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Total 791 results found since Jan 2013.

Role of Connexins and Pannexins in Ischemic Stroke.
Abstract Synaptic plasticity requires the careful synchronization and coordination of neurons and glial cells via various mechanisms of intercellular communication. Among them, are those mediated by i) connexin gap junction channels (GJCs), ii) connexin hemichannels and iii) pannexin channels. Whereas GJCs directly communicate the cytoplasm of contacting cells and coordinate electric and metabolic activities, connexin hemichannels and pannexin channels serve as diffusional pathways for ions and small molecules between the intra- and extracellular compartments. A growing body of evidence has revealed that intercell...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Orellana JA, Avendaño BC, Montero TD Tags: Curr Med Chem Source Type: research

Neuroprotective Effects of Ginkgolide B against Ischemic Stroke: a Review of Current Literature.
Abstract Extensive evidences have shown the promising effects of Ginkgo biloba consumption on several diseases such as Alzheimer, Parkinson, ischemic stroke, etc. Several studies also reported its beneficial role on motor activity and cognitive function. This species contain unique class of diterpene, namely Ginkgolide B, which possess several pharmacological activities such as protective effect against cardiovascular disease; the most important causes of death worldwide. The promising effects of Ginkgolide B on stroke, both ischemic and hemorrhagic, are suggested by an overwhelming body of scientific evidences. M...
Source: Current Topics in Medicinal Chemistry - June 10, 2015 Category: Chemistry Authors: Nabavi SM, Habtemariam S, Daglia M, Braidy N, Loizzo MR, Tundis R, Nabavi SF Tags: Curr Top Med Chem Source Type: research

Predictive value of thrombospondin-1 for outcomes in patients with acute ischemic stroke.
CONCLUSIONS: Plasma thrombospondin-1 concentrations are elevated obviously and are highly associated with long-term outcome of ischemic stroke. PMID: 26296896 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - August 19, 2015 Category: Chemistry Authors: Gao JB, Tang WD, Wang HX, Xu Y Tags: Clin Chim Acta Source Type: research

The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors Signal Transduction
We previously reported that the cell cycle–related cyclin-dependent kinase 4–retinoblastoma (RB) transcriptional corepressor pathway is essential for stroke-induced cell death both in vitro and in vivo. However, how this signaling pathway induces cell death is unclear. Previously, we found that the cyclin-dependent kinase 4 pathway activates the pro-apoptotic transcriptional co-regulator Cited2 in vitro after DNA damage. In the present study, we report that Cited2 protein expression is also dramatically increased following stroke/ischemic insult. Critically, utilizing conditional knockout mice, we show that Cited2 is r...
Source: Journal of Biological Chemistry - May 23, 2019 Category: Chemistry Authors: Tianwen Huang, Yasmilde Rodriguez Gonzalez, Dianbo Qu, En Huang, Farzaneh Safarpour, Eugene Wang, Alvin Joselin, Doo Soon Im, Steve M. Callaghan, Wassamon Boonying, Lisa Julian, Sally L. Dunwoodie, Ruth S. Slack, David S. Park Tags: Molecular Bases of Disease Source Type: research

Functionalized silicon dioxide self-referenced plasmonic chip as point-of-care biosensor for stroke biomarkers NT-proBNP and S100 β.
In this study, a self-referenced PWR (SRPWR) silicon dioxide (SiO2) chip was examined. The self-referenced measurement is important to compensate for temperature fluctuations, other instabilities and allows RI signal measurement without an additional reference sample, thus minimising the sample volume needed. The chip was fabricated with a multi-layer of metals and dielectrics, consisting of a 420 nm SiO2 layer, a 40 nm Ag layer and another 480 nm SiO2 layer. This chip was shown to give one internal plasmon excited on the bottom interface SiO2/Ag, which is used as self-reference in the detection. The top layer acts as a...
Source: Talanta - March 3, 2020 Category: Chemistry Authors: Harpaz D, Koh B, Seet RCS, Abdulhalim I, Tok AIY Tags: Talanta Source Type: research

Meta ‐Analyzing Count Events over Varying Durations Using the Piecewise Poisson Model:The Case for Post Stroke Seizures
This article is protected by copyright. All rights reserved.
Source: Research Synthesis Methods - November 1, 2020 Category: Chemistry Authors: Wei ‐Jhih Wang, Beth Devine, Aasthaa Bansal, H. Steve White, Anirban Basu Tags: RESEARCH ARTICLE Source Type: research

Monitoring of the decreased mitochondrial viscosity during heat stroke with a mitochondrial AIE probe
Anal Bioanal Chem. 2021 May 2. doi: 10.1007/s00216-021-03335-2. Online ahead of print.ABSTRACTHeat stroke is a fatal condition which usually results in central nervous system dysfunction, organism damage and even death. The relationship between heat stroke and mitochondria is still relatively unknown due to a lack of suitable tools. Herein, an aggregation-induced emission (AIE) probe CSP, by introducing a pyridinium cation as the mitochondria-targeted group to an AIE active core cyanostilbene skeleton, is highly sensitive to viscosity changes due to the restriction of intramolecular motion (RIM) and inhibition of twisted i...
Source: Analytical and Bioanalytical Chemistry - May 2, 2021 Category: Chemistry Authors: Yuewei Zhang Shuohang Wang Xiaodong Wang Qi Zan Xue Yu Li Fan Chuan Dong Source Type: research

Inflammation, Oxidative Stress, Vascular Aging And Atherosclerotic Ischemic Stroke
Curr Med Chem. 2021 Sep 21. doi: 10.2174/0929867328666210921161711. Online ahead of print.ABSTRACTVascular aging is a crucial risk factor for atherosclerotic ischemic stroke. Vascular aging is characterized by oxidative stress, endothelial dysfunction, inflammation, intimal and media thickening, as well as the gradual development of arterial stiffness, among other pathophysiological features. Regarding oxidative stress, increased concentration of reactive oxygen and nitrogen species is linked to atherosclerotic ischemic stroke in vascular aging. Additionally, oxidative stress is associated with an inflammatory response. In...
Source: Current Medicinal Chemistry - September 22, 2021 Category: Chemistry Authors: Ioannis K Koutsaliaris Iraklis C Moschonas Louisa M Pechlivani Aikaterini N Tsouka Alexandros D Tselepis Source Type: research

Molecules, Vol. 27, Pages 3099: The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke
This study aims to update and summarize the signaling pathways and targets of natural compounds in the treatment of IS, and provide a base of information for the future development of effective treatments for IS.
Source: Molecules - May 12, 2022 Category: Chemistry Authors: Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang Tags: Review Source Type: research

Discovery of phenylcarbamoyl xanthone derivatives as potent neuroprotective agents for treating ischemic stroke
Eur J Med Chem. 2023 Mar 7;251:115251. doi: 10.1016/j.ejmech.2023.115251. Online ahead of print.ABSTRACTCompounds of natural sources are widespread discovered in the treatment of ischemic stroke. Alpha-mangostin, a natural prenylated xanthone, has been found to display a therapeutic potential to treat ischemic stroke. However, the direct application of α-mangostin is limited due to its cytotoxicity and relatively low efficacy. Herein, structural modification of α-mangostin was necessary to improve its drug-ability. Currently, 34 α-mangostin phenylcarbamoyl derivatives were synthesized and evaluated for their neuroprotec...
Source: European Journal of Medicinal Chemistry - March 15, 2023 Category: Chemistry Authors: Yi-Li Chen Yu-Chen Chen Lin-An Xiong Qu-Yang Huang Ting-Ting Gong Yan Chen Lie-Feng Ma Luo Fang Zha-Jun Zhan Source Type: research

Development of sertraline analogues as potential anti-ischemic stroke agents
Eur J Med Chem. 2023 Mar 15;252:115273. doi: 10.1016/j.ejmech.2023.115273. Online ahead of print.ABSTRACTIschemic stroke (IS) is harmful to human health and social development, and there is no medicine available at present. To find the hit compound for treating ischemic stroke, we screened 28 FDA approved nervous system drugs by using an in vitro OGD-induced stroke model. Notably, our in vitro and in vivo studies demonstrated that low-dose sertraline had good neuroprotective activities, while high-dose sertraline showed significant toxicity. Interestingly, the same high-dose sertraline in the control group did not exhibit ...
Source: European Journal of Medicinal Chemistry - March 22, 2023 Category: Chemistry Authors: Xin Chen Hong-Yuan Liu Sheng-Li Niu Ting Zhou Wen Yuan Peng-Fei Zheng Qiong Chen Su-Lan Luo Jing Gu Dong-Ting Zhangsun Qin Ouyang Source Type: research