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Deep Learning in the Prediction of Ischaemic Stroke Thrombolysis Functional Outcomes: A Pilot Study
ConclusionDL models may aid in the prediction of functional thrombolysis outcomes. Further investigation with larger datasets and additional imaging sequences is indicated.
Source: Academic Radiology - May 2, 2019 Category: Radiology Source Type: research
Moringa oleifera seed extract protects against brain damage in both the acute and delayed stages of ischemic stroke.
Abstract The extract of Moringa oleifera (M. oleifera) seeds exerts various pharmacological effects. Our previous study demonstrated that M. oleifera seed extract (MSE) alleviates scopolamine-induced learning and memory impairment in mice. In the present study, we investigate the neuropharmacological properties of 70% ethanolic MSE in the acute and delayed stages of ischemic stroke. MSE may be effective for the prevention and/or treatment of acute ischemic stroke. The most effective dose was 500 mg/kg, and the therapeutic window seemed to be within 4 h after reperfusion. Additionally, we found that MSE treatme...
Source: Experimental Gerontology - April 26, 2019 Category: Geriatrics Authors: Zeng K, Li Y, Yang W, Ge Y, Xu L, Ren T, Zhang H, Zhuo R, Peng L, Chen C, Zhou Y, Zhao Y, Li WJ, Jin X, Yang L Tags: Exp Gerontol Source Type: research
A review of transcranial electrical stimulation methods in stroke rehabilitation
Cassandra D Solomons, Vivekanandan ShanmugasundaramNeurology India 2019 67(2):417-423 Transcranial electrical stimulation (TES) uses direct or alternating current to non-invasively stimulate the brain. Neuronal activity in the brain is modulated by the electrical field according to the polarity of the current being applied. TES includes transcranial direct current stimulation (tDCS), transcranial random noise stimulation, and transcranial alternating current stimulation (tACS). tDCS and tACS are the two non-invasive brain stimulation techniques that have been used alone or in combination with other rehabilitative therapie...
Source: Neurology India - May 12, 2019 Category: Neurology Authors: Cassandra D Solomons Vivekanandan Shanmugasundaram Source Type: research
Self-regulation of language areas using real-time functional MRI in stroke patients with expressive aphasia
The objectives of this study were to test (i) If stroke patients with expressive Aphasia could learn to up-regulate the Blood Oxygenation Level Dependent (BOLD) signal in language areas of the brain, namely Inferior Frontal Gyrus (Broca ’s area) and Superior Temporal Gyrus (Wernicke’s area), with real-time fMRI based neurofeedback of the BOLD activation and functional connectivity between the language areas; and (ii) acquired up-regulation could lead to an improvement in expression of language. The study was performed on three groups: Group 1 (n = 4) of Test patients and group 2 (n = 4) of healthy volunteers un...
Source: Brain Imaging and Behavior - May 13, 2019 Category: Neurology Source Type: research
Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the Rat Hippocampus After Heat Stroke
Heat stroke, the most serious type of heat illness, refers to the presence of hyperthermia (core temperature>40°C), accompanied by central nervous system dysfunction. The hippocampus is a particularly vulnerable region in the early stage of heat stroke. Increasing evidence suggests that dysregulation of brain iron metabolism is involved in many neurodegenerative diseases. However, whether heat stroke causes dysfunction of iron metabolism, as well as iron-regulatory proteins, in the hippocampus remains unknown. The present study was conducted to explore the effects on spatial learning and memory, as well as iron content, f...
Source: Shock - May 15, 2019 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
Delayed exposure to environmental enrichment improves functional outcome after stroke
Publication date: Available online 18 May 2019Source: Journal of Pharmacological SciencesAuthor(s): Ying Tang, Ming-Yue Li, Xin Zhang, Xing Jin, Jing Liu, Ping-He WeiAbstractStroke is one of the leading causes of long-term disabilities worldwide. Although exposure to an enriched environment (EE) initiated in the acute phase after stroke has neuroprotective effects and improves stroke outcome, it remains unclear whether EE has positive effects when started in a delayed time frame. Here we show that exposure to EE in the delayed phase notably ameliorates the ischemia-induced impairments in neurological functions and spatial ...
Source: Journal of Pharmacological Sciences - May 18, 2019 Category: Drugs & Pharmacology Source Type: research
Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): Gary A Ford, Bipin B Bhakta, Alastair Cozens, Suzanne Hartley, Ivana Holloway, David Meads, John Pearn, Sharon Ruddock, Catherine M Sackley, Eirini-Christina Saloniki, Gillian Santorelli, Marion F Walker, Amanda J FarrinSummaryBackgroundDopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials of dopamine agonists after stroke provide equivocal evidence of effectiveness on improving motor recovery. We aimed to assess the safety and efficacy of co-careldopa plus routi...
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research
Longitudinal Analysis of Stroke Patients' Brain Rhythms during an Intervention with a Brain-Computer Interface.
Abstract Stroke is a leading cause of motor disability worldwide. Upper limb rehabilitation is particularly challenging since approximately 35% of patients recover significant hand function after 6 months of the stroke's onset. Therefore, new therapies, especially those based on brain-computer interfaces (BCI) and robotic assistive devices, are currently under research. Electroencephalography (EEG) acquired brain rhythms in alpha and beta bands, during motor tasks, such as motor imagery/intention (MI), could provide insight of motor-related neural plasticity occurring during a BCI intervention. Hence, a longitudin...
Source: Neural Plasticity - May 22, 2019 Category: Neurology Authors: Carino-Escobar RI, Carrillo-Mora P, Valdés-Cristerna R, Rodriguez-Barragan MA, Hernandez-Arenas C, Quinzaños-Fresnedo J, Galicia-Alvarado MA, Cantillo-Negrete J Tags: Neural Plast Source Type: research
IJERPH, Vol. 16, Pages 1876: The Use of Deep Learning to Predict Stroke Patient Mortality
e Lim The increase in stroke incidence with the aging of the Korean population will rapidly impose an economic burden on society. Timely treatment can improve stroke prognosis. Awareness of stroke warning signs and appropriate actions in the event of a stroke improve outcomes. Medical service use and health behavior data are easier to collect than medical imaging data. Here, we used a deep neural network to detect stroke using medical service use and health behavior data; we identified 15,099 patients with stroke. Principal component analysis (PCA) featuring quantile scaling was used to extract relevant background feat...
Source: International Journal of Environmental Research and Public Health - May 27, 2019 Category: Environmental Health Authors: Songhee Cheon Jungyoon Kim Jihye Lim Tags: Article Source Type: research
Aura and Stroke: relationship and what we have learnt from preclinical models
ConclusionPreclinical models suggest a key role for enhanced SD susceptibility and microembolization to explain both the occurrence of migraine attacks and the increased stroke risk in migraineurs. Therapeutic targeting of SD and microembolic events, or potential causes thereof, will be promising for treatment of aura and may also prevent ischemic infarction in vulnerable brains.
Source: The Journal of Headache and Pain - May 28, 2019 Category: Neurology Source Type: research
White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts – The MRI-GENIE study
Publication date: Available online 29 May 2019Source: NeuroImage: ClinicalAuthor(s): Markus D. Schirmer, Adrian V. Dalca, Ramesh Sridharan, Anne-Katrin Giese, Kathleen L. Donahue, Marco J. Nardin, Steven J.T. Mocking, Elissa C. McIntosh, Petrea Frid, Johan Wasselius, John W. Cole, Lukas Holmegaard, Christina Jern, Jordi Jimenez-Conde, Robin Lemmens, Arne G. Lindgren, James F. Meschia, Jaume Roquer, Tatjana Rundek, Ralph L. SaccoAbstractWhite matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis of diseases, such as acute ischemic stroke (AIS)....
Source: NeuroImage: Clinical - May 29, 2019 Category: Radiology Source Type: research
Pharmacological Enhancement of Stroke Recovery
AbstractPurpose of ReviewThis review aims to discuss the recent literature relating to drugs for stroke recovery and to identify some of the challenges in conducting translational research for stroke recovery.Recent FindingsAdvances in our understanding of neural repair mechanisms in pre-clinical stroke models have provided insights into potential targets for drugs that enhance the repair/recovery process. Few drugs that act on serotonergic and dopaminergic systems have been tested in humans with mixed results. The FOCUS trial, a phase III study of early administration of fluoxetine for stroke recovery, failed to replicate...
Source: Current Neurology and Neuroscience Reports - May 29, 2019 Category: Neuroscience Source Type: research
An RFID-based activity tracking system to monitor individual rodent behavior in environmental enrichment: Implications for post-stroke cognitive recovery
ConclusionThis study represents an attempt to better align preclinical and clinical implementations of EE and facilitate the uptake of this intervention in the clinical setting.
Source: Journal of Neuroscience Methods - May 30, 2019 Category: Neuroscience Source Type: research
Pericytes in Ischemic Stroke.
Authors: Dalkara T, Alarcon-Martinez L, Yemisci M Abstract Recent stroke research has shifted the focus to the microvasculature from neuron-centric views. It is increasingly recognized that a successful neuroprotection is not feasible without microvascular protection. On the other hand, recent studies on pericytes, long-neglected cells on microvessels have provided insight into the regulation of microcirculation. Pericytes play an essential role in matching the metabolic demand of nervous tissue with the blood flow in addition to regulating the development and maintenance of the blood-brain barrier (BBB), leukocyte...
Source: Advances in Experimental Medicine and Biology - June 1, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research
AI-Based Stroke Rehab System Shown to Be as Effective as One-on-One Therapy
The idea that the brain is capable of rewiring after a stroke is not new, but the therapy needed to achieve this is cumbersome at best. âStudies show that neuroplasticity requires hundreds to thousands of hours of repetition of focused, concentrated training to get the brain to have those functional changes,â said David Wu, Motus Novaâs CEO, in an interview with MD+DI. But he explained that those many hours of therapy with a clinician are not always feasible for patients, because of concerns about time and logistics, cost, and sometimes even a lack of motivation. So, Mo...
Source: MDDI - June 1, 2019 Category: Medical Devices Authors: Susan Shepard Tags: Digital Health Source Type: news
Infographic: Causes of ischemic stroke
Learn more about stroke care.Other health tip infographics: mayohealthhighlights.startribune.com
Source: News from Mayo Clinic - May 28, 2019 Category: Databases & Libraries Source Type: news
Effects and safety of combined rTMS and action observation for recovery of function in the upper extremities in stroke patients: A randomized controlled trial.
CONCLUSIONS: Distal upper extremity function, as measured by MFT and grip power, was improved after rTMS and AO in combination. The combination of rTMS with AO may be applied safely to improve upper extremity function after stroke. PMID: 31177248 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - June 11, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
Finding the Intersection of Neuroplasticity, Stroke Recovery, and Learning: Scope and Contributions to Stroke Rehabilitation.
Conclusions: Our novel approach developed for this review allowed the identification of the common themes/topics that intersect the concepts of neuroplasticity, stroke recovery, and learning. These may be synthesised to advance a neuroscience-informed approach to stroke rehabilitation. We also identified gaps in available literature using this approach. These may help guide future targeted research. PMID: 31191637 [PubMed - in process]
Source: Neural Plasticity - June 15, 2019 Category: Neurology Authors: Carey L, Walsh A, Adikari A, Goodin P, Alahakoon D, De Silva D, Ong KL, Nilsson M, Boyd L Tags: Neural Plast Source Type: research
Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice.
Abstract Stroke remains a leading cause of disability worldwide. Recently, we have established an animal model of stroke that results in delayed impairment in spatial memory, allowing us to better investigate cognitive deficits. Young and aged brains show different recovery profiles after stroke; therefore, we assessed aged-related differences in poststroke cognition. As neurotrophic support diminishes with age, we also investigated the involvement of brain-derived neurotrophic factor (BDNF) in these differences. Young (3-6 months old) and aged (16-21 months old) mice were trained in operant touchscreen chambers t...
Source: Neural Plasticity - June 15, 2019 Category: Neurology Authors: Houlton J, Zhou LYY, Barwick D, Gowing EK, Clarkson AN Tags: Neural Plast Source Type: research
Collateral Automation for Triage in Stroke: Evaluating Automated Scoring of Collaterals in Acute Stroke on Computed Tomography Scans
In conclusion, e-CTA provides a real-time and fully automated approach to collateral scoring with the potential to improve consistency of image interpretation and to independently quantify collateral scores even without expert rater input.Cerebrovasc Dis
Source: Cerebrovascular Diseases - June 19, 2019 Category: Neurology Source Type: research
The effects of five sessions of continuous theta burst stimulation over contralesional sensorimotor cortex paired with paretic skilled motor practice in people with chronic stroke.
CONCLUSIONS: Multiple sessions of STT practice can improve paretic arm function and decrease TCI bilaterally, with no additional benefit of prior cTBS. Our results suggest that improvement in STT practice following M1c cTBS scaled with change in paretic arm function in some individuals. Our results highlight the need for a better understanding of the mechanisms of cTBS to effectively identify who may benefit from this form of brain stimulation. PMID: 31227676 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - June 23, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
What is the impact of user affect on motor learning in virtual environments after stroke? A scoping review
The purported affective impact of virtual reality (VR) and active video gaming (AVG) systems is a key marketing strategy underlying their use in stroke rehabilitation, yet little is known as to how affective c...
Source: Journal of NeuroEngineering and Rehabilitation - June 27, 2019 Category: Rehabilitation Authors: Nina Rohrbach, Emily Chicklis and Danielle Elaine Levac Tags: Review Source Type: research
A Machine Learning Approach for Classifying Ischemic Stroke Onset Time From Imaging
Current clinical practice relies on clinical history to determine the time since stroke (TSS) onset. Imaging-based determination of acute stroke onset time could provide critical information to clinicians in deciding stroke treatment options, such as thrombolysis. The patients with unknown or unwitnessed TSS are usually excluded from thrombolysis, even if their symptoms began within the therapeutic window. In this paper, we demonstrate a machine learning approach for TSS classification using routinely acquired imaging sequences. We develop imaging features from the magnetic resonance (MR) images and train machine learning ...
Source: IEE Transactions on Medical Imaging - June 30, 2019 Category: Biomedical Engineering Source Type: research
Inhibition of Reactive Astrocytes with Fluorocitrate Ameliorates Learning and Memory Impairment Through Upregulating CRTC1 and Synaptophysin in Ischemic Stroke Rats.
Abstract Ischemic stroke often causes motor and cognitive deficits. Deregulated glia gap junction communication, which is reflected by increased protein levels of glial fibrillary acidic protein (GFAP) and connexin 43 (Cx43), has been observed in ischemic hippocampus and has been associated with cognitive impairment in animal stroke models. Here, we tested the hypothesis that reactive astrocytes-mediated loss of synaptophysin (SYP) and CREB-regulated transcription coactivator 1 (CRTC1) contribute to dysfunction in glia gap junction communication and memory impairment after ischemic stroke. Male Sprague-Dawley rats...
Source: Cellular and Molecular Neurobiology - July 2, 2019 Category: Cytology Authors: Zhang X, Shen X, Dong J, Liu WC, Song M, Sun Y, Shu H, Towse CL, Liu W, Liu CF, Jin X Tags: Cell Mol Neurobiol Source Type: research
Japan approves iSchemaView ’ s Rapid stroke imaging device
iSchemaView today announced that it received registration approval in Japan for its Rapid imaging platform. The company received registration approval through the Japanese Pharmaceutical Affairs Law and through a third party review by the Japanese Assn. for the Advancement of Medical Equipment for the Rapid imaging platform. Rapid is designed to give physicians a fast, fully automated and easy-to-interpret imaging system that can help doctors make clinical decisions about stroke. “Stroke remains the fourth most common cause of death in Japan, and as the population ages, stroke is likely to become an increasing health...
Source: Mass Device - July 8, 2019 Category: Medical Devices Authors: Danielle Kirsh Tags: Cardiovascular Hospital Care Imaging ischemaview Source Type: news
Deficit of Motor Skill Acquisition on the Upper Limb Ipsilesional to the Injured Hemisphere in Individuals with Stroke.
CONCLUSIONS Our findings provide evidence that individuals with stroke might have difficulty in performing visuo-spatial movements and acquiring motor skills with the ipsilateral upper limb. Improvement of ipsilesional limb function increases self-care activity in daily life. Therefore, we recommend that clinicians adopt remedial strategies for ipsilesional limbs. PMID: 31283752 [PubMed - in process]
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research
A Platform for Collection and Analysis of Image Data on Stroke.
Authors: Dolotova D, Donitova V, Arhipov I, Sharifullin F, Zagriazkina T, Kobrinskii B, Gavrilov A Abstract Identifying imaging biomarkers (IBs) of stroke remains a priority in neurodiagnostics. There is a number of different methods for image analysis and learning rules applicable in this field, but all of them require large arrays of DICOM images and clinical data. In order to amass such dataset,we havedesigneda platform for systematic collection of clinical data and medical images in different modalities. The platform provides easy-to-use tools to create formalized radiology reports, contour and tag the regions ...
Source: Studies in Health Technology and Informatics - July 28, 2019 Category: Information Technology Tags: Stud Health Technol Inform Source Type: research
A single session of anodal transcranial direct current stimulation applied over the affected primary motor cortex does not alter gait parameters in chronic stroke survivors
ConclusionA single session of a-tDCS delivered to the leg motor cortex did not immediately improve gait parameters in individuals with chronic stroke, regardless of their BDNF genotype.
Source: Neurophysiologie Clinique - July 31, 2019 Category: Neuroscience Source Type: research
Cognitive and neural mechanisms underlying the mnemonic effect of songs after stroke
Publication date: Available online 5 August 2019Source: NeuroImage: ClinicalAuthor(s): Vera Leo, Aleksi J. Sihvonen, Tanja Linnavalli, Mari Tervaniemi, Matti Laine, Seppo Soinila, Teppo SärkämöAbstractSung melody provides a mnemonic cue that can enhance the acquisition of novel verbal material in healthy subjects. Recent evidence suggests that also stroke patients, especially those with mild aphasia, can learn and recall novel narrative stories better when they are presented in sung than spoken format. Extending this finding, the present study explored the cognitive mechanisms underlying this effect by determining wheth...
Source: NeuroImage: Clinical - August 6, 2019 Category: Radiology Source Type: research
Forced use of paretic leg induced by constraining the non-paretic leg leads to motor learning in individuals post-stroke.
Abstract The purpose of this study was to determine whether applying repetitive constraint forces to the non-paretic leg during walking would induce motor learning of enhanced use of the paretic leg in individuals post-stroke. Sixteen individuals post chronic (> 6 months) stroke were recruited in this study. Each subject was tested in two conditions, i.e., applying a constraint force to the non-paretic leg during treadmill walking and treadmill walking only. For the constraint condition, subjects walked on a treadmill with no force for 1 min (baseline), with force for 7 min (adaptation), and then without f...
Source: Experimental Brain Research - August 11, 2019 Category: Neuroscience Authors: Wu M, Hsu CJ, Kim J Tags: Exp Brain Res Source Type: research
Neurotechnology for Upper Limb Motor Rehabilitation in Stroke Neurotechnology for Upper Limb Motor Rehabilitation in Stroke
Learn how neurotechnologies, including robotics, muscular electrical stimulation, brain stimulation and brain-computer/machine interfaces can support upper limb motor recovery in severe stroke.Brain
Source: Medscape Today Headlines - September 3, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
Electroacupuncture ameliorates learning and memory deficits via hippocampal 5-HT1A receptors and the PKA signaling pathway in rats with ischemic stroke
This study aimed to investigate whether PKA signaling mediated by 5-HT1A receptors was involved in the electroacupuncture (EA)-mediated learning and memory in a rat model of middle cerebral artery occlusion-induced cognitive deficit (MICD). Compared to no treatment or non-acupoint EA treatment, EA at DU20 and DU24 acupoints improved the neurological deficit of scores, shortened escape latency and increased the frequency of crossing the platform in the Morris water maze test. T2-weighted imaging demonstrated that the MICD rat brain lesions were mainly located in the cortex and hippocampus, and injured volumes were reduced a...
Source: Metabolic Brain Disease - September 11, 2019 Category: Neurology Source Type: research
A Public Health Framework to Improve Population Health Through Health Care and Community Clinical Linkages: The ASTHO/CDC Heart Disease and Stroke Prevention Learning Collaborative
Source: CDC Preventing Chronic Disease - September 12, 2019 Category: International Medicine & Public Health Tags: Public Health Source Type: news
224 Dance Artist and Physiotherapist Collaboration in Stroke Rehabilitation
ConclusionWithin this study we questioned: what is required to create successful collaboration within a medical context? We hope that describing how this particular collaboration was successful will benefit those interested in similar collaborations.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research
Re-learning to be different: Increased neural differentiation supports post-stroke language recovery
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Jeremy J. Purcell, Robert W. Wiley, Brenda RappAbstractIdentifying the neural changes that support recovery of cognitive functions after a brain lesion is important to advance our understanding of human neuroplasticity, which, in turn, forms the basis for the development of effective treatments. To date, the preponderance of neuroimaging studies has focused on localizing changes in average brain activity associated with functional recovery. Here, we took a novel approach by evaluating whether cognitive recovery in chronic stroke is related to increa...
Source: NeuroImage - September 17, 2019 Category: Neuroscience Source Type: research
DWI-MRI predicts stroke recurrence in low-risk patients
A diffusion-weighted MRI (DWI-MRI) brain sequence can confirm the presence...Read more on AuntMinnie.comRelated Reading: Deep-learning model detects cerebral microbleeds on MRI MRI measurements of iron content show impact of stroke Deep-learning MRI algorithm aids in neurological diagnoses Key MRI markers link vascular brain injury to health risks MRI links lifestyle factors to stroke, dementia risk
Source: AuntMinnie.com Headlines - September 24, 2019 Category: Radiology Source Type: news
A Unique Signature of Cardiac-Induced Cranial Forces During Acute Large Vessel Stroke and Development of a Predictive Model
ConclusionsHeadpulse recordings performed on patients with suspected acute stroke significantly identify those with LVO. The lack of temporal correlation of the headpulse with cardiac contraction and resolution to normal may reflect changes in cerebral blood flow and may provide a useful technique to triage stroke patients for thrombectomy using a noninvasive device.
Source: Neurocritical Care - October 6, 2019 Category: Neurology Source Type: research
Gait training with auditory feedback improves trunk control, muscle activation and dynamic balance in patients with hemiparetic stroke: A randomized controlled pilot study.
CONCLUSION: Our findings indicate that gait training with auditory feedback was beneficial for improving trunk control and muscle activation in patients with hemiparetic stroke. PMID: 31594193 [PubMed - as supplied by publisher]
Source: Journal of Back and Musculoskeletal Rehabilitation - October 10, 2019 Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research
A Paradigm Shift: Rehabilitation Robotics, Cognitive Skills Training, and Function After Stroke
Conclusion: The ALPS protocol was the first to extend cognitive strategy training to robot-assisted therapy. The intervention in this development of concept pilot trial was feasible and well-tolerated, with good potential to optimize paretic UE performance following robot-assisted therapy.
Source: Frontiers in Neurology - October 14, 2019 Category: Neurology Source Type: research
Generalizing post-stroke prognoses from research data to clinical data
Publication date: Available online 14 October 2019Source: NeuroImage: ClinicalAuthor(s): Robert Loughnan, Diego L. Lorca-Puls, Andrea Gajardo-Vidal, Valeria Espejo-Videla, Céline R. Gillebert, Dante Mantini, Cathy J. Price, Thomas M.H. HopeAbstractAround a third of stroke survivors suffer from acquired language disorders (aphasia), but current medicine cannot predict whether or when they might recover. Prognostic research in this area increasingly draws on datasets associating structural brain imaging data with outcome scores for ever-larger samples of stroke patients. The aim is to learn brain-behavior trends from these ...
Source: NeuroImage: Clinical - October 15, 2019 Category: Radiology Source Type: research
Temporal Features of Muscle Synergies in Sit-to-Stand Motion Reflect the Motor Impairment of Post-Stroke Patients
Sit-to-stand (STS) motion is an important daily activity, and many post-stroke patients have difficulty performing STS motion. Previous studies found that there are four muscle synergies (synchronized muscle activations) in the STS motion of healthy adults. However, for post-stroke patients, it is unclear whether muscle synergies change and which features primarily reflect motor impairment. Here, we use a machine learning method to demonstrate that temporal features in two muscle synergies that contribute to hip rising and balance maintenance motion reflect the motor impairment of post-stroke patients. Analyzing the muscle...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - September 30, 2019 Category: Neuroscience Source Type: research
Rehab-Net: Deep Learning Framework for Arm Movement Classification Using Wearable Sensors for Stroke Rehabilitation
In this paper, we present a deep learning framework “Rehab-Net” for effectively classifying three upper limb movements of the human arm, involving extension, flexion, and rotation of the forearm, which, over the time, could provide a measure of rehabilitation progress. The proposed framework, Rehab-Net is formulated with a personalized, light weight and low-complex, customized convolutional neural network (CNN) model, using two-layers of CNN, interleaved with pooling layers, followed by a fully connected layer that classifies the three movements from tri-axial acceleration input data collected from the wrist....
Source: IEEE Transactions on Biomedical Engineering - October 23, 2019 Category: Biomedical Engineering Source Type: research
Reduced striatal activation in response to rewarding motor performance feedback after stroke
ConclusionStriatal hypoactivation in stroke survivors may cause impaired consolidation of motor skills. Stronger rewarding stimuli or drug-mediated enhancement may be needed to normalize reward processing after stroke with positive effects on recovery.
Source: NeuroImage: Clinical - October 24, 2019 Category: Radiology Source Type: research
A hybrid machine learning approach to cerebral stroke prediction based on imbalanced medical dataset
Conclusion: The approach proposed in this paper has effectively reduced the false negative rate with a relatively high overall accuracy, which means a successful decrease in the misdiagnosis rate for stroke prediction. The results are more reliable and valid as the reference in stroke prognosis, and also can be acquired conveniently at a low cost.
Source: Artificial Intelligence in Medicine - October 25, 2019 Category: Bioinformatics Source Type: research
Development of a deep learning model to identify hyperdense MCA sign in patients with acute ischemic stroke
ConclusionThe deep learning method appears potentially beneficial for identifying HMCAS on non-contrast CT in patients with acute ischemic stroke.
Source: Japanese Journal of Radiology - October 30, 2019 Category: Radiology Source Type: research
Infographic: Phases of stroke care
Learn more about stroke care. Other health tip infographics: mayoclinichealthhighlights.startribune.com
Source: News from Mayo Clinic - October 29, 2019 Category: Databases & Libraries Source Type: news
Detecting compensatory movements of stroke survivors using pressure distribution data and machine learning algorithms
Compensatory movements are commonly employed by stroke survivors during seated reaching and may have negative effects on their long-term recovery. Detecting compensation is useful for coaching the patient to r...
Source: Journal of NeuroEngineering and Rehabilitation - November 4, 2019 Category: Rehabilitation Authors: Siqi Cai, Guofeng Li, Xiaoya Zhang, Shuangyuan Huang, Haiqing Zheng, Ke Ma and Longhan Xie Tags: Research Source Type: research
Using telerehabilitation to improve cognitive function in post-stroke survivors: is this the time for the continuity of care?
Post-stroke cognitive disorders can affect different domains, depending on typology of stroke and lesion localization, onset time, age and diagnostic tools used. In recent years, telerehabilitation using virtual reality has been used to reduce the healthcare costs encouraging continuity of care. The aim of our study is to evaluate the efficacy of a virtual reality rehabilitation system in improving cognitive function in stroke survivors. Forty patients affected by stroke were enrolled in this study and randomized into either the control or the experimental groups in order of recruitment. The study lasted 6 months, and incl...
Source: International Journal of Rehabilitation Research - November 7, 2019 Category: Rehabilitation Tags: Original Articles Source Type: research
Evaluation of sex differences in acid/base and electrolyte concentrations in acute large vessel stroke.
CONCLUSION: Acid/base and electrolyte response to ischemic conditions differ between men and women, and these early changes could be used to predict local acid/base changes and how they develop differently in men and women during ischemia. These findings provide a novel insight into the pathology of large vessel stroke in humans, particularly potential variations based on sex. PMID: 31697942 [PubMed - as supplied by publisher]
Source: Experimental Neurology - November 3, 2019 Category: Neurology Authors: Martha SR, Collier LA, Davis SM, Erol A, Lukins D, Pennypacker KR, Fraser JF Tags: Exp Neurol Source Type: research
A review of stroke in pregnancy: incidence, investigations and management
AbstractKey contentThe incidence of stroke in young and middle ‐aged adults is increasing, with pregnancy‐related strokes occurring in 30 in 100 000 pregnancies; strokes are three times more common among pregnant than among nonpregnant individuals aged 15–44 years.The investigation and management of stroke is changing because of the time ‐sensitive benefits of thrombolysis and thrombectomy in the acute management of ischaemic stroke.The approach to clinical assessment and investigation of a pregnant woman presenting with suspected stroke is not different from that of a non ‐pregnant patient:; timely brain imagi...
Source: The Obstetrician and Gynaecologist - November 13, 2019 Category: OBGYN Authors: Azy Khalid, Adriana Hadbavna, David Williams, Bridgette Byrne Tags: Reviews Source Type: research