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Identifying Neuroimaging Markers of Motor Disability in Acute Stroke by Machine Learning Techniques
In conclusion, multivariate fMRI analyses offer the potential to serve as markers for endophenotypes of functional impairment.
Source: Cerebral Cortex - August 14, 2015 Category: Neurology Authors: Rehme, A. K., Volz, L. J., Feis, D.- L., Bomilcar-Focke, I., Liebig, T., Eickhoff, S. B., Fink, G. R., Grefkes, C. Tags: Articles Source Type: research

Could be the Predominantly-Used Hemibody Related to the Weight Bearing Distribution Modified by the Chronic Hemiparesis After Stroke?
Since the first Broca publications issued from 1970s, lateralized functions in the human brain have urged the researchers to postulate hypothesis based in the right-left asymmetries and, according to some theories, the lateralization of the voluntary motor control could represent a solution to avoid redundant process optimizing space and time. Supported by this idea, the clinicians and researchers tend to concept that the chronic hemiplegic stroke patients learn to use predominantly the non-affected hemibody after stroke in which is more convenient to execute their daily life activities, modifying their natural preference in some cases.
Source: Medical Hypotheses - August 17, 2015 Category: Biomedical Science Authors: Anderson Castro Mundim, Clarissa Cardoso dos Santos Couto Paz, Emerson Fachin-Martins Source Type: research

015: the effectiveness of collaborative and cooperative method in increasing cadre ability for stroke campaign
Conclusion Collaborative and cooperative method can increase cadre's knowledge and self efficacy of stroke effectively than one way traffic method.
Source: BMJ Open - August 24, 2015 Category: Journals (General) Authors: Hariyanti, T. W., Prabandari, Y. S., Wiyoto, H. M. Tags: Open access Global Forum on Research and Innovation for Health 2015 Source Type: research

Transcranial Stimulation Aids Motor Learning After StrokeTranscranial Stimulation Aids Motor Learning After Stroke
Transcranial direct current stimulation (tDCS) helps patients' motor learning after stroke, new research suggests. Reuters Health Information
Source: Medscape Medical News Headlines - September 15, 2015 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Robotic therapy for chronic stroke: general recovery of impairment or improved task-specific skill?
There is a great need to develop new approaches for rehabilitation of the upper limb after stroke. Robotic therapy is a promising form of neurorehabilitation that can be delivered in higher doses than conventional therapy. Here we sought to determine whether the reported effects of robotic therapy, which have been based on clinical measures of impairment and function, are accompanied by improved motor control. Patients with chronic hemiparesis were trained for 3 wk, 3 days a week, with titrated assistive robotic therapy in two and three dimensions. Motor control improvements (i.e., skill) in both arms were assessed with a ...
Source: Journal of Neurophysiology - September 18, 2015 Category: Neurology Authors: Kitago, T., Goldsmith, J., Harran, M., Kane, L., Berard, J., Huang, S., Ryan, S. L., Mazzoni, P., Krakauer, J. W., Huang, V. S. Tags: Control Of Movement Source Type: research

The use of a planar and simple robotic device to investigate how chronic stroke patients learn a movement
Introduction: The ability of chronic stroke patients to learn a new movement is not well known in literature yet. A way to investigate motor outcome after rehabilitation is to use robotic devices that allow the objective and repeatable assessment of the acquired movement.
Source: Gait and Posture - September 1, 2015 Category: Orthopaedics Authors: G. Lamola, C. Fanciullacci, F. Bertolucci, A. Panarese, S. Micera, B. Rossi, C. Chisari Tags: O13 Source Type: research

First‐time stroke survivors and caregivers’ perceptions of being engaged in rehabilitation
ConclusionThe findings of this study challenge service providers to realize a true partnership with stroke survivors and caregivers by working with them as one team that is led by nurses. Making the necessary changes requires mutual effort at both the systemic and individual levels with rehabilitation nurse‐led coordination of rehabilitation programmes.
Source: Journal of Advanced Nursing - September 25, 2015 Category: Nursing Authors: Langduo Chen, Lily Dongxia Xiao, Anita De Bellis Tags: Original Research: Empirical Research – Qualitative Source Type: research

Predicting discharge mortality after acute ischemic stroke using balanced data.
Authors: Ho KC, Speier W, El-Saden S, Liebeskind DS, Saver JL, Bui AA, Arnold CW Abstract Several models have been developed to predict stroke outcomes (e.g., stroke mortality, patient dependence, etc.) in recent decades. However, there is little discussion regarding the problem of between-class imbalance in stroke datasets, which leads to prediction bias and decreased performance. In this paper, we demonstrate the use of the Synthetic Minority Over-sampling Technique to overcome such problems. We also compare state of the art machine learning methods and construct a six-variable support vector machine (SVM) model ...
Source: AMIA Annual Symposium Proceedings - September 25, 2015 Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research

Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): study protocol for a randomized controlled trial
This study is a double-blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke.Methods/DesignSixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex and sham stimulation. Each group will receive transcranial direct current stimulation at an intensity of 2 mA for 20 minutes daily for 10 consecutive days. Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go-no ...
Source: Trials - September 29, 2015 Category: Journals (General) Authors: Suellen AndradeBernardino Fernández-CalvoPaulo BoggioEliane de OliveiraLilze GomesJosé Pinheiro JúniorRafaela RodriguesNatália de AlmeidaGioconda MoreiraNelson Alves Source Type: research

A Multifaceted Approach to the Enhancement of Motor Recovery After Stroke
Despite aggressive conventional therapy, lasting hemiplegia persists in a large percentage of stroke survivors. This project critically reviewed the rationale behind targeting motor recovery at multiple sites along the motor learning network by combining robotic therapy with pharmacotherapy and virtual reality-based reward learning for stroke survivors.
Source: Archives of Physical Medicine and Rehabilitation - October 1, 2015 Category: Rehabilitation Authors: Duc Tran, Marta Pajaro, Jean Francois Daneault, Jaime G. Gallegos, Mary Alexis Iaccarino, Felipe Fregni, Ross Zafonte Tags: Systematic/meta-analytic review poster Source Type: research

Motor Imagery Training on Muscle Strength and Gait Performance in Ambulant Stroke Subjects: A Randomized Clinical Trial
50%-65% of stroke survivors have residual motor deficits; principal among them is hemi paretic gait that limits mobility, increases the risk of falls and promoting sedentary life style. Increased strength in the lower extremity muscles has been shown to be associated with improvements in walking performance. Recently Motor Imagery training (MIT) are enhancing motor learning, neural reorganization and cortical activation in stroke patients. However, efficacy MIT involving lower extremity mobility tasks are limited in stroke rehabilitation.
Source: Archives of Physical Medicine and Rehabilitation - October 1, 2015 Category: Rehabilitation Authors: Vijaya Kumar Tags: Research poster Source Type: research

The presence of a single-nucleotide polymorphism in the BDNF gene affects the rate of locomotor adaptation after stroke.
Abstract Induction of neural plasticity through motor learning has been demonstrated in animals and humans. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of growth factors, is thought to play an integral role in modulation of central nervous system plasticity during learning and motor skill recovery. Thirty percent of humans possess a single-nucleotide polymorphism on the BDNF gene (Val66Met), which has been linked to decreased activity-dependent release of BDNF. Presence of the polymorphism has been associated with altered cortical activation, short-term plasticity and altered skil...
Source: Experimental Brain Research - October 20, 2015 Category: Neuroscience Authors: Helm EE, Tyrell CM, Pohlig RT, Brady LD, Reisman DS Tags: Exp Brain Res Source Type: research

Machine Learning For Identifying Potentially Undiagnosed Post-Stroke Spasticity Patients In United Kingdom
Spasticity is one of the well-recognized complications of stroke which may give rise to pain and limit patients’ ability to perform daily activities. The predisposing factors and direct effects of post-stroke spasticity (PSS) also involve high management costs in terms of healthcare resources and case-control designs are required for establishing such differences. In ‘The Health Improvement Network’ (THIN) database, such a study was difficult to provide reliable estimates since the prevalence of post-stroke spasticity was found to be substantially below the most conservative previously reported estimates.
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: A Cox, M Raluy-Callado, M Wang, A Bakheit, AP Moor, J Dinet Source Type: research

Discovery could lead to better recovery after stroke
UCLA researchers have identified a molecule that, after a stroke, signals brain tissue to form new connections to compensate for the damage and initiate repairs to the brain. The finding could eventually lead to a new treatment to promote brain repair and functional recovery in people who have suffered a stroke, which is the leading cause of serious long-term disability in adults. The five-year study, performed in an animal model, was the first to identify growth differentiation factor 10, or GDF10, a molecule that previously had no known role in the adult brain, said Dr. S. Thomas Carmichael, the study’s senior author ...
Source: UCLA Newsroom: Health Sciences - October 26, 2015 Category: Universities & Medical Training Source Type: news

How to Learn the Warning Signs of a Stroke F.A.S.T
What if singing a song or rapping lyrics could give someone the power to spot stroke signs and take action? And what if sharing that song could spread power all around the world? Would you use it to save lives? Imagine the impact it could have. Well the American Heart Association/American Stroke Association (AHA/ASA) has partnered with me and David Augustine, aka Dee-1, a former teacher and now an up and coming hip hop artist, to do just that -- spread the word about stroke warning signs through music. Our version of the song includes a music video that will bring life to the letters F.A.S.T.! Although we had plenty of...
Source: Healthy Living - The Huffington Post - October 27, 2015 Category: Consumer Health News Source Type: news

Severe paraneoplastic hypoglycemia secondary to a gastrointestinal stromal tumour masquerading as a stroke.
We report the case of a 70-year-old previously healthy female who presented acutely to the Accident and Emergency department with left-sided vasomotor symptoms including reduced muscle tone, weakness upon walking and slurred speech. Physical examination confirmed hemiparesis with VIIth nerve palsy and profound hepatomegaly. A random glucose was low at 1.7 mmol/l, which upon correction resolved her symptoms. In hindsight, the patient recalled having had similar episodes periodically over the past 3 months to which she did not give much attention. While hospitalized, she continued having episodes of symptomatic hypoglycaem...
Source: Diabetes Metab - November 7, 2015 Category: Endocrinology Authors: Dimitriadis GK, Gopalakrishnan K, Rao R, Grammatopoulos DK, Randeva HS, Weickert MO, Murthy N Tags: Endocrinol Diabetes Metab Case Rep Source Type: research

Spontaneous white matter lesion in brain of stroke-prone renovascular hypertensive rats: a study from MRI, pathology and behavior
This study aimed to investigate the WML in RHRSP from MRI, pathology and behavior. RHRSP model was established by two-kidney, two-clipmethod and kept for 20 weeks. WML was decteted by magnetic resonance imaging (MRI) and loyez staining. Cognition was tested by morris water maze (MWM). Vascular changes were observed by HE staining on brain and carotid sections. Ultrastucture of blood brain barrier (BBB) were observed by transmission electron microscope. Immunofluorescence was used to detect albumin leakage and cell proliferation. T2-weighted MRI scans of RHRSP displayed diffuse, confluent white-matter hyperintensities. Pat...
Source: Metabolic Brain Disease - November 11, 2015 Category: Neurology Source Type: research

Study on the behavioral changes of a post-stroke depression rat model.
In conclusion, rats with PSD exhibited a significantly reduced memory capacity and altered behavior. The changes in the PSD rats were more severe than those in the rats in the stroke group. PMID: 26170928 [PubMed - as supplied by publisher]
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Development of clinical practice guidelines for urinary continence care of adult stroke survivors in acute and rehabilitation settings.
This study developed evidence-based clinical practice guidelines for the urinary continence care of adult stroke survivors in acute and rehabilitation settings. The research team conducted a comprehensive review of the literature on urinary continence interventions and outcomes. The team then developed a set of recommendations outlined in the resulting clinical practice guidelines titled Clinical Practice Guidelines (CPGs) for the Urinary Continence Care of Stroke Survivors in Acute and Rehabilitation Settings. The evaluation of the CPGs consisted of a two-part assessment and pilot implementation. An expert panel of 25 loc...
Source: Canadian Journal of Neuroscience Nursing - November 18, 2015 Category: Nursing Tags: Can J Neurosci Nurs Source Type: research

Pilot evaluation of the family informal caregiver stroke self-management program.
CONCLUSIONS: The pilot evaluation of the program validated the content of the FICSS program and indicated recommendations for improvement. PMID: 24180208 [PubMed - indexed for MEDLINE]
Source: Canadian Journal of Neuroscience Nursing - November 18, 2015 Category: Nursing Tags: Can J Neurosci Nurs Source Type: research

Intra-arterial treatment in acute ischaemic stroke: what we learn from the MR CLEAN trial.
Authors: Sekhar A PMID: 25874830 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - November 30, 2015 Category: Journals (General) Tags: J R Coll Physicians Edinb Source Type: research

Development of an educational program for staffs of emergency medical service to improve their awareness of stroke within 3 hours of symptom onset: a pilot study.
CONCLUSION: The educational program increased knowledge about stroke and improved the accuracy of triage by dedicated EMS providers. Further investigation is needed to determine the effectiveness of similar educational programs for non-dedicated EMS responders. PMID: 23479240 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Impaired implicit learning and feedback processing after stroke
Publication date: 9 February 2016 Source:Neuroscience, Volume 314 Author(s): J.M. Lam, C. Globas, J.A. Hosp, H.-O. Karnath, T. Wächter, A.R. Luft The ability to learn is assumed to support successful recovery and rehabilitation therapy after stroke. Hence, learning impairments may reduce the recovery potential. Here, the hypothesis is tested that stroke survivors have deficits in feedback-driven implicit learning. Stroke survivors (n =30) and healthy age-matched control subjects (n =21) learned a probabilistic classification task with brain activation measured using functional magnetic resonance imaging in a subse...
Source: Neuroscience - December 18, 2015 Category: Neuroscience Source Type: research

Dyad Training Protocol on Learning of Bimanual Cup Stacking in Individuals with Stroke: Effects of Observation Duration.
CONCLUSION: For individuals with chronic stroke, compared with the 1-minute observation alternating with physical practice, the 6-minute duration resulted in greater persistent learning. Moreover the 6-minute duration greatly enhanced the planning of bimanual cup stacking. PMID: 26387420 [PubMed - indexed for MEDLINE]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - December 20, 2015 Category: Journals (General) Tags: J Med Assoc Thai Source Type: research

Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults—The Reasons for Geographic and Racial Differences in Stroke Study
ConclusionHigher levels of objectively measured MVPA%, rather than LPA% or ST%, were associated with lower prevalence of cognitive impairment and better performance in memory and executive function in aging people. The amount of MVPA associated with lower prevalence of cognitive impairment is consistent with meeting PA guidelines.
Source: Journal of the American Geriatrics Society - December 22, 2015 Category: Geriatrics Authors: Wenfei Zhu, Virginia J. Howard, Virginia G. Wadley, Brent Hutto, Steven N. Blair, John E. Vena, Natalie Colabianchi, David Rhodes, Steven P. Hooker Tags: Clinical Investigations Source Type: research

Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we e...
Source: eLife - January 6, 2016 Category: Biomedical Science Authors: Pielecka-Fortuna, J., Kalogeraki, E., Fortuna, M. G., Löwel, S., Sengpiel, F. Tags: Neuroscience Source Type: research

Automated segmentation of chronic stroke lesions using LINDA: Lesion identification with neighborhood data analysis
Abstract The gold standard for identifying stroke lesions is manual tracing, a method that is known to be observer dependent and time consuming, thus impractical for big data studies. We propose LINDA (Lesion Identification with Neighborhood Data Analysis), an automated segmentation algorithm capable of learning the relationship between existing manual segmentations and a single T1‐weighted MRI. A dataset of 60 left hemispheric chronic stroke patients is used to build the method and test it with k‐fold and leave‐one‐out procedures. With respect to manual tracings, predicted lesion maps showed a mean dice overlap of...
Source: Human Brain Mapping - January 1, 2016 Category: Neurology Authors: Dorian Pustina, H. Branch Coslett, Peter E. Turkeltaub, Nicholas Tustison, Myrna F. Schwartz, Brian Avants Tags: Research Article Source Type: research

Effectiveness of motor imagery or mental practice in functional recovery after stroke: a systematic review
Conclusions MP is effective when used in conjunction with conventional physical therapy for functional rehabilitation of both upper and lower limbs, as well as for the recovery of daily activities and skills. Owing to the heterogeneity of the studies with regard to the intervention protocol, specific imagery technique, time spent practicing, patient characteristics, etc., more studies are needed in order to determine the optimal treatment protocol and patient profile.
Source: Neurologia - January 13, 2016 Category: Neurology Source Type: research

The inclination for conscious motor control after stroke: validating the Movement-Specific Reinvestment Scale for use in inpatient stroke patients.
CONCLUSIONS: The MSRS is a valid and reliable tool and suitable to assess the relationship between reinvestment and motor recovery in the first months post-stroke. Eventually, this may help therapists to individualize motor learning interventions based on patients' reinvestment preferences. Implications for rehabilitation This study showed that the Movement-Specific Reinvestment Scale (MSRS) is a valid and reliable tool to objectify stroke patients' inclination for conscious motor control. The MSRS may be used to identify stroke patients who are strongly inclined to consciously control their movements, as this disposition ...
Source: Disability and Rehabilitation - January 10, 2016 Category: Rehabilitation Authors: Kal E, Houdijk H, Van Der Wurff P, Groet E, Van Bennekom C, Scherder E, Van der Kamp J Tags: Disabil Rehabil Source Type: research

The role of learning in improving functional writing in stroke aphasia.
CONCLUSIONS: These results show that small doses of writing therapy can lead to large gains in specific types of writing. These gains did not extend to improvements in frequency of writing in daily living, nor ecological measures of email writing. There is a need to develop bridging interventions between experimental tasks towards more multi-faceted and ecological everyday writing tasks. Implications for Rehabilitation Acquired dysgraphia can restrict people from participating in social, educational and professional life. This study has shown that copy and recall spelling therapies can improve the spelling of treated words...
Source: Disability and Rehabilitation - January 5, 2016 Category: Rehabilitation Authors: Thiel L, Sage K, Conroy P Tags: Disabil Rehabil Source Type: research

Sensors, Vol. 16, Pages 134: A Machine Learning Framework for Gait Classification Using Inertial Sensors: Application to Elderly, Post-Stroke and Huntington’s Disease Patients
Machine learning methods have been widely used for gait assessment through the estimation of spatio-temporal parameters. As a further step, the objective of this work is to propose and validate a general probabilistic modeling approach for the classification of different pathological gaits. Specifically, the presented methodology was tested on gait data recorded on two pathological populations (Huntington’s disease and post-stroke subjects) and healthy elderly controls using data from inertial measurement units placed at shank and waist. By extracting features from group-specific Hidden Markov Models (HMMs) and signal in...
Source: Sensors - January 21, 2016 Category: Biotechnology Authors: Andrea ManniniDiana TrojanielloAndrea CereattiAngelo Sabatini Tags: Article Source Type: research

Depressive symptoms influence use of feedback for motor learning and recovery in chronic stroke.
CONCLUSION: The presence of PSD diminished the ability to use auditory feedback for arm motor recovery and motor learning. PMID: 26444639 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Motor imagery learning across a sequence of trials in stroke patients.
CONCLUSIONS: Trial-dependent changes during motor imagery learning presented in a different manner in stroke patients. Understanding motor imagery learning in stroke patients is crucial for enhancing the effectiveness of motor-imagery-based BCIs. PMID: 26410210 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Using stroke thrombolysis to describe the role of repetition in learning a cognitive skill
ConclusionsAccruing sufficient experience of a new cognitive clinical skill can be challenging for independent physicians, with expertise gradually emerging in a largely linear fashion only after much repetition.
Source: Medical Education - January 26, 2016 Category: Universities & Medical Training Authors: Christopher A K Y Chong Tags: Repetition ‐Based Learning Source Type: research

The effect of sleep on motor learning in the aging and stroke population - a systematic review.
Authors: Backhaus W, Kempe S, Hummel FC Abstract There is extensive evidence for positive effects of sleep on motor learning in young individuals; however, the effects of sleep on motor learning in people with stroke and in healthy older individuals are not well understood. The aim of this systematic review was to quantify the association between sleep and procedural memory performance - a marker for motor learning - in healthy older people and people with stroke. After searches in PubMed, Medline and Embase fourteen studies, including 44 subjects after stroke and 339 healthy older participants were included. Overa...
Source: Restorative Neurology and Neuroscience - February 4, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Identification of the factors conditioning times and indicators of quality in the intrahospital care of acute stroke.
CONCLUSIONS: Knowledge of the current situation of the times and quality indicators and their determinants are essential to provide the motivation to start an initiative to improve the quality of care in patients with acute stroke. PMID: 26860720 [PubMed - in process]
Source: Revista de Neurologia - February 12, 2016 Category: Neurology Authors: Palazon-Cabanes B, Lopez-Picazo Ferrer JJ, Morales-Ortiz A, Tomas-Garcia N Tags: Rev Neurol Source Type: research

RPS Wales calls for pharmacists to raise awareness of mini stroke
The Royal Pharmaceutical Society in Wales (RPS Wales) is calling for pharmacists to use their skills to educate patients on the risks factors that can cause a stroke and to help patients with these risks to learn the early warning signs so they can act and act fast.   T
Source: Royal Pharmaceutical Society News - April 30, 2014 Category: Drugs & Pharmacology Source Type: news

Dorsal premotor activity and connectivity relate to action selection performance after stroke
Abstract Compensatory activation in dorsal premotor cortex (PMd) during movement execution has often been reported after stroke. However, the role of PMd in the planning of skilled movement after stroke has not been well studied. The current study investigated the behavioral and neural response to the addition of action selection (AS) demands, a motor planning process that engages PMd in controls, to movement after stroke. Ten individuals with chronic, left hemisphere stroke and 16 age‐matched controls made a joystick movement with the right hand under two conditions. In the AS condition, participants moved right or left...
Source: Human Brain Mapping - February 15, 2016 Category: Neurology Authors: Jill Campbell Stewart, Pritha Dewanjee, Umar Shariff, Steven C. Cramer Tags: Research Article Source Type: research

Defining Optimal Aerobic Exercise Parameters to Affect Complex Motor and Cognitive Outcomes after Stroke: A Systematic Review and Synthesis.
Abstract Although poststroke aerobic exercise (AE) increases markers of neuroplasticity and protects perilesional tissue, the degree to which it enhances complex motor or cognitive outcomes is unknown. Previous research suggests that timing and dosage of exercise may be important. We synthesized data from clinical and animal studies in order to determine optimal AE training parameters and recovery outcomes for future research. Using predefined criteria, we included clinical trials of stroke of any type or duration and animal studies employing any established models of stroke. Of the 5,259 titles returned, 52 artic...
Source: Neural Plasticity - February 18, 2016 Category: Neurology Authors: Hasan SM, Rancourt SN, Austin MW, Ploughman M Tags: Neural Plast Source Type: research

Modulation of Synaptic Plasticity by Exercise Training as a Basis for Ischemic Stroke Rehabilitation.
Abstract In recent years, rehabilitation of ischemic stroke draws more and more attention in the world, and has been linked to changes of synaptic plasticity. Exercise training improves motor function of ischemia as well as cognition which is associated with formation of learning and memory. The molecular basis of learning and memory might be synaptic plasticity. Research has therefore been conducted in an attempt to relate effects of exercise training to neuroprotection and neurogenesis adjacent to the ischemic injury brain. The present paper reviews the current literature addressing this question and discusses ...
Source: Cellular and Molecular Neurobiology - February 24, 2016 Category: Cytology Authors: Nie J, Yang X Tags: Cell Mol Neurobiol Source Type: research

Predictive analysis for identifying potentially undiagnosed post-stroke spasticity patients in United Kingdom
Conclusions Using machine learning techniques, additional unrecorded post-stroke spasticity patients were identified, increasing the condition’s prevalence in THIN from 2% to 13%. This work shows the potential for under-reporting of PSS in primary care data, and provides a method for improved identification of cases and control records for future studies. Graphical abstract
Source: Journal of Biomedical Informatics - February 29, 2016 Category: Information Technology Source Type: research

Progesterone improves long-term functional and histological outcomes after permanent stroke in older rats.
Abstract Previous studies have shown progesterone to be beneficial in animal models of central nervous system injury, but less is known about its longer-term sustained effects on recovery of function following stroke. We evaluated progesterone's effects on a panel of behavioral tests up to 8 weeks after permanent middle cerebral artery occlusion (pMCAO). Male Sprague-Dawley rats 12m.o. were subjected to pMCAO and, beginning 3h post-pMCAO, given intraperitoneal injections of progesterone (8mg/kg) or vehicle, followed by subcutaneous injections at 8h and then every 24h for 7 days, with tapering of the last 2 treatme...
Source: Behavioural Brain Research - February 24, 2016 Category: Neurology Authors: Wali B, Ishrat T, Stein DG, Sayeed I Tags: Behav Brain Res Source Type: research

The role of auditory feedback in music-supported stroke rehabilitation:A single-blinded randomised controlled intervention.
CONCLUSIONS: Auditory feedback-based motor learning is not the beneficial mechanism of music-supported therapy. Immediate auditory feedback therapy may be suboptimal. Jittered delay may increase efficacy of the proposed therapy and allow patients to fully benefit from motivational factors of music training. Our study shows a novel way to test hypotheses concerning music training in a single-blinded way, which is an important improvement over existing unblinded tests of music interventions. PMID: 26923616 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - March 1, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

A Remote Quantitative Fugl-Meyer Assessment Framework for Stroke Patients Based on Wearable Sensor Networks
To extend the use of wearable sensor networks for stroke patients training and assessment in non-clinical settings, this paper proposes a novel remote quantitative Fugl-Meyer assessment (FMA) framework, in which two accelerometer and seven flex sensors were used to monitoring the movement function of upper limb, wrist and fingers. The extreme learning machine based ensemble regression model was established to map the sensor data to clinical FMA scores while the RRelief algorithm was applied to find the optimal features subset.
Source: Computer Methods and Programs in Biomedicine - March 2, 2016 Category: Bioinformatics Authors: Lei Yu, Daxi Xiong, Liquan Guo, Jiping Wang Source Type: research

Developing a novel peer support intervention to promote resilience after stroke
This study demonstrates the application of the revised UKMRC framework to systematically develop an empirically and theoretically robust intervention to promote resilience after stroke. A future randomised feasibility study is needed to determine whether a full trial is feasible with a larger sample and wider age range of people with stroke.
Source: Health and Social Care in the Community - March 1, 2016 Category: Health Management Authors: Euan Sadler, Sophie Sarre, Anthea Tinker, Ajay Bhalla, Christopher McKevitt Tags: Original Article Source Type: research

Test-retest reliability and convergent validity of three manual dexterity measures in persons with chronic stroke
Conclusion The test-retest reliability of the BBT, NHPT and mSHFT was high but all measures showed learning effects. The relationships between the three measures indicate that they partly complement one another. The BBT may be preferred for persons with moderate impairments of the upper extremity and the NHPT and the mSHFT for persons with milder impairments. As the mSHFT has the advantage of reflecting activities in daily life it may be a suitable alternative to the NHPT.
Source: PMandR - March 11, 2016 Category: Rehabilitation Source Type: research

Rapid learning curve for Solitaire FR stent retriever therapy: evidence from roll-in and randomised patients in the SWIFT trial
Conclusions Thrombectomy in AIS using the Solitaire stent retriever device can be performed safely and effectively when used by experienced neurointerventionalists without previous experience with the device. Trial registration number The SWIFT study is registered with ClinicalTrials.gov, number NCT 01054560.
Source: Journal of NeuroInterventional Surgery - March 15, 2016 Category: Neurosurgery Authors: Sheth, S. A., Jahan, R., Levy, E. I., Jovin, T. G., Baxter, B., Nogueira, R. G., Clark, W., Budzik, R., Zaidat, O. O., Saver, J. L., for the SWIFT Trialists Tags: Ischemic stroke Source Type: research

Reports Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke
Anodal transcranial direct current stimulation (tDCS) can boost the effects of motor training and facilitate plasticity in the healthy human brain. Motor rehabilitation depends on learning and plasticity, and motor learning can occur after stroke. We tested whether brain stimulation using anodal tDCS added to motor training could improve rehabilitation outcomes in patients after stroke. We performed a randomized, controlled trial in 24 patients at least 6 months after a first unilateral stroke not directly involving the primary motor cortex. Patients received either anodal tDCS (n = 11) or sham treatment (n = 13) paired wi...
Source: Science Translational Medicine - March 16, 2016 Category: Biomedical Science Authors: Allman, C., Amadi, U., Winkler, A. M., Wilkins, L., Filippini, N., Kischka, U., Stagg, C. J., Johansen-Berg, H. Tags: Reports Source Type: research

Brain activation is related to smoothness of upper limb movements after stroke.
This study suggests that recruitment of secondary motor areas at 6 weeks after stroke is highly associated with increased jerk during reaching and grasping. As jerk represents the change in acceleration, the recruitment of additional sensorimotor areas seems to reflect a type of control in which deviations from an optimal movement pattern are continuously corrected. This relationship suggests that additional recruitment of sensorimotor areas after stroke may not correspond to restitution of motor function, but more likely to adaptive motor learning strategies to compensate for motor impairments. PMID: 26979435 [PubMe...
Source: Experimental Brain Research - March 15, 2016 Category: Neuroscience Authors: Buma FE, van Kordelaar J, Raemaekers M, van Wegen EE, Ramsey NF, Kwakkel G Tags: Exp Brain Res Source Type: research

Procedural learning as a measure of functional impairment in a mouse model of ischemic stroke.
Abstract Basal ganglia stroke is often associated with functional deficits in patients, including difficulties to learn and execute new motor skills (procedural learning). To measure procedural learning in a murine model of stroke (30min. right MCAO), we submitted C57Bl/6J mice to various sensorimotor tests, then to an operant procedure (Serial Order Learning) specifically assessing the ability to learn a simple motor sequence. Results showed that MCAO affected the performance in some of the sensorimotor tests (accelerated rotating rod and amphetamine rotation test) and the way animals learned a motor sequence. Th...
Source: Behavioural Brain Research - March 17, 2016 Category: Neurology Authors: Linden J, Beeck LV, Plumier JC, Ferrara A Tags: Behav Brain Res Source Type: research