MALDI IMS of Intraperitoneally Injected Danegaptide (ZP1609) for Treatment of Stroke-Reperfusion Injury in Mice.

CONCLUSIONS: Overall, the data reveals successful penetration of ZP1609 across the blood-brain barrier. The benefits of tissue acidification in the enhancement of detection sensitivity for low abundance peptides were demonstrated. MALDI IMS has shown to be a useful technique in the direct detection of drugs within intact brain tissue sections.
PMID: 29575411 [PubMed - as supplied by publisher]

Source: Rapid Communications in Mass Spectrometry : RCM - March 25, 2018 Category: Chemistry Authors: Wang JSH, Freitas-Andrade M, Bechberger JF, Naus C, Yeung KK, Whitehead SN Tags: Rapid Commun Mass Spectrom Source Type: research