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The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients.
We present the current data on the role of BDNF and polymorphisms of the BDNF gene in stroke patients, concentrating on human studies. PMID: 28291539 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - March 5, 2017 Category: Neurology Authors: Kotlęga D, Peda B, Zembroń-Łacny A, Gołąb-Janowska M, Nowacki P Tags: Neurol Neurochir Pol Source Type: research

Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice.
Abstract Stroke remains a leading cause of disability worldwide. Recently, we have established an animal model of stroke that results in delayed impairment in spatial memory, allowing us to better investigate cognitive deficits. Young and aged brains show different recovery profiles after stroke; therefore, we assessed aged-related differences in poststroke cognition. As neurotrophic support diminishes with age, we also investigated the involvement of brain-derived neurotrophic factor (BDNF) in these differences. Young (3-6 months old) and aged (16-21 months old) mice were trained in operant touchscreen chambers t...
Source: Neural Plasticity - June 15, 2019 Category: Neurology Authors: Houlton J, Zhou LYY, Barwick D, Gowing EK, Clarkson AN Tags: Neural Plast Source Type: research

The Evolving Concept of Cryptogenic Stroke
This article discusses cryptogenic stroke and the results of recent randomized trials that can inform its evaluation and management. RECENT FINDINGS Most cryptogenic strokes appear embolic, leading to the term embolic stroke of undetermined source. It was previously thought that embolic stroke of undetermined source was a single, therapeutically relevant entity, the underlying sources of which would respond to anticoagulant therapy; however, two large randomized trials found no benefit with anticoagulation compared to antiplatelet therapy for secondary stroke prevention after embolic stroke of undetermined source. A sin...
Source: CONTINUUM: Lifelong Learning in Neurology - April 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

IgA natural antibodies are produced following T-cell independent B-cell activation following stroke.
Abstract Up to 30% of stroke patients experience cognitive decline within one year of their stroke. There are currently no FDA-approved drugs that can prevent post-stroke cognitive decline, in part due to a poor understanding of the mechanisms involved. We have previously demonstrated that a B-lymphocyte response to stroke, marked by IgA+ cells, can cause delayed cognitive dysfunction in mice and that a similar adaptive immune response occurs in the brains of some human stroke patients that suffer from vascular dementia. The stimuli which trigger B-lymphocyte activation following stroke, and their target antigens,...
Source: Brain, Behavior, and Immunity - September 17, 2020 Category: Neurology Authors: Zbesko JC, Frye JB, Becktel DA, Gerardo DK, Stokes J, Calderon K, Nguyen TV, Bhattacharya D, Doyle KP Tags: Brain Behav Immun Source Type: research

Know the signs of heat stroke and exhaustion
Heat can be deadly.As summer temperatures climb — and as climate change contributes to more 100-degree days each year — heat illnesses become a more serious risk, particularly for young children, older adults, outdoor workers, athletes and people with chronic conditions.“On any day with extreme heat, emergency rooms in Los Angeles see an additional 1,500 patients,” said Dr. David Eisenman, a professor at the UCLA Fielding School of Public Health and co-leader of aresearch project to address extreme heat in Los Angeles.“We estimate that an additional 16 people die on a single day of heat in Los Angeles County,...
Source: UCLA Newsroom: Health Sciences - June 23, 2022 Category: Universities & Medical Training Source Type: news

Why John Fetterman Needs Closed Captioning Technology After His Stroke
Five months after the Democratic nominee in one of the nation’s most competitive Senate races suffered a stroke, there’s still a lot to learn about his recovery. In the final weeks of the Pennsylvania Senate campaign, a key Republican attack against the state’s lieutenant governor, John Fetterman, has centered on his use of closed-captioning technology, which translates audio into text on a screen in real-time. He relied on the technology during an interview conducted Friday with NBC News, his first in-person, on-camera sit-down since his stroke in May. [time-brightcove not-tgx=”true”] “...
Source: TIME: Health - October 13, 2022 Category: Consumer Health News Authors: Mini Racker Tags: Uncategorized elections Explainer healthscienceclimate uspoliticspolicy Source Type: news

Risk Assessment of the Acute Stroke Diagnostic Process Using Failure Modes, Effects, and Criticality Analysis
CONCLUSION: Our study results highlight the critical importance of upstream steps in the acute stroke diagnostic process, particularly the use of existing tools to identify stroke patients who may be eligible for time-sensitive treatments.PMID:36565234 | DOI:10.1111/acem.14648
Source: Accident and Emergency Nursing - December 24, 2022 Category: Emergency Medicine Authors: Ava L Liberman Jane L Holl Elida Romo Matthew Maas Sarah Song Shyam Prabhakaran Source Type: research

Data lake-driven analytics identify nocturnal non-dipping of heart rate as predictor of unfavorable stroke outcome at discharge
ConclusionsOur data suggest that a lack of circadian HR modulation, specifically nocturnal non-dipping, is associated with short-term unfavorable functional outcome after stroke, and that including HR into machine learning-based prediction models may lead to improved stroke outcome prediction.
Source: Journal of Neurology - April 20, 2023 Category: Neurology Source Type: research

Predicting new-onset post-stroke depression from real-world data using machine learning algorithm
DiscussionMachine learning models can provide as potential predictive tools for PSD and important factors are identified to alert clinicians for early detection of depression in high-risk stroke patients.
Source: Frontiers in Psychiatry - June 19, 2023 Category: Psychiatry Source Type: research

Physical rehabilitation approaches for the recovery of function and mobility following stroke.
CONCLUSIONS: Physical rehabilitation, comprising a selection of components from different approaches, is effective for recovery of function and mobility after stroke. Evidence related to dose of physical therapy is limited by substantial heterogeneity and does not support robust conclusions. No one approach to physical rehabilitation is any more (or less) effective in promoting recovery of function and mobility after stroke. Therefore, evidence indicates that physical rehabilitation should not be limited to compartmentalised, named approaches, but rather should comprise clearly defined, well-described, evidenced-based phys...
Source: Cochrane Database of Systematic Reviews - April 22, 2014 Category: Journals (General) Authors: Pollock A, Baer G, Campbell P, Choo PL, Forster A, Morris J, Pomeroy VM, Langhorne P Tags: Cochrane Database Syst Rev Source Type: research

Long-term recovery trajectory after stroke: an ongoing negotiation between body, participation and self.
Conclusions: This study stresses the importance of developing new forms of professional support during the long-term recovery trajectory, to stimulate and increase interaction and coherence in the relationship between the stroke survivor's bodily perception, participation in everyday life and sense of self. Implications for Rehabilitation The study deepening how the long-term recovery trajectory after stroke is about ongoing embodied, practical and socially situated negotiations. The study demonstrates that the recovery trajectory is a long term process of learning where the stroke survivor, as an embodied agent, gradually...
Source: Disability and Rehabilitation - October 16, 2014 Category: Rehabilitation Authors: Arntzen C, Borg T, Hamran T Tags: Disabil Rehabil Source Type: research

Immediately After A Stroke, Your Next Steps Are Crucial
By Shereen Lehman (Reuters Health) - Time is critical when someone has a stroke, but care can be delayed when victims, bystanders or even health workers don't recognize the emergency, a new study in the UK finds. Better public awareness of the signs of stroke and the importance of seeking immediate emergency care are needed, the authors say. Stroke signs include the sudden onset of various symptoms such as confusion, difficulty speaking, droopy face or slurred speech, weakness in a limb, numbness, being off-balance, visual loss or a really severe headache. "Getting to hospital quickly is...
Source: Science - The Huffington Post - December 12, 2014 Category: Science Source Type: news

Ipsilateral hippocampal atrophy is associated with long‐term memory dysfunction after ischemic stroke in young adults
Abstract Memory impairment after stroke in young adults is poorly understood. In elderly stroke survivors memory impairments and the concomitant loss of hippocampal volume are usually explained by coexisting neurodegenerative disease (e.g., amyloid pathology) in interaction with stroke. However, neurodegenerative disease, such as amyloid pathology, is generally absent at young age. Accumulating evidence suggests that infarction itself may cause secondary neurodegeneration in remote areas. Therefore, we investigated the relation between long‐term memory performance and hippocampal volume in young patients with first‐eve...
Source: Human Brain Mapping - March 1, 2015 Category: Neurology Authors: Pauline Schaapsmeerders, Inge W.M. van Uden, Anil M. Tuladhar, Noortje A.M. Maaijwee, Ewoud J. van Dijk, Loes C.A. Rutten‐Jacobs, Renate M. Arntz, Hennie C. Schoonderwaldt, Lucille D.A. Dorresteijn, Frank‐Erik de Leeuw, Roy P.C. Kessels Tags: Research Article Source Type: research