activities, and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 7, 2021 Category: Chemistry Authors: Chungha Lee Source Type: research

Biomedical optical fibers
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01155J, Critical ReviewMisagh Rezapour Sarabi, Nan Jiang, Ece Ozturk, Ali Kemal Yetisen, Savas Tasoglu Optical fibers with the ability to propagate and transfer data via optical signals have been used for decades in medicine. Biomaterials featuring the properties of softness, biocompatibility, and biodegradability enable... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 7, 2021 Category: Chemistry Authors: Misagh Rezapour Sarabi Source Type: research

Microliter ultrafast centrifuge platform for size-based particle and cell separation and extraction using novel omnidirectional spiral surface acoustic waves
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01012J, PaperNaiqing Zhang, Juan P Zuniga-Hertz, Elizabeth Zhang-Chen, Tilvawala Gopesh, Mckenzie Fannon, Jiaying Wang, Yue Wen, Hemal Patel, James Friend Asymmetric surface acoustic waves have been shown useful in separating particles and cells in many microfluidics designs, mostly notably sessile microdroplets. However, no one has successfully extracted target particles or... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 7, 2021 Category: Chemistry Authors: Naiqing Zhang Source Type: research

Contact Photolithography-Free Integration of Patterned and Semi-Transparent Indium Tin Oxide Stimulation Electrodes into Polydimethylsiloxane-Based Heart-on-a-Chip Devices for Streamlining Physiological Recordings
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC00948B, PaperJoycelyn K Yip, Debarghya Sarkar, Andrew P Petersen, Jennifer Gipson, Jun Tao, Salil Kale, Megan L Rexius-Hall, Nathan Cho, Natalie N Khalil, Rehan Rashid Kapadia, Megan Laura McCain Controlled electrical stimulation is essential for evaluating the physiology of cardiac tissues engineered in Heart-on-a-Chip devices. However, existing stimulation techniques, such as external platinum electrodes or opaque microelectrode arrays patterned... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 7, 2021 Category: Chemistry Authors: Joycelyn K Yip Source Type: research

Microdissected “cuboids” for microfluidic drug testing of intact tissues
Lab Chip, 2021,21,122-142 DOI: 10.1039/D0LC00801J, PaperLisa F. Horowitz, Adan D. Rodriguez, Allan Au-Yeung, Kevin W. Bishop, Lindsey A. Barner, Gargi Mishra, Aashik Raman, Priscilla Delgado, Jonathan T. C. Liu, Taranjit S. Gujral, Mehdi Mehrabi, Mengsu Yang, Robert H. Pierce, Albert Folch A microfluidic platform permits multiple drug testing of uniformly-sized microscale “cuboids” of live tissue with well-preserved microenvironments. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 6, 2021 Category: Chemistry Authors: Lisa F. Horowitz Source Type: research

Role of glucose in repair of cell membrane damage during squeeze distortion of erythrocytes in microfluidic capillaries
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC00411A, PaperYuanyuan Chen, Yunfan Pan, Yuzhen Feng, Donghai Li, Jia Man, Lin Feng, Deyuan Zhang, Huawei Chen, Haosheng Chen The rapid development of portable precision detection methods and the crisis of insufficient blood supply worldwide has led scientists to study mechanical visualization features beyond the biochemical properties of erythrocytes.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 6, 2021 Category: Chemistry Authors: Yuanyuan Chen Source Type: research

Programmable multilayer printing of mechanically-tunable 3D hydrogel co-culture system for high-throughput investigation of complex cellular behavior
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01230K, PaperJisu Hong, Yoonkyung Shin, Jiseok Lee, Chaenyung Cha Hydrogels are widely used as a 3D cell culture platform, as they can be tailored to provide suitable microenvironments to induce cellular phenotypes with physiological significance. Hydrogels are especially deemed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 5, 2021 Category: Chemistry Authors: Jisu Hong Source Type: research

A Distance-based Capillary Biosensor Using Wettability Alteration
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01147A, PaperYansheng Li, Xiujin Men, Guowei Gao, Ye Tian, Yongqiang Wen, Xueji Zhang Distance-based detection methods with quantitative readout are of great significance to point-of-care testing (POCT), which are low-cost, user-friendly and can be integrated into portable analytical devices. Here, we submit a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 5, 2021 Category: Chemistry Authors: Yansheng Li Source Type: research

Rapid sample preparation for detection of antibiotic resistance on a microfluidic disc platform
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00838A, PaperAlexandra Perebikovsky, Yujia Liu, Alexander Hwu, Horacio Kido, Ehsan Shamloo, Dian Song, Gabriel Monti, Oren Shoval, Daniel Gussin, Marc Madou We demonstrated a novel instrument and a centrifugal microfluidics disc design that is capable of remarkably accomplishing the sample treatment steps, which pave the way to realize the antibody susceptibility test in point-of-care situation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 4, 2021 Category: Chemistry Authors: Alexandra Perebikovsky Source Type: research

Phase separation of a nonionic surfactant aqueous solution in a standing surface acoustic wave for submicron particle manipulation
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00986E, CommunicationLei Zhao, Pengfei Niu, Eudald Casals, Muling Zeng, Chen Wu, Yang Yang, Sheng Sun, Zongwei Zheng, Zhaoxun Wang, Yuan Ning, Xuexin Duan, Wei Pang Acoustic induced nanoparticle patterning and location migration in inhomogeneous media formedin situ. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 4, 2021 Category: Chemistry Authors: Lei Zhao Source Type: research

Thin-Film-Transistor Digital Microfluidics for High Value in Vitro Diagnostics at the Point of Need
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01143F, PaperSally Anderson, Ben Hadwen, Chris Brown The latest developments in Thin-Film-Transistor Digital-microfluidics (TFT-DMF, also known by the commercial name aQdropTM) are reported, and proof of concept application to molecular diagnostics (e.g. for coronavirus disease, COVID-19) at... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 31, 2020 Category: Chemistry Authors: Sally Anderson Source Type: research

A Thread/Fabric-Based Band as A Flexible and Wearable Microfluidic Device for Sweat Sensing and Monitoring
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC01075H, PaperZhiqi Zhao, Qiujin Li, Linna Chen, Yu Zhao, Jixian Gong, Zheng Li, Jianfei Zhang Flexible biosensors for monitoring systems have emerged as a promising portable diagnostics platform due to their potential for in situ point-of-care (POC) analytic devices. Assessment of biological analytes in sweat... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 31, 2020 Category: Chemistry Authors: Zhiqi Zhao Source Type: research

Microfluidic-based capture and release of cancer-derived exosomes via peptide –nanowire hybrid interface
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00899K, PaperThanawat Suwatthanarak, Ivan Adiyasa Thiodorus, Masayoshi Tanaka, Taisuke Shimada, Daiki Takeshita, Takao Yasui, Yoshinobu Baba, Mina Okochi A peptide –nanowire interface that can effectively capture cancer-derived exosomes and release captured intact exosomes was constructed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 25, 2020 Category: Chemistry Authors: Thanawat Suwatthanarak Source Type: research

High-resolution integrated piezoresistive sensors for microfluidic monitoring
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC01046D, CommunicationYongxiao Zhou, Erik M. Werner, Eugene Lee, Michael Chu, Thao Nguyen, Kevin D. Costa, Elliot E. Hui, Michelle Khine We have developed a soft piezoresistive sensor to measure micron-level strains that can be easily integrated into devices via soft lithography. We apply this sensor to achieve fast and localized monitoring of pressure, flow, and valve actuation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 23, 2020 Category: Chemistry Authors: Yongxiao Zhou Source Type: research

A 3D human adipose tissue model within a microfluidic device
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00981D, PaperFeipeng Yang, Alanis Carmona, Katerina Stojkova, Eric Ivan Garcia Huitron, Anna Goddi, Abhinav Bhushan, Ronald N. Cohen, Eric M. Brey This work presents a microfluidic system for the engineering and analysis of 3D human adipose tissue under controlled flow. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 23, 2020 Category: Chemistry Authors: Feipeng Yang Source Type: research

Flow shear stress controls the initiation of neovascularization via heparan sulfate proteoglycans within a biomimetic microfluidic model
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00493F, PaperPing Zhao, Xiao Liu, Xing Zhang, Li Wang, Haoran Su, Liyi Wang, Ningxiang He, Dongrui Zhang, Zhengxing Li, Hongyan Kang, Anqiang Sun, Zengsheng Chen, Li Zhou, Min Wang, Yinghui Zhang, Xiaoyan Deng, Yubo Fan The role of shear stress was investigated in a biomimetic microfluidic model that recapitulates the initial physiological microenvironment of neovascularization. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 23, 2020 Category: Chemistry Authors: Ping Zhao Source Type: research

Rapid isolation of circulating cancer associated fibroblasts by acoustic microstreaming for assessing metastatic propensity of breast cancer patients
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00969E, PaperRuoyu Jiang, Sudhanshu Agrawal, Mohammad Aghaamoo, Ritesh Parajuli, Anshu Agrawal, Abraham P. Lee We demonstrate a label free and high-throughput microbubble-based acoustic microstreaming technique to isolate rare circulating cells from cancer patients with a capture efficiency of 94% while preserving cell functional integrity within 8 minutes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 23, 2020 Category: Chemistry Authors: Ruoyu Jiang Source Type: research

Plasmonic Nanobowtiefluidic Device for Sensitive Detection of Glioma Extracellular Vesicles by Raman Spectrometry
Lab Chip, 2021, Accepted Manuscript DOI: 10.1039/D0LC00957A, PaperMahsa Jalali, Sayed Iman Isaac Hosseini, Tamer Abdelfatah, Laura Montermini, Sebastian Wachsmann-Hogiu, Janusz Rak, Sara Mahshid Cancer cells shed into biofluids extracellular vesicles (EVs) — nanoscale membrane particles carrying diagnostic information. EVs shed by heterogeneous populations of tumor cells offer a unique opportunity to access biologically... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 23, 2020 Category: Chemistry Authors: Mahsa Jalali Source Type: research

Microfluidic organ-on-a-chip model of the outer blood –retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Yusuf B. Ar ık, Wesley Buijsman, Joshua Loessberg-Zahl, Carlos Cuartas-Vélez, Colin Veenstra, Sander Logtenberg, Anne M. Grobbink, Piet Bergveld, Giuliana Gagliardi, Anneke I. den Hollander, Nienke Bosschaart, Albert van den Berg, Robert Passier, Andries D. van der Meer This organ-on-a-chip device of the outer blood retinal barrier will allow future studies of complex disease mechanisms and treatments of visual disorders using clinically relevant endpointsin vitro. To cite this article before page numbers are assigned, use the DOI for...
Source: RSC - Lab Chip latest articles - December 22, 2020 Category: Chemistry Authors: Yusuf B. Ar ık Source Type: research

Gear-shaped micromixer for synthesis of silica particles utilizing inertio-elastic flow instability
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00834F, PaperSun Ok Hong, Ki-Su Park, Dong-Yeong Kim, Sung Sik Lee, Chang-Soo Lee, Ju Min Kim A novel gear-shaped micromixer utilizing inertio-elastic flow instability and its application to the continuous synthesis of silica nanoparticle. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 22, 2020 Category: Chemistry Authors: Sun Ok Hong Source Type: research

Microfluidic thin film pressure balance for the study of complex thin films
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00974A, PaperS ébastien Andrieux, Pierre Muller, Manish Kaushal, Nadia Sofía Macias Vera, Robin Bollache, Clément Honorez, Alain Cagna, Wiebke Drenckhan Free-standing thin films of complex fluids can be investigated at controlled pressure conditions using a sandwich-type microfluidic chip design. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 22, 2020 Category: Chemistry Authors: S ébastien Andrieux Source Type: research

Engineering inclined orientations of piezoelectric films for integrated acoustofluidics and lab-on-a-chip operated in liquid environments
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Yong-Qing Fu, Hua-Feng Pang, Hamdi Torun, Ran Tao, Glen McHale, Julien Reboud, Kai Tao, Jian Zhou, Jingting Luo, Desmond Gibson, Jikui Luo, PingAn Hu Engineering orientations of inclined piezoelectric films allows simultaneous generation of multiple acoustic wave modes with multiple biosensing and acoustofluidic functions for an effective and integrated acoustic wave based lab-on-a-chip. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society o...
Source: RSC - Lab Chip latest articles - December 19, 2020 Category: Chemistry Authors: Yong-Qing Fu Source Type: research

A high-throughput multiplexed microfluidic device for COVID-19 serology assays
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC01068E, PaperRoberto Rodriguez-Moncayo, Diana F. Cedillo-Alcantar, Pablo E. Guevara-Pantoja, Oriana G. Chavez-Pineda, Jose A. Hernandez-Ortiz, Josue U. Amador-Hernandez, Gustavo Rojas-Velasco, Fausto Sanchez-Mu ñoz, Daniel Manzur-Sandoval, Luis D. Patino-Lopez, Daniel A. May-Arrioja, Rosalinda Posadas-Sanchez, Gilberto Vargas-Alarcon, Jose L. Garcia-Cordero A microfluidic device to quantitate antibody reactivities to SARS-CoV-2 antigens: spike protein, RDB, S1 subunit, and nucleocapsid, from 50 serum samples. To cite this article before page numbers are assigned, use ...
Source: RSC - Lab Chip latest articles - December 18, 2020 Category: Chemistry Authors: Roberto Rodriguez-Moncayo Source Type: research

HiPSC-derived multi-organoids-on-chip system for safety assessment of antidepressant drugs
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00921K, PaperFangchao Yin, Xu Zhang, Li Wang, Yaqing Wang, Yujuan Zhu, Zhongyu Li, Tingting Tao, Wenwen Chen, Hao Yu, Jianhua Qin We developed a multi-organoids-on-a-chip system which allows for the assessment of the cardiac safety of clomipramine following liver metabolism. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 18, 2020 Category: Chemistry Authors: Fangchao Yin Source Type: research

The MRD disk: automated minimal residual disease monitoring by highly sensitive centrifugal microfluidic multiplex qPCR
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00945H, PaperPeter Juelg, Elena Kipf, Mara Specht, Marion Fillies, Cornelia Eckert, Nils Paust, Roland Zengerle, Michael Lehnert, Tobias Hutzenlaub A centrifugal microfluidic system for automated, highly sensitive and multiplexed qPCR analyses, demonstrated for minimal residual disease monitoring in acute lymphoblastic leukaemia. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 18, 2020 Category: Chemistry Authors: Peter Juelg Source Type: research

Direct current electric field regulates endothelial permeability under physiologically relevant fluid forces in a microfluidic vessel bifurcation model
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC00507J, PaperPrashanth Mohana Sundaram, Kaushik K. Rangharajan, Ehsan Akbari, Tanner J. Hadick, Jonathan W. Song, Shaurya Prakash In vitro model for blood vessel on-chip reporting on the use of direct current electric fields (DC-EFs) to regulate vascular endothelial permeability, which is important for tissue regeneration and wound healing. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 18, 2020 Category: Chemistry Authors: Prashanth Mohana Sundaram Source Type: research

Microfluidic Organ-on-a-Chip Model of the Outer Blood-Retinal Barrier with Clinically Relevant Read-Outs for Tissue Permeability and Vascular Structure
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Yusuf Bilgehan Ar ık, Wesley Buijsman, Joshua Loessberg-Zahl, Carlos Cuartas-Vélez, Colin Veenstra, Sander Logtenberg, Anne Martine Grobbink, Piet Bergveld, Giuliana Gagliardi, Anneke I. den Hollander, Nienke Bosschaart, Albert van den Berg, Robert Passier, Andries D. van der Meer The outer blood-retinal barrier (oBRB) tightly controls the transport processes between the neural tissue of the retina and the underlying blood vessel network. The barrier is formed by the retinal... The content of this RSS Feed (c) The Royal Society of Che...
Source: RSC - Lab Chip latest articles - December 18, 2020 Category: Chemistry Authors: Yusuf Bilgehan Ar ık Source Type: research

Flexural wave-based soft attractor walls for trapping microparticles and cells
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Amirreza aghakhani, hakan cetin, Pelin Erkoc, Guney Isik Tombak, Metin Sitti Acoustic manipulation of microparticles and cells, called acoustophoresis, inside microfluidic systems has significant potential in biomedical applications. In particular, using acoustic radiation force to push microscopic objects toward the wall... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 18, 2020 Category: Chemistry Authors: Amirreza aghakhani Source Type: research

Predicting the fluid behavior of random microfluidic mixers using convolutional neural networks
Lab Chip, 2021, Advance Article DOI: 10.1039/D0LC01158D, PaperJunchao Wang, Naiyin Zhang, Jinkai Chen, Guodong Su, Hailong Yao, Tsung-Yi Ho, Lingling Sun Predicting the fluid behavior of complex microfluidic channel networks using convolutional neural networks. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 18, 2020 Category: Chemistry Authors: Junchao Wang Source Type: research

Super-resolution optofluidic scanning microscopy
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Biagio Mandracchia, Jeonghwan Son, Shu Jia We report an optofluidic microscope that exploits multi-focal excitation using the fluidic motion of the specimens for super-resolution, live-cell imaging. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - December 18, 2020 Category: Chemistry Authors: Biagio Mandracchia Source Type: research