[ASAP] Design and Discovery of Natural Cyclopeptide Skeleton Based Programmed Death Ligand 1 Inhibitor as Immune Modulator for Cancer Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01262 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 21, 2020 Category: Chemistry Authors: Haixia Sun, Daoyuan Chen, Siyue Zhan, Weijian Wu, Huiying Xu, Chunxiang Luo, Hui Su, Yanqiao Feng, Weiyan Shao, Arabella Wan, Binhua Zhou, Guohui Wan, and Xianzhang Bu Source Type: research

[ASAP] Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00654 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 21, 2020 Category: Chemistry Authors: Konstantin Hinnah, Sabine Willems, Johannes Morstein, Jan Heering, Felix W. W. Hartrampf, Johannes Broichhagen, Philipp Leippe, Daniel Merk, and Dirk Trauner Source Type: research

[ASAP] Development of Nonpeptidic Inverse Agonists of the Ghrelin Receptor (GHSR) Based on the 1,2,4-Triazole Scaffold
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02122 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 21, 2020 Category: Chemistry Authors: Khoubaib Ben Haj Salah, Mathieu Maingot, Anne-Laure Blayo, Ce ́line M’Kadmi, Marjorie Damian, Sophie Mary, Sonia Cantel, Jérémie Neasta, Catherine Oiry, Sylvie Péraldi-Roux, Gimena Fernandez, Guadalupe García Romero, Mario Perello, Jacky Marie, Source Type: research

[ASAP] Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00223 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 21, 2020 Category: Chemistry Authors: Tong Zhao, Qing Meng, Zhuosen Sun, Yanyu Chen, Wei Ai, Zean Zhao, Dongwei Kang, Yue Dong, Ruipeng Liang, Ting Wu, Jianxin Pang, Xinyong Liu, and Peng Zhan Source Type: research

[ASAP] Synthesis and Evaluation of 4-Hydroxycoumarin Imines as Inhibitors of Class II Myosins
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01062 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Jhonnathan Brawley, Emily Etter, Dante Heredia, Amarawan Intasiri, Kyle Nennecker, Joshua Smith, Brandon M. Welcome, Richard K. Brizendine, Thomas W. Gould, Thomas W. Bell, and Christine Cremo Source Type: research

[ASAP] Recent Advances on Nitrones Design for Stroke Treatment < subtitle > Miniperspective < /subtitle >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00976 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Jose ́ Marco-Contelles Source Type: research

[ASAP] Design, Synthesis, and Structure –Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein–Protein Interaction Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01116 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Hai-Shan Zhou, Lv-Bin Hu, Han Zhang, Wen-Xin Shan, Yan Wang, Xue Li, Tian Liu, Jing Zhao, Qi-Dong You, and Zheng-Yu Jiang Source Type: research

[ASAP] DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00545 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Katsuhiko Mitachi, Rita G. Kansal, Kirk E. Hevener, Cody D. Gillman, Syed M. Hussain, Hyun Gi Yun, Gustavo A. Miranda-Carboni, Evan S. Glazer, William M. Clemons, Jr., and Michio Kurosu Source Type: research

[ASAP] Bifunctional and Unusual Amino Acid β- or γ-Ester Prodrugs of Nucleoside Analogues for Improved Affinity to ATB < sup > 0,+ < /sup > and Enhanced Metabolic Stability: An Application to Floxuridine
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00149 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Yongbing Sun, Yu Ke, Chunshi Li, Jian Wang, Liangxing Tu, Lvjiang Hu, Yi Jin, Hao Chen, Jianping Gong, and Zhiqiang Yu Source Type: research

[ASAP] Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01006 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Lucy Lin, Margaret E. Olson, Takashi Sugane, Lewis D. Turner, Margarita A. Tararina, Alexander L. Nielsen, Elbek K. Kurbanov, Sabine Pellett ■, Eric A. Johnson■, Seth M. Cohen, Karen N. Allen, and Kim D. Janda Source Type: research

[ASAP] Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00640 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Kim Huard, Aaron C. Smith, Gregg Cappon, Robert L. Dow, David J. Edmonds, Ayman El-Kattan, William P. Esler, Dilinie P. Fernando, David A. Griffith, Amit S. Kalgutkar, Trenton T. Ross, Scott W. Bagley, David Beebe, Yi-An Bi, Shawn Cabral, Collin Crowley, Source Type: research

[ASAP] Correction to Synthesis and Antichlamydial Activity of Molecules Based on Dysregulators of Cylindrical Proteases
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01490 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Mohamed A. Seleem, Nathalia Rodrigues de Almeida, Yashpal Singh Chhonker, Daryl J. Murry, Zaira da Rosa Guterres, Amanda M. Blocker, Shiomi Kuwabara, Derek J. Fisher, Emilse S. Leal, Manuela R. Martinefski, Mariela Bollini, Mari ́a Eugenia Monge, Scot P. Source Type: research

[ASAP] Identification, Structure –Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1 < italic toggle="yes" > H < /italic > -pyrido[4,3- < italic toggle="yes" > b < /italic > ]indoles as a Novel Class of CFTR Potentiators
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01050 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 18, 2020 Category: Chemistry Authors: Nicoletta Brindani, Ambra Gianotti, Simone Giovani, Francesca Giacomina, Paolo Di Fruscia, Federico Sorana ⧫, Sine Mandrup Bertozzi, Giuliana Ottonello, Luca Goldoni, Ilaria Penna, Debora Russo, Maria Summa, Rosalia Bertorelli, Loretta Ferrera, Emanuela Source Type: research

[ASAP] Novel 2-Substituted 3-Hydroxy-1,6-dimethylpyridin-4(1 < italic toggle="yes" > H < /italic > )-ones as Dual-Acting Biofilm Inhibitors of < italic toggle="yes" > Pseudomonas aeruginosa < /italic >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00763 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 17, 2020 Category: Chemistry Authors: Jun Liu, Jin-Song Hou, Yi-Bin Li, Zhi-Ying Miao, Ping-Hua Sun, Jing Lin, and Wei-Min Chen Source Type: research

[ASAP] Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00949 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 17, 2020 Category: Chemistry Authors: Markus Schade, Beatrix Merla, Bernhard Lesch, Markus Wagener, Simone Timmermanns, Katrien Pletinckx, and Torsten Hertrampf Source Type: research

[ASAP] Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00744 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 17, 2020 Category: Chemistry Authors: Tizhi Wu, Zhen Qin, Yucheng Tian, Jubo Wang, Chenxi Xu, Zhiyu Li, and Jinlei Bian Source Type: research

[ASAP] Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01128 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 17, 2020 Category: Chemistry Authors: Cheng Wang, Shang Li, Jinhua Zhao, Huali Yang, Fucheng Yin, Ming Ding, Jianguang Luo, Xiaobing Wang, and Lingyi Kong Source Type: research

[ASAP] Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00956 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 17, 2020 Category: Chemistry Authors: John T. Randolph, Eric A. Voight, Stephen N. Greszler, Brice E. Uno, James N. Newton, Kenneth M. Gleason, DeAnne Stolarik, Cecilia Van Handel, Daniel A. J. Bow, and David A. DeGoey Source Type: research

[ASAP] Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00996 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 17, 2020 Category: Chemistry Authors: Christopher L. Cioffi, Parthasarathy Muthuraman, Arun Raja, Andras Varadi, Boglarka Racz, and Konstantin Petrukhin Source Type: research

[ASAP] Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00842 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 16, 2020 Category: Chemistry Authors: Yuqin Ma, Qichao Luo, Jie Fu, Yanxin Che, Fei Guo, Lianghe Mei, Qiansen Zhang, Yang Li, and Huaiyu Yang Source Type: research

[ASAP] Anti- < italic toggle="yes" > Giardia < /italic > Drug Discovery: Current Status and Gut Feelings
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00910 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 16, 2020 Category: Chemistry Authors: Andrew Riches, Christopher J. S. Hart, Katharine R. Trenholme, and Tina S. Skinner-Adams Source Type: research

[ASAP] Discovery of Potent and Selective PI3K γ Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01203 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 16, 2020 Category: Chemistry Authors: Samuel L. Drew, Rhiannon Thomas-Tran, Joel W. Beatty, Jeremy Fournier, Kenneth V. Lawson, Dillon H. Miles, Guillaume Mata, Ehesan U. Sharif, Xuelei Yan, Artur K. Mailyan, Elaine Ginn, Jie Chen, Kent Wong, Divyank Soni, Puja Dhanota, Pei-Yu Chen, Stefan G. Source Type: research

[ASAP] Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01049 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 15, 2020 Category: Chemistry Authors: Stefano Federico, Luca Pozzetti, Alessandro Papa, Gabriele Carullo, Sandra Gemma, Stefania Butini, Giuseppe Campiani, and Nicola Relitti Source Type: research

[ASAP] Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00825 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 15, 2020 Category: Chemistry Authors: Ine ̀s Li de la Sierra-Gallay, Mathilde Belnou, Béatrice Chambraud, Melanie Genet, Herman van Tilbeurgh, Magali Aumont-Nicaise, Michel Desmadril, Etienne-Emile Baulieu, Yves Jacquot, and Cillian Byrne Source Type: research

[ASAP] Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01044 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 15, 2020 Category: Chemistry Authors: Jenna L. Jeffrey, Kenneth V. Lawson, and Jay P. Powers Source Type: research

[ASAP] Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T Cell-Mediated Antitumor Responses and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00489 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 14, 2020 Category: Chemistry Authors: Ozgun Kilic, Marcos R. Matos de Souza, Abdulaziz A. Almotlak, Yiao Wang, Jill M. Siegfried, Mark D. Distefano, and Carston R. Wagner Source Type: research

[ASAP] Correction to Bicyclic α-Iminophosphonates as High Affinity Imidazoline I < sub > 2 < /sub > Receptor Ligands for Alzheimer ’s Disease
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01324 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 14, 2020 Category: Chemistry Authors: So ̀nia Abás, Sergio Rodríguez-Arévalo, Andrea Bagán, Christian Griñán-Ferré, Foteini Vasilopoulou, Iria Brocos-Mosquera, Carolina Muguruza, Belén Pérez, Elies Molins, F. Javier Luque, Pilar Pérez-Lozano, Steven de Jonghe, Dirk Daelem Source Type: research

[ASAP] XGen: Real-Space Fitting of Complex Ligand Conformational Ensembles to X-ray Electron Density Maps
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01373 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 14, 2020 Category: Chemistry Authors: Ajay N. Jain, Ann E. Cleves, Alexander C. Brueckner, Charles A. Lesburg, Qiaolin Deng, Edward C. Sherer, and Mikhail Y. Reibarkh Source Type: research

[ASAP] Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01125 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 14, 2020 Category: Chemistry Authors: Se ́bastien L. Degorce, Omid Tavana, Erica Banks, Claire Crafter, Lakshmaiah Gingipalli, David Kouvchinov, Yumeng Mao, Fiona Pachl, Anisha Solanki, Viia Valge-Archer, Bin Yang, and Scott D. Edmondson Source Type: research

[ASAP] Correction to “Bifunctional Naphtho[2,3- < italic toggle="yes" > d < /italic > ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects < italic toggle="yes" > In Vitro < /italic > and < italic toggle="yes" > In Vivo < /italic > by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production ”
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01455 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 14, 2020 Category: Chemistry Authors: Zeping Zuo, Xiaocong Liu, Xinying Qian, Ting Zeng, Na Sang, Huan Liu, Yue Zhou, Lei Tao, Xia Zhou, Na Su, Yamei Yu, Qiang Chen, Youfu Luo, and Yinglan Zhao Source Type: research

[ASAP] Discovery of < italic toggle="yes" > N < /italic > -Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors —Design, Synthesis, < italic toggle="yes" > In Vivo < /italic > Glucose Lowering Effects, and X-ray Crystal Complex Analysis
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00726 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 12, 2020 Category: Chemistry Authors: Jie Zhou, Jianbo Bie, Xiaoyu Wang, Quan Liu, Rongcui Li, Hualong Chen, Jinping Hu, Hui Cao, Wenming Ji, Yan Li, Shuainan Liu, Zhufang Shen, and Bailing Xu Source Type: research

[ASAP] DFG-1 Binding: A New Residue for Developing Selective Kinase Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01501 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 11, 2020 Category: Chemistry Authors: Erik B. Faber and Gunda I. Georg Source Type: research

[ASAP] Characterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00728 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 11, 2020 Category: Chemistry Authors: Andrea Shergalis, Ding Xue, Fatma Z. Gharbia, Hannah Driks, Binita Shrestha, Amina Tanweer, Kirin Cromer, Mats Ljungman, and Nouri Neamati Source Type: research

[ASAP] Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00961 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 11, 2020 Category: Chemistry Authors: Katja Silbermann, Jiyang Li, Vigneshwaran Namasivayam, Fabian Baltes, Gerd Bendas, Sven Marcel Stefan, and Michael Wiese Source Type: research

[ASAP] Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00626 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 11, 2020 Category: Chemistry Authors: Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zifeng Yang, and Jianxin Chen Source Type: research

[ASAP] The Essential Medicinal Chemistry of Cannabidiol (CBD)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00724 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 10, 2020 Category: Chemistry Authors: Kathryn M. Nelson, Jonathan Bisson, Gurpreet Singh, James G. Graham, Shao-Nong Chen, J. Brent Friesen, Jayme L. Dahlin, Matthias Niemitz, Michael A. Walters, and Guido F. Pauli Source Type: research

[ASAP] Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00939 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 9, 2020 Category: Chemistry Authors: Satoshi Endo, Hiroaki Oguri, Jin Segawa, Mina Kawai, Dawei Hu, Shuang Xia, Takuya Okada, Katsumasa Irie, Shinya Fujii, Hiroaki Gouda, Kazuhiro Iguchi, Takuo Matsukawa, Naohiro Fujimoto, Toshiyuki Nakayama, Naoki Toyooka, Toshiyuki Matsunaga ⧫, and Akira Source Type: research

[ASAP] Discovery of Potent Small-Molecule SIRT6 Activators: Structure –Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01183 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 9, 2020 Category: Chemistry Authors: Xiuli Chen, Weining Sun, Shenzhen Huang, Hailin Zhang, Guifeng Lin, Hui Li, Jingxin Qiao, Linli Li, and Shengyong Yang Source Type: research

[ASAP] Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01086 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 9, 2020 Category: Chemistry Authors: Xiaohui Du, Jared Moore, Brian R. Blank, John Eksterowicz, Dena Sutimantanapi, Natalie Yuen, Todd Metzger, Brenda Chan, Tom Huang, Xi Chen, Yuping Chen, Frank Duong, Wayne Kong, Jae H. Chang, Jessica Sun, Tatiana Zavorotinskaya, Qiuping Ye, Melissa R. Jun Source Type: research

[ASAP] Platinum-Based Combination Therapy: Molecular Rationale, Current Clinical Uses, and Future Perspectives
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00950 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 9, 2020 Category: Chemistry Authors: Chunqiu Yu, Zhibin Wang, Zeren Sun, Lei Zhang, Wanwan Zhang, Yungen Xu, and Jing-Jing Zhang Source Type: research

[ASAP] Design and Identification of a GPR40 Full Agonist ( < bold > SCO-267 < /bold > ) Possessing a 2-Carbamoylphenyl Piperidine Moiety
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00843 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 9, 2020 Category: Chemistry Authors: Hideki Furukawa, Yasufumi Miyamoto, Yasuhiro Hirata, Koji Watanabe, Yuko Hitomi, Yayoi Yoshitomi, Jumpei Aida, Naoyoshi Noguchi, Nobuyuki Takakura, Kazuaki Takami, Seiji Miwatashi, Yoshihiko Hirozane, Teruki Hamada, Ryo Ito, Mitsugi Ookawara, Yusuke Morit Source Type: research

[ASAP] New Polyaminoisoprenyl Antibiotics Enhancers against Two Multidrug-Resistant Gram-Negative Bacteria from < italic toggle="yes" > Enterobacter < /italic > and < italic toggle="yes" > Salmonella < /italic > Species
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01335 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 4, 2020 Category: Chemistry Authors: Aure ́lie Lieutaud, Cyril Pieri, Jean Michel Bolla, and Jean Michel Brunel Source Type: research

[ASAP] Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of < bold > AL-611 < /bold > as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00935 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 3, 2020 Category: Chemistry Authors: Guangyi Wang, Natalia Dyatkina, Marija Prhavc, Caroline Williams, Vladimir Serebryany, Yujian Hu, Yongfei Huang, Xiangyang Wu, Tongqian Chen, Wensheng Huang, Vivek K. Rajwanshi, Jerome Deval, Amy Fung, Zhinan Jin, Antitsa Stoycheva, Kenneth Shaw, Kusum Gu Source Type: research

[ASAP] Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00567 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 2, 2020 Category: Chemistry Authors: Satish Noonepalle, Sida Shen, Jakub Pta ́ček, Maurício T. Tavares, Guiping Zhang, Jan Stránský, Jiří Pavlíček, Glaucio M. Ferreira, Melissa Hadley, Guido Pelaez, Cyril Bařinka, Alan P. Kozikowski, and Alejandro Villagra Source Type: research

[ASAP] Correction to Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01416 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 1, 2020 Category: Chemistry Authors: Anthony Knight, Jennifer L. Hemmings, Ian Winfield, Michele Leuenberger, Eugenia Frattini, Bruno G. Frenguelli, Simon J. Dowell, Martin Lochner, and Graham Ladds Source Type: research

[ASAP] Multicomponent Synthesis, Binding Mode, and Structure –Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01888 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 1, 2020 Category: Chemistry Authors: Nina Re ßing, Melf Sönnichsen, Jeremy D. Osko, Andrea Schöler, Julian Schliehe-Diecks, Alexander Skerhut, Arndt Borkhardt, Julia Hauer, Matthias U. Kassack, David. W. Christianson, Sanil Bhatia, and Finn K. Hansen Source Type: research

[ASAP] Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00778 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 1, 2020 Category: Chemistry Authors: Ahmed Haider, Luca Gobbi, Julian Kretz, Christoph Ullmer, Andreas Brink, Michael Honer, Thomas J. Woltering, Dieter Muri, Hans Iding, Markus Bu ̈rkler, Martin Binder, Christian Bartelmus, Irene Knuesel, Pal Pacher, Adrienne Müller Herde, Francesco Spin Source Type: research

[ASAP] Correction to Peptide- β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01358 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 1, 2020 Category: Chemistry Authors: Tonko Draz ̌ić, Sara Kopf, James Corridan, Mila M. Leuthold, Branimir Bertoša, and Christian D. Klein Source Type: research

[ASAP] Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00433 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - September 1, 2020 Category: Chemistry Authors: Shuimu Lin, Jiayong Liu, Hongxia Li, Ying Liu, Yongzhi Chen, Jiachun Luo, and Shouping Liu Source Type: research

[ASAP] Tailoring the Physicochemical Properties of Antimicrobial Peptides onto a Thiazole-Based γ-Peptide Foldamer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00077 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 31, 2020 Category: Chemistry Authors: Cle ́ment Bonnel†⊥∥, Baptiste Legrand†, Matthieu Simon†, Margaux Clavié†, Agnès Masnou‡, Estelle Jumas-Bilak‡, Young Kee Kang§, Patricia Licznar-Fajardo*‡, Ludovic T. Maillard*†, and Nicolas Masurier† Source Type: research