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Featured Review: Electromechanical and robot ‐assisted arm training for improving activities of daily living, arm function, and arm muscle strength after stroke
Updated review: Electromechanical and robot ‐assisted arm training for improving activities of daily living, arm function, and arm muscle strength after strokeIn thisupdated review authors from Germany came together to re-assess the effects of electromechanical and robot ‐assisted arm training for improving arm function in people who have had a stroke. The review was updated from having low/very low quality evidence of benefit to high quality evidence of benefit.Electromechanical and robot ‐assisted arm training uses specialised machines to assist rehabilitation in supporting shoulder, elbow, or hand movements. Howev...
Source: Cochrane News and Events - September 6, 2018 Category: Information Technology Authors: Katie Abbotts Source Type: news

The key challenges of discussing end-of-life stroke care with patients and families: a mixed-methods electronic survey of hospital and community healthcare professionals.
CONCLUSION: Key topics of unmet need for education in end-of-life care in stroke have been identified and these have influenced the content of an open access, web-based educational resource. PMID: 30191909 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - September 8, 2018 Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research

Experiences of living with persisting post-stroke dysphagia and of dysphagia management - a qualitative study.
CONCLUSIONS: Findings indicated that people with dysphagia experienced a lack of support from health care professionals. Better health care support following discharge from hospital is required to ensure an optimal quality of life. Actions to achieve this may include developing national guidelines for adequate dysphagia follow-up and establishing multidisciplinary dysphagia teams in hospitals and long-term care facilities. PMID: 30257150 [PubMed - in process]
Source: International Journal of Qualitative Studies on Health and Well-being - September 27, 2018 Category: International Medicine & Public Health Tags: Int J Qual Stud Health Well-being Source Type: research

The Role of the Left Atrial Appendage in Stroke and Arrhythmia Provocation
AbstractPurpose of the reviewThe review will provide an overview of the potential use of left atrial appendage (LAA) exclusion in patients with atrial fibrillation (AF), highlighting the benefits and risks involved with LAA exclusion.Recent findingsLAA ligation leads to electrical isolation of the LAA and a decrease in LA mass which is associated with a decrease in AF burden and occasional termination of AF in patients with persistent AF. This potential new indication will further expand the use of LAA exclusion and necessitate planning of combining LAA exclusion with catheter ablation for both stroke prevention and antiar...
Source: Current Cardiovascular Risk Reports - March 19, 2018 Category: Cardiology Source Type: research

Dissociating motor learning from recovery in exoskeleton training post-stroke
A large number of robotic or gravity-supporting devices have been developed for rehabilitation of upper extremity post-stroke. Because these devices continuously monitor performance data during training, they ...
Source: Journal of NeuroEngineering and Rehabilitation - October 5, 2018 Category: Rehabilitation Authors: Nicolas Schweighofer, Chunji Wang, Denis Mottet, Isabelle Laffont, Karima Bakthi, David J. Reinkensmeyer and Olivier R émy-Néris Tags: Research Source Type: research

The key features and role of peer support within group self-management interventions for stroke? A systematic review.
CONCLUSION: Future self-management interventions should be designed to maximize peer support and incorporate techniques which facilitate, knowledge building, goal setting, access to resources, problem solving, and communication. Implications for rehabilitation Group self-management interventions offer a way to provide peer support to stroke survivors and should be utilized in practice. Peer support is seen by stroke survivors as valuable because it can facilitate the sharing of experiences, social comparison, vicarious learning, and increase motivation. Knowledge building, goal setting, problem solving, collaborative skill...
Source: Disability and Rehabilitation - October 16, 2018 Category: Rehabilitation Authors: Clark E, MacCrosain A, Ward NS, Jones F Tags: Disabil Rehabil Source Type: research

Corrigendum to “Predicting Motor and Cognitive Improvement Through Machine Learning Algorithm in Human Subject That Underwent a Rehabilitation Treatment in the Early Stage of Stroke” J Stroke Cerebrovasc Dis 27/11 (2018) 2962-2972
The authors would like to inform the readers of a needed clarification in this article.
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2018 Category: Neurology Authors: Patrizio Sale, Giorgio Ferriero, Lucio Ciabattoni, Anna Maria Cortese, Giovanni Gentile, Francesco Ferracuti, Luca Romeo, Francesco Piccione, Stefano Masiero Tags: Corrigendum Source Type: research

Effect of Stride Management Assist Gait Training for Poststroke Hemiplegia: A Single Center, Open-Label, Randomized Controlled Trial
Poststroke gait disorders negatively impact activities of daily living. Rehabilitation for stroke patients is aimed at improving their walking ability, balance, and quality of life. Robot-assisted gait training (RAGT) is associated with an increased number of task-specific exercises, which may benefit poststroke motor learning. We investigated the effects of RAGT using Stride Management Assist (SMA, which increases walk ratio by inducing hip-joint flexion and extension) in subacute stroke patients with hemiplegia.
Source: Journal of Stroke and Cerebrovascular Diseases - November 9, 2018 Category: Neurology Authors: Naojiro Tanaka, Shinro Matsushita, Yasushi Sonoda, Yoshikatsu Maruta, Yuta Fujitaka, Masashi Sato, Miki Simomori, Rhyuki Onaka, Keiji Harada, Takashi Hirata, Shoji Kinoshita, Takatsugu Okamoto, Hitoshi Okamura Source Type: research

Brain ‐State Dependent Stimulation boosts functional recovery following stroke
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Natalie Mrachacz ‐Kersting, Andrew J.T. Stevenson, Helle R. M. Jørgensen, Kåre Eg Severinsen, Susan Aliakbaryhosseinabadi, Ning Jiang, Dario Farina Tags: Research Article Source Type: research

Inter- and Intra-Rater Reliability of Computer-Assisted Planimetry in Experimental Stroke Research
ConclusionComputer-assisted planimetry can be an appropriate method to determine hemispheric or ischemic lesion volume in rodents but requires a sufficiently long learning period of approximately two months. Even an experienced investigator can generate data with serious variation. Inter- and intra-rater-dependent bias should be considered during the design and performance of respective studies.
Source: Journal of Neuroscience Methods - November 19, 2018 Category: Neuroscience Source Type: research

Attributes of evidence-based occupational therapists in stroke rehabilitation.
Abstract BACKGROUND.: A better understanding of the features characterizing expert evidence-based occupational therapists in stroke rehabilitation is needed to inform the design of educational and knowledge translation interventions aimed at addressing research-practice gaps. PURPOSE.: The study aimed to identify the attributes of evidence-based occupational therapy stroke rehabilitation experts from the perspective of their peers. METHOD.: Forty-six occupational therapy clinicians and managers completed an online questionnaire asking them to nominate "outstanding" and "expert evidence-based" occupationa...
Source: Canadian Journal of Occupational Therapy - November 19, 2018 Category: Occupational Health Authors: Hallé MC, Mylopoulos M, Rochette A, Vachon B, Menon A, McCluskey A, Amari F, Thomas A Tags: Can J Occup Ther Source Type: research

Sensors, Vol. 18, Pages 4107: Compressibility of High-Density EEG Signals in Stroke Patients
sco C. Morabito Stroke is a critical event that causes the disruption of neural connections. There is increasing evidence that the brain tries to reorganize itself and to replace the damaged circuits, by establishing compensatory pathways. Intra- and extra-cellular currents are involved in the communication between neurons and the macroscopic effects of such currents can be detected at the scalp through electroencephalographic (EEG) sensors. EEG can be used to study the lesions in the brain indirectly, by studying their effects on the brain electrical activity. The primary goal of the present work was to investigate po...
Source: Sensors - November 23, 2018 Category: Biotechnology Authors: Nadia Mammone Simona De Salvo Cosimo Ieracitano Silvia Marino Emanuele Cartella Alessia Bramanti Roberto Giorgianni Francesco C. Morabito Tags: Article Source Type: research

The effect of transcranial direct current stimulation combined with functional task training on motor recovery in stroke patients.
This article reviews the state-of-the-art of neuromodulation for stroke and discusses the opportunities and challenges available for clinicians and researchers interested in advancing neuromodulation therapy. The annual worldwide incidence of stroke ranges from 27.5 to 63 individuals per 100,000. Stroke, a major cause of adult disability, has devastating effects on patients and their caregivers, which has a tremendous socioeconomic impact on families and healthcare systems around the world. There are only a few treatments available for the improvement of motor function in stroke patients. The majority of these treatments a...
Source: European Review for Medical and Pharmacological Sciences - November 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Neuropsychological outcome following thalamic stroke in adolescence: an identical twin comparison.
CONCLUSIONS: These results suggest risk for deficits in encoding of new verbal information following bilateral thalamic stroke in adolescence, as well as risk for persistent cognitive deficits despite initial improvements. This is consistent with descriptions of anterograde memory impairments in adults with similar lesions. PMID: 30472911 [PubMed - as supplied by publisher]
Source: The Clinical Neuropsychologist - November 24, 2018 Category: Psychiatry & Psychology Authors: Godfrey M, Gillis MM, Khurana D, Poletto E, Tarazi RA Tags: Clin Neuropsychol Source Type: research

Management of Stroke in the Neurocritical Care Unit
This article provides updated information regarding the diagnosis and treatment (specifically critical care management) of acute ischemic stroke. This article also discusses the increased use of thrombolysis and thrombectomy in clinical practice. RECENT FINDINGS Stroke is the leading cause of disability in the United States. A significant proportion of patients with acute ischemic stroke require critical care management. Much has changed in the early evaluation and treatment of patients presenting with acute ischemic stroke. The introduction of embolectomy in large vessel occlusions for up to 24 hours post–symptom ons...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2018 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats
Conclusion: SQTS showed therapeutic benefits on sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity.
Source: Chinese Herbal Medicines - December 7, 2018 Category: Complementary Medicine Source Type: research

Insights Into Women and Stroke Risk
TUESDAY, Dec. 11, 2018 -- You might be surprised to learn that stroke is the number three killer of women. Women and men have many of the same risk factors for stroke, but some -- like high blood pressure, migraine with aura, diabetes and stress --...
Source: Drugs.com - Daily MedNews - December 11, 2018 Category: General Medicine Source Type: news

Using Machine Learning to Improve the Prediction of Functional Outcome in Ischemic Stroke Patients
Ischemic stroke is a leading cause of disability and death worldwide among adults. The individual prognosis after stroke is extremely dependent on treatment decisions physicians take during the acute phase. In the last five years, several scores such as the ASTRAL, DRAGON, and THRIVE have been proposed as tools to help physicians predict the patient functional outcome after a stroke. These scores are rule-based classifiers that use features available when the patient is admitted to the emergency room. In this paper, we apply machine learning techniques to the problem of predicting the functional outcome of ischemic stroke ...
Source: IEEE/ACM Transactions on Computational Biology and Bioinformatics - December 11, 2018 Category: Bioinformatics Source Type: research

The immediate influence of implicit motor learning strategies on spatiotemporal gait parameters in stroke patients: a randomized within-subjects design.
CONCLUSION:: Analogy instructions and environmental constraints can lead to specific, immediate changes in the walking performance and were in general experienced as feasible by the participants. However, the response of an individual patient may vary quite considerably. PMID: 30537847 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - December 12, 2018 Category: Rehabilitation Authors: Kleynen M, Jie LJ, Theunissen K, Rasquin SM, Masters RS, Meijer K, Beurskens AJ, Braun SM Tags: Clin Rehabil Source Type: research

Community-Based Stroke Recognition Education and Response: An Evidence-Based Intervention Project.
CONCLUSIONS: FAST was simple to teach and engaging for participants. Using the FAST curriculum in senior center populations increased the participants' awareness of stroke signs and symptoms, and their willingness to activate the 911 emergency system. IMPLICATIONS FOR PRACTICE: Educational interventions in the community with older adults can produce increased awareness of stroke symptoms and willingness to respond when necessary. PMID: 30567968 [PubMed - in process]
Source: Creative Nursing - November 1, 2018 Category: Nursing Authors: Sposito J, Zipf A, Alhowaymel F, Almutairi MT, Breda K Tags: Creat Nurs Source Type: research

Automated ASPECTS on Noncontrast CT Scans in Patients with Acute Ischemic Stroke Using Machine Learning FUNCTIONAL
CONCLUSIONS: The proposed automated ASPECTS scoring approach shows reasonable ability to determine ASPECTS on NCCT images in patients presenting with acute ischemic stroke.
Source: American Journal of Neuroradiology - January 11, 2019 Category: Radiology Authors: Kuang, H., Najm, M., Chakraborty, D., Maraj, N., Sohn, S. I., Goyal, M., Hill, M. D., Demchuk, A. M., Menon, B. K., Qiu, W. Tags: FUNCTIONAL Source Type: research

Targeting 'hidden pocket' for treatment of stroke and seizure
(Cold Spring Harbor Laboratory) By closely examining a special neuron receptor that is involved in memory, learning, and much more, researchers have identified a hidden molecular 'pocket.' By creating chemical compounds that affect this pocket only in very specific circumstances, they are one step closer to creating ideal treatments for stroke and seizures.
Source: EurekAlert! - Medicine and Health - January 18, 2019 Category: International Medicine & Public Health Source Type: news

Inhibition of tropomyosin-related kinase B (TrkB) reduces the benefit of cortical stimulation combined with motor rehabilitation in experimental stroke
Clinical and experimental studies suggest that combining impaired limb rehabilitation (RT) with low-frequency inhibitory contra-lesion or high-frequency excitatory ipsi-lesion motor cortical stimulation (CS) can improve motor recovery and increase neural remodeling. However, results have been mixed and there is no consensus on which CS approach is more beneficial. Further, the mechanism by which excitatory CS (ECS) and inhibitory CS (ICS) alter motor recovery after stroke are unknown. Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) are important for motor learning and neural pl...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: S. Kinley Cooper, D. Adkins, A. Rizzo, K. Kinley-Howard Source Type: research

The feasibility and acceptability of smart home technology using the Howz system for people with stroke.
CONCLUSIONS: The Howz system was feasible and acceptable for stroke survivors. It gave users and their family an enhanced sense of security and peace of mind that help would be at hand if needed. Implications for rehabilitation Although most stroke survivors are elderly and often suffer physical, visual and cognitive disabilities which are often considered as barriers to using smart home technology, this project has demonstrated the well-developed smart home technology is feasible and acceptable. Users were able and willing to engage with the technology (to varying degrees) and had no concerns about invasion of privacy. Th...
Source: Disability and Rehabilitation. Assistive Technology. - January 21, 2019 Category: Rehabilitation Authors: Rogerson L, Burr J, Tyson S Tags: Disabil Rehabil Assist Technol Source Type: research

Stroke survivors' experiences of occupation in hospital-based stroke rehabilitation: a qualitative exploration.
CONCLUSION: This study provides a preliminary understanding of how stroke survivors experience occupational engagement during rehabilitation. There was an apparent shift in priorities with therapy considered the most important occupation and a strong need expressed for rest and relaxation to be factored into people's days. It appears the increasing activity levels may not always align with people's occupations and that due consideration of this malalignment may further enhance engagement and outcomes. Implications for rehabilitation During hospital-based stroke rehabilitation, stroke survivors prioritized the occupations o...
Source: Disability and Rehabilitation - January 23, 2019 Category: Rehabilitation Authors: Purcell S, Scott P, Gustafsson L, Molineux M Tags: Disabil Rehabil Source Type: research

Deep learning fully convolution network for lumen characterization in diabetic patients using carotid ultrasound: a tool for stroke risk
AbstractManual ultrasound (US)-based methods are adapted for lumen diameter (LD) measurement to estimate the risk of stroke but they are tedious, error prone, and subjective causing variability. We propose an automated deep learning (DL)-based system for lumen detection. The system consists of a combination of two DL systems: encoder and decoder for lumen segmentation. The encoder employs a 13-layer convolution neural network model (CNN) for rich feature extraction. The decoder employs three up-sample layers of fully convolution network (FCN) for lumen segmentation. Three sets of manual tracings were used during the traini...
Source: Medical and Biological Engineering and Computing - January 26, 2019 Category: Biomedical Engineering Source Type: research

CT matches MRI for late-window stroke evaluation
Stroke patients who underwent endovascular therapy had similar improvement...Read more on AuntMinnie.comRelated Reading: Machine learning can predict stroke treatment outcomes Study reveals steep cost of delaying stroke treatment 3 CTA signs show which stroke patients can skip surgery Perfusion imaging expands window for stroke treatment CTA helps direct use of clot removal for stroke patients
Source: AuntMinnie.com Headlines - February 6, 2019 Category: Radiology Source Type: news

Improving Door-to-needle Times in the Treatment of Acute Ischemic Stroke Across a Canadian Province: Methodology
Background: Alteplase is a proven medical treatment for acute ischemic stroke; however, the effectiveness of this treatment is highly time dependent. Therefore, it is imperative that hospitals treat acute ischemic stroke patients as quickly as possible. The measure, door-to-needle time, is the time from hospital arrival to when alteplase administration begins. Objective: The goal in the Canadian province of Alberta was to reduce the door-to-needle time to a median of 30 minutes and to increase the percent of patients treated within 60 minutes to 90%. Overview of Methodology: A modified version of Institute for Heal...
Source: Critical Pathways in Cardiology - February 13, 2019 Category: Cardiology Tags: Pathway Source Type: research

Cerebral microbleeds are associated with cognitive decline early after ischemic stroke
ConclusionCognitive abilities are more severely impaired in CMB-positive stroke patients compared to CMB-free controls, whereby memory-associated functions are most affected. CMB might be associated with post-stroke cognitive decline, particularly with impaired memory and phonemic fluency.
Source: Journal of Neurology - February 14, 2019 Category: Neurology Source Type: research

Combination of hand-crafted and unsupervised learned features for ischemic stroke lesion detection from Magnetic Resonance Images
Publication date: Available online 14 February 2019Source: Biocybernetics and Biomedical EngineeringAuthor(s): G.B. Praveen, Anita Agrawal, Ponraj Sundaram, Sanjay SardesaiAbstractDetection of ischemic stroke lesions plays a vital role in the assessment of stroke treatments such as thrombolytic therapy and embolectomy. Manual detection and quantification of stroke lesions is a time-consuming and cumbersome process. In this paper, we present a novel automatic method to detect acute ischemic stroke lesions from Magnetic Resonance Image (MRI) volumes using textural and unsupervised learned features. The proposed method profic...
Source: Biocybernetics and Biomedical Engineering - February 15, 2019 Category: Biomedical Engineering Source Type: research

Neuropsychological and neuroimaging evidences of cerebral dysfunction in stroke-free patients with atrial fibrillation: A review
Atrial fibrillation (AF) is the most common heart arrhythmia, with the highest prevalence in the elderly. AF has been correlated with silent lesions and cognitive impairment, even in the absence of stroke. The cognitive impairment in AF represents a risk of functional decline, morbidity, mortality and high costs, constituting a public health problem due to the increasing prevalence of this arrhythmia. Cognitive analysis of patients with AF without stroke has shown poor performance in executive, memory and learning functions.
Source: Journal of the Neurological Sciences - February 18, 2019 Category: Neurology Authors: D.S. Silva, A.C. Coan, W.M. Avelar Tags: Review Article Source Type: research

A missing gene makes a big difference in patients ’ recovery from mild stroke
More than 6 million Americans live with disabilities following a stroke. Even mild strokes can leave survivors with arm and leg weakness, poor muscle control and memory lapses that worsen with age. Now UCLA neuroscientists have found that patients born without a gene called CCR5 recover better from mild stroke than patients with the gene. The team partnered with Israeli researchers to study the missing gene ’s effect on brain function.Published Feb. 21 in the journal Cell,  the findings could lead to the first pill to reverse the physical and mental aftermath of mild stroke.“This is the first time that a human gene h...
Source: UCLA Newsroom: Health Sciences - February 21, 2019 Category: Universities & Medical Training Source Type: news

Comparison of Automated and Visual DWI ASPECTS in Acute Ischemic Stroke
Conclusions: Agreement values are on the same order or higher compared to a literature review of CT-based ASPECTS. Automated methods perform slightly worse than human expert ratings, but they still have enough power to determine the DWI-ASPECTS with good precision in a clinical setting.
Source: Journal of Neuroradiology - March 9, 2019 Category: Radiology Source Type: research

MRI measurements of iron content show impact of stroke
French researchers have taken a basic MR imaging technique to break new ground...Read more on AuntMinnie.comRelated Reading: Deep-learning MRI algorithm aids in neurological diagnoses CT matches MRI for late-window stroke evaluation Women less likely to receive poststroke imaging Is CCTA, MRI, or transthoracic echo best for predicting stroke? Study reveals steep cost of delaying stroke treatment
Source: AuntMinnie.com Headlines - March 12, 2019 Category: Radiology Source Type: news

White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study.
Abstract Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. The main objective of the present study was to assess white matter biomarkers of response to cTBS paired with skilled motor practice in individuals with chronic stroke. We tested the effects...
Source: Neural Plasticity - March 15, 2019 Category: Neurology Authors: Wadden KP, Peters S, Borich MR, Neva JL, Hayward KS, Mang CS, Snow NJ, Brown KE, Woodward TS, Meehan SK, Boyd LA Tags: Neural Plast Source Type: research

Commentary on: "Practice Structure and Locomotor Learning After Stroke".
PMID: 30883496 [PubMed - in process]
Source: Physical Therapy - March 20, 2019 Category: Physiotherapy Authors: Leech KA, Holleran CL Tags: J Neurol Phys Ther Source Type: research

Practice Structure and Locomotor Learning After Stroke.
CONCLUSIONS: The results suggest that variable practice utilizing alternating belt speed ratios does not influence the ability of those with chronic stroke to adapt and retain a novel locomotor pattern. The effects of other forms of variable practice within other locomotor learning paradigms should be explored in those with chronic hemiparesis after stroke.Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A257). PMID: 30883495 [PubMed - in process]
Source: Physical Therapy - March 20, 2019 Category: Physiotherapy Authors: Helm EE, Pohlig RT, Kumar DS, Reisman DS Tags: J Neurol Phys Ther Source Type: research

Classifying Acute Ischemic Stroke Onset Time using Deep Imaging Features.
Authors: Ho KC, Speier W, El-Saden S, Arnold CW Abstract Models have been developed to predict stroke outcomes (e.g., mortality) in attempt to provide better guidance for stroke treatment. However, there is little work in developing classification models for the problem of unknown time-since-stroke (TSS), which determines a patient's treatment eligibility based on a clinical defined cutoff time point (i.e., <4.5hrs). In this paper, we construct and compare machine learning methods to classify TSS<4.5hrs using magnetic resonance (MR) imaging features. We also propose a deep learning model to extract hidden rep...
Source: AMIA Annual Symposium Proceedings - March 20, 2019 Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research

SIR: Stroke treatment training program improves outcomes
Interventional radiologists at Johns Hopkins University have developed an innovative...Read more on AuntMinnie.comRelated Reading: MRI measurements of iron content show impact of stroke CT matches MRI for late-window stroke evaluation Machine learning can predict stroke treatment outcomes Study reveals steep cost of delaying stroke treatment MRI links lifestyle factors to stroke, dementia risk
Source: AuntMinnie.com Headlines - March 25, 2019 Category: Radiology Source Type: news

Practice Structure and Locomotor Learning After Stroke
Conclusions: The results suggest that variable practice utilizing alternating belt speed ratios does not influence the ability of those with chronic stroke to adapt and retain a novel locomotor pattern. The effects of other forms of variable practice within other locomotor learning paradigms should be explored in those with chronic hemiparesis after stroke. Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A257).
Source: Journal of Neurologic Physical Therapy - March 28, 2019 Category: Physiotherapy Tags: Research Articles Source Type: research

The unsolved role of heightened connectivity from the unaffected hemisphere to paretic arm muscles in chronic stroke.
CONCLUSIONS: Despite enhanced ipsilateral connectivity, arm function and learning was related most strongly to contralateral pathway integrity from the stroke hemisphere. SIGNIFICANCE: Further work is needed to decipher the role of ipsilateral connections. PMID: 30925310 [PubMed - as supplied by publisher]
Source: Clinical Neurophysiology - March 17, 2019 Category: Neurology Authors: Hammerbeck U, Hoad D, Greenwood R, Rothwell JC Tags: Clin Neurophysiol Source Type: research

When Time Is Critical: How Involving Frontline Health Workers Can Improve Stroke Survival Rates
By Carmen Graffagnino, Neurologist, Duke Hospital ; Nilima Mehta , Philanthropy program manager, Medtronic Foundation ; Anne Katharine Wales, Senior philanthropy portfolio lead, Medtronic FoundationApril 09, 2019Here are three ways to change a system of acute care.April 10 started as an ordinary day for Sarah. But while eating breakfast, her husband noticed that her face had started to droop and she was unable to find her words. Immediately he called 911.Within 10 minutes, the ambulance arrived with emergency medical services (EMS), a segment of the local health system that recently became partners in a new regional ...
Source: IntraHealth International - April 9, 2019 Category: International Medicine & Public Health Authors: mnathe Tags: Noncommunicable Diseases Education & Performance Private-Sector Approaches SwitchPoint Health Workforce Systems USA Source Type: news

Metabolic stroke in a patient with bi-allelic OPA1 mutations
We describe metabolic stroke in a patient with bi-allelicOPA1 mutations. A twelve-year old girl presented with a complex neurological disorder that includes: early onset optic atrophy at one year of age, progressive gait ataxia, dysarthria, tremor and learning impairment. A metabolic stroke occurred at the age of 12  years. The patient was found to harbor a de novo heterozygous frame shift mutation c.1963_1964dupAT; p.Lys656fs (NM_015560.2) and a missense mutation c.1146A >  G; Ile382Met (NM_015560.2) inherited from her mother. The mother, aunt, and grandmother are heterozygous for the Ile382Met mutation and are as...
Source: Metabolic Brain Disease - April 9, 2019 Category: Neurology Source Type: research

Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke
Publication date: Available online 11 April 2019Source: NeuronAuthor(s): Junhua Yang, Maria del Carmen Vitery, Jianan Chen, James Osei-Owusu, Jiachen Chu, Zhaozhu QiuSummaryBy releasing glutamate, astrocytes actively regulate synaptic transmission and contribute to excitotoxicity in neurological diseases. However, the mechanisms of astrocytic glutamate release have been debated. Here, we report non-vesicular release of glutamate through the glutamate-permeable volume-regulated anion channel (VRAC). Both cell swelling and receptor stimulation activated astrocytic VRAC, which requires its only obligatory subunit, Swell1. Ast...
Source: Neuron - April 12, 2019 Category: Neuroscience Source Type: research

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Endpoint accuracy of goal-directed ankle movements correlates to over-ground walking in stroke.
CONCLUSIONS: Impaired accuracy of goal-directed, ankle movements is correlated to over-ground walking in stroke. SIGNIFICANCE: Quantifying accuracy of goal-directed ankle movements may provide insights into walking function post-stroke. PMID: 31005051 [PubMed - as supplied by publisher]
Source: Clinical Neurophysiology - April 12, 2019 Category: Neurology Authors: Lodha N, Patel P, Casamento-Moran A, Gauger K, Christou EA Tags: Clin Neurophysiol Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

A Special Report on Changing Trends in Preventive Stroke/Cardiovascular Risk Assessment Via B-Mode Ultrasonography
AbstractPurpose of ReviewCardiovascular disease (CVD) and stroke risk assessment have been largely based on the success of traditional statistically derived risk calculators such as Pooled Cohort Risk Score or Framingham Risk Score. However, over the last decade, automated computational paradigms such as machine learning (ML) and deep learning (DL) techniques have penetrated into a variety of medical domains including CVD/stroke risk assessment. This review is mainly focused on the changing trends in CVD/stroke risk assessment and its stratification from statistical-based models to ML-based paradigms using non-invasive car...
Source: Current Atherosclerosis Reports - April 30, 2019 Category: Cardiology Source Type: research

Predictive analytics and machine learning in stroke and neurovascular medicine.
Authors: Saber H, Somai M, Rajah GB, Scalzo F, Liebeskind DS Abstract Advances in predictive analytics and machine learning supported by an ever-increasing wealth of data and processing power are transforming almost every industry. Accuracy and precision of predictive analytics have significantly increased over the past few years and are evolving at an exponential pace. There have been significant breakthroughs in using Predictive Analytics in healthcare where it is held as the foundation of precision medicine. Yet, although the research in the field is expanding with the profuse volume of papers applying machine l...
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research