[ASAP] Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01380 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2021 Category: Chemistry Authors: Xingchen Liu, Cheng Wang, Shang Li, Lailiang Qu, Fucheng Yin, Dehua Lu, Heng Luo, Xinye Chen, Zhongwen Luo, Ningjie Cui, Xiaobing Wang, and Lingyi Kong Source Type: research

[ASAP] Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01333 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2021 Category: Chemistry Authors: Monica Barone, Simone Rampelli, Elena Biagi, Sine Mandrup Bertozzi, Federico Falchi, Andrea Cavalli, Andrea Armirotti, Patrizia Brigidi, Silvia Turroni, and Marco Candela Source Type: research

[ASAP] Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00946 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2021 Category: Chemistry Authors: Matthew G. Lloyd, Rosemary Huckvale, Kwai-Ming J. Cheung, Matthew J. Rodrigues, Gavin W. Collie, Olivier A. Pierrat, Mahad Gatti Iou, Michael Carter, Owen A. Davis, P. Craig McAndrew, Emma Gunnell, Yann-Vai ̈ Le Bihan, Rachel Talbot, Alan T. Henley, Loui Source Type: research

[ASAP] Synthetic Sansanmycin Analogues as Potent < italic toggle="yes" > Mycobacterium tuberculosis < /italic > Translocase I Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01407 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2021 Category: Chemistry Authors: Wendy Tran, Ali S. Kusay, Paige M. E. Hawkins, Chen-Yi Cheung, Gayathri Nagalingam, Venugopal Pujari, Daniel J. Ford, Alexander Stoye, Jessica L. Ochoa, Rebecca E. Audette, Elinor Hortle, Stefan H. Oehlers, Susan A. Charman, Roger G. Linington, Eric J. Ru Source Type: research

[ASAP] New Insights into the Structure –Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of < bold > Neurounina-1 < /bold > as Modulators of the Na < sup > + < /sup > /Ca < sup > 2+ < /sup > Exchanger Isoforms
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01212 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2021 Category: Chemistry Authors: Elisa Magli, Caterina Fattorusso, Marco Persico, Angela Corvino, Gianluca Esposito, Ferdinando Fiorino, Paolo Luciano, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Valentina Tedeschi, Anna Pannaccione, Giuseppe Pignataro, Giuseppe Caliendo, Lu Source Type: research

[ASAP] Dual Cathepsin B and Glutathione-Activated Dimeric and Trimeric Phthalocyanine-Based Photodynamic Molecular Beacons for Targeted Photodynamic Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01634 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 30, 2021 Category: Chemistry Authors: Leo K. B. Tam, Ligang Yu, Roy C. H. Wong, Wing-Ping Fong, Dennis K. P. Ng, and Pui-Chi Lo Source Type: research

[ASAP] Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01411 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2021 Category: Chemistry Authors: Shengtao Xu, Hong Yao, Yangyi Qiu, Manzhen Zhou, Dahong Li, Liang Wu, Dong-Hua Yang, Zhe-Sheng Chen, and Jinyi Xu Source Type: research

[ASAP] Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro- < italic toggle="yes" > N < /italic > -(2 ′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01403 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2021 Category: Chemistry Authors: Nilesh Raghunath Khedkar, Nageswara Rao Irlapatti, Disha Dadke, Vijay Kanoje, Zubair Shaikh, Vijay Karche, Vikas Shinde, Gokul Deshmukh, Amit Patil, Santosh Jachak, Samiron Phukan, Praveenkumar Anidil Kizhakinagath, Milind Gholve, Trupti Bhankhede, Jagade Source Type: research

[ASAP] First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00605 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2021 Category: Chemistry Authors: Radosaw P. Nowak, Anthony Tumber, Eline Hendrix, Mohammad Salik Zeya Ansari, Manuela Sabatino, Lorenzo Antonini, Regina Andrijes, Eidarus Salah, Nicola Mautone, Francesca Romana Pellegrini, Klemensas Simelis, Akane Kawamura, Catrine Johansson, Daniela Pas Source Type: research

[ASAP] Relaxed Substrate Requirements of Sterol 14 α-Demethylase from < italic toggle="yes" > Naegleria fowleri < /italic > Are Accompanied by Resistance to Inhibition
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01710 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2021 Category: Chemistry Authors: Tatiana Y. Hargrove, Zdzislaw Wawrzak, Girish Rachakonda, W. David Nes, Fernando Villalta, F. Peter Guengerich, and Galina I. Lepesheva Source Type: research

[ASAP] Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of < italic toggle="yes" > trans < /italic > -4- < sc > l < /sc > -Hydroxyprolyl- < sc > l < /sc > -serine
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01276 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 29, 2021 Category: Chemistry Authors: Qikun Jiang, Qiuchi Xu, Yingli Wang, Pengyan Li, Yunran Zhang, Yongjun Wang, Jin Sun, Tianhong Zhang, and Zhonggui He Source Type: research

[ASAP] Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01156 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 28, 2021 Category: Chemistry Authors: Jinle Tang, Beihua Dong, Ming Liu, Shuyan Liu, Xiaogang Niu, Christina Gaughan, Abhishek Asthana, Huan Zhou, Zhengshuang Xu, Guoliang Zhang, Robert H. Silverman, and Hao Huang Source Type: research

[ASAP] The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01663 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 27, 2021 Category: Chemistry Authors: Alisa Lang, Laura Isigkeit, Manfred Schubert-Zsilavecz, and Daniel Merk Source Type: research

[ASAP] Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01693 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 25, 2021 Category: Chemistry Authors: Adria ́n Gironda-Martínez, Émile M. D. Gorre, Luca Prati, Jean-François Gosalbes, Sheila Dakhel, Samuele Cazzamalli, Florent Samain, Etienne J. Donckele, and Dario Neri Source Type: research

[ASAP] Discovery of Pyrazolo[3,4- < italic toggle="yes" > d < /italic > ]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01205 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 25, 2021 Category: Chemistry Authors: Xiaoqin Tanah, Chunpu Libc, Ruirui Yangade, Sen Zhaob, Fei Lif, Xutong Liad, Lifan Chenad, Xiaozhe Wanad, Xiaohong Liuae, Tianbiao Yangac, Xiaochu Tongad, Tingyang Xug, Rongrong Cuiai, Hualiang Jiangacde, Sulin Zhanga, Hong Liubc, and Mingyue Zhengacd Source Type: research

[ASAP] Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01331 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 24, 2021 Category: Chemistry Authors: Felix F. Lillich, Sabine Willems, Xiaomin Ni, Whitney Kilu, Carmen Borkowsky, Mirko Brodsky, Jan S. Kramer, Steffen Brunst, Victor Hernandez-Olmos, Jan Heering, Simone Schierle, Roxane-I. Kestner, Franziska M. Mayser, Moritz Helmsta ̈dter, Tamara Göbel Source Type: research

[ASAP] High-Throughput Screening Platform in Postnatal Heart Cells and Chemical Probe Toolbox to Assess Cardiomyocyte Proliferation
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01173 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 24, 2021 Category: Chemistry Authors: Carmen Carrillo Garci ́a, Cora Becker, Michael Forster, Stefan Lohmann, Patricia Freitag, Stefan Laufer, Sonja Sievers, Bernd K. Fleischmann◇, Michael Hesse, and Dennis Schade Source Type: research

[ASAP] Stapled Peptides Targeting SARS-CoV-2 Spike Protein HR1 Inhibit the Fusion of Virus to Its Cell Receptor
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01681 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 24, 2021 Category: Chemistry Authors: Mengjun Zheng, Wei Cong, Haoran Peng, Jie Qing, Huaxing Shen, Yaxin Tang, Chenchen Geng, Si Chen, Yan Zou, Wei-Dong Zhang, Hong-Gang Hu, and Xiang Li Source Type: research

[ASAP] Selection of QPX7831, an Orally Bioavailable Prodrug of Boronic Acid β-Lactamase Inhibitor QPX7728
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01722 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 24, 2021 Category: Chemistry Authors: K. Raja Reddy, Jonathan Parkinson, Mojgan Sabet, Ziad Tarazi, Serge H. Boyer, Olga Lomovskaya, David C. Griffith, Scott J. Hecker, and Michael N. Dudley Source Type: research

[ASAP] Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01547 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 23, 2021 Category: Chemistry Authors: Henry R. O ’Donnell, Tia A. Tummino, Conner Bardine, Charles S. Craik, and Brian K. Shoichet Source Type: research

[ASAP] Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01535 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 23, 2021 Category: Chemistry Authors: Shu-Ping Wang, Yu Li, Shi-Hui Huang, Shi-Qi Wu, Ling-Li Gao, Qin Sun, Qian-Wen Lin, Lei Huang, Liu-Qiong Meng, Yi Zou, Qi-Hua Zhu, and Yun-Gen Xu Source Type: research

[ASAP] Subphthalocyanines as Efficient Photosensitizers with Nanomolar Photodynamic Activity against Cancer Cells
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01584 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 23, 2021 Category: Chemistry Authors: Jiri Demuth, Lucia Gallego, Magdalena Kozlikova, Miloslav Machacek, Radim Kucera, Tomas Torres, M. Victoria Martinez-Diaz, and Veronika Novakova Source Type: research

[ASAP] Targeting of the FOXM1 Oncoprotein by E3 Ligase-Assisted Degradation
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01069 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 23, 2021 Category: Chemistry Authors: Guoshun Luo, Xin Lin, Antonio Vega-Medina, Maoxu Xiao, Guolong Li, Hanlin Wei, Carlos A. Vela ́zquez-Martínez, and Hua Xiang Source Type: research

[ASAP] Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01287 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 22, 2021 Category: Chemistry Authors: Weitao Fu, Minkui Zhang, Jianing Liao, Qing Tang, Yixuan Lei, Zhou Gong, Luhu Shan, Mojie Duan, Xin Chai, Jinping Pang, Chun Tang, Xuwen Wang, Xiaohong Xu, Dan Li, Rong Sheng, and Tingjun Hou Source Type: research

[ASAP] What is in Our Kit? An Analysis of Building Blocks Used in Medicinal Chemistry Parallel Libraries
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01139 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 22, 2021 Category: Chemistry Authors: Ying Wang, Isabella Haight, Rishi Gupta, and Anil Vasudevan Source Type: research

[ASAP] Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00804 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 22, 2021 Category: Chemistry Authors: Nicole Bata, Apirat Chaikuad, Nicole A. Bakas, Allison S. Limpert, Lester J. Lambert, Douglas J. Sheffler, Lena M. Berger, Guoxiong Liu, Cunxiang Yuan, Li Wang, Yi Peng, Jing Dong, Maria Celeridad, Fabiana Layng, Stefan Knapp, and Nicholas D. P. Cosford Source Type: research

[ASAP] Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00918 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 22, 2021 Category: Chemistry Authors: Cle ́ment Monsarrat, Guillaume Compain, Christophe André, Sylvain Engilberge, Isabelle Martiel, Vincent Oliéric, Philippe Wolff, Karl Brillet, Marie Landolfo, Cyrielle Silva da Veiga, Jérôme Wagner, Gilles Guichard, and Dominique Y. Burnouf Source Type: research

[ASAP] Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01161 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 22, 2021 Category: Chemistry Authors: Sharan K. Bagal, Clare Gregson, Daniel H. O ’ Donovan, Kurt G. Pike, Andrew Bloecher, Peter Barton, Alexandra Borodovsky, Erin Code, Shaun M. Fillery, Jessie Hao-Ru Hsu, Sameer P. Kawatkar, Chengzhi Li, David Longmire, Youfeng Nai, Samuel C. Nash, Andre Source Type: research

[ASAP] COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01254 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2021 Category: Chemistry Authors: Enrique Ortega-Forte, Anna Rovira, Albert Gandioso, Joaqui ́n Bonelli, Manel Bosch, José Ruiz, and Vicente Marchán Source Type: research

[ASAP] Zanamivir –Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01531 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2021 Category: Chemistry Authors: Xun Lv, Pengfei Wang, Chenning Li, Shuihong Cheng, Yuhai Bi, and Xuebing Li Source Type: research

[ASAP] Perspectives on SARS-CoV-2 Main Protease Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00409 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2021 Category: Chemistry Authors: Kaifu Gao, Rui Wang, Jiahui Chen, Jetze J. Tepe, Faqing Huang, and Guo-Wei Wei Source Type: research

[ASAP] 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D < sub > 2 < /sub > Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01327 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2021 Category: Chemistry Authors: Wenzhong Yan, Luyu Fan, Jing Yu, Ruiquan Liu, Huan Wang, Liang Tan, Sheng Wang, and Jianjun Cheng Source Type: research

[ASAP] Engineering of a Biologically Active Insulin Dimer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01594 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2021 Category: Chemistry Authors: Mengjie Liu, Barbara F. White, Praveen Praveen, Wenyi Li, Feng Lin, Hongkang Wu, Rong Li, Carlie Delaine, Briony E. Forbes, John D. Wade, and Mohammed Akhter Hossain Source Type: research

[ASAP] Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin E Conjugate
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01157 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2021 Category: Chemistry Authors: Aleksei E. Machulkin, Anastasia A. Uspenskaya, Nikolay U. Zyk, Ekaterina A. Nimenko, Anton P. Ber, Stanislav A. Petrov, Vladimir I. Polshakov, Radik R. Shafikov, Dmitry A. Skvortsov, Ekaterina A. Plotnikova, Andrei A. Pankratov, Galina B. Smirnova, Yulia Source Type: research

[ASAP] Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01694 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 18, 2021 Category: Chemistry Authors: Gemma S. Perry, Mohua Das, and Esther C. Y. Woon Source Type: research

[ASAP] Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00390 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 18, 2021 Category: Chemistry Authors: Bharvi Sharma and Vipan Kumar Source Type: research

[ASAP] Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Fluorinated Candidates as PI3K Inhibitors: Targeting Fluorophilic Binding Sites
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01674 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 18, 2021 Category: Chemistry Authors: Ahmed H. Tantawy, Mohammed Farrag El-Behairy, Walaa Hamada Abd-Allah, Hong Jiang, Man-Qun Wang, and Adel A. Marzouk Source Type: research

[ASAP] Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5 –6-mer) Peptides
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01334 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 17, 2021 Category: Chemistry Authors: Gabriele Fumagalli, Rodrigo J. Carbajo, J. Willem M. Nissink, Jonathan Tart, Rongxuan Dou, Andrew P. Thomas, and David R. Spring Source Type: research

[ASAP] Multifunctional Antibiotic –Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01712 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Hashem Etayash, Morgan Alford, Noushin Akhoundsadegh, Matthew Drayton, Suzana K. Straus, and Robert E. W. Hancock Source Type: research

[ASAP] Biotin ’s Lessons in Drug Design
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00975 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Darryl B. McConnell Source Type: research

[ASAP] Fabrication of Supramolecular Antibacterial Nanofibers with Membrane-Disruptive Mechanism
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00829 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Tingting Chen, Yinfeng Lyu, Meishu Tan, Chengyi Yang, Ying Li, Changxuan Shao, Yongjie Zhu, and Anshan Shan Source Type: research

[ASAP] New Heights for ProTides?
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01908 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Carlo Ballatore Source Type: research

[ASAP] Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A < sub > 2A < /sub > Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01155 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Wenzhong Yan, Lijun Ling, Yiran Wu, Kexin Yang, Ruiquan Liu, Jinfeng Zhang, Simeng Zhao, Guisheng Zhong, Suwen Zhao, Hualiang Jiang, Chengying Xie, and Jianjun Cheng Source Type: research

[ASAP] Oxidative Metabolism as a Modulator of Kratom ’s Biological Actions
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01111 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Soumen Chakraborty, Rajendra Uprety, Samuel T. Slocum, Takeshi Irie, Valerie Le Rouzic, Xiaohai Li, Lisa L. Wilson, Brittany Scouller, Amy F. Alder, Andrew C. Kruegel, Michael Ansonoff, Andras Varadi, Shainnel O. Eans, Amanda Hunkele, Abdullah Allaoa, San Source Type: research

[ASAP] NSAIDs: Old Acquaintance in the Pipeline for Cancer Treatment and Prevention ─Structural Modulation, Mechanisms of Action, and Bright Future
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01460 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Sandra Ramos-Inza, Ana Carolina Ruberte, Carmen Sanmarti ́n, Arun K. Sharma, and Daniel Plano Source Type: research

[ASAP] Novel Cyclic Endomorphin Analogues with Multiple Modifications and Oligoarginine Vector Exhibit Potent Antinociception with Reduced Opioid-like Side Effects
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01631 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 15, 2021 Category: Chemistry Authors: Yu-zhe Zhang, Meng-meng Wang, Si-yu Wang, Xiao-fang Wang, Wen-jiao Yang, Ya-nan Zhao, Feng-tong Han, Yao Zhang, Ning Gu, and Chang-lin Wang Source Type: research

[ASAP] Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01308 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 15, 2021 Category: Chemistry Authors: Zhuqing Zhang, Zuhao Guo, Xiaowei Xu, Danyan Cao, Hong Yang, Yanlian Li, Qiongyu Shi, Zhiyan Du, Xiaobin Guo, Xin Wang, Danqi Chen, Ying Zhang, Lin Chen, Kaixin Zhou, Jian Li, Meiyu Geng, Xun Huang, and Bing Xiong Source Type: research

[ASAP] From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01163 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 15, 2021 Category: Chemistry Authors: Lewis D. Turner, Chi H. Trinh, Ryan A. Hubball, Kyle M. Orritt, Chi-Chuan Lin, Julie E. Burns, Margaret A. Knowles, and Colin W. G. Fishwick Source Type: research

[ASAP] Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure –Activity Relationships, and Perspectives
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01318 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 15, 2021 Category: Chemistry Authors: Ange ́lica Rocha Joaquim, Mariana Pies Gionbelli, Grace Gosmann, Alexandre Meneghello Fuentefria, Marcela Silva Lopes, and Saulo Fernandes de Andrade Source Type: research

[ASAP] Active Learning for Drug Design: A Case Study on the Plasma Exposure of Orally Administered Drugs
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01683 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 15, 2021 Category: Chemistry Authors: Xiaoyu Ding, Rongrong Cui, Jie Yu, Tiantian Liu, Tingfei Zhu, Dingyan Wang, Jie Chang, Zisheng Fan, Xiaomeng Liu, Kaixian Chen, Hualiang Jiang, Xutong Li, Xiaomin Luo, and Mingyue Zheng Source Type: research