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Total 1715 results found since Jan 2013.

Electrical Bioimpedance Cardiography: An Old Technology With New Hopes for the Future
THE POSITIVE IMPACT of early goal-directed hemodynamic therapy on postoperative outcome increasingly has been investigated over the last few years in high-risk patients undergoing noncardiac and cardiac surgeries. However, these preemptive strategies require advanced hemodynamic monitoring to assess cardiac output and stroke volume. The classic available tools (intermittent pulmonary arterial or transpulmonary thermodilution or esophageal Doppler), either invasive or operator-dependent and necessitating a learning curve, are not convenient for routine practice. Therefore, they remain insufficiently used among North America...
Source: Journal of Cardiothoracic and Vascular Anesthesia - June 1, 2014 Category: Anesthesiology Authors: Jean-Luc Fellahi, Marc-Olivier Fischer Tags: Review Articles Source Type: research

Infective endocarditis: old problem, new guidelines and still much to learn
Despite major advances in treating valvular heart disease, the in-hospital mortality (15–20%) and 1-year mortality (~=40%) for infective endocarditis (IE) has not improved even with modern antibiotics and surgical therapy. Further, stroke (17%), embolisation other than stroke (23%), heart failure (HF) (32%) and other complications remain common; therefore, all precautions to help prevent IE should be employed where indicated. In underdeveloped countries, IE is most often associated with rheumatic heart disease. In developed countries, IE is increasingly associated with prosthetic valves and intracardiac devices, with...
Source: Heart - June 9, 2014 Category: Cardiology Authors: Erwin, J. P., Otto, C. M. Tags: Drugs: cardiovascular system, Echocardiography, Clinical diagnostic tests, Epidemiology, Diabetes, Metabolic disorders Editorials Source Type: research

Periodic Estrogen Receptor-Beta Activation: A Novel Approach to Prevent Ischemic Brain Damage.
Abstract In women, the risk for cerebral ischemia climbs rapidly after menopause. At menopause, production of ovarian hormones; i.e., progesterone and estrogen, slowly diminishes. Estrogen has been suggested to confer natural protection to premenopausal women from ischemic stroke and some of its debilitating consequences. This notion is also strongly supported by laboratory studies showing that a continuous chronic 17β-estradiol (E2; a potent estrogen) regimen protects brain from ischemic injury. However, concerns regarding the safety of the continuous intake of E2 were raised by the failed translation to the cli...
Source: Neurochemical Research - June 7, 2014 Category: Neuroscience Authors: Cue L, Diaz F, Briegel KJ, Patel HH, Raval AP Tags: Neurochem Res Source Type: research

Poor cardiovascular health linked to memory, learning deficits
People with poor cardiovascular health have a substantially higher incidence of cognitive impairment. Better cardiovascular health was more common in men and among people with higher education and higher income. The incidence of mental impairment was found more commonly in those with a lower income, who lived in the 'stroke belt' or had cardiovascular disease.
Source: ScienceDaily Headlines - June 11, 2014 Category: Science Source Type: news

Disassociation of verbal learning and hippocampal volume in type 2 diabetes and major depression
ConclusionsThe relationship between hippocampal volume and performance on the California Verbal Learning Test is decoupled in subjects with type 2 diabetes and major depression and this decoupling may contribute to poor verbal learning and memory performance in this study population. Copyright © 2014 John Wiley & Sons, Ltd.
Source: International Journal of Geriatric Psychiatry - June 12, 2014 Category: Geriatrics Authors: O. Ajilore, M. Lamar, J. Medina, K. Watari, V. Elderkin‐Thompson, A. Kumar Tags: Research Article Source Type: research

With the right rehabilitation, paralyzed rats learn to grip again
(University of Zurich) After a large stroke, motor skills barely improve, even with rehabilitation. An experiment conducted on rats demonstrates that a course of therapy combining the stimulation of nerve fiber growth with drugs and motor training can be successful. The key, however, is the correct sequence: Paralyzed animals only make an almost complete recovery if the training is delayed until after the growth promoting drugs have been administered, as researchers from the University of Zurich, ETH Zurich and the University of Heidelberg reveal.
Source: EurekAlert! - Medicine and Health - June 12, 2014 Category: Global & Universal Source Type: news

Learning More From the Dabigatran Concentrations in the RE-LY Study
We read with great interest the paper by Reilly et al. (1), which demonstrated that higher trough plasma dabigatran concentrations were associated with: 1) decreasing risk of stroke/systemic embolic event (SEE); and 2) increasing major bleeding risk in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial (2). The paper provides useful insights into the relationship between dabigatran exposure and clinical events but raises several questions.1.Time lag from blood samples to events.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 16, 2014 Category: Cardiology Source Type: research

Glun2b N‐methyl‐D‐aspartic acid receptor subunit mediates atorvastatin‐Induced neuroprotection after focal cerebral ischemia
This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and GluN2B subunits of the N‐methyl‐D‐aspartic acid receptor in the somatosensory cerebral cortex at short and long periods following ischemia. Sham and ischemic male Wistar rats received 10 mg/kg of ATV or placebo by gavage every 24 hr for 3 consecutive days. The first dose was administered 6 hr after ischemia–reperfusion or the sham operation. ATV treatment resulted in faster recovery of neurological scores than placebo, prevented the appearance of pyknotic neurons, and restored microtubule‐associated protein 2 and neuronal nuclei stain...
Source: Journal of Neuroscience Research - June 17, 2014 Category: Neuroscience Authors: Johanna Andrea Gutierrez‐Vargas, Juan Ignacio Muñoz‐Manco, Luis Miguel Garcia‐Segura, Gloria Patricia Cardona‐Gómez Tags: Research Article Source Type: research

Variations and inter-relationship in outcome from emergency admissions in England: a retrospective analysis of Hospital Episode Statistics from 2005-2010
This study quantifies the scale of variation in three outcomes for a contemporary cohort of patients undergoing emergency medical and surgical admissions. The way in which the outcomes of different diagnoses relate to each other is investigated. Methods: A retrospective study using the English Hospital Episode Statistics 2005-2010 with one-year follow-up for all patients with one of 20 of the commonest and highest-risk emergency medical or surgical conditions. The primary outcome was in-hospital all-cause risk-standardised mortality rate (in-RSMR). Secondary outcomes were 1-year all-cause risk-standardised mortality rate (...
Source: BMC Health Services Research - June 19, 2014 Category: Journals (General) Authors: Peter HoltSidhartha SinhaBaris OzdemirAlan KarthikesalingamJan PolonieckiMatt Thompson Source Type: research

Cerebellum Tunes the Excitability of the Motor System: Evidence from Peripheral Motor Axons.
Abstract Cerebellum is highly connected with the contralateral cerebral cortex. So far, the motor deficits observed in acute focal cerebellar lesions in human have been mainly explained on the basis of a disruption of the cerebello-thalamo-cortical projections. Cerebellar circuits have also numerous anatomical and functional interactions with brainstem nuclei and projects also directly to the spinal cord. Cerebellar lesions alter the excitability of peripheral motor axons as demonstrated by peripheral motor threshold-tracking techniques in cerebellar stroke. The biophysical changes are correlated with the function...
Source: Cerebellum - June 25, 2014 Category: Neuroscience Authors: Nodera H, Manto M Tags: Cerebellum Source Type: research

The Utah Remote Monitoring Project: Improving Health Care One Patient at a Time.
Conclusions: Telemonitoring improved clinical outcomes and may be a useful tool to help enhance disease management and care of patients with diabetes and/or hypertension. PMID: 24991923 [PubMed - as supplied by publisher]
Source: Rural Remote Health - July 3, 2014 Category: Rural Health Authors: Shane-McWhorter L, Lenert L, Petersen M, Woolsey S, McAdam-Marx C, Coursey JM, Whittaker TC, Hyer C, LaMarche D, Carroll P, Chuy L Tags: Diabetes Technol Ther Source Type: research

The Week Ahead: Stroke, Prostate Ca, Sports Med
(MedPage Today) -- After learning he has localized prostate cancer, what key factors influence a patient's choice of active surveillance over treatment? That question will be answered in the week ahead.
Source: MedPage Today Primary Care - July 13, 2014 Category: Primary Care Source Type: news

Abstract 172: Patients' Experiences from Symptom Onset to Initial Treatment for Atrial Fibrillation Session Title: Poster Session I
Conclusions: Providers’ played a critical role in reducing patients' emotional distress and helping them to develop an accurate understanding of AF symptoms and treatment. This study provides new insight into participant experiences from symptom onset through initial treatment of AF which may inform development of patient centered interventions to promote early effective AF self-management.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: McCabe, P. J., Rhudy, L., DeVon, H. Tags: Session Title: Poster Session I Source Type: research

Preparing an E-learning-based Speech Therapy (EST) efficacy study: Identifying suitable outcome measures to detect within-subject changes of speech intelligibility in dysarthric speakers.
Abstract Abstract We explored the suitability of perceptual and acoustic outcome measures to prepare E-learning based Speech Therapy (EST) efficacy tests regarding speech intelligibility in dysarthric speakers. Eight speakers with stroke (n = 3), Parkinson's disease (n = 4) and traumatic brain injury (n = 1) participated in a 4 weeks EST trial. A repeated measures design was employed. Perceptual measures were (a) scale ratings for "ease of intelligibility" and "pleasantness" in continuous speech and (b) orthographic transcription scores of semantically unpredictable sentences. Acoustic measures were (c...
Source: Clinical Linguistics and Phonetics - July 15, 2014 Category: Speech Therapy Authors: Beijer LJ, Rietveld AC, Ruiter MB, Geurts AC Tags: Clin Linguist Phon Source Type: research

Carotid endarterectomy versus stenting for stroke prevention: what we have and will learn from Carotid Revascularization Endarterectomy versus Stenting Trial
Source: American Journal of Surgery - March 28, 2014 Category: Surgery Authors: Fred A. Weaver Tags: Historian's Lecture Source Type: research

Memory deficits and oxidative stress in cerebral ischemia-reperfusion: Neuroprotective role of physical exercise and green tea supplementation.
Abstract Ischemic stroke is a major cause of morbidity and mortality all over the world. Among impairments observed in survivors there is a significant cognitive learning and memory deficit. Neuroprotective strategies are being investigated to minimize such deficits after an ischemia event. Here we investigated the neuroprotective potential of physical exercise and green tea in an animal model of ischemia-reperfusion. Eighty male rats were divided in 8 groups and submitted to either transient brain ischemia-reperfusion or a sham surgery after 8 weeks of physical exercise and/or green tea supplementation. Ischemia-...
Source: Neurobiology of Learning and Memory - July 22, 2014 Category: Neurology Authors: Schimidt HL, Vieira A, Altermann C, Martins A, Sosa P, Santos FW, Mello-Carpes PB, Izquierdo I, Carpes FP Tags: Neurobiol Learn Mem Source Type: research

Health industry leaders honored among this year's 40 Under 40 winners
From running a hospital to reforming care at the Veterans Health Administration to developing new biomedical devices to solving global health problems, the eight people from health organizations who were included among this year's Puget Sound Business Journal 40 Under 40 honorees are all involved in important work. NanoString Technologies held its initial public offering in June of last year, raising $54 million. Cadence Biomedical is helping stroke patients and injured people learn to walk again…
Source: bizjournals.com Health Care:Physician Practices headlines - July 31, 2014 Category: American Health Authors: Becky Monk Source Type: research

Shotgun approaches to gait analysis: insights & limitations
Discussion & conclusion: Extracting a measure's classification capacity cannot solely rely on its statistical validity but typically requires proper post-hoc analysis. However, choosing the latter inevitably introduces some arbitrariness, which may affect outcome in general. We hence advocate the use of generic expert systems, possibly based on machine-learning.
Source: Journal of NeuroEngineering and Rehabilitation - August 12, 2014 Category: Rehabilitation Authors: Ronald KapteinDaphne WezenbergTrienke IJmkerHan HoudijkPeter BeekClaudine LamothAndreas Daffertshofer Source Type: research

Community-Based Exercise for Upper Limb Paresis: A Controlled Trial With Telerehabilitation
Conclusions. Home- and community-based exercise for arm paresis is safe and effective. Telerehabilitation interventions will need additional enhancements to improve effectiveness. The optimal upper extremity exercise prescription poststroke remains to be established.
Source: Neurorehabilitation and Neural Repair - August 13, 2014 Category: Neurology Authors: Benvenuti, F., Stuart, M., Cappena, V., Gabella, S., Corsi, S., Taviani, A., Albino, A., Scattareggia Marchese, S., Weinrich, M. Tags: Clinical Research Articles Source Type: research

Neurorehabilitation: From sensorimotor adaptation to motor learning, or the opposite?
In a recent editorial, Vasudevan (2014) argued that amplifying movement errors through sensorimotor adaptation can be an interesting way to improve walking post-stroke and more generally to develop new approach in neurorehabilitation. I would like to comment further this idea and to raise some key issues that should be addressed to complete this discussion.
Source: Clinical Neurophysiology - February 5, 2014 Category: Neuroscience Authors: François Bonnetblanc Tags: Letters to the Editor Source Type: research

Rationale and Design of FIRE AND ICE: A Multicenter Randomized Trial Comparing Efficacy and Safety of Pulmonary Vein Isolation using a Cryoballoon Versus Radiofrequency Ablation with 3D‐reconstruction
ConclusionThe FIRE AND ICE trial compares two different technologies to perform catheter ablation of PAF with respect to efficacy and safety. It aims at providing objective data to guide selection and usage of ablation catheters in the treatment of AF.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - August 1, 2014 Category: Cardiology Authors: ALEXANDER FÜRNKRANZ, JOSEP BRUGADA, JEAN‐PAUL ALBENQUE, CLAUDIO TONDO, KURT BESTEHORN, KARL WEGSCHEIDER, FEIFAN OUYANG, KARL‐HEINZ KUCK Tags: Original Article Source Type: research

Reaching tasks in an altered dynamic environment: Motor adaptation in FRDA patients
Introduction: In the last few years, robotic devices are extensively employed to exploit how the Central Nervous System (CNS) learns to control movements in different dynamical conditions. It was demonstrate that normally developed subjects can adapt to novel dynamic environments, tuning an internal model of the arm environment to compensate systematically applied forces, and showing an after-effect that appears when the force field is unexpectedly removed [1]. It was also found that this capability is at least partially still present in subjects affected by Huntington's disease, or in stroke survivor, but not in subjects ...
Source: Gait and Posture - August 1, 2014 Category: Orthopaedics Authors: M. Germanotta, M. Petrarca, S. Rossi, S. Carniel, E. Castelli, P. Cappa Source Type: research

Scientists plug into a learning brain
(NIH/National Institute of Neurological Disorders and Stroke) Scientists explored the brain's capacity to learn and found learning is easier when it only requires nerve cells to rearrange existing patterns of activity than when the nerve cells have to generate new patterns.
Source: EurekAlert! - Medicine and Health - August 27, 2014 Category: Global & Universal Source Type: news

Claims magnetic brain stimulation helps memory
ConclusionIn this study, TMS was found to improve performance on the associative memory test by more than 20%, whereas sham stimulation had no significant effect.TMS also increased connectivity between specific cortical (grey-matter) regions of the brain and the hippocampus.This interesting research increases our knowledge of how memory works. However, it was a very small trial with only 16 participants. It is also unclear whether electromagnetic stimulation would be effective for people with memory disorders such as dementia. The media has reported that the researchers are now planning to study the effect of TMS on people...
Source: NHS News Feed - August 29, 2014 Category: Consumer Health News Tags: Neurology Source Type: news

G.P.157: Clinical and pathological features associated with mutations in MICU1
We present the clinical/pathological features in a cohort of 18 patients. Patients presented between birth and 8years with a mild, relatively static, proximal myopathy associated with high Creatinine Kinase (2000–10,000iu/L), learning difficulties and frequent microcephaly. At follow up (5–28yrs), all remained ambulant but variable extrapyramidal symptoms had developed in the majority by the end of the 1st decade. Other features suggestive of mitochondrial dysfunction included peripheral neuropathy, icthyosis, stroke like episodes, episodic weakness, ataxia and cataracts. Cardiomyopathy was not seen. Serum and CSF lact...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: A.M. Childs, K. Pysden, H. Roper, G. Chow, E.H. Niks, M. Kriek, P.F. Chinnery, D. Lewis-Smith, M. Duchen, G. Szabadkai, C. Logan, E. Sheridan, C. Sewry, F. Muntoni Source Type: research

Transition From Blinded Study Drug to Open-LabelTransition From Blinded Study Drug to Open-Label
Learn about an end-of-trial transition plan to minimize bleeding and stroke risks during a critical period. Journal of the American College of Cardiology
Source: Medscape Today Headlines - September 8, 2014 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Augmented reality dynamic holography for neurology
Conclusion Dynamic holography has been applied to common neurological topics as short presentations to medical students. ARDH was well received and represents a new educational tool for teaching complex topics.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Lelos, N., Campos, P., Sugand, K., Bailey, C., Mirza, K. Tags: Abstracts Source Type: research

Rare platelet G protein‐coupled receptor variants: What Can We Learn?
Summary Platelet expressed G protein‐coupled receptors (GPCRs) are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side‐effects. In order to optimise the use of existing antiplatelet drugs and to develop new therapies more detailed knowledge is required relating to the molecular mechanisms that reg...
Source: British Journal of Pharmacology - September 18, 2014 Category: Drugs & Pharmacology Authors: S. P. Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: Review Article – 5th BPS Focused Meeting on Cell Signalling Themed Issue Source Type: research

Nurses’ fidelity to theory‐based core components when implementing Family Health Conversations – a qualitative inquiry
Background and aimA family systems nursing intervention, Family Health Conversation, has been developed in Sweden by adapting the Calgary Family Assessment and Intervention Models and the Illness Beliefs Model. The intervention has several theoretical assumptions, and one way translate the theory into practice is to identify core components. This may produce higher levels of fidelity to the intervention. Besides information about how to implement an intervention in accordance to how it was developed, evaluating whether it was actually implemented as intended is important. Accordingly, we describe the nurses’ fidelity to ...
Source: Scandinavian Journal of Caring Sciences - September 18, 2014 Category: Nursing Authors: Ulrika Östlund, Britt Bäckström, Viveca Lindh, Karin Sundin, Britt‐Inger Saveman Tags: Methods and Methodologies Source Type: research

Leveraging business intelligence to make better decisions: Part III.
Abstract Accounts receivable and scheduling datasets have been available to medical practices since the 1990s, and discrete medical records data have become available over the past few years. But the frustrations that arose from the difficulties in reporting data grew with each keyboard stroke and mouse click. With reporting mandated to meet changing payment models, measuring quality of care and medical outcomes, practice managers must find more efficient and effective methods of extracting and compiling the data they have in their systems. Taming the reporting beast and learning to effectively apply business inte...
Source: The Journal of Medical Practice Management : MPM - July 1, 2014 Category: Practice Management Authors: Reimers M Tags: J Med Pract Manage Source Type: research

Visual scanning training for neglect after stroke with and without a computerized lane tracking dual task - van Kessel ME, Geurts AC, Brouwer WH, Fasotti L.
Neglect patients typically fail to explore the contralesional half-space. During visual scanning training, these patients learn to consciously pay attention to contralesional target stimuli. It has been suggested that combining scanning training with metho...
Source: SafetyLit: All (Unduplicated) - September 25, 2014 Category: Global & Universal Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

What Are the Essential Amino Acids and How Much Protein Do I Need?
Discussion Vegetarians have a diet pattern that emphasizes consuming plant foods (i.e. vegetables, grains and nuts) and avoiding flesh food (i.e. red meat, poultry, fish). Some vegetarians include milk and egg products in their diets and would be more accurately described as lacto-ova-vegetarians. Vegans are vegetarians who avoid all animal products including foods such as dairy products, eggs, butter, honey and gelatin. One of the most common questions that vegetarian are asked is about how they obtain enough protein from their diets. In general, a mixed diet of a variety of foods with appropriate calories should provide...
Source: PediatricEducation.org - September 29, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

The Dance Between The Immune System and Stem Cells
We named it the  immunoLinkTM We have been testing a growing number of Clients with our Quantibody Arrays. Many of of these clients have Autoimmune Disorder Diseases. These range from Rheumatoid Arthritis to Multiple Sclerosis.These arrays are designed to precisely measure factors or markers (proteins) that are dysregulated by these diseases. We measure the levels of these biomarkers in our Clients' Blood serum. The arrays have also been used to measure the levels of markers in plasma and cell culture supernatants.Based on results, we are finding links between immune system and stem cell health. We call this the ...
Source: Neuromics - September 30, 2014 Category: Neuroscience Tags: autoimmune disease G-CSF GM-CSF Human Mesenchymal Stem Cells immune response immunoLink Neural Progenitor Cells Neural Stem Cell Markers Source Type: news

Single-Center Experience and Short-term Outcome With the JenaValve: A Second-Generation Transapical Transcatheter Aortic Valve Implantation Device
ConclusionsThis second-generation repositionable transcatheter aortic valve implantation device could safely and successfully be implanted with a fast learning curve, significant reduction in pressure gradients, overall clinical improvement at discharge, as well as an acceptable morbidity and mortality rate in this highest-risk patient cohort.
Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery - September 1, 2014 Category: Cardiovascular & Thoracic Surgery Tags: Original Articles Source Type: research

Understanding and Modulating Motor Learning with Cerebellar Stimulation
Abstract Non-invasive brain stimulation techniques are a powerful approach to investigate the physiology and function of the central nervous system. Recent years have seen numerous investigations delivering transcranial magnetic stimulation (TMS) and or transcranial direct current stimulation (tDCS) to the cerebellum to determine its role in motor, cognitive and emotional behaviours. Early studies have shown that it is possible to assess cerebellar-motor cortex (CB-M1) connectivity using a paired-pulse TMS paradigm called cerebellar inhibition (CBI), and indirectly infer the state of cerebellar excitability. Thus,...
Source: The Cerebellum - October 5, 2014 Category: Neurology Source Type: research

Test Validity and Performance Validity: Considerations in Providing a Framework for Development of an Ability-Focused Neuropsychological Test Battery.
Abstract Literature on test validity and performance validity is reviewed to propose a framework for specification of an ability-focused battery (AFB). Factor analysis supports six domains of ability: first, verbal symbolic; secondly, visuoperceptual and visuospatial judgment and problem solving; thirdly, sensorimotor skills; fourthly, attention/working memory; fifthly, processing speed; finally, learning and memory (which can be divided into verbal and visual subdomains). The AFB should include at least three measures for each of the six domains, selected based on various criteria for validity including sensitivi...
Source: Archives of Clinical Neuropsychology - October 3, 2014 Category: Psychiatry & Psychology Authors: Larrabee GJ Tags: Arch Clin Neuropsychol Source Type: research

5 Things You Should Know About Vascular Disease
Vascular disease is known as a silent killer because many people don’t experience symptoms until it is too late. Read on to learn about the risk factors for vascular disease and what tools are available to you to prevent it. 1. It can lead to a limb loss, aneurysm or stroke. This is caused by the build-up of plaque in the arteries of your legs, neck and aorta. 2. It leads to more deaths than cancer. This is an indisputable fact. Fortunately, there are easy tests to screen for vascular disease,…
Source: bizjournals.com Health Care:Hospitals headlines - October 7, 2014 Category: Hospital Management Authors: Dr. Joel Reginelli Source Type: research

Long-Term Blood Pressure Variability Throughout Young Adulthood and Cognitive Function in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study Epidemiology/Population
Whether long-term blood pressure (BP) variability throughout young adulthood is associated with cognitive function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults aged 18 to 30 years (mean age, 25 years) at baseline (Y0), we assessed BP variability by SD and average real variability (ARV) for 25 years (8 visits). Cognitive function was assessed with the Digit Symbol Substitution Test (psychomotor speed test), the Rey Auditory Verbal Learning Test (verbal memory test), and the modified Stroop test (executive function test) at f...
Source: Hypertension - October 8, 2014 Category: Cardiology Authors: Yano, Y., Ning, H., Allen, N., Reis, J. P., Launer, L. J., Liu, K., Yaffe, K., Greenland, P., Lloyd-Jones, D. M. Tags: Cerebrovascular disease/stroke Epidemiology/Population Source Type: research

Understanding and Modulating Motor Learning with Cerebellar Stimulation.
Abstract Non-invasive brain stimulation techniques are a powerful approach to investigate the physiology and function of the central nervous system. Recent years have seen numerous investigations delivering transcranial magnetic stimulation (TMS) and or transcranial direct current stimulation (tDCS) to the cerebellum to determine its role in motor, cognitive and emotional behaviours. Early studies have shown that it is possible to assess cerebellar-motor cortex (CB-M1) connectivity using a paired-pulse TMS paradigm called cerebellar inhibition (CBI), and indirectly infer the state of cerebellar excitability. Thus,...
Source: Cerebellum - October 5, 2014 Category: Neuroscience Authors: Celnik P Tags: Cerebellum Source Type: research

Self-detection of atrial fibrillation in an aged population: the LietoAF Study
Conclusion Active older people are motivated and seem to learn pulse palpation. Our early experience suggests that simple nurse-based education is effective and useful in the early detection of asymptomatic AF.
Source: European Journal of Preventive Cardiology - October 14, 2014 Category: Cardiology Authors: Virtanen, R., Kryssi, V., Vasankari, T., Salminen, M., Kivela, S.-L., Airaksinen, K. J. Tags: Original scientific paper Source Type: research

Accelerated three‐dimensional cine phase contrast imaging using randomly undersampled echo planar imaging with compressed sensing reconstruction
The aim of this study was to implement and evaluate an accelerated three‐dimensional (3D) cine phase contrast MRI sequence by combining a randomly sampled 3D k‐space acquisition sequence with an echo planar imaging (EPI) readout. An accelerated 3D cine phase contrast MRI sequence was implemented by combining EPI readout with randomly undersampled 3D k‐space data suitable for compressed sensing (CS) reconstruction. The undersampled data were then reconstructed using low‐dimensional structural self‐learning and thresholding (LOST). 3D phase contrast MRI was acquired in 11 healthy adults using an overall acceleratio...
Source: NMR in Biomedicine - October 16, 2014 Category: Radiology Authors: Tamer A. Basha, Mehmet Akçakaya, Beth Goddu, Sophie Berg, Reza Nezafat Tags: Research article Source Type: research

Moving in extreme environments: what’s extreme and who decides?
Abstract Humans work, rest and play in immensely varied extreme environments. The term ‘extreme’ typically refers to insufficiency or excess of one or more stressors, such as thermal energy or gravity. Individuals’ behavioural and physiological capacity to endure and enjoy such environments varies immensely. Adverse effects of acute exposure to these environments are readily identifiable (e.g. heat stroke or bone fracture), whereas adverse effects of chronic exposure (e.g. stress fractures or osteoporosis) may be as important but much less discernable. Modern societies have increasingly sought to protect pe...
Source: Extreme Physiology and Medicine - June 11, 2014 Category: Physiology Source Type: research

Timing of motor cortical stimulation during planar robotic training differentially impacts neuroplasticity in older adults
Neurorehabilitation efforts have focused on intense structured interventions to promote neuroplasticity because stroke is a leading cause of long-term disability world-wide. Robotic rehabilitation devices assist massed practice of upper extremity movement at high repetition rates (Lo et al., 2010; Conroy et al., 2011). They can also be used to change the learning environment, e.g., provide assistance or resistance to the motor task or train new mappings for movement to environmental effect (Krebs et al., 1998; Stein et al., 2004; MacClellan et al., 2005).
Source: Clinical Neurophysiology - September 15, 2014 Category: Neuroscience Authors: Crystal L. Massie, Shailesh S. Kantak, Priya Narayanan, George F. Wittenberg Source Type: research

Make Halloween healthy: If you dare!
Meaghan O’Keeffe, RN, BSN, is a mother, writer and nurse. She worked at Boston Children’s Hospital for nearly a decade, in both the Cardiac Intensive Care Unit and the Pre-op Clinic.  She is a regular contributor to Thriving. Happy Halloween! This is a festive time of year when kids get excited to dress up in fantastical costumes and enjoy some light-hearted scares. But let’s be honest. Most kids dream about one thing and one thing only: the enormous bounty of candy that awaits them. Didn’t you? Besides tasting great, sugar intake heightens the pleasure and reward centers of the brain. Feel-good hormones like dopa...
Source: Thrive, Children's Hospital Boston - October 21, 2014 Category: Pediatrics Authors: Meaghan O'Keeffe Tags: All posts Source Type: news

Death by a Thousand Cuts
It is likely that you don't realize what your state and our nation have lost in economic terms and research productivity as a result of recent cuts in the federal budget and budget instability brought on by a failure of Congress to pass a budget in a timely manner. Although some members of Congress strongly support increased funding for U.S. research, others argue that the time has come for the cost of basic biomedical research to be borne by industry and philanthropy. Those who make that argument either ignore, or are unaware, that this experiment has already been tried -- unsuccessfully. Nearly 80 years ago, Louisiana ...
Source: Science - The Huffington Post - October 24, 2014 Category: Science Source Type: news

June 2014
Managing Asthma: Learn To Breathe Easier...Protect Your Tendons: Preventing the Pain of Tendinitis...Patient’s Own Cells Helped Fight Cancer...Videos and Eye Health Resources for Kids...Featured Web Site: Know Stroke
Source: NIH News in Health - June 1, 2014 Category: Consumer Health News Source Type: news

Scientists plug into a learning brain
Learning is easier when it only requires nerve cells to rearrange existing patterns of activity than when the nerve cells have to generate new patterns, a study of monkeys has found. The scientists explored the brain’s capacity to learn through recordings of electrical activity of brain cell networks. The study was partly funded by the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - August 27, 2014 Category: Neurology Source Type: news

Smoking 'increases risk of chronic back pain'
Conclusion This longitudinal study found sub-acute back pain was three times more likely to progress to persistent back pain in smokers. The researchers presented functional MRI findings, which indicated brain pathways that could be involved in this process. But further research will be required to fully understand the mechanisms at play. The study did not find that smoking provided any pain relief, and indeed the pain intensity did not increase for those people who stopped smoking. The study sample was quite small, meaning the results may not be applicable to larger and more diverse groups of people. As such, the results...
Source: NHS News Feed - November 5, 2014 Category: Consumer Health News Tags: Heart/lungs Lifestyle/exercise Source Type: news

Registration of challenging pre-clinical brain images
Publication date: 30 May 2013 Source:Journal of Neuroscience Methods, Volume 216, Issue 1 Author(s): William R. Crum , Michel Modo , Anthony C. Vernon , Gareth J. Barker , Steven C.R. Williams The size and complexity of brain imaging studies in pre-clinical populations are increasing, and automated image analysis pipelines are urgently required. Pre-clinical populations can be subjected to controlled interventions (e.g., targeted lesions), which significantly change the appearance of the brain obtained by imaging. Existing systems for registration (the systematic alignment of scans into a consistent anatomical coordinate...
Source: Journal of Neuroscience Methods - November 8, 2014 Category: Neuroscience Source Type: research