Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells
Lab Chip, 2024, Advance Article DOI: 10.1039/D3LC00745F, PaperMaedeh Mozneb, Amelia Jenkins, Samuel Sances, Stephany Pohlman, Michael J. Workman, Dylan West, Briana Ondatje, Kareem El-Ghazawi, Amanda Woodbury, Veronica J. Garcia, Shachi Patel, Madelyn Arzt, Felipe Dezem, Alex H. Laperle, V. Alexandra Moser, Ritchie Ho, Nur Yucer, Jasmine Plummer, Robert J. Barrett, Clive N. Svendsen, Arun Sharma Cardiovascular toxicity causes adverse drug reactions and may lead to drug removal from the pharmaceutical market. We have developed a cardiac organ-chip using pluripotent stem cells to enhance cell maturity and model drug cardioto...
Source: RSC - Lab Chip latest articles - January 22, 2024 Category: Chemistry Authors: Maedeh Mozneb Source Type: research

High-throughput microfluidic systems accelerated by artificial intelligence for biomedical applications
Lab Chip, 2024, Advance Article DOI: 10.1039/D3LC01012K, Critical ReviewJianhua Zhou, Jianpei Dong, Hongwei Hou, Lu Huang, Jinghong Li This review outlines the current advances of high-throughput microfluidic systems accelerated by AI. Furthermore, the challenges and opportunities in this field are critically discussed as well. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 22, 2024 Category: Chemistry Authors: Jianhua Zhou Source Type: research

Cascaded elasto-inertial separation of malignant tumor cells from untreated malignant pleural and peritoneal effusions
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Chen Ni, Dan Wu, Yao Chen, Silin Wang, Nan Xiang Separation of malignant tumor cells (MTCs) from large background cells in untreated malignant pleural and peritoneal effusions (MPPEs) is critical for improving the sensitivity and efficiency of cytological diagnosis. Herein,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 20, 2024 Category: Chemistry Authors: Chen Ni Source Type: research

Synthesis and protection: a controllable electrochemical approach to polypyrrole-coated copper azide with superior safety for MEMS
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00986F, PaperMinghao Bao, Chunpei Yu, Gexing Yang, Junhong Chen, He Cheng, Jianyong Xu, Wei Shi, Changkun Song, Xiaoting Lei, Zhongbo Han, Wenchao Zhang Traditional lead-based primary explosives present challenges in application to micro-energetics-on-a-chip. It is highly desired but still remains challenging to design a primary explosive for the development of powerful yet safe... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 20, 2024 Category: Chemistry Authors: Minghao Bao Source Type: research

Multi-step PDMS curing and a controlled separation method for mass manufacturing of high-performance and user-friendly micro-devices: valved micropumps
Lab Chip, 2024, Advance Article DOI: 10.1039/D3LC00786C, PaperZhichang Du, Wei Sun, Shengli Mi A multi-step PDMS curing method and a local PDMS separation strategy were proposed to achieve mass, standardized, and low-cost manufacturing of valved micropumps, satisfying a wider range of fluid-driven applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 19, 2024 Category: Chemistry Authors: Zhichang Du Source Type: research

Modelling and breaking down the biophysical barriers to drug delivery in pancreatic cancer
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Delanyo Kpeglo, Malcolm Haddrick, Margaret A. Knowles, Stephen D. Evans, Sally A. Peyman Developing tumour models that recapitulate the biophysical barriers that lead to drug resistance in cancer is critical in assessing new drugs and delivery mechanisms. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 19, 2024 Category: Chemistry Authors: Delanyo Kpeglo Source Type: research

Scalable droplet-based radiosynthesis of [18F]fluorobenzyltriphenylphosphonium cation ([18F]FBnTP) via a “numbering up” approach
Lab Chip, 2024, Advance Article DOI: 10.1039/D3LC01068F, PaperYingqing Lu, Jeffrey Collins, Kuo-Shyan Lin, R. Michael van Dam Rapid, efficient and straightforward radiosynthesis scale-up strategy for droplet-based reactionsvia a numbering up technique. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 19, 2024 Category: Chemistry Authors: Yingqing Lu Source Type: research

Lipid vesicle-based molecular robots
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Zugui Peng, Shoji Iwabuchi, Kayano Izumi, Sotaro Takiguchi, Misa Yamaji, Shoko Fujita, Harune Suzuki, Fumika Kambara, Genki Fukasawa, Aileen Cooney, Lorenzo Di Michele, Yuval Elani, Tomoaki Matsuura, Ryuji Kawano A molecular robot, which is a system comprised of one or more molecular machines and computers, can execute sophisticated tasks in many fields that span from nanomedicine to green nanotechnology. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Socie...
Source: RSC - Lab Chip latest articles - January 19, 2024 Category: Chemistry Authors: Zugui Peng Source Type: research

Oscillating high aspect ratio micro-channels can effectively atomize liquids into uniform aerosol droplets and dial their size on-demand
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00816A, PaperHoai An Nguyen Le, Jason Brenker, Abanoub Shenoda, Zara Sheikh, Jackson Gum, Hui Xin Ong, Daniela Traini, Tuncay Alan Ultrasonic atomization of liquids into micrometer-diameter droplets is crucial across multiple fields, ranging from drug delivery, to spectrometry and printing. Controlling the size and uniformity of the generated droplets on-demand... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 19, 2024 Category: Chemistry Authors: Hoai An Nguyen Le Source Type: research

High-performance magnetic metal microrobot prepared by a two-photon polymerization and sintering method
Lab Chip, 2024, Advance Article DOI: 10.1039/D3LC01084H, PaperRui Li, Modong Jiang, Bingrui Liu, Shaojun Jiang, Chao Chen, Mengxue Liang, Lijie Qu, Chaowei Wang, Gang Zhao, Yanlei Hu, Dong Wu, Jiaru Chu, Jiawen Li A high-performance pure-nickel magnetically-actuated microrobot (Ni-MAR) is printed by a ‘femtosecond laser polymerization + sintering’ method with great potential applications in controlled locomotion in fast-flowing blood and massive drugs delivery. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Sour...
Source: RSC - Lab Chip latest articles - January 18, 2024 Category: Chemistry Authors: Rui Li Source Type: research

Joule heating and electroosmotic flow in cellular micro/nano electroporation
Lab Chip, 2024, Advance Article DOI: 10.1039/D3LC00568B, PaperJunjie Pan, Xinyu Wang, Chi-ling Chiang, Yifan Ma, Junao Cheng, Paul Bertani, Wu Lu, L. James Lee Joule heating and electrokinetic phenomena in micro/nano-electroporation (MEP/NEP) is investigated. An ‘electroporation zone’ is defined for NEP/MEP to avoid the negative impact of Joule heating and electro-osmosis on cargo transport. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 18, 2024 Category: Chemistry Authors: Junjie Pan Source Type: research

Single-cell fluid-based force spectroscopy reveals near lipid size nano-topography effects on neural cell adhesion
Lab Chip, 2024, Advance Article DOI: 10.1039/D3LC00984J, PaperZeina Habli, Rima Lahoud, Ahmad Zantout, Wassim Abou-Kheir, Massoud L. Khraiche Nano-topography of polyimide surfaces plays a critical role in determining neural cellular adhesion. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 17, 2024 Category: Chemistry Authors: Zeina Habli Source Type: research

Progress in developing microphysiological systems for biological product assessment
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Mona Mansouri, Johnny Lam, Kyung E. Sung This review delves into microphysiological systems, miniature physiological environments used to evaluate biological products, reducing the need for animal experimentation. We consider their benefits as well as persistent challenges in material selection/fabrication and reproducibility. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 17, 2024 Category: Chemistry Authors: Mona Mansouri Source Type: research

Centrifugal microfluidic system for colorimetric sample-to-answer detection of viral pathogens
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Matthias Geissler, Daniel Brassard, Nadine Adam, Neda Nasheri, Ana Victoria C. Pilar, Kyle Tapp, Liviu Clime, Caroline Miville-Godin, Maxence Mounier, Christina Nassif, Ljuboje Lukic, Lidija Malic, Nathalie Corneau, Teodor Veres Automated on-chip sample-to-answer workflow for multiplexed colorimetric detection of foodborne viruses using an embedded polymer micropillar array for read-out. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society o...
Source: RSC - Lab Chip latest articles - January 16, 2024 Category: Chemistry Authors: Matthias Geissler Source Type: research

Separation of platelets by size in a microfluidic device based on controlled incremental filtration
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00842H, PaperMai T.P. Dinh, Anton Mukhamedshin, Kumar Abhishek, Fong W. Lam, Sean C. Gifford, Sergey S. Shevkoplyas The significant biological and functional differences between small and large platelets suggested by recent studies could have profound implications for transfusion medicine. However, investigating the relationship between platelet size and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - January 16, 2024 Category: Chemistry Authors: Mai T.P. Dinh Source Type: research