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Molecules, Vol. 21, Pages 1191: Pharmacokinetic Comparison of Scutellarin and Paeoniflorin in Sham-Operated and Middle Cerebral Artery Occlusion Ischemia and Reperfusion Injury Rats after Intravenous Administration of Xin-Shao Formula
Xin-Shao formula is a folk remedy widely used in China to prevent and cure stroke. Cerebral ischemic reperfusion (I/R) injury often takes place during the treatment of stroke. Information about the pharmacokinetic behavior of the remedy under cerebral I/R injury conditions is lacking. The present study aimed to compare the pharmacokinetic properties of scutellarin and paeoniflorin, two major bioactive components of Xin-Shao formula, under physiological state in cerebral I/R injury rats. Neurobehavioral dysfunction was evaluated and cerebral infarcted volume was measured in middle cerebral artery occlusion I/R injury (MCAO)...
Source: Molecules - September 6, 2016 Category: Chemistry Authors: Yueting Li Yuan Lu Jianchun Hu Zipeng Gong Wu Yang Aimin Wang Jiang Zheng Ting Liu Tingting Chen Jie Hu Ling Mi Yongjun Li Yanyu Lan Yonglin Wang Tags: Article Source Type: research
Application of Biomarkers for Risk Stratification in Patients with Atrial Fibrillation Reviews
BACKGROUND:
Atrial fibrillation is the most common sustained arrhythmia and an important contributor to cardiovascular morbidity and mortality. Several strategies have been proposed for prediction of outcomes and individualization of treatments to better balance the benefits of stroke prevention and risks of bleeding during anticoagulation.
CONTENT:
The availability of analytically more specific and sensitive methods to measure circulating biomarkers of cellular and organ stress and dysfunction has led to testing of their utility in several cardiovascular conditions. In patients with atrial fibrillation, biomarkers of myo...
Source: Clinical Chemistry - December 29, 2016 Category: Chemistry Authors: Hijazi, Z., Oldgren, J., Siegbahn, A., Wallentin, L. Tags: Proteomics and Protein Markers Reviews Source Type: research
High-Sensitivity Troponin I in Stable Patients with Atherosclerotic Disease in the TRA 2{degrees}P - TIMI 50 Trial Lipids, Lipoproteins, and Cardiovascular Risk Factors
CONCLUSIONS:
In stable patients with established atherosclerosis, hs-TnI concentrations effectively stratified the risk of new or recurrent cardiovascular (CV) events, in particular CV death and MI. High-risk patients with prior MI identified by increased hs-TnI had a substantial absolute improvement in net clinical outcome with vorapaxar.
Source: Clinical Chemistry - December 29, 2016 Category: Chemistry Authors: Eisen, A., Bonaca, M. P., Jarolim, P., Scirica, B. M., White, H. D., Tendera, M., Dellborg, M., Nicolau, J. C., Morais, J., Fox, K. A. A., Bohula, E. A., Murphy, S. A., Braunwald, E., Morrow, D. A. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Source Type: research
Molecules, Vol. 22, Pages 273: Synthesis and Positive Inotropic Activity of 1,2,4Triazolo4,3-a Quinoxaline Derivatives Bearing Substituted Benzylpiperazine and Benzoylpiperazine Moieties
In an attempt to search for more potent positive inotropic agents, two series of [1,2,4]triazolo[4,3-a] quinoxaline derivatives bearing substituted benzylpiperazine and benzoylpiperazine moieties were synthesized and their positive inotropic activities evaluated by measuring left atrial stroke volume in isolated rabbit heart preparations. Several compounds showed favorable activities compared with the standard drug, milrinone. Compound 6c was the most potent agent, with an increased stroke volume of 12.53% ± 0.30% (milrinone: 2.46% ± 0.07%) at 3 × 10−5 M. The chronotropic effects of compounds having considerable inotr...
Source: Molecules - February 10, 2017 Category: Chemistry Authors: Xue-Kun Liu Long-Xu Ma Zhi-Yu Wei Xun Cui Shi Zhan Xiu-Mei Yin Hu-Ri Piao Tags: Article Source Type: research
Sex-Genetic Interaction in the Risk for Cerebrovascular Disease.
Abstract
Cerebrovascular disease (CeVD) is one of the major cause of death and a leading cause of disability worldwide. CeVD is a complex and multifactorial disease caused by the interaction of environment and genetic factors. Women have lower CeVD incidence than men until an advanced age, when the incidence of CeVD rises dramatically in women. Therefore, sex has been validated as an important risk factor in the etiology of CeVD, especially ischemic stroke. Although the importance of sex steroids have been heavily studied in the mechanism of neuronal injury, the experimental and clinical data suggest that hormones...
Source: Current Medicinal Chemistry - April 17, 2017 Category: Chemistry Authors: Pastore D, Pacifici F, Capuani B, Palmirotta R, Dong C, Coppola A, Abete P, Roselli M, Sbraccia P, Guadagni F, Lauro D, Rundek T, Della-Morte D Tags: Curr Med Chem Source Type: research
Macrophage migration inhibitory factor levels in serum from patients with acute intracerebral hemorrhage: Potential contribution to prognosis.
CONCLUSIONS: MIF in serum might be a potential biomarker for reflecting inflammation, severity and prognosis of ICH patients.
PMID: 28729134 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - July 17, 2017 Category: Chemistry Authors: Lin Q, Cai JY, Lu C, Sun J, Ba HJ, Chen MH, Chen XD, Dai JX, Lin JH Tags: Clin Chim Acta Source Type: research
Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection Cell Biology
Docosahexaenoic acid, enriched in the brain and retina, generates docosanoids in response to disruptions of cellular homeostasis. Docosanoids include neuroprotectin D1 (NPD1), which is decreased in the CA1 hippocampal area of patients with early-stage Alzheimer's disease (AD). We summarize here how NPD1 elicits neuroprotection by up-regulating c-REL, a nuclear factor (NF)-κB subtype that, in turn, enhances expression of BIRC3 (baculoviral inhibitor of apoptosis repeat-containing protein 3) in the retina and in experimental stroke, leading to neuroprotection. Elucidating the mechanisms of action of docosanoids will contrib...
Source: Journal of Biological Chemistry - July 28, 2017 Category: Chemistry Authors: Aram Asatryan, Nicolas G. Bazan Tags: Minireviews Source Type: research
Effect of anisotropic thermal expansion on the torsional actuation of twist oriented polymer fibres
Publication date: 27 October 2017 Source:Polymer, Volume 129 Author(s): Shazed Aziz, Sina Naficy, Javad Foroughi, Hugh R. Brown, Geoffrey M. Spinks Torsional actuation of twisted polymer fibres is the basis for high performance tensile actuation when these fibres are formed into coils. The thermally-induced torsional actuation of twisted polyamide-6 fibres can be predicted by a single helix approximation when the measured diameter and length direction thermal expansion coefficients are known. The single helix model illustrates the sensitivity of the magnitude of torsional actuation to the volume expansion anisotropy for a...
Source: Polymer - October 1, 2017 Category: Chemistry Source Type: research
Homocysteine in non-valvular atrial fibrillation: Role and clinical implications.
Abstract
Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with a series of adverse complications that cause so-called AF socioeconomic burden. Apart from the classical risk factors, it seems to be novel factors that increase the risk of AF and AF-related stroke. Recently, more and more evidence has well documented the close relationships between homocysteine (Hcy) and AF. As a well-known marker for pro-oxidation and pro-inflammation, Hcy plays an important role in a number of vascular diseases having strong association with AF. This review will discuss the expression of Hcy and its ass...
Source: International Journal of Clinical Chemistry - October 16, 2017 Category: Chemistry Authors: Yao Y, Shang MS, Dong JZ, Ma CS Tags: Clin Chim Acta Source Type: research
Urokinase-type plasminogen activator (uPA) promotes ezrin-mediated reorganization of the synaptic cytoskeleton in the ischemic brain Molecular Bases of Disease
Synaptic repair in the ischemic brain is a complex process that requires reorganization of the actin cytoskeleton. Ezrin, radixin, and moesin (ERM) are a group of evolutionarily conserved proteins that link the plasma membrane to the actin cytoskeleton and act as scaffolds for signaling transduction. Urokinase-type plasminogen activator (uPA) is a serine proteinase that upon binding to the urokinase-type plasminogen activator receptor (uPAR) catalyzes the conversion of plasminogen into plasmin on the cell surface and activates intracellular signaling pathways. Early studies indicate that uPA and uPAR expression increase du...
Source: Journal of Biological Chemistry - June 15, 2018 Category: Chemistry Authors: Paola Merino, Ariel Diaz, Luis Guillermo Manrique, Lihong Cheng, Manuel Yepes Tags: Neurobiology Source Type: research
Molecules, Vol. 23, Pages 1747: Preparation, Characterization, Pharmacokinetics and Biodistribution of Baicalin-Loaded Liposome on Cerebral Ischemia-Reperfusion after i.v. Administration in Rats
In conclusion, BA-LP might be a potential drug delivery system to improve the therapeutic efficacy of BA. In addition, these results also suggest that the pathological damages of ischemia-reperfusion have a significant impact on the pharmacokinetic traits of BA.
Source: Molecules - July 17, 2018 Category: Chemistry Authors: Nan Li Lingling Feng Yujun Tan Yan Xiang Ruoqi Zhang Ming Yang Tags: Article Source Type: research
Serum myeloperoxidase concentrations for outcome prediction in acute intracerebral hemorrhage.
CONCLUSIONS: Serum MPO concentrations rise in ICH patients and there is a correlation between MPO concentrations and severity or prognosis.
PMID: 30347182 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - October 19, 2018 Category: Chemistry Authors: Zheng GR, Chen B, Shen J, Qiu SZ, Yin HM, Mao W, Wang HX, Gao JB Tags: Clin Chim Acta Source Type: research
Molecules, Vol. 23, Pages 2828: 8e Protects against Acute Cerebral Ischemia by Inhibition of PI3K γ-Mediated Superoxide Generation in Microglia
Molecules, Vol. 23, Pages 2828: 8e Protects against Acute Cerebral Ischemia by Inhibition of PI3Kγ-Mediated Superoxide Generation in Microglia
Molecules doi: 10.3390/molecules23112828
Authors:
Linna Wang
Xiaoli Wang
Tingting Li
Yihua Zhang
Hui Ji
The inflammatory response mediated by microglia plays a critical role in the progression of ischemic stroke. Phosphoinositide 3-kinase gamma (PI3Kγ) has been implicated in multiple inflammatory and autoimmune diseases, making it a promising target for therapeutic intervention. The aim of this study was to evaluate the efficacy of 8e, a hydrogen sulfi...
Source: Molecules - October 31, 2018 Category: Chemistry Authors: Linna Wang Xiaoli Wang Tingting Li Yihua Zhang Hui Ji Tags: Article Source Type: research
ASAP New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( < italic toggle="yes" > Z < /italic > )- < italic toggle="yes" > N < /italic > - < italic toggle="yes" > tert < /italic > -Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01987
Source: Journal of Medicinal Chemistry - February 15, 2019 Category: Chemistry Authors: Mourad Chioua, Emma Mart ínez-Alonso, Rafael Gonzalo-Gobernado, Maria I. Ayuso, Alejandro Escobar-Peso, Lourdes Infantes, Dimitra Hadjipavlou-Litina, Juan J. Montoya, Joan Montaner, Alberto Alcázar, José Marco-Contelles Source Type: research
Molecules, Vol. 24, Pages 1722: Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats
The objective of the present work was to study the neuroprotective activity of a new specific JNK inhibitor, IQ-1S (11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt), in the model of global cerebral ischemia (GCI) in rats compared with citicoline (cytidine-5&prime;-diphosphocholine), a drug approved for the treatment of acute ischemic stroke and to search for pleiotropic mechanisms of neuroprotective effects of IQ-1S. The experiments were performed in a rat model of ischemic stroke with three-vessel occlusion (model of 3VO) affecting the brachiocephalic artery, the left subclavian artery, and the left common ca...
Source: Molecules - May 2, 2019 Category: Chemistry Authors: Mark B. Plotnikov Galina A. Chernysheva Oleg I. Aliev Vera I. Smol ’iakova Tatiana I. Fomina Anton N. Osipenko Victoria S. Rydchenko Yana J. Anfinogenova Andrei I. Khlebnikov Igor A. Schepetkin Dmitriy N. Atochin Tags: Article Source Type: research
