[ASAP] Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( < italic toggle="yes" > S < /italic > )-2,2-Difluorocyclopropyl)((1 < italic toggle="yes" > R < /italic > ,5 < italic toggle="yes" > S < /italic > )-3-(2-((1-methyl-1 < italic toggle="yes" > H < /italic > -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00917 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 16, 2018 Category: Chemistry Authors: Andrew Fensome, Catherine M. Ambler, Eric Arnold, Mary Ellen Banker, Matthew F. Brown, Jill Chrencik, James D. Clark, Martin E. Dowty, Ivan V. Efremov, Andrew Flick, Brian S. Gerstenberger, Ariamala Gopalsamy, Matthew M. Hayward, Martin Hegen, Brett D. Ho Source Type: research

[ASAP] Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe- < sc > d < /sc > Pro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and > 600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00684 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 16, 2018 Category: Chemistry Authors: Katlyn A. Fleming, Katie T. Freeman, Mark D. Ericson, Carrie Haskell-Luevano Source Type: research

[ASAP] Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00224 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 16, 2018 Category: Chemistry Authors: Wentao Ning, Zhiye Hu, Chu Tang, Lu Yang, Silong Zhang, Chune Dong, Jian Huang, Hai-Bing Zhou Source Type: research

[ASAP] Resurrection Biology: Aged Acetylcholinesterase Brought Back to Life
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01122 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 15, 2018 Category: Chemistry Authors: Daniel M. Quinn Source Type: research

[ASAP] Synthesis and Activity of a Novel Autotaxin Inhibitor –Icodextrin Conjugate
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00935 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 15, 2018 Category: Chemistry Authors: Natalie Fisher, Michael G. Edwards, Ryan Hemming, Steven M. Allin, John D. Wallis, Philip C. Bulman Page, Michael J. Mckenzie, Stefanie M Jones, Mark R. J. Elsegood, John King-Underwood, Alan Richardson Source Type: research

[ASAP] Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00700 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 15, 2018 Category: Chemistry Authors: Haigen Fu, Jielin Zhang, Pieter G. Tepper, Lennart Bunch, Anders A. Jensen, Gerrit J. Poelarends Source Type: research

[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00450 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 15, 2018 Category: Chemistry Authors: Huy H. Nguyen, Michelle B. Kim, Robert J. Wilson, Christopher J. Butch, Katie M. Kuo, Eric J. Miller, Yesim A. Tahirovic, Edgars Jecs, Valarie M. Truax, Tao Wang, Chi S. Sum, Mary E. Cvijic, Gretchen M. Schroeder, Lawrence J. Wilson, Dennis C. Liotta Source Type: research

[ASAP] Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant < italic toggle="yes" > Staphylococcus aureus < /italic > (MRSA)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00989 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 14, 2018 Category: Chemistry Authors: Sanofar Abdeen, Trent Kunkle, Nilshad Salim, Anne-Marie Ray, Najiba Mammadova, Corey Summers, Mckayla Stevens, Andrew J. Ambrose, Yangshin Park, Peter G. Schultz, Arthur L. Horwich, Quyen Q. Hoang, Eli Chapman, Steven M. Johnson Source Type: research

[ASAP] Thermodynamics of DNA Minor Groove Binders < subtitle > Perspective < /subtitle >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00233 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 14, 2018 Category: Chemistry Authors: Hasan Y. Alniss Source Type: research

[ASAP] Molecular Imaging of Sirtuin1 Expression –Activity in Rat Brain Using Positron-Emission Tomography–Magnetic-Resonance Imaging with [ < sup > 18 < /sup > F]-2-Fluorobenzoylaminohexanoicanilide
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00253 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 13, 2018 Category: Chemistry Authors: Robin Bonomi, Vadim Popov, Maxwell T. Laws, David Gelovani, Anjoy Majhi, Aleksandr Shavrin, Xin Lu, Otto Muzik, Nashaat Turkman, Renshyan Liu, Thomas Mangner, Juri G. Gelovani Source Type: research

[ASAP] Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8 –13)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00175 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 13, 2018 Category: Chemistry Authors: Marc Sousbie, M élanie Vivancos, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Richard Leduc, Philippe Sarret, Éric Marsault Source Type: research

[ASAP] Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b01699 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 13, 2018 Category: Chemistry Authors: Puneet Saxena, Leda Severi, Matteo Santucci, Laura Taddia, Stefania Ferrari, Rosaria Luciani, Gaetano Marverti, Chiara Marraccini, Donatella Tondi, Marco Mor, Laura Scalvini, Simone Vitiello, Lorena Losi, Sergio Fonda, Salvatore Pacifico, Remo Guerrini, D Source Type: research

[ASAP] Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01007 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 10, 2018 Category: Chemistry Authors: Huan-Chieh Chien, Claire Colas, Karissa Finke, Seth Springer, Laura Stoner, Arik A. Zur, Brooklynn Venteicher, Jerome Campbell, Colton Hall, Andrew Flint, Evan Augustyn, Christopher Hernandez, Nathan Heeren, Logan Hansen, Abby Anthony, Justine Bauer, Dimi Source Type: research

[ASAP] Synthesis, Characterization, and Biological Evaluation of a Porphyrin-Based Photosensitizer and Its Isomer for Effective Photodynamic Therapy against Breast Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00547 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 10, 2018 Category: Chemistry Authors: Xiaolan Feng, Yin Shi, Lifen Xie, Kun Zhang, Xiaobing Wang, Quanhong Liu, Pan Wang Source Type: research

[ASAP] A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 < italic toggle="yes" > H < /italic > ,2 < italic toggle="yes" > H < /italic > ,3 < italic toggle="yes" > H < /italic > -pyrrolo[3,2- < italic toggle="yes" > b < /italic > ]pyridin-1-yl)-2-[(2 < italic toggle="yes" > R < /italic > ,5 < italic toggle="yes" > R < /italic > )-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00900 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 9, 2018 Category: Chemistry Authors: Christopher N. Johnson, Jong Sook Ahn, Ildiko M. Buck, Elisabetta Chiarparin, James E. H. Day, Anna Hopkins, Steven Howard, Edward J. Lewis, Vanessa Martins, Alessia Millemaggi, Joanne M. Munck, Lee W. Page, Torren Peakman, Michael Reader, Sharna J. Rich, Source Type: research

[ASAP] Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00825 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 9, 2018 Category: Chemistry Authors: Mariarosaria Ferraro, Ilda D ’Annessa, Elisabetta Moroni, Giulia Morra, Antonella Paladino, Silvia Rinaldi, Federica Compostella, Giorgio Colombo Source Type: research

[ASAP] Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00664 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 9, 2018 Category: Chemistry Authors: Shipeng He, Guoqiang Dong, Shanchao Wu, Kun Fang, Zhenyuan Miao, Wei Wang, Chunquan Sheng Source Type: research

[ASAP] Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F < sub > 1 < /sub > /F < sub > O < /sub > -Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00278 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 9, 2018 Category: Chemistry Authors: Giampaolo Morciano, Delia Preti, Gaia Pedriali, Giorgio Aquila, Sonia Missiroli, Anna Fantinati, Natascia Caroccia, Salvatore Pacifico, Massimo Bonora, Anna Talarico, Claudia Morganti, Paola Rizzo, Roberto Ferrari, Mariusz R. Wieckowski, Gianluca Campo, C Source Type: research

[ASAP] 5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer ’s Disease Phenotypes
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00151 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 9, 2018 Category: Chemistry Authors: Hsueh-Yun Lee, Sheng-Jun Fan, Fang-I Huang, Hsin-Yi Chao, Kai-Cheng Hsu, Tony Eight Lin, Teng-Kuang Yeh, Mei-Jung Lai, Yu-Hsuan Li, Hsiang-Ling Huang, Chia-Ron Yang, Jing-Ping Liou Source Type: research

[ASAP] Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel –Lindau (VHL) E3 Ubiquitin Ligase
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00842 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 8, 2018 Category: Chemistry Authors: Xavier Lucas, Inge Van Molle, Alessio Ciulli Source Type: research

[ASAP] Design, Synthesis, and Biological Evaluation of Novel 7-[(3 < italic toggle="yes" > aS < /italic > ,7 < italic toggle="yes" > aS < /italic > )-3 < italic toggle="yes" > a < /italic > -Aminohexahydropyrano[3,4- < italic toggle="yes" > c < /italic > ]pyrrol-2(3 < italic toggle="yes" > H < /italic > )-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00644 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 8, 2018 Category: Chemistry Authors: Takashi Odagiri, Hiroaki Inagaki, Masatoshi Nagamochi, Takahiro Kitamura, Satoshi Komoriya, Hisashi Takahashi Source Type: research

[ASAP] Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure –Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00782 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 7, 2018 Category: Chemistry Authors: Liam Hudson, James Mui, Santiago V ázquez, Diana M. Carvalho, Eleanor Williams, Chris Jones, Alex N. Bullock, Swen Hoelder Source Type: research

[ASAP] Yeast Chemogenomic Profiling Reveals Iron Chelation To Be the Principle Cell Inhibitory Mode of Action of Gossypol
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00692 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 6, 2018 Category: Chemistry Authors: Thomas A. K. Prescott, Tiphaine Jaeg, Dominic Hoepfner Source Type: research

[ASAP] Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00399 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 6, 2018 Category: Chemistry Authors: Mar ía Dolores Moya-Garzón, Cristina Martín Higueras, Pablo Peñalver, Manuela Romera, Miguel X. Fernandes, Francisco Franco-Montalbán, José A. Gómez-Vidal, Eduardo Salido, Mónica Díaz-Gavilán Source Type: research

[ASAP] Polypharmacology by Design: A Medicinal Chemist ’s Perspective on Multitargeting Compounds
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00760 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 3, 2018 Category: Chemistry Authors: Ewgenij Proschak, Holger Stark, Daniel Merk Source Type: research

[ASAP] From Naproxen Repurposing to Naproxen Analogues and Their Antiviral Activity against Influenza A Virus
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00557 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 3, 2018 Category: Chemistry Authors: S ébastien Dilly, Aurélien Fotso Fotso, Nathalie Lejal, Gloria Zedda, Mohamad Chebbo, Fryad Rahman, Simon Companys, Hélène C. Bertrand, Jasmina Vidic, Magali Noiray, Marie-Christine Alessi, Bogdan Tarus, Stéphane Quideau, Béatrice Riteau, Anny Slama Source Type: research

[ASAP] Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00906 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 2, 2018 Category: Chemistry Authors: Feng Chen, John Moat, Daniel McFeely, Guy Clarkson, Ian J. Hands-Portman, Jessica P. Furner-Pardoe, Freya Harrison, Christopher G. Dowson, Peter J. Sadler Source Type: research

[ASAP] Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 < italic toggle="yes" > H < /italic > -indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00807 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 2, 2018 Category: Chemistry Authors: Tim F. Ryder, Matthew F. Calabrese, Gregory S. Walker, Kimberly O. Cameron, Allan R. Reyes, Kris A. Borzilleri, Jake Delmore, Russell Miller, Ravi G. Kurumbail, Jessica Ward, Daniel W. Kung, Janice A. Brown, David J. Edmonds, Heather Eng, Angela C. Wolfor Source Type: research

[ASAP] From Oxiranes to Oligomers: Architectures of U.S. FDA Approved Pharmaceuticals Containing Oxygen Heterocycles
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00876 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 1, 2018 Category: Chemistry Authors: Michael D. Delost, David T. Smith, Benton J. Anderson, Jon T. Njardarson Source Type: research

[ASAP] Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 < italic toggle="yes" > R < /italic > ,3a < italic toggle="yes" > S < /italic > ,5a < italic toggle="yes" > R < /italic > ,5b < italic toggle="yes" > R < /italic > ,7a < italic toggle="yes" > R < /italic > ,11a < italic toggle="yes" > S < /italic > ,11b < italic toggle="yes" > R < /italic > ,13a < italic toggle="yes" > R < /italic > ,13b < italic toggle="yes" > R < /italic > )-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 < italic toggle="yes" > H < /italic > -cyclopenta[ < italic toggle="yes" > a < /italic > ]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00854 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 1, 2018 Category: Chemistry Authors: Alicia Regueiro-Ren, Jacob J. Swidorski, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Jie Chen, Brian L. Venables, Juliang Zhu, Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Brian Terry, Himadri Samanta, Sharon Zhang, Zhufang Li, John Easter, Brett R. Beno Source Type: research

[ASAP] Discovery of ß-Arrestin Biased Ligands of 5-HT < sub > 7 < /sub > R
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00642 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 1, 2018 Category: Chemistry Authors: Youngjae Kim, Hyunguk Kim, Jieon Lee, Jae Kyun Lee, Sun-Joon Min, Jihye Seong, Hyewhon Rhim, Jinsung Tae, Hyunjoo Jenny Lee, Hyunah Choo Source Type: research

[ASAP] Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00084 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 1, 2018 Category: Chemistry Authors: Travis T. Denton, Pramod Srivastava, Zuping Xia, Gang Chen, Christy J. W. Watson, Alec Wynd, Philip Lazarus Source Type: research

[ASAP] Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood –Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b01588 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - August 1, 2018 Category: Chemistry Authors: Ronan Gealageas, Alice Devineau, Pauline P. L. So, Catrina M. J. Kim, Jayakumar Surendradoss, Christian Buchwalder, Markus Heller, Verena Goebeler, Edith M. Dullaghan, David S. Grierson, Edward E. Putnins Source Type: research

[ASAP] Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00908 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Valentina Noemi Madia, Antonella Messore, Luca Pescatori, Francesco Saccoliti, Valeria Tudino, Alessandro De Leo, Martina Bortolami, Luigi Scipione, Roberta Costi, Silvia Rivara, Laura Scalvini, Marco Mor, Fabiana Fosca Ferrara, Emiliano Pavoni, Giuseppe Source Type: research

[ASAP] Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00808 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Ryo Iwamura, Masayuki Tanaka, Eiji Okanari, Tomoko Kirihara, Noriko Odani-Kawabata, Naveed Shams, Kenji Yoneda Source Type: research

[ASAP] Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) ß Inhibitor
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00797 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Jayaraman Chandrasekhar, Ryan Dick, Joshua Van Veldhuizen, David Koditek, Eve-Irene Lepist, Mary E. McGrath, Leena Patel, Gary Phillips, Kassandra Sedillo, John R. Somoza, Joseph Therrien, Nicholas A. Till, Jennifer Treiberg, Armando G. Villase ñor, Yele Source Type: research

[ASAP] The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of < italic toggle="yes" > Clostridium difficile < /italic >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00632 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Shiv K. Sharma, Christopher Yip, Emilio Xavier Esposito, Prateek V. Sharma, Matthew P. Simon, Ernesto Abel-Santos, Steven M. Firestine Source Type: research

[ASAP] Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-? (ROR? or RORc) Inhibitors: Hits and Misses
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00588 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Vrajesh B. Pandya, Sanjay Kumar, Sachchidanand, Rajiv Sharma, Ranjit C. Desai Source Type: research

[ASAP] Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00566 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Chunyang Jin, Ann M. Decker, Viren H. Makhijani, Joyce Besheer, Emmanuel Darcq, Brigitte L. Kieffer, Rangan Maitra Source Type: research

[ASAP] Structure –Function Analysis of Immune Checkpoint Receptors to Guide Emerging Anticancer Immunotherapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00541 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Rita C. Ac úrcio, Anna Scomparin, João Conniot, Jorge A. R. Salvador, Ronit Satchi-Fainaro, Helena F. Florindo, Rita C. Guedes Source Type: research

[ASAP] Novel Pyrrole –Imidazole Polyamide Hoechst Conjugate Suppresses Epstein–Barr Virus Replication and Virus-Positive Tumor Growth
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00496 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Zhehong Cheng, Wei Wang, Chunlei Wu, Xiaohua Zou, Lijing Fang, Wu Su, Pu Wang Source Type: research

[ASAP] Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00305 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Clarissa G. Jakob, Anup K. Upadhyay, Pamela L. Donner, Emily Nicholl, Sadiya N. Addo, Wei Qiu, Christopher Ling, Sujatha M. Gopalakrishnan, Maricel Torrent, Steven P. Cepa, Jason Shanley, Alexander R. Shoemaker, Chaohong C. Sun, Anil Vasudevan, Kevin R. W Source Type: research

[ASAP] Recent Advances in the Medicinal Chemistry of Liver X Receptors < subtitle > Miniperspective < /subtitle >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00045 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 30, 2018 Category: Chemistry Authors: Bahaa El-Dien M. El-Gendy, Shaimaa S. Goher, Lamees S. Hegazy, Mohamed M. H. Arief, Thomas P. Burris Source Type: research

[ASAP] De Novo Molecular Design of a Novel Octapeptide That Inhibits In Vivo Melanogenesis and Has Great Transdermal Ability
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00737 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 27, 2018 Category: Chemistry Authors: Lan Feng, Nannan Shi, Shasha Cai, Xue Qiao, Peng Chu, Hui Wang, Feida Long, Huaixin Yang, Yongliang Yang, Yipeng Wang, Haining Yu Source Type: research

[ASAP] Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00633 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 27, 2018 Category: Chemistry Authors: Sharan K. Bagal, Mark Andrews, Bruce M. Bechle, Jianwei Bian, James Bilsland, David C. Blakemore, John F. Braganza, Peter J. Bungay, Matthew S. Corbett, Ciaran N. Cronin, Jingrong Jean Cui, Rebecca Dias, Neil J. Flanagan, Samantha E. Greasley, Rachel Grim Source Type: research

[ASAP] < italic toggle="yes" > Pseudomonas aeruginosa < /italic > Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00540 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 27, 2018 Category: Chemistry Authors: Fadi Soukarieh, Paul Williams, Michael J Stocks, Miguel C ámara Source Type: research

[ASAP] Lead-like Drugs: A Perspective < subtitle > Miniperspective < /subtitle >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00407 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 27, 2018 Category: Chemistry Authors: Brian Raymer, Samit K. Bhattacharya Source Type: research

[ASAP] Design and Synthesis of Natural Product Inspired Libraries Based on the Three-Dimensional (3D) Cedrane Scaffold: Toward the Exploration of 3D Biological Space
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00194 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 27, 2018 Category: Chemistry Authors: Fatemeh Mazraati Tajabadi, Rebecca H. Pouwer, Miaomiao Liu, Yousef Dashti, Marc R. Campitelli, Mariyam Murtaza, George D. Mellick, Stephen A. Wood, Ian D. Jenkins, Ronald J. Quinn Source Type: research

[ASAP] Identification of Morpholino Thiophenes as Novel < italic toggle="yes" > Mycobacterium tuberculosis < /italic > Inhibitors, Targeting QcrB
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00172 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 26, 2018 Category: Chemistry Authors: Laura A. T. Cleghorn, Peter C. Ray, Joshua Odingo, Anuradha Kumar, Heather Wescott, Aaron Korkegian, Thierry Masquelin, Abraham Lopez Moure, Caroline Wilson, Susan Davis, Margaret Huggett, Penelope Turner, Alasdair Smith, Ola Epemolu, Fabio Zuccotto, Jenn Source Type: research

[ASAP] Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on < italic toggle="yes" > iso < /italic > -Combretastatin A-4
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00050 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - July 26, 2018 Category: Chemistry Authors: Diana Lamaa, Hsin-Ping Lin, Lena Zig, Cyril Bauvais, Guillaume Bollot, J érôme Bignon, Helene Levaique, Olivier Pamlard, Joelle Dubois, Mehdi Ouaissi, Martin Souce, Athena Kasselouri, François Saller, Delphine Borgel, Chantal Jayat-Vignoles, Hazar Al-M Source Type: research