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Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion
Abstract IMM-H004, a 3-piperazinylcoumarin compound derived from coumarin, has been proved effective against CA1 cell loss and spatial learning impairments resulting from transient global ischemia/reperfusion (TGCI/R), while the mechanism is still largely unknown. Here, we confirmed that treatment of rats with IMM-H004 immediately after TGCI/R ameliorated delayed neuronal death (DND) in the CA1 of hippocampus and cortex. Further study suggested that IMM-H004 contributed to the expression of antiapoptotic protein survivin through the activation of PI3K-dependent protein kinase B (PKB/Akt), which led to the phosphor...
Source: Molecular Neurobiology - January 7, 2016 Category: Neurology Source Type: research

This Is By Far The Best Way To Avoid Lower Back Pain
By: Cari Nierenberg Published: 01/11/2016 06:35 PM EST on LiveScience Shoe inserts, back-support belts and other gadgets aimed at preventing low back pain may be a waste of money. Instead, exercise is the best way to ward off this common problem, a new review of studies suggests. The researchers found evidence that an exercise program alone, or exercise along with education about how to prevent back pain, was effective in averting an episode of low back pain and reducing people's use of sick time at work. Education may include receiving training in proper lifting techniques, learning about correct posture or attending...
Source: Science - The Huffington Post - January 12, 2016 Category: Science Source Type: news

From the 90׳s to now: A brief historical perspective on more than two decades of estrogen neuroprotection.
This article is part of a Special Issue entitled SI:50th Anniversary Issue. PMID: 26740397 [PubMed - as supplied by publisher]
Source: Brain Research - December 29, 2015 Category: Neurology Authors: Engler-Chiurazzi EB, Singh M, Simpkins JW Tags: Brain Res Source Type: research

Automated Outcome Classification of Computed Tomography Imaging Reports for Pediatric Traumatic Brain Injury
ConclusionsA hybrid NLP and machine learning automated classification system continues to show promise in coding free‐text electronic clinical data. For complex outcomes, it can reliably identify negative reports, but manual review of positive reports may be required. As such, it can still streamline data collection for clinical research and performance improvement.
Source: Academic Emergency Medicine - January 14, 2016 Category: Emergency Medicine Authors: Kabir Yadav, Efsun Sarioglu, Hyeong−Ah Choi, Walter B. Cartwright, Pamela S. Hinds, James M. Chamberlain Tags: Original Contribution Source Type: research

Automated Outcome Classification of Computed Tomography Imaging Reports for Pediatric Traumatic Brain Injury.
CONCLUSIONS: A hybrid NLP and machine learning automated classification system continues to show promise in coding free-text electronic clinical data. For complex outcomes, it can reliably identify negative reports, but manual review of positive reports may be required. As such, it can still streamline data collection for clinical research and performance improvement. PMID: 26766600 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - January 14, 2016 Category: Emergency Medicine Authors: Yadav K, Sarioglu E, Choi HA, Cartwright WB, Hinds PS, Chamberlain JM Tags: Acad Emerg Med Source Type: research

How Did He Die?
Was he sick? Was it suicide? Was it a heart attack? Overdose? Did he die instantly? Who found him? Did he have a stroke? Did they try CPR? Who was he with? Did they do an autopsy? Have you read the report? Where was he? What is the cause of death? Is there a history of drugs or alcohol? Do anything of those things matter? Really? Do they matter? He is dead. Another family is grieving. They are making plans to bury their son. I, too, have questions. But I know the answers don't matter. It is not my place to ask those questions. The answers are not for me to know. What matters is that the parents are hurting. They loved thei...
Source: Healthy Living - The Huffington Post - January 19, 2016 Category: Consumer Health News Source Type: news

Low to moderate quality evidence demonstrates the potential benefits and adverse events of cannabinoids for certain medical indications
Commentary on: Whiting PF, Wolff RF, Deshpande S, et al.. Cannabinoids for medical use: a systematic review and meta-analysis. JAMA 2015;313:2456–73. Context As of September 2015, 23 states and the District of Columbia in the USA legalised the medicinal use of marijuana, underscoring the need for physicians to understand the science underlying medical marijuana as well as the practical issues associated with it. For years policymakers, scientists and physicians alike have debated the potential risks associated with marijuana use.1 Now marijuana's utility as a treatment for certain medical indications has taken focus....
Source: Evidence-Based Medicine - January 22, 2016 Category: Internal Medicine Authors: Hill, K. P., Hurley-Welljams-Dorof, W. M. Tags: Sexual transmitted infections (viral), Clinical trials (epidemiology), General practice / family medicine, Genetics, Immunology (including allergy), HIV/AIDS, Drugs: CNS (not psychiatric), Pain (neurology), Sleep disorders (neurology), Stroke, Ophthalmolo Source Type: research

Save Time With These Tips for Making Documentation Easier
Speech-language pathologists have a pretty sweet gig, am I right? We get to spend our working hours immersed in myriad rewarding tasks like teaching new moms to safely feed their precious babies, helping families learn strategies to communicate with their children and helping people who have had a stroke regain their voices. And when our day of using our communication superpowers for the greater good is through? We get to sit in front of a computer for hours and write about it. Not in an “I love this work and want to chronicle my experiences” sort of way. More in a “this tedious, painstaking documentation somehow bec...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - January 7, 2016 Category: Speech Therapy Authors: Amanda Rhodes Fyfe Tags: Audiology Speech-Language Pathology Health Care Schools Technology Source Type: blogs

Buried in Pills
By Drs. David Niesel and Norbert Herzog, Medical Discovery News Have you ever heard doctors referred to as "pill pushers"? While medical professionals provide necessary and admirable services, it does make you wonder how many pills we take in a day, a month, a year or even a lifetime. In the British Museum in London, along with the Rosetta Stone and an Easter Island head, there is an exhibit with an expansive glass table, more than a yard wide and at least 20 yards long. On it rests a tapestry-like depiction of the number of pills two individuals would take over their lifetimes in various colors and sizes. On one side is ...
Source: Science - The Huffington Post - January 21, 2016 Category: Science Source Type: news

How to prevent diabetes from sneaking up on your patients
An AMA Viewpoints post by AMA Board Chair Stephen R. Permut, MD A major health threat has been silently taking hold of 86 million Americans, with 90 percent of them unaware of it. A new public health campaign is about to change that—and you’re the key to helping these patients take their health back. A campaign to prevent type 2 diabetes If you’re not already talking to your patients about prediabetes and the risks associated with it, it’s time to start. People with prediabetes—more than 1 in 3 adults—are at higher risk of developing serious health problems such as type 2 diabetes, heart disease and s...
Source: AMA Wire - January 21, 2016 Category: Journals (General) Authors: Amy Farouk Source Type: news

Court case could increase liability exposure, redefine injury
A state supreme court is set to determine whether “loss of chance” for a better outcome should be recognized as a legal injury in medical liability lawsuits—which could leave physicians exposed to increased liability. The details of the case At stake in Smith v. Providence Health Services is whether or not the Oregon Supreme Court should redefine what constitutes an injury legally to include the lost possibility of a better outcome, known in legal terms as the “loss of chance” doctrine. Existing law does not include loss of chance as grounds for medical liability. The case is an attempt to expand the definiti...
Source: AMA Wire - January 11, 2016 Category: Journals (General) Authors: Amy Farouk Source Type: news

Top 9 takeaways from heart health tweet chat
How can physicians partner with their patients to ensure a healthy heart environment? The AMA hosted a vibrant tweet chat on World Heart Day Tuesday to explore answers to this question. Primary care physician Michael Rakotz, MD, sat down with leading cardiologist Clyde Yancy, MD, as his guest. Dr. Yancy is past president of the American Heart Association (AHA) and current chief of the Division of Medicine-Cardiology and Magerstadt Professor at Northwestern University’s Feinberg School of Medicine. And Dr. Rakotz is director of chronic disease prevention with the AMA’s Improving Health Outcomes initiative. The two d...
Source: AMA Wire - September 30, 2015 Category: Journals (General) Authors: amamod Source Type: news

How to help patients make heart health changes: Q&A with Dr. Rakotz
Dietary and lifestyle changes are difficult to make. Once habits are formed, the effort that is required to change is often overwhelming for both patients and physicians. This week, Michael Rakotz, MD, director of chronic disease prevention with the AMA’s Improving Health Outcomes initiative, provides guidance from his own experience as a primary care physician on approaching heart healthy changes with patients. AMA Wire®: In our Twitter poll, the public thought 2:1 that exercise would benefit their heart health more than dietary changes. Why is that? Dr. Rakotz: It’s hard to know for sure why people voted this w...
Source: AMA Wire - September 29, 2015 Category: Journals (General) Authors: amamod Source Type: news

An exploratory study using an openEHR 2-level modeling approach to represent common data elements
Conclusion The findings from this research show that the openEHR archetype has structural coverage for the CDEs, namely the openEHR archetype is able to represent the CDEs and meet the functional expectations of the CDEs. This work can be used as a reference when improving CDE structure using an advanced modeling approach.
Source: Journal of the American Medical Informatics Association - January 23, 2016 Category: Information Technology Authors: Lin, C.-H., Fann, Y.-C., Liou, D.-M. Tags: Research and Applications Source Type: research

Systemic inflammation affects reperfusion following transient cerebral ischaemia.
Abstract Reperfusion after stroke is critical for improved patient survival and recovery and can be achieved clinically through pharmacological (recombinant tissue plasminogen activator) or physical (endovascular intervention) means. Yet these approaches remain confined to a small percentage of stroke patients, often with incomplete reperfusion, and therefore there is an urgent need to learn more about the mechanisms underlying the no-reflow phenomenon that prevents restoration of adequate microvascular perfusion. Recent evidence suggests systemic inflammation as an important contributor to no-reflow and to furthe...
Source: Experimental Neurology - January 18, 2016 Category: Neurology Authors: Burrows F, Haley MJ, Scott E, Coutts G, Lawrence CB, Allan SM, Schiessl I Tags: Exp Neurol Source Type: research

Probable Nootropic-induced Psychiatric Adverse Effects: A Series of Four Cases
Conclusion Healthcare providers in general, and specifically those in the mental health and substance abuse fields, should keep in mind that nootropic use is an under recognized and evolving problem. Nootropic use should be considered in cases where there are sudden or unexplained exacerbations of psychiatric symptoms in patients who have been stable and medication adherent. It is also important to remember that most nootropics are not detected on standard drug toxicology screening tests. We have very little clinical information on how nootropics may interact with psychotropics (or other medications) and potentially cause ...
Source: Innovations in Clinical Neuroscience - December 1, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Case Series and Literature Review Current Issue Mental Disorders Psychiatry Psychopharmacology Substance Use Disorders Ampakines Armodafinil brain enhancer Cerebrolysin Citicoline cognitive enhancer homeopathic medicine natural r Source Type: research

L-dopa does not add to the success of high-intensity language training in aphasia.
CONCLUSION: High-intensity language training in chronic aphasia may take learning to a ceiling that precludes additive benefits from l-dopa. Effects of l-dopa on post-stroke recovery during less intense treatment in chronic aphasia remain to be evaluated. PMID: 25588456 [PubMed - indexed for MEDLINE]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats Basic Sciences
Conclusions— Exogenous LXA4 inhibited inflammation by activating FPR2 and inhibiting p38 after SAH. LXA4 may serve as an alternative treatment to relieve early brain injury after SAH.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Guo, Z., Hu, Q., Xu, L., Guo, Z.-N., Ou, Y., He, Y., Yin, C., Sun, X., Tang, J., Zhang, J. H. Tags: Animal Models of Human Disease Basic Sciences Source Type: research

Oversleeping: The Effects and Health Risks of Sleeping Too Much
This article originally appeared on the Amerisleep blog. Rosie Osmun is the Creative Content Manager at Amerisleep, a progressive memory foam mattress brand focused on eco-friendly sleep solutions. Rosie writes more posts on the Amerisleep blog about the science of sleep, eco-friendly living, leading a healthy lifestyle and more. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - January 29, 2016 Category: Consumer Health News Source Type: news

A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference
This report ends with a list of priorities for research in AF patients.
Source: Europace - February 3, 2016 Category: Cardiology Authors: Kirchhof, P., Breithardt, G., Bax, J., Benninger, G., Blomstrom-Lundqvist, C., Boriani, G., Brandes, A., Brown, H., Brueckmann, M., Calkins, H., Calvert, M., Christoffels, V., Crijns, H., Dobrev, D., Ellinor, P., Fabritz, L., Fetsch, T., Freedman, S. B., Tags: EHRA CONSENSUS STATEMENT Source Type: research

5 ways to promote better heart health among your patients
American Heart Month starts today. Find out how can you participate as a physician and help your patients focus on their heart health throughout the next four weeks.   How you and your patients can raise awareness for heart health this month Uncontrolled hypertension is one of the leading causes of death in the country. This February, help turn the tide and improve heart health across the nation.   Here are the five ways to promote better heart health during American Heart Month:   1. Learn insights from experts on hypertension Take part in a Google Hangout focused on the latest compelling information, r...
Source: AMA Wire - February 1, 2016 Category: Journals (General) Authors: Amy Farouk Source Type: news

The Jekyll and Hyde of Statins
By Drs. David Niesel and Norbert Herzog, Medical Discovery News Cholesterol-lowering drugs called statins are the most prescribed drug ever. About 30 percent of Americans are currently taking statins such as Crestor, Lipitor, Mevacor and Zocor. Overall, statins can be good thing, but as with all drugs, there are some negative effects. Statins lower cholesterol by inhibiting a protein called HMG-CoA reductase. Since high cholesterol levels are linked to heart disease, statins can reduce the risks of heart attack and stroke, two of the leading causes of death in the United States. Recent reports from the American Heart Assoc...
Source: Science - The Huffington Post - February 3, 2016 Category: Science Source Type: news

Clinical and haemodynamic outcomes in 658 patients receiving the Perceval sutureless aortic valve: early results from a prospective European multicentre study (the Cavalier Trial) ADULT CARDIAC
CONCLUSIONS The current 30-day results show that the Perceval valve is safe (favourable haemodynamic effect and low complication rate), and can be implanted with a fast and reproducible technique after a short learning period. Short cross-clamp and CPB times were achieved in both isolated and combined procedures. The Perceval valve represents a promising alternative to biological AVR, especially with a less invasive approach and in older patients.
Source: European Journal of Cardio-Thoracic Surgery - February 6, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Laborde, F., Fischlein, T., Hakim-Meibodi, K., Misfeld, M., Carrel, T., Zembala, M., Madonna, F., Meuris, B., Haverich, A., Shrestha, M., on behalf of the Cavalier Trial Investigators, on behalf of the Cavalier Trial Investigators, Folliguet, Zannis, Pfei Tags: Basic research vascular ADULT CARDIAC Source Type: research

How one ED uses telemedicine in the ambulance
When you think of telemedicine, what comes to mind? Often the answer is a split screen—physician and patient in separate locations on their computers or tablets. But one health system has shown the true breadth of telemedicine’s reach by using the technology to treat patients during the critical early moments of a stroke. Find out how. The risk of damage and disability in patients who are experiencing a stroke increases with any delay in care delivery. Two emergency physicians at the University of Virginia (UVA) Health System understood the need for speed when it comes to caring for patients in the midst of acute str...
Source: AMA Wire - February 5, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news

5 tips to help teens stay heart healthy
As parents, we want our kids to stay healthy throughout their lives. The teen years are an important time to build healthy cardiovascular habits. In 2010, the American Heart Association set the bold goal of improving the cardiovascular health of all Americans by 20 percent. In setting this goal, they created a paradigm shift from the treatment of cardiovascular disease to the promotion of cardiovascular health. Their recommendation was based on more than a decade of data showing adults who reach middle age without any major cardiovascular disease risk factors have a high chance of staying healthy well into old age. They do...
Source: Thrive, Children's Hospital Boston - February 8, 2016 Category: Pediatrics Authors: Holly Gooding Tags: Health & Wellness Research Teen Health heart health Holly Gooding Source Type: news

Brain Stimulation: Neuromodulation as a Potential Treatment for Motor Recovery Following Traumatic Brain Injury.
Abstract There is growing evidence that electrical and magnetic brain stimulation can improve motor function and motor learning following brain damage. Rodent and primate studies have strongly demonstrated that combining cortical stimulation (CS) with skilled motor rehabilitative training enhances functional motor recovery following stroke. Brain stimulation following traumatic brain injury (TBI) is less well studied, but early pre-clinical and human pilot studies suggest that it is a promising treatment for TBI-induced motor impairments as well. This review will first discuss the evidence supporting brain stimula...
Source: Brain Research - February 5, 2016 Category: Neurology Authors: Clayton E, Kinley-Cooper SK, Weber RA, Adkins DL Tags: Brain Res Source Type: research

What it’s like to be in vascular surgery: Shadowing Dr. Aziz
As a medical student, do you ever wonder what it’s like to be a vascular surgeon? Here’s your chance to find out. Meet Faisal Aziz, MD, a vascular surgeon, educator and featured physician in AMA Wire’s® “Shadow Me” Specialty Series, which offers advice directly from physicians about life in their specialties. Read his insights to help determine whether a career in vascular surgery might be a good fit for you. “Shadowing” Dr. Aziz Specialty: Vascular surgery Practice setting: Academic university hospital   Employment type: Employed Years in practice: 4 A typical week in my practice: A typic...
Source: AMA Wire - February 8, 2016 Category: Journals (General) Authors: Lyndra Vassar Source Type: news

Compensatory Reserve Index Can Aid in Early Shock Detection
EARLY SHOCK DETECTION Convertino VA, Howard JT, Hinojosa-Laborde C. Individual-specific, beat-to-beat trending of significant human blood loss: The compensatory reserve. Shock. Jan. 6, 2015. [Epub ahead of print.] Hemorrhagic shock is the leading cause of death in trauma. The challenge is detecting shock early enough to intervene clinically. The human body is masterful at compensating with a variety of seemingly undetectable mechanisms, such as autonomic activity, vasoconstriction, increased stroke volume, improved cardiac filling and more efficient breathing. So by the time we see alterations in vital sign metrics, the p...
Source: JEMS Patient Care - August 10, 2015 Category: Emergency Medicine Authors: Alexander L. Trembley, NREMT P Tags: Resuscitation & Shock Special Topics Research Columns Patient Care Source Type: news

Developments in the management of Chagas cardiomyopathy.
Authors: Tanowitz HB, Machado FS, Spray DC, Friedman JM, Weiss OS, Lora JN, Nagajyothi J, Moraes DN, Garg NJ, Nunes MC, Ribeiro AL Abstract Over 100 years have elapsed since the discovery of Chagas disease and there is still much to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs available, such as benznidazole and nifurtimox, they are not totally reliable and often toxic. A recently released negative clinical trial with benznidazole in patients with chronic Chagas cardiomyopathy further reinforces the concerns regarding its effectiveness. New drugs and new delivery systems, incl...
Source: Expert Review of Cardiovascular Therapy - February 17, 2016 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

How a public health solution is reducing hypertension disparities
Addressing health care disparities can help practices improve the health of patients in vulnerable at-risk populations. Learn how eight family medicine practices boosted hypertension control rates for diverse patients by more than 3 percentage points in just three months. A targeted pilot As part of the Million Hearts initiative, the Summit County Public Health department (SCPH) and several partners in Ohio launched a pilot project with several family medicine practices to help reduce hypertension rates among black men. In Ohio, 38.5 percent of black patients have a diagnosis of hypertension, compared to 33.7 percent...
Source: AMA Wire - February 16, 2016 Category: Journals (General) Authors: Lyndra Vassar Source Type: news

A Quantitative Summary of The Listening Program (TLP) Efficacy Studies: What Areas Were Found to Improve by TLP Intervention?
Abstract A quantitative summary of existing research examining the effects of The Listening Program (TLP) on various functions in children is presented. Nine studies were used, looking at TLP intervention effects across studies, within each study and for various outcome measures. The studies looked at TLP intervention on children with autism spectrum disorder, Down syndrome, learning disabilities, auditory processing disorders, attention deficit hyperactivity disorders, Rhett syndrome, dyspraxia, cerebral palsy, fibromyalgia, arthritis and stroke. The magnitude of the TLP effect size revealed a mean value of 0.41 across al...
Source: Occupational Therapy International - February 17, 2016 Category: Occupational Health Authors: Sadako Vargas, Jay R. Lucker Tags: Research Article Source Type: research

Heart Health -- Love, Happiness, Gratitude, and Learning
"Money is of no value to me. Love gives you more. You can't get rid of love, when you give more, you get more." --Warren Buffett My friend Emily Sachs Wong texted me these words after having dinner with Warren Buffett, I have no idea what they were eating and for the first time in my life I wasn't interested. Perhaps because when someone says something like that, you just let it soak in. I was struck by the fact that he so clearly expressed what seemed to me to be a profound statement about what is important in life. Emily Sachs Wong and Warren Buffett February is heart month and organizations like Go Red for Women are fo...
Source: Healthy Living - The Huffington Post - February 19, 2016 Category: Consumer Health News Source Type: news

Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats
Publication date: 23 March 2016 Source:Neuroscience Letters, Volume 617 Author(s): Yaning Liu, Shangwu Wang, Shijian Luo, Zhendong Li, Fengyin Liang, Yanan Zhu, Zhong Pei, Ruxun Huang Glial cell line-derived neurotrophic factor (GDNF) is a potential therapeutic protein on a variety of central nervous system diseases including ischemic stroke. However, GDNF is a large molecule that cannot cross the blood–brain barrier (BBB), which is still intact in the early hours after stroke when neural rescue is possible. PEP-1 protein transduction domain can deliver protein cargo across the cell membrane and the BBB. In the...
Source: Neuroscience Letters - February 20, 2016 Category: Neuroscience Source Type: research

4 Surprising Everyday Items That Can Hurt Your Health
SPECIAL FROM You may watch what you eat, drink filtered water, and use your seat belt to protect yourself on the road. Yet many health hazards are lurking around us in not-so-obvious places. Here, a few to steer clear of:  1. Scented candles A fragrant candle may help you unwind and de-stress. But burning those containing a chemical calledlimonene, often used for citrus-scented candles, as well as many cleaning products, can produce fumes that are downright unhealthy. Recent British research found that households with a high levels of limonene correlated with high levels of formaldehyde, which irritates the eyes and ...
Source: Healthy Living - The Huffington Post - February 20, 2016 Category: Consumer Health News Source Type: news

If You Eat Any Fruits Or Vegetables At All, You're Doing Better Than Half Of America
If you’re feeling down about how you eat, consider this: if you eat about one cup of fruit and more than 1.5 cups of vegetables a day, you’re actually eating better than about half of all Americans. If you eat 1.5 cups of fruit (the recommended serving size for an adult), you’re doing better than more than three-fourths of Americans. And if you eat two cups of vegetables a day (another recommended serving size), that’s better than almost 90 percent of your neighbors. We say this not to put down our fellow Americans, but to point out that eating more fruits and vegetables is linked to lower rate...
Source: Science - The Huffington Post - February 29, 2016 Category: Science Source Type: news

Visceral Fat Triggers Heart Disease
I tell my patients to avoid drinking soda not just because they make you fat. Each sip of soda affects your health. Soda puts you at risk for health problems like metabolic syndrome. This is a collection of symptoms that can lead to diabetes, heart disease and other chronic diseases, like cancer. Soft drinks are the beverage of choice for millions of Americans. The latest research now reveals that sodas are a major cause of visceral fat — the deadliest kind of fat you can have, inflaming your tissues, rotting your blood vessels and upsetting your body chemistry. In a minute I’m going to tell you about a great healthy ...
Source: Al Sears, MD Natural Remedies - February 29, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health heart disease metabolic syndrome Visceral Fat Source Type: news

PCA-based Polling Strategy in Machine Learning Framework for Coronary Artery Disease Risk Assessment in Intravascular Ultrasound: A Link between Carotid and Coronary Grayscale Plaque Morphology
The major cause of morbidity in the world is due to cardiovascular disease (CVD). In 2012 alone, CVDs caused 17.5 million deaths worldwide, out of which, 7.4 million deaths were due to coronary arterial disease and 6.7 million were due to stroke or cerebrovascular disease [1]. A higher occurrence of CVD in the young and middle-aged population is observed in the south-east Asia region. About 35% of all such deaths are between the age group of 35 to 64 years and are estimated to happen in India [2] between the years of 2000 and 2030.
Source: Computer Methods and Programs in Biomedicine - March 1, 2016 Category: Bioinformatics Authors: Tadashi Araki, Nobutaka Ikeda, Devarshi Shukla, Pankaj K. Jain, Narendra D. Londhe, Vimal K. Shrivastava, Sumit K. Banchhor, Luca Saba, Andrew Nicolaides, Shoaib Shafique, John R. Laird, Jasjit S. Suri Source Type: research

Public Health and Citizens, Truly United
There are just two problems with the prevailing conception of "public health" -- the public, and health. Neither means what we think it means. For starters, there is no public. The public is an anonymous mass, a statistical conception, nameless, faceless, unknowable, and unlovable. I have made the case before that laboring under this crippling fiction, the potential good that all things "public health" might do is much forestalled. We talk, for instance, about the genuine potential to eliminate up to 80 percent of the total global burden of chronic disease -- heart disease, cancer, stroke, diabetes, dementia -- but somehow...
Source: Healthy Living - The Huffington Post - March 3, 2016 Category: Consumer Health News Source Type: news

A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5
Abstract Cdk5, a cyclin-dependent kinase family member, is a global orchestrator of neuronal cytoskeletal dynamics. During embryogenesis, Cdk5 is indispensable for brain development. In adults, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation, drug addiction, pain signaling, and long-term behavior changes through long-term potentiation and long-term depression, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity becomes deregulated in various brain disorders, including Alzheimer’s disease, Parkinson’s disease, Hunt...
Source: Molecular Neurobiology - March 5, 2016 Category: Neurology Source Type: research

Eye cells may use math to detect motion
(NIH/National Institute of Neurological Disorders and Stroke) In a study of mice, National Institutes of Health scientists showed how one type of neuron in the eye may distinguish moving objects. The study suggests that the NMDA receptor, a protein normally associated with learning and memory, may help neurons in the eye and the brain relay that information.
Source: EurekAlert! - Medicine and Health - March 7, 2016 Category: Global & Universal Source Type: news

A rat model of vascular dementia for evaluating Chinese medicine prescriptions
Conclusions For evaluating Chinese medicine, a model of vascular dementia in rats is set up with the lacunar stroke from self-thrombosis during hypercholesterolemia. This model from lacunar stroke is useful to investigate the pathogenesis and treatment of vascular dementia.
Source: Chinese Journal of Integrative Medicine - March 8, 2016 Category: Internal Medicine Source Type: research

What Your Tongue And Tonsils Could Tell You About Your Sleeping Habits
Your dentist might be able to tell if you're having trouble sleeping.  Yes. A new study published in the Saudi Medical Journal found that the size of a person's tonsils may indicate their risk for obstructive sleep apnea, a condition in which blocked upper airways cause breathing to stop and restart repeatedly during sleep. Tongue indentations, or teeth imprints on the tongue that suggest it's too big for the mouth, may also be a sign.  More than 18 million adults in the United States are affected by OSA. Since people with the condition are often suffering from interrupted and reduced sleep, it can lead to ...
Source: Science - The Huffington Post - March 9, 2016 Category: Science Source Type: news

Neuroscience meets salivary bioscience: An integrative perspective.
Advances in salivary bioscience enable unique opportunities to explore individual differences in biological mechanisms related to learning and memory, psychiatric disorders, and more recently neurodegenerative diseases, neurotrauma/stroke, pain, and sleep. Sampling oral fluid is not only minimally invasive, but specimens can be collected easily and quickly in clinical and field settings. Salivary analytes allow neuroscientists to index endocrine, autonomic, immune, metabolic, and inflammatory processes within close proximity of discrete behavioral, biological, and social events, which is particularly important to advancing...
Source: Behavioral Neuroscience - March 14, 2016 Category: Neuroscience Authors: Segal, Sabrina K. Source Type: research

Experience Journal: Growing up with cerebral palsy
Cerebral palsy (CP) is the most common physical disability of childhood. The term CP is an umbrella term for a group of disorders that affect body movement and posture as a result of damage to a baby’s developing brain. There are many causes for CP, but all occur either during pregnancy, birth or shortly after birth. Common causes include differences in brain development, infection or stroke. Oxygen deprivation is accountable for only a small percentage of cases of CP; often, the cause is unknown. Although CP is a lifelong condition that can’t be reversed, children with the diagnosis can lead rich, fulfilling lives wit...
Source: Thrive, Children's Hospital Boston - March 18, 2016 Category: Pediatrics Authors: Erin Horan Tags: Experience Journal Cerebral Palsy Program Source Type: news

MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy
This article is part of the 60th Anniversary special issue. MMP‐9, through cleavage of specific target proteins, plays a major role in synaptic plasticity and neuroinflammation, and by those virtues contributes to brain physiology and a host of neurological and psychiatric disorders. This article is part of the 60th Anniversary special issue.
Source: Journal of Neurochemistry - March 21, 2016 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Bench to Bedside Source Type: research

A twist on the genetic link between Alzheimer’s and heart disease
Alzheimer’s disease often strikes fear in people’s hearts because it gradually erodes a person’s ability to remember, think, and learn. There is no cure, and available treatments alleviate symptoms only temporarily. An estimated 5.3 million Americans currently have Alzheimer’s disease, yet this brain disorder is far less common than heart disease. More than 85 million people in the United States are living with some form of cardiovascular disease or the after-effects of stroke, which also affects brain function. Many people don’t realize that Alzheimer’s and heart disease share a genetic link: the apolipoprotei...
Source: New Harvard Health Information - March 25, 2016 Category: Consumer Health News Authors: Julie Corliss Tags: Alzheimer's Disease Behavioral Health Brain and cognitive health Genes Healthy Aging Heart Health Memory Mental Health Source Type: news

You Are What You Sleep
If I asked you to think of the last time that you slept poorly, that would probably be easy to recall, wouldn't it? What about the last time you were well-rested? And not just quality sleep for one night, but chronically well-rested, well-rested over a long period of time? That's probably a little harder. For college students, this phenomenon is all too familiar. Having just become self-sustaining adults, students are learning for the first time how to balance work, rest, and fun. The growing pains are showing. Research at the University of Alabama suggests that 60 percent of college students aren't getting enough sleep,...
Source: Healthy Living - The Huffington Post - March 25, 2016 Category: Consumer Health News Source Type: news

Pinkies Up! There Could Be Some Real Health Benefits To Drinking Tea
Tea gets short shrift as coffee’s milder little sister. But these leaves may have a lot more to offer drinkers than just their subtle taste. Large, observational studies have found lifelong tea drinkers are less likely to face early cognitive decline and get certain types of cancer, stroke, coronary heart disease, and type 2 diabetes. We should also note that by “tea,” we mean the leaves from the Camellia sinensis plant that are plucked and processed in different ways to make black, green, white, oolong and pu’er teas -- not herbal infusions like peppermint, hibiscus and chamomile teas. Researchers ...
Source: Healthy Living - The Huffington Post - March 25, 2016 Category: Consumer Health News Source Type: news

Health system makes cutting-edge telemedicine affordable
With the right kind of equipment, can a video conference between an ambulance and an on-call neurologist deliver the same stroke assessment results as at the bedside in the emergency room? The University of Virginia Health System, after over one year of research, is poised to find out. Previously, AMA Wire® brought you the theory behind the University of Virginia (UVA) Health System’s research efforts to bring telemedicine to the ambulance so they can improve care for patients who are experiencing a stroke. We recently caught up with the UVA team to find out that their telestroke model iTreat is now in action. Andre...
Source: AMA Wire - March 25, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news