[ASAP] Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01424 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 10, 2018 Category: Chemistry Authors: Xingsen Wu, Xiang Li, Zhihong Li, Yancheng Yu, Qidong You, Xiaojin Zhang Source Type: research

[ASAP] Identification of 5-(2,3-Dihydro-1 < italic toggle="yes" > H < /italic > -indol-5-yl)-7 < italic toggle="yes" > H < /italic > -pyrrolo[2,3- < italic toggle="yes" > d < /italic > ]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01652 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 10, 2018 Category: Chemistry Authors: Yueshan Li, Yu Xiong, Guo Zhang, Liting Zhang, Wei Yang, Jiao Yang, Luyi Huang, Zeen Qiao, Zhuang Miao, Guifeng Lin, Qiu Sun, Ting Niu, Lijuan Chen, Dawen Niu, Linli Li, Shengyong Yang Source Type: research

[ASAP] Aliphatic Azides as Selective Cysteine Labeling Reagents for Integral Membrane Proteins
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01302 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 10, 2018 Category: Chemistry Authors: Dennis Szymanski, Malvina Papanastasiou, Lakshmipathi Pandarinathan, Nikolai Zvonok, David R. Janero, Spiro Pavlopoulos, Paul Vouros, Alexandros Makriyannis Source Type: research

[ASAP] Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01252 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 10, 2018 Category: Chemistry Authors: Yingjun Li, Kalyan Kumar Pasunooti, Ruo-Jing Li, Wukun Liu, Sarah A. Head, Wei Q. Shi, Jun O. Liu Source Type: research

[ASAP] Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00909 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 10, 2018 Category: Chemistry Authors: Yangbing Li, Jiuling Yang, Angelo Aguilar, Donna McEachern, Sally Przybranowski, Liu Liu, Chao-Yie Yang, Mi Wang, Xin Han, Shaomeng Wang Source Type: research

[ASAP] Correction to Optimization of 1,4-Oxazine ß-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01859 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 7, 2018 Category: Chemistry Authors: Harrie J. M. Gijsen, Sergio A. Alonso de Diego, Michel De Cleyn, Ar ánzazu García-Molina, Gregor J. Macdonald, Carolina Martinez-Lamenca, Daniel Oehlrich, Hana Prokopcova, Frederik J. R. Rombouts, Michel Surkyn, Andrés A. Trabanco, Sven Van Brandt, Dri Source Type: research

[ASAP] Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01224 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 7, 2018 Category: Chemistry Authors: Eleni Kyriakou, Stefanie Schmidt, Garron T. Dodd, Katrin Pfuhlmann, Stephanie E. Simonds, Dominik Lenhart, Arie Geerlof, Sonja C. Schriever, Meri De Angelis, Karl-Werner Schramm, Oliver Plettenburg, Michael A. Cowley, Tony Tiganis, Matthias H. Tsch öp, P Source Type: research

[ASAP] < italic toggle="yes" > qFit-ligand < /italic > Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01292 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 6, 2018 Category: Chemistry Authors: Gydo C. P. van Zundert, Brandi M. Hudson, Saulo H. P. de Oliveira, Daniel A. Keedy, Rasmus Fonseca, Amelie Heliou, Pooja Suresh, Kenneth Borrelli, Tyler Day, James S. Fraser, Henry van den Bedem Source Type: research

[ASAP] Structural and Functional Assessment of mBjAMP1, an Antimicrobial Peptide from < italic toggle="yes" > Branchiostoma japonicum < /italic > , Revealed a Novel a-Hairpinin-like Scaffold with Membrane Permeable and DNA Binding Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01135 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 6, 2018 Category: Chemistry Authors: Jiyoung Nam, Hyosuk Yun, Ganesan Rajasekaran, S. Dinesh Kumar, Jae Il Kim, Hye Jung Min, Song Yub Shin, Chul Won Lee Source Type: research

[ASAP] Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki –Miyaura Cross-Coupling Reactions
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01580 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 5, 2018 Category: Chemistry Authors: Youchao Deng, Meng Su, Dingding Kang, Xingyun Liu, Zhongqing Wen, Yuling Li, Lin Qiu, Ben Shen, Yanwen Duan, Yong Huang Source Type: research

[ASAP] Selective Inhibitors of Human Neuraminidase 1 (NEU1)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01411 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 5, 2018 Category: Chemistry Authors: Tianlin Guo, Rachel H éon-Roberts, Chunxia Zou, Ruixiang Zheng, Alexey V. Pshezhetsky, Christopher W. Cairo Source Type: research

[ASAP] Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00513 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 5, 2018 Category: Chemistry Authors: Xiaoqin Wu, Gang Xu, Xiaobo Li, Weiren Xu, Qianjin Li, Wei Liu, Karen A. Kirby, Mignon L. Loh, Jun Li, Stefan G. Sarafianos, Cheng-Kui Qu Source Type: research

[ASAP] Structure –Activity Relationships of Photoswitchable Diarylethene-Based ß-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01428 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 4, 2018 Category: Chemistry Authors: Oleg Babii, Sergii Afonin, Aleksandr Yu. Ishchenko, Tim Schober, Anatoliy O. Negelia, Ganna M. Tolstanova, Liudmyla V. Garmanchuk, Liudmyla I. Ostapchenko, Igor V. Komarov, Anne S. Ulrich Source Type: research

[ASAP] Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01025 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 3, 2018 Category: Chemistry Authors: Malgorzata Gizynska, Julia Witkowska, Przemyslaw Karpowicz, Rafal Rostankowski, Estrella S. Chocron, Andrew M. Pickering, Pawel Osmulski, Maria Gaczynska, Elzbieta Jankowska Source Type: research

[ASAP] Polyheteroaryl Oxazole/Pyridine-Based Compounds Selected in Vitro as G-Quadruplex Ligands Inhibit Rock Kinase and Exhibit Antiproliferative Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01023 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 3, 2018 Category: Chemistry Authors: Daniela Verga, Chi-Hung N ’Guyen, Malika Dakir, Jean-Luc Coll, Marie-Paule Teulade-Fichou, Annie Molla Source Type: research

[ASAP] The Chimera That Curbs Appetite
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01809 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 3, 2018 Category: Chemistry Authors: Leonard G. Luyt Source Type: research

[ASAP] A Drug with Lipophilicity-Dependent Potency Can Be Metabolically Stable: Discovery of a Potent and Selective Retinoic Acid Receptor-Related Orphan Receptor C2 (RORC2) Inverse Agonist as an Orally Bioavailable Anti-Inflammatory Agent
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01545 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 3, 2018 Category: Chemistry Authors: Yibing Wang, Hong Liu Source Type: research

[ASAP] Design, Synthesis, and Antifibrosis Activity in Liver of Nonsecosteroidal Vitamin D Receptor Agonists with Phenyl-pyrrolyl Pentane Skeleton
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01165 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 3, 2018 Category: Chemistry Authors: Cong Wang, Bin Wang, Lingjing Xue, Zisheng Kang, Siyuan Hou, Junjie Du, Can Zhang Source Type: research

[ASAP] Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01000 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 3, 2018 Category: Chemistry Authors: Paul W. Heron, Marta Abell án-Flos, Laurent Salmon, Jurgen Sygusch Source Type: research

[ASAP] Sterol 14a-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01671 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2018 Category: Chemistry Authors: Laura Friggeri, Tatiana Y. Hargrove, Girish Rachakonda, Anna L. Blobaum, Paxtyn Fisher, Gabriel Melo de Oliveira, Cristiane Fran ça da Silva, Maria de Nazaré C. Soeiro, W. David Nes, Craig W. Lindsley, Fernando Villalta, F. Peter Guengerich, Galina I. L Source Type: research

[ASAP] A Survey of the Structures of US FDA Approved Combination Drugs
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01610 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2018 Category: Chemistry Authors: Pradipta Das, Michael D. Delost, Munaum H. Qureshi, David T. Smith, Jon T. Njardarson Source Type: research

[ASAP] Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer ’s Disease < subtitle > Miniperspective < /subtitle >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01530 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2018 Category: Chemistry Authors: Ahmed Morsy, Paul C. Trippier Source Type: research

[ASAP] Computational Method to Evaluate Progress in Lead Optimization
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01626 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2018 Category: Chemistry Authors: Martin Vogt, Dimitar Yonchev, J ürgen Bajorath Source Type: research

[ASAP] Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01308 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2018 Category: Chemistry Authors: Agustin Casimiro-Garcia, John I. Trujillo, Felix Vajdos, Brian Juba, Mary Ellen Banker, Ann Aulabaugh, Paul Balbo, Jonathan Bauman, Jill Chrencik, Jotham W. Coe, Robert Czerwinski, Martin Dowty, John D. Knafels, Soojin Kwon, Louis Leung, Sidney Liang, Ral Source Type: research

[ASAP] Optimization of Novel 1-Methyl-1 < italic toggle="yes" > H < /italic > -Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber ’s Pole Worm
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01544 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2018 Category: Chemistry Authors: Thuy G. Le, Abhijit Kundu, Atanu Ghoshal, Nghi H. Nguyen, Sarah Preston, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Jennifer Keiser, Andreas Hofmann, Bill C. H. Chang, Jose Garcia-Bustos, Abdul Jabbar, Timothy N. C. Wells, Michael J. Palmer, Robin B. Source Type: research

[ASAP] Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01497 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2018 Category: Chemistry Authors: Antonella Messore, Valentina Noemi Madia, Luca Pescatori, Francesco Saccoliti, Valeria Tudino, Alessandro De Leo, Martina Bortolami, Daniela De Vita, Luigi Scipione, Federico Pepi, Roberta Costi, Silvia Rivara, Laura Scalvini, Marco Mor, Fabiana Fosca Fer Source Type: research

[ASAP] Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01445 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2018 Category: Chemistry Authors: Xinhua Liu, Benlong Li, Zhen Zhang, Yujiao Wei, Zhongxin Xu, Shuanglin Qin, Ning Liu, Rui Zhao, Junya Peng, Guang Yang, Min Qi, Tongtong Liu, Maodun Xie, Shuangwei Liu, Xian Gao, Cheng Lu, Lijun Zhu, Xinyu Long, Hong Kang, Tao Sun, Honggang Zhou, Mingming Source Type: research

[ASAP] Discovery of Clinical Candidate 2-(4-(2-((1 < italic toggle="yes" > H < /italic > -Benzo[ < italic toggle="yes" > d < /italic > ]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- < italic toggle="yes" > N < /italic > -(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol < italic toggle="yes" > O < /italic > -Acyltransferase-1 Inhibitor
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01256 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2018 Category: Chemistry Authors: Kimiyuki Shibuya, Katsumi Kawamine, Chiyoka Ozaki, Tadaaki Ohgiya, Toshiyuki Edano, Yasunobu Yoshinaka, Yoshihiko Tsunenari Source Type: research

[ASAP] 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01504 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 28, 2018 Category: Chemistry Authors: Alessio Nocentini, Elena Trallori, Srishti Singh, Carrie L. Lomelino, Gianluca Bartolucci, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Robert McKenna, Paola Gratteri, Claudiu T. Supuran Source Type: research

[ASAP] Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01121 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 28, 2018 Category: Chemistry Authors: Zheng-Yu Jiang, Meng-Chen Lu, Qi-Dong You Source Type: research

[ASAP] Reducing the Lipophilicity of Perfluoroalkyl Groups by CF < sub > 2 < /sub > –F/CF < sub > 2 < /sub > –Me or CF < sub > 3 < /sub > /CH < sub > 3 < /sub > Exchange
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01222 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 28, 2018 Category: Chemistry Authors: Benjamin Jeffries, Zhong Wang, J érôme Graton, Simon D. Holland, Thomasin Brind, Ryan D. R. Greenwood, Jean-Yves Le Questel, James S. Scott, Elisabetta Chiarparin, Bruno Linclau Source Type: research

[ASAP] Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00975 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 28, 2018 Category: Chemistry Authors: Gabriel Castro-Falc ón, Grant S. Seiler, Özlem Demir, Manoj K. Rathinaswamy, David Hamelin, Reece M. Hoffmann, Stefanie L. Makowski, Anne-Catrin Letzel, Seth J. Field, John E. Burke, Rommie E. Amaro, Chambers C. Hughes Source Type: research

[ASAP] Design, Synthesis, and Biological Evaluation of Cytochrome P450 1B1 Targeted Molecular Imaging Probes for Colorectal Tumor Detection
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01633 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 27, 2018 Category: Chemistry Authors: Qingqing Meng, Zengtao Wang, Jiahua Cui, Qing Cui, Jinyun Dong, Qijing Zhang, Shaoshun Li Source Type: research

[ASAP] Highly Potent 17 ß-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01373 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 27, 2018 Category: Chemistry Authors: Lorenz Siebenbuerger, Victor Hernandez-Olmos, Ahmed S. Abdelsamie, Martin Frotscher, Chris J. van Koppen, Sandrine Marchais-Oberwinkler, Claudia Scheuer, Matthias W. Laschke, Michael D. Menger, Carsten Boerger, Rolf W. Hartmann Source Type: research

[ASAP] Functional Characterization of a Novel Lipopolysaccharide-Binding Antimicrobial and Anti-Inflammatory Peptide in Vitro and in Vivo
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01358 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 27, 2018 Category: Chemistry Authors: Baishuang Zeng, Jinwei Chai, Zhenhui Deng, Tiaofei Ye, Wenbin Chen, Dan Li, Xin Chen, Ming Chen, Xueqing Xu Source Type: research

[ASAP] Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01060 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 27, 2018 Category: Chemistry Authors: Sofie Knutsson, Cecilia Engdahl, Rashmi Kumari, Nina Forsgren, Cecilia Lindgren, Tomas Kindahl, Stanley Kitur, Lucy Wachira, Luna Kamau, Fredrik Ekstr öm, Anna Linusson Source Type: research

[ASAP] Aminergic GPCR –Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00836 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 27, 2018 Category: Chemistry Authors: M árton Vass, Sabina Podlewska, Iwan J. P. de Esch, Andrzej J. Bojarski, Rob Leurs, Albert J. Kooistra, Chris de Graaf Source Type: research

[ASAP] Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an a7-nAChR, a9-nAChR Antagonist and of a Pro-Oxidant Mitocan
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01052 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 26, 2018 Category: Chemistry Authors: Francesco Bavo, Susanna Pucci, Francesca Fasoli, Carmen Lammi, Milena Moretti, Vanessa Mucchietto, Donatella Lattuada, Paola Viani, Clara De Palma, Roberta Budriesi, Irene Corradini, Cheryl Dowell, J. Michael McIntosh, Francesco Clementi, Cristiano Bolchi Source Type: research

[ASAP] Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01457 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 26, 2018 Category: Chemistry Authors: David Heidenreich, Moses Moustakim, Jurema Schmidt, Daniel Merk, Paul E. Brennan, Oleg Fedorov, Apirat Chaikuad, Stefan Knapp Source Type: research

[ASAP] Fragment-to-Lead Medicinal Chemistry Publications in 2017 < subtitle > Miniperspective < /subtitle >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01472 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 21, 2018 Category: Chemistry Authors: Paul N. Mortenson, Daniel A. Erlanson, Iwan J. P. de Esch, Wolfgang Jahnke, Christopher N. Johnson Source Type: research

[ASAP] State of the Art in Respiratory Syncytial Virus Drug Discovery and Development
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01361 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 21, 2018 Category: Chemistry Authors: G. Stuart Cockerill, James A. D. Good, Neil Mathews Source Type: research

[ASAP] Battle against Vancomycin-Resistant Bacteria: Recent Developments in Chemical Strategies
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01093 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 21, 2018 Category: Chemistry Authors: Geetika Dhanda, Paramita Sarkar, Sandip Samaddar, Jayanta Haldar Source Type: research

[ASAP] Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ < italic toggle="yes" > c < /italic > ]pyrrolo[2,3- < italic toggle="yes" > h < /italic > ][1,6]naphthyridin-5-one (BPN) Series
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00510 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 21, 2018 Category: Chemistry Authors: Mohamed S. A. Elsayed, Jeffery J. Nielsen, Sungtae Park, Jeongho Park, Qingyang Liu, Chang H. Kim, Yves Pommier, Keli Agama, Philip S. Low, Mark Cushman Source Type: research

[ASAP] Pyridinium Oximes with < italic toggle="yes" > Ortho < /italic > -Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01398 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 20, 2018 Category: Chemistry Authors: Tamara Zorbaz, David Malinak, Nikola Marakovic, Nikolina Macek Hrvat, Antonio Zandona, Michal Novotny, Adam Skarka, Rudolf Andrys, Marketa Benkova, Ondrej Soukup, Maja Katalinic, Kamil Kuca, Zrinka Kovarik, Kamil Musilek Source Type: research

[ASAP] Design of Y < sub > 2 < /sub > Receptor Selective and Proteolytically Stable PYY < sub > 3 –36 < /sub > Analogues
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01046 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 20, 2018 Category: Chemistry Authors: S øren Østergaard, Jacob Kofoed, Johan F. Paulsson, Kim Grimstrup Madsen, Rasmus Jorgensen, Birgitte S. Wulff Source Type: research

[ASAP] Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01407 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2018 Category: Chemistry Authors: Bohdan Waszkowycz, Kate M. Smith, Alison E. McGonagle, Allan M. Jordan, Ben Acton, Emma E. Fairweather, Louise A. Griffiths, Niall M. Hamilton, Nicola S. Hamilton, James R. Hitchin, Colin P. Hutton, Dominic I. James, Clifford D. Jones, Stuart Jones, Danie Source Type: research

[ASAP] Tanshinone-IIA-Based Analogues of Imidazole Alkaloid Act as Potent Inhibitors To Block Breast Cancer Invasion and Metastasis in Vivo
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01018 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2018 Category: Chemistry Authors: Qiong Wu, Kangdi Zheng, Xiaoting Huang, Li Li, Wenjie Mei Source Type: research

[ASAP] Fibroblast Growth Factor Receptor 4 (FGFR4) Selective Inhibitors as Hepatocellular Carcinoma Therapy: Advances and Prospects < subtitle > Miniperspective < /subtitle >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01531 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2018 Category: Chemistry Authors: Xiaoyun Lu, Hao Chen, Adam V. Patterson, Jeff B. Smaill, Ke Ding Source Type: research

[ASAP] Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00189 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2018 Category: Chemistry Authors: Yepeng Luan, Jerry Li, Jean A. Bernatchez, Rongshi Li Source Type: research

[ASAP] Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of < italic toggle="yes" > Staphylococcus aureus < /italic >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01293 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 15, 2018 Category: Chemistry Authors: Trent Kunkle, Sanofar Abdeen, Nilshad Salim, Anne-Marie Ray, Mckayla Stevens, Andrew J. Ambrose, Jos é Victorino, Yangshin Park, Quyen Q. Hoang, Eli Chapman, Steven M. Johnson Source Type: research