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Total 791 results found since Jan 2013.

A strategy based on gene sequencing and molecular docking for analysis and prediction of bioactive peptides in Shuxuetong injection
Biophys Chem. 2021 Dec 24;282:106749. doi: 10.1016/j.bpc.2021.106749. Online ahead of print.ABSTRACTPeptides are a class of protein fragments with relatively high biological activity and intense specificity, which play crucial role in the treatment of Shuxuetong injection (SXT). However, the extraordinary complexity of Chinese medicinal formulates and the lack of systematic identification methods are primary challenges for study of pharmacodynamic peptides. In addition, infinitesimal peptides contents further hinder the identification and structural characterization of polypeptide by traditional means. In this paper, we de...
Source: Biophysical Chemistry - December 31, 2021 Category: Chemistry Authors: Xinyi Jiao Yanchao Xing Haitao Wang Xin Jin Tingting Zhang Xingru Peng Rui Li Liuyi Liang Rui Liu Lifeng Han Zheng Li Source Type: research

Serum calcium channel subunit α2δ-1 concentrations and outcomes in patients with acute spontaneous intracerebral hemorrhage
CONCLUSIONS: Serum α2δ-1 subunit concentrations are intimately correlated with illness severity and are independently associated with poor 90-day outcome, substantializing serum α2δ-1 subunit as a potential prognostic biomarker for ICH.PMID:35007528 | DOI:10.1016/j.cca.2022.01.002
Source: International Journal of Clinical Chemistry - January 10, 2022 Category: Chemistry Authors: Hao Zhang Ze-Sheng Wu Jing-Quan Liu Huan Huang Source Type: research

Predictive value of serum visinin-like protein-1 for early neurologic deterioration and three-month clinical outcome in acute primary basal ganglia hemorrhage: a prospective and observational study
CONCLUSIONS: Serum VILIP-1 may be a good biomarker for assessing hemorrhagic severity and clinical outcomes after ICH.PMID:35292254 | DOI:10.1016/j.cca.2022.03.008
Source: International Journal of Clinical Chemistry - March 16, 2022 Category: Chemistry Authors: Xin-Jiang Yan Yang-Bo Li Wei Liu Wei-Min Dai Chuan-Liu Wang Source Type: research

Molecules, Vol. 27, Pages 2484: Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
k Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons. Furthermore, the beneficial effects of capsaicin in cardiovascular and oncological disorders have been described. Many recent publications show the positive effects of capsaicin in animal models of brain disorders. In Alzheimer’s disease, capsaicin reduces neurodegeneration and memory impairment. The beneficial effects of capsaicin in Parkinson’s disease and depression have also be...
Source: Molecules - April 12, 2022 Category: Chemistry Authors: Micha ł Pasierski Bart łomiej Szulczyk Tags: Review Source Type: research

Investigation on the potential targets of Astragaloside IV against intracerebral hemorrhage based on network pharmacology and experimental validation
This study demonstrated that AS-IV could play a critical role on hematoma absorption after ICH by regulating the PI3K/AKT signaling pathway and promoting CD36 phagocytosis, which provided a new thought for the drug development of ICH.PMID:35728292 | DOI:10.1016/j.bioorg.2022.105975
Source: Bioorganic Chemistry - June 21, 2022 Category: Chemistry Authors: Yingyi Zheng Ruoqi Li Yuan Zhou Shanshan Zhang Xiang Fan Source Type: research

Discovery of 1,2,4-triazole derivatives as novel neuroprotectants against cerebral ischemic injury by activating antioxidant response element
Bioorg Chem. 2022 Aug 13;128:106096. doi: 10.1016/j.bioorg.2022.106096. Online ahead of print.ABSTRACTAcute ischemic stroke is an important cause of death and long-term disability worldwide. In this work, we have synthesized a series of derivatives with 3,5‑diaryl substituent triazole scaffolds. The derivatives showed favorable protective effective in SNP-induced oxidative stress model, of which compound 5 was the most active. In vivo experiments showed that compound 5 could ameliorate neurological deficits, attenuate infarction sizes, reduce malonaldehyde (MDA) level and increase superoxide dismutase (SOD) level in midd...
Source: Bioorganic Chemistry - August 19, 2022 Category: Chemistry Authors: Yaoqiang Lao Ping Huang Jianwen Chen Yang Wang Ruiqi Su Weiyan Shao Wenhao Hu Jingxia Zhang Source Type: research

Molecules, Vol. 27, Pages 7286: Anticancer, Cardio-Protective and Anti-Inflammatory Potential of Natural-Sources-Derived Phenolic Acids
Saif A. Alharthy Phenolic acids (PAs) are one of the utmost prevalent classes of plant-derived bioactive chemicals. They have a specific taste and odor, and are found in numerous medicinal and food plants, such as Cynomorium coccineum L., Prunus domestica (L.), and Vitis vinifera L. Their biosynthesis, physical and chemical characteristics and structure–activity relationship are well understood. These phytochemicals and their derivatives exert several bioactivities including but not limited to anticancer, cardioprotective, anti-inflammatory, immune-regulatory and anti-obesity properties. They are strong...
Source: Molecules - October 26, 2022 Category: Chemistry Authors: Afnan Ammara Saleem Muhammad Furqan Akhtar Ali Sharif Bushra Akhtar Rida Siddique Ghulam Md Ashraf Badrah S. Alghamdi Saif A. Alharthy Tags: Review Source Type: research

Prognostic and predictive significance of serum soluble scavenger receptor A in acute primary basal ganglia hemorrhage: a prospective cohort study
CONCLUSIONS: Serum soluble SRA concentrations may reflect illness severity and neurologic function after ICH, indicating serum soluble SRA may serve as a promising prognostic biochemical marker of ICH.PMID:36436572 | DOI:10.1016/j.cca.2022.11.023
Source: International Journal of Clinical Chemistry - November 27, 2022 Category: Chemistry Authors: Bin Chen Guan-Rong Zheng Cai-Yan Ma Jian-Jun Huang Ge Huang Hai Hua Shen-Zhong Qiu Source Type: research

Increased serum pannexin-1 concentrations reflect illness severity and predict a poor prognosis after acute supratentorial intracerebral hemorrhage:a prospective longitudinal cohort study
CONCLUSION: Rising serum pannexin-1 concentrations following ICH, in strong correlation with hemorrhagic severity, independently distinguish the risk of END and 90-day poor outcome. Assumably, serum pannexin-1 may represent a valuable prognostic biomarker of ICH.PMID:36610467 | DOI:10.1016/j.cca.2023.117218
Source: International Journal of Clinical Chemistry - January 7, 2023 Category: Chemistry Authors: Lixin Zhang Qin Xie Huayong Hong Xiaofeng Wang Liming Miao Xiaole Zhang Source Type: research

Increased serum pannexin-1 concentrations reflect illness severity and predict a poor prognosis after acute supratentorial intracerebral hemorrhage: A prospective longitudinal cohort study
CONCLUSION: Rising serum pannexin-1 concentrations following ICH, in strong correlation with hemorrhagic severity, independently distinguish the risk of END and 90-day poor outcome. Assumably, serum pannexin-1 may represent a valuable prognostic biomarker of ICH.PMID:36610467 | DOI:10.1016/j.cca.2023.117218
Source: International Journal of Clinical Chemistry - January 7, 2023 Category: Chemistry Authors: Lixin Zhang Qin Xie Huayong Hong Xiaofeng Wang Liming Miao Xiaole Zhang Source Type: research