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2-Cl-MGV-1 Ameliorates Apoptosis in the Thalamus and Hippocampus and Cognitive Deficits After Cortical Infarct in Rats Basic Sciences
We examined the effects of the novel TSPO ligand 2-(2-chlorophenyl) quinazolin-4-yl dimethylcarbamate (2-Cl-MGV-1) on poststroke cognitive deficits, neuronal mitochondrial apoptosis, and secondary damage in the ipsilateral thalamus and hippocampus after cortical infarction.Methods—One hundred fourteen hypertensive rats underwent successful distal middle cerebral artery occlusion (n=76) or sham procedures (n=38). 2-Cl-MGV-1 or dimethyl sulfoxide as vehicle was administrated 2 hours after distal middle cerebral artery occlusion and then for 6 or 13 days (n=19 per group). Spatial learning and memory were tested using the Mo...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Yicong Chen, Leo Veenman, Sukhdev Singh, Fubing Ouyang, Jiahui Liang, Weixian Huang, Ilan Marek, Jinsheng Zeng, Moshe Gavish Tags: Translational Studies, Cognitive Impairment, Ischemic Stroke Original Contributions Source Type: research

The efficacy of problem solving therapy to reduce post stroke emotional distress in younger (18-65) stroke survivors.
CONCLUSION: The between-subject results suggest that there was no significant difference between those that received problem solving therapy and a waitlist control group between baseline and post-waitlist/post-therapy. The within-subject design suggests that problem solving therapy may be beneficial for younger stroke survivors when they are given some time to learn and implement the skills into their day to day life. However, additional research with a control group is required to investigate this further. This study provides limited evidence for the provision of support groups for younger stroke survivors post stroke, ho...
Source: Disability and Rehabilitation - November 26, 2017 Category: Rehabilitation Authors: Chalmers C, Leathem J, Bennett S, McNaughton H, Mahawish K Tags: Disabil Rehabil Source Type: research

World Stroke Day
NOTE: The following is an op-ed piece by Neala Gill, Cardiovascular Health Nova Scotia. Friday, Oct. 29 is World Stroke Day. It is an opportunity to encourage Nova Scotians to learn more about the signs of a stroke, and what you can do to reduce your risk.
Source: Government of Nova Scotia News Releases - Health - October 28, 2010 Category: American Health Authors: Health (To Jan. 11) Source Type: news

Relevance of the cerebral collateral circulation in ischaemic stroke: time is brain, but collaterals set the pace.
Abstract Blood supply to the brain is secured by an extensive collateral circulation system, which can be divided into primary routes, i.e., the Circle of Willis, and secondary routes, e.g., collaterals from the external to the internal carotid artery and leptomeningeal collaterals. Collateral flow is the basis for acute stroke treatment, since neurones will only survive long enough to be rescued with reperfusion therapies if there is sufficient collateral flow. Poor collateral flow is associated with worse outcome and faster growth of larger infarcts in acute stroke treatment. Therapeutic promotion of collateral ...
Source: Swiss Medical Weekly - December 12, 2017 Category: General Medicine Authors: Jung S, Wiest R, Gralla J, McKinley R, Mattle H, Liebeskind D Tags: Swiss Med Wkly Source Type: research

Virtual reality to augment robot-assisted gait training in non-ambulatory patients with a subacute stroke: a pilot randomized controlled trial.
CONCLUSIONS: VR-augmented RAGT resulted in high acceptability and motivation, and in a reduced drop-out rate and an extended training time compared to standard RAGT. This pilot trial provides guidance for a prospective RCT on the effectiveness of VR-augmented RAGT. CLINICAL REHABILITATION IMPACT: VR might be a promising approach to enrich and improve gait rehabilitation after stroke. PMID: 29265791 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - December 21, 2017 Category: Rehabilitation Authors: Bergmann J, Krewer C, Bauer P, Koenig A, Riener R, Müller F Tags: Eur J Phys Rehabil Med Source Type: research

Different learning curves between stent retrieval and a direct aspiration first-pass technique for acute ischemic stroke.
CONCLUSIONS In this initial experience, a higher recanalization rate and shorter procedure time were achieved with SR than with ADAPT. A high recanalization rate with SR was possible with relatively less clinical experience, whereas procedure time dramatically decreased with experience. These observed effects on the learning curve might be useful when choosing the method for initial endovascular treatment of acute ischemic stroke at relatively small stroke centers. PMID: 29303452 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 5, 2018 Category: Neurosurgery Authors: Nishi H, Ishii A, Nakahara I, Matsumoto S, Sadamasa N, Kai Y, Ishibashi R, Yamamoto M, Morita S, Nagata I Tags: J Neurosurg Source Type: research

Emotional and social characteristics of stroke patients with low verbal memory.
CONCLUSIONS: Because the social engagement may be treated as protective factor in the course of recovery we would recommend that during rehabilitation more attention should be paid to emotional and social functioning of stroke patients with low verbal memory. PMID: 29340965 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - January 17, 2018 Category: Geriatrics Authors: Zawadzka E, Domańska Ł Tags: Aging Clin Exp Res Source Type: research

Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion
AbstractMost large vessel stroke patients have permanent occlusion, for which there are no current treatment options. Recent case studies have indicated delayed recanalization, that is recanalization outside of the 6-h treatment window, may lead to improved outcome. We hypothesized that delayed recanalization will restore cerebral blood flow, leading to improved function in rats. Male SD rats were subjected to pMCAO or sham surgery. Delayed recanalization was performed on either day 3, 7, or 14 after pMCAO in a subset of animals. Cerebral blood flow was monitored during suture insertion, during recanalization, and then at ...
Source: Translational Stroke Research - January 21, 2018 Category: Neurology Source Type: research

Robot Training With Vector Fields Based on Stroke Survivors’ Individual Movement Statistics
The wide variation in upper extremity motor impairments among stroke survivors necessitates more intelligent methods of customized therapy. However, current strategies for characterizing individual motor impairments are limited by the use of traditional clinical assessments (e.g., Fugl-Meyer) and simple engineering metrics (e.g., goal-directed performance). Our overall approach is to statistically identify the range of volitional movement capabilities, and then apply a robot-applied force vector field intervention that encourages under-expressed movements. We investigated whether explorative training with such customized f...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - February 1, 2018 Category: Neuroscience Source Type: research

Evaluation and Acute Management of Ischemic Stroke in Infants and Children
This article provides an overview of stroke in neonates, infants, and children.RECENT FINDINGSArterial ischemic stroke and cerebral venous sinus thrombosis are increasingly recognized in childhood as important causes of lifelong morbidity and mortality. Diagnosis of arterial ischemic stroke is frequently delayed, as acute neurologic deficits can be challenging to detect in the young child, and stroke is often not considered in the differential diagnosis. Neurologic sequelae following stroke are common, and strategies to minimize stroke size and optimize recovery are being developed. Recurrent arterial ischemic stroke is no...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2018 Category: Neurology Tags: Review Articles Source Type: research

FDA clears software using AI to evaluate CT scans for stroke
Artificial Intelligence healthcare developer Viz.ai said this week it won approval from the FDA for its LVO Stroke platform designed to analyze computed tomography results and notify providers of potential strokes, touting it as the first such system to win FDA clearance. The company’s LVO Stroke platform is designed using deep learning and connects to a hospital CT scanner to alert stroke specialists that a suspected LVO stroke has been identified, with the ability to send radiological images directly to the physician’s phones. “Timely LVO stroke identification and transfer to a specialist hospital that ...
Source: Mass Device - February 16, 2018 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Regulatory/Compliance Software / IT vizai Source Type: news

Motor imagery: a systematic review of its effectiveness in the rehabilitation of the upper limb following a stroke.
CONCLUSIONS: Motor imagery, combined with conventional therapy (physiotherapy or occupational therapy), seems to have positive effects on the motor rehabilitation of the upper limb following a stroke. Further research is needed to improve the heterogeneity of the interventions and to evaluate their effectiveness in the long term. PMID: 29480509 [PubMed - in process]
Source: Revista de Neurologia - February 27, 2018 Category: Neurology Authors: Fernandez-Gomez E, Sanchez-Cabeza A Tags: Rev Neurol Source Type: research

Life After Stroke
Throughout March theCochrane UK team will be looking at the theme of ' life after stroke. ' This will include Cochrane evidence, ongoing research and the perspectives of stroke survivors, researchers and health professionals on life after stroke from the acute phase to rehabilitation and long-term effects and adjustments.See below for a round-up of materials or follow along on Twitter with the hastag#LifeAfterStrokeBlogpostsLife after stroke: a special series from Cochrane UKCochrane EvidenceLife After Stroke: a round up of Cochrane evidenceAll of the Cochrane Reviews on stroke can be found here, in the Cochrane Library.Fi...
Source: Cochrane News and Events - February 15, 2018 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Comment Learning from TARDIS: time for more focused trials in stroke prevention
Antithrombotic therapy immediately following stroke is important to minimise the risk of recurrence, but the optimum choice and number of drugs to use are unclear, and efficacy in preventing thrombosis needs to be weighed against bleeding risk. In The Lancet, the TARDIS investigators report findings from a randomised trial1 that tested intensive antiplatelet therapy with three agents (aspirin, clopidogrel, and dipyridamole) against therapy based on current UK guidelines2 (either clopidogrel, or aspirin plus dipyridamole) for 30 days in patients with transient ischaemic attack (TIA) or ischaemic stroke.
Source: LANCET - December 20, 2017 Category: General Medicine Authors: Pierre Amarenco Tags: Comment Source Type: research

Structural Plasticity in Adulthood with Motor Learning and Stroke Rehabilitation.
Abstract The development of advanced noninvasive techniques to image the human brain has enabled the demonstration of structural plasticity during adulthood in response to motor learning. Understanding the basic mechanisms of structural plasticity in the context of motor learning is essential to improve motor rehabilitation in stroke patients. Here, we review and discuss the emerging evidence for motor-learning-related structural plasticity and the implications for stroke rehabilitation. In the clinical context, a few studies have started to assess the effects of rehabilitation on structural measures to understand...
Source: Annual Review of Neuroscience - February 28, 2018 Category: Neurology Authors: Sampaio-Baptista C, Sanders ZB, Johansen-Berg H Tags: Annu Rev Neurosci Source Type: research

A retrospective study to assess resource utilization and costs in patients with post-stroke spasticity in the United Kingdom.
CONCLUSION: Costs after stroke for patients developing PSS are twice as high compared to patients who do not develop it, with the major driver being the number of hospital admissions. This highlights the need for better recording and closer management of PSS. PMID: 29490512 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - March 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Paired associative stimulation modulates corticomotor excitability in chronic stroke: A preliminary investigation.
CONCLUSION: These results provide preliminary evidence for the potential of PAS to increase corticomotor excitability that could favorably impact motor skill performance in chronic individuals post-stroke and are an important first step for future studies investigating the clinical application and behavioral relevance of PAS interventions in post stroke patient populations. PMID: 29526858 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - March 13, 2018 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Sung melody enhances verbal learning and recall after stroke
Abstract Coupling novel verbal material with a musical melody can potentially aid in its learning and recall in healthy subjects, but this has never been systematically studied in stroke patients with cognitive deficits. In a counterbalanced design, we presented novel verbal material (short narrative stories) in both spoken and sung formats to stroke patients at the acute poststroke stage and 6 months poststroke. The task comprised three learning trials and a delayed recall trial. Memory performance on the spoken and sung tasks did not differ at the acute stage, whereas sung stories were learned and recalled significantly ...
Source: Annals of the New York Academy of Sciences - March 15, 2018 Category: Science Authors: Vera Leo, Aleksi J. Sihvonen, Tanja Linnavalli, Mari Tervaniemi, Matti Laine, Seppo Soinila, Teppo S ärkämö Tags: ORIGINAL ARTICLE Source Type: research

The Role of the Left Atrial Appendage in Stroke and Arrhythmia Provocation
AbstractPurpose of the reviewThe review will provide an overview of the potential use of left atrial appendage (LAA) exclusion in patients with atrial fibrillation (AF), highlighting the benefits and risks involved with LAA exclusion.Recent findingsLAA ligation leads to electrical isolation of the LAA and a decrease in LA mass which is associated with a decrease in AF burden and occasional termination of AF in patients with persistent AF. This potential new indication will further expand the use of LAA exclusion and necessitate planning of combining LAA exclusion with catheter ablation for both stroke prevention and antiar...
Source: Current Cardiovascular Risk Reports - March 19, 2018 Category: Cardiology Source Type: research

Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Diabetic Rats via Enhanced Post-Ischemic Mitochondrial Dysfunction
AbstractDiabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function has been implicated as a central player in the development of cerebral ischemic damage. Hypoglycemia is also known to affect mitochondrial functioning. The present study tested the hypothesis that prior exposure of insulin-treated diabetic (ITD) rats to RH exacerbates brain damage via enhanced post-is...
Source: Translational Stroke Research - March 22, 2018 Category: Neurology Source Type: research

A single exercise bout and locomotor learning after stroke: physiological, behavioral, and computational outcomes.
This article is protected by copyright. All rights reserved. PMID: 29569729 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - March 23, 2018 Category: Physiology Authors: Charalambous CC, Alcantara CC, French MA, Li X, Matt KS, Kim HE, Morton SM, Reisman DS Tags: J Physiol Source Type: research

Risk Predictors for Ischemic Stroke in CF-LVAD Patients by Pump Flow Type
Risk of stroke continues to be a major adverse event post-LVAD implantation, limiting wider application and utility of the device. Even with aggressive blood pressure control, patients with LVADs are at higher risk of stroke due to combination of pump-dependent factors including loss of natural pulsatility, anticoagulation, and thrombosis risk from blood-pump interaction. We used a Bayesian Network machine-learning approach to derive comparative risk factors for ischemic stroke in patients with axial versus centrifugal flow pumps at 3 months post LVAD implant.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: M. Kanwar, L. Lohmueller, R. Kormos, S. Bailey, C. Mcilvennan, S. Murali, J. Antaki Source Type: research

Acute cardiovascular exercise does not enhance locomotor learning in people with stroke.
This article is protected by copyright. All rights reserved. PMID: 29603752 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - March 31, 2018 Category: Physiology Authors: Roig M, de Las Heras B Tags: J Physiol Source Type: research

Combined Transcranial Direct Current Stimulation and Virtual Reality-Based Paradigm for Upper Limb Rehabilitation in Individuals with Restricted Movements. A Feasibility Study with a Chronic Stroke Survivor with Severe Hemiparesis
We present a virtual reality-based paradigm for upper limb rehabilitation that allows for interaction of individuals with restricted movements from active responses triggered when they attempt to perform a movement. The experimental system also provides multisensory stimulation in the visual, auditory, and tactile channels, and transcranial direct current stimulation coherent to the observed movements. A feasibility study with a chronic stroke survivor with severe hemiparesis who seemed to reach a rehabilitation plateau after two years of its inclusion in a physical therapy program showed clinically meaningful improvement ...
Source: Journal of Medical Systems - April 2, 2018 Category: Information Technology Source Type: research

SENSory re-learning of the UPPer limb after stroke (SENSUPP): study protocol for a pilot randomized controlled trial
Many stroke survivors suffer from sensory impairments of their affected upper limb (UL). Although such impairments can affect the ability to use the UL in everyday activities, very little attention is paid to ...
Source: Trials - April 17, 2018 Category: General Medicine Authors: H åkan Carlsson, Birgitta Rosén, Hélène Pessah-Rasmussen, Anders Björkman and Christina Brogårdh Tags: Study protocol Source Type: research

Brain mapping for long-term recovery of gait after supratentorial stroke: A retrospective cross-sectional study
The recovery of independent gait after stroke is a main goal of patients and understanding the relationship between brain lesions and the recovery of gait can help physicians set viable rehabilitation plans. Our study investigated the association between variables of gait parameters and brain lesions. Fifty poststroke patients with a mean age of 67.5 ± 1.3 years and an average duration after onset of 62.2 ± 7.9 months were included. Three-dimensional gait analysis and magnetic resonance imaging were conducted for all patients. Twelve quantified gait parameters of temporal-spatial, kinematic, and kinetic data wer...
Source: Medicine - April 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

AHA: Therapy Dogs Like Katie Are Good Medicine After Stroke
FRIDAY, April 27, 2018 (American Heart Association) -- When Scott Vande Zande had a serious stroke 15 years ago, his beloved golden retriever Hollie was key to his recovery. " I had to learn to speak again, but there were times I couldn ' t talk, " ...
Source: Drugs.com - Daily MedNews - April 27, 2018 Category: General Medicine Source Type: news

Precise isometric hand grip learning of hemiparetic stroke patients
Rehabilitation of hand movements after stroke aims at skills that can be well retained and transferred to novel conditions. These functions may be altered by training schedules such as constant and variable practice. A total of 36 participants with hemiparesis completed one of these schedules counterbalanced. Precise isometric hand grip force production was practiced for 4 days with a target force of 25% maximum voluntary contraction. The constant group practiced only the target force, whereas the variable group practiced the same amount including ±5 and 10% maximum voluntary contraction. Target force presentation and fee...
Source: International Journal of Rehabilitation Research - May 1, 2018 Category: Rehabilitation Tags: Brief research report Source Type: research

AI Becoming Prevalent in Identifying Stroke, Head Trauma
Another company is throwing its hat into the ring to use artificial intelligence to help identify bleeds, fractures and other critical abnormalities in head CT scans. San Mateo, CA-based Qure.ai released the results of a clinical validation study confirming its algorithm’s near-radiologist performance on 21, 000 patients and has made a dataset of almost 500 AI-analyzed head CT scans available for download. The results have been published in a research paper on Cornell University's online distribution system for research, arXiv.org. The paper is titled “Development and Validation of Deep Learning Algorithms for Detectio...
Source: MDDI - May 3, 2018 Category: Medical Devices Authors: Omar Ford Tags: Business Digital Health Source Type: news

Targeted Neuromodulation of Abnormal Interhemispheric Connectivity to Promote Neural Plasticity and Recovery of Arm Function after Stroke: A Randomized Crossover Clinical Trial Study Protocol.
Conclusion: The findings from this single-site early stage clinical trial will provide foundational results to inform the design of larger-scale, multisite clinical trials to evaluate the therapeutic potential of ihPAS-based neuromodulation for upper limb recovery after stroke. This trial is registered with NCT02465034. PMID: 29721010 [PubMed - in process]
Source: Neural Plasticity - May 4, 2018 Category: Neurology Authors: Borich MR, Wolf SL, Tan AQ, Palmer JA Tags: Neural Plast Source Type: research

The Role of Apathy and Depression on Verbal Learning and Memory Performance After Stroke.
Conclusions: These results suggest that apathy, not depression, is related to verbal memory performance in stroke patients. Future research should explore whether treatment of apathy (e.g., improving motivation) could be a novel target for improving cognition after stroke. Researchers should also examine whether this model can be applied to other aspects of cognition, including executive function and other areas of memory including autobiographical and working memory. PMID: 29788381 [PubMed - as supplied by publisher]
Source: Archives of Clinical Neuropsychology - May 18, 2018 Category: Psychiatry & Psychology Authors: Fishman KN, Ashbaugh AR, Lanctôt KL, Cayley ML, Herrmann N, Murray BJ, Sicard M, Lien K, Sahlas DJ, Swartz RH Tags: Arch Clin Neuropsychol Source Type: research

Sex Differences in the Effects of Parp Inhibition on Microglial Phenotypes Following Neonatal Stroke
This study aims to examine the effects of PJ34, a PARP inhibitor, on microglial phenotypes at 3 and 8 days and on neurobehavioral disorders in adulthood for both male and female P9 mice subjected to permanent middle cerebral artery occlusion (pMCAo). PJ34 significantly reduced the lesion size by 78% and reduced the density of CX3CR1gfp-labeled microglial cells by 46% when examined 3 days after pMCAo in male but not in female mice. Eight days after pMCAo, the number of Iba1+/Cox-2+ cells did not differ between male and female mice in the cortical peri-infarct region. In the amygdala, Iba1+/Cox-2+ (M1-like) cell numbers were...
Source: Brain, Behavior, and Immunity - May 29, 2018 Category: Neurology Source Type: research

Motor learning with the PNF-concept, an alternative to Constrained Induced Movement Therapy in a patient after a stroke; a case report
Over sixteen million people suffer a stroke each year. Stroke is characterized by a one-sided paresis. Upper extremity and hand function are most limited. The current view on “neuro rehabilitation” advocates a constrained induced movement therapy (CIMT) setting. This case report seeks to illustrate the clinical reasoning and the feasibility of applying an alternative approach in patients who are not accepted or not suitable for the constrained induced movement therap y.
Source: Journal of Bodywork and Movement Therapies - May 31, 2018 Category: Physiotherapy Authors: Fred Smedes, Leandro Giacometti da Silva Tags: Case Report Source Type: research

Primary Progressive Aphasia and Stroke Aphasia
This article summarizes the clinical and anatomic features of the three named variants of primary progressive aphasia (PPA): semantic variant PPA, nonfluent/agrammatic variant PPA, and logopenic variant PPA. Three stroke aphasia syndromes that resemble the PPA variants (Broca aphasia, Wernicke aphasia, and conduction aphasia) are also presented. RECENT FINDINGS Semantic variant PPA and Wernicke aphasia are characterized by fluent speech with naming and comprehension difficulty; these syndromes are associated with disease in different portions of the left temporal lobe. Patients with nonfluent/agrammatic variant PPA or B...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2018 Category: Neurology Tags: Review Articles Source Type: research

Sex Differences in the Effects of Parp Inhibition on Microglial Phenotypes Following Neonatal Stroke.
This study aims to examine the effects of PJ34, a PARP inhibitor, on microglial phenotypes at 3 and 8 days and on neurobehavioral disorders in adulthood for both male and female P9 mice subjected to permanent middle cerebral artery occlusion (pMCAo). PJ34 significantly reduced the lesion size by 78% and reduced the density of CX3CR1gfp-labeled microglial cells by 46% when examined 3 days after pMCAo in male but not in female mice. Eight days after pMCAo, the number of Iba1+/Cox-2+ cells did not differ between male and female mice in the cortical peri-infarct region. In the amygdala, Iba1+/Cox-2+ (M1-like) cell numbers were...
Source: Brain, Behavior, and Immunity - May 28, 2018 Category: Neurology Authors: Charriaut-Marlangue C, Leconte C, Csaba Z, Chafa L, Pansiot J, Talatizi M, Simon K, Moretti R, Marchand-Leroux C, Baud O, Besson VC Tags: Brain Behav Immun Source Type: research

Health Tip: Learn Warning Signs of Heat Stroke
-- As summer weather heats up, it is important to recognize symptoms of heat stroke. Normally, you regulate your body temperature by sweating. But in some cases, the body ' s temperature-control system is overtaxed and your temperature rises too...
Source: Drugs.com - Daily MedNews - June 20, 2018 Category: General Medicine Source Type: news

Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke: A Pilot Study
Conclusions This study's data support a role for eNOS in cognitive performance after stroke. This finding may lead to the development of novel interventions to treat poststroke cognitive deficits.
Source: American Journal of Physical Medicine and Rehabilitation - June 20, 2018 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Sport simulation as a form of implicit motor training in a geriatric athlete after stroke: a case report.
DISCUSSION: Implicit motor learning techniques were incorporated through sport and job task simulation activities along with task-oriented neuromuscular reeducation. The patient demonstrated improvements with gait, balance, gross motor function, and decreased fall risk. PMID: 29939811 [PubMed - as supplied by publisher]
Source: Physiotherapy Theory and Practice - June 25, 2018 Category: Physiotherapy Authors: Young SN, VanWye WR, Wallmann HW Tags: Physiother Theory Pract Source Type: research

Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke
This study aims to examine the effects of PJ34, a PARP inhibitor, on microglial phenotypes at 3 and 8 days and on neurobehavioral disorders in adulthood for both male and female P9 mice subjected to permanent middle cerebral artery occlusion (pMCAo). PJ34 significantly reduced the lesion size by 78% and reduced the density of CX3CR1gfp-labeled microglial cells by 46% when examined 3 days after pMCAo in male but not in female mice. Eight days after pMCAo, the number of Iba1+/Cox-2+ cells did not differ between male and female mice in the cortical peri-infarct region. In the amygdala, Iba1+/Cox-2+ (M1-like) cell numbers ...
Source: Brain, Behavior, and Immunity - July 5, 2018 Category: Neurology Source Type: research

Effect of single-session dual-tDCS before physical therapy on lower-limb performance in sub-acute stroke patients: A randomized sham-controlled crossover study
Publication date: Available online 12 May 2018Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Wanalee Klomjai, Benchaporn Aneksan, Anuchai Pheungphrarattanatrai, Thanwarat Chantanachai, Nattha Choowong, Soontaree Bunleukhet, Paradee Auvichayapat, Yongchai Nilanon, Vimonwan HiengkaewAbstractAnodal stimulation increases cortical excitably, whereas cathodal stimulation decreases cortical excitability. Dual transcranial direct current stimulation (tDCS; anodal over the lesioned hemisphere, cathodal over the non-lesioned hemisphere) was found to enhance motor learning. The corresponding tDCS-induced changes wer...
Source: Annals of Physical and Rehabilitation Medicine - July 5, 2018 Category: Rehabilitation Source Type: research

Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke
This study aims to examine the effects of PJ34, a PARP inhibitor, on microglial phenotypes at 3 and 8 days and on neurobehavioral disorders in adulthood for both male and female P9 mice subjected to permanent middle cerebral artery occlusion (pMCAo). PJ34 significantly reduced the lesion size by 78% and reduced the density of CX3CR1gfp-labeled microglial cells by 46% when examined 3 days after pMCAo in male but not in female mice. Eight days after pMCAo, the number of Iba1+/Cox-2+ cells did not differ between male and female mice in the cortical peri-infarct region. In the amygdala, Iba1+/Cox-2+ (M1-like) cell numbers ...
Source: Brain, Behavior, and Immunity - July 10, 2018 Category: Neurology Source Type: research

Effect of single-session dual-tDCS before physical therapy on lower-limb performance in sub-acute stroke patients: A randomized sham-controlled crossover study
Publication date: Available online 12 May 2018Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Wanalee Klomjai, Benchaporn Aneksan, Anuchai Pheungphrarattanatrai, Thanwarat Chantanachai, Nattha Choowong, Soontaree Bunleukhet, Paradee Auvichayapat, Yongchai Nilanon, Vimonwan HiengkaewAbstractAnodal stimulation increases cortical excitably, whereas cathodal stimulation decreases cortical excitability. Dual transcranial direct current stimulation (tDCS; anodal over the lesioned hemisphere, cathodal over the non-lesioned hemisphere) was found to enhance motor learning. The corresponding tDCS-induced changes wer...
Source: Annals of Physical and Rehabilitation Medicine - July 10, 2018 Category: Rehabilitation Source Type: research

Medical News Today: Spinal stroke: Causes, treatment, and outcome
Strokes in the spinal cord are rare, accounting for just over 1 percent of all strokes. They can cause a variety of symptoms, including pain in the neck and back, long-term paralysis, and incontinence. In this article, learn more about the symptoms, causes, and treatment. We also cover what to expect during recovery.
Source: Health News from Medical News Today - July 13, 2018 Category: Consumer Health News Tags: Stroke Source Type: news

Retention of Stroke Education Provided during Hospitalization: Does Provision of Required Education Increase Stroke Knowledge?
Discussion: While stroke education is required during hospitalization, its ability to produce retention may be poor. We propose study of test-enhanced learning methods through the Targeted Education in Stroke Trial (TEST) to examine the effect of novel teaching methods on patient/caregiver knowledge retention.Intervent Neurol 2018;7:471 –478
Source: Interventional Neurology - July 26, 2018 Category: Neurology Source Type: research

Detection of early infarction signs with machine learning-based diagnosis by means of the Alberta Stroke Program Early CT score (ASPECTS) in the clinical routine
ConclusionFor ASPECTS assessment, the examined software may provide valid data in case of normal brain. It may enhance the work of neuroradiologists in clinical decision making. A final human check for plausibility is needed, particularly in patient groups with pre-existing cerebral changes.
Source: Neuroradiology - July 31, 2018 Category: Radiology Source Type: research

Remote Limb Ischemic Conditioning and Motor Learning: Evaluation of Factors Influencing Response in Older Adults
AbstractRemote limb ischemic conditioning (RLIC) is a clinically feasible method of promoting tissue protection against subsequent ischemic insult. Recent findings from our lab demonstrated that RLIC robustly enhances motor learning in young, healthy humans. The next step is to determine which individuals would receive maximum benefit from RLIC before applying these findings to clinical rehabilitation populations such as stroke. Numerous factors, such as age, sex, body mass index (BMI), and cardiovascular comorbidities may influence the response. Sixty-nine participants aged 40 –80 were randomized to receive either RLIC ...
Source: Translational Stroke Research - August 7, 2018 Category: Neurology Source Type: research

Post Stroke Cognitive Impairment and Hippocampal Neurovascular Remodeling: The Impact of Diabetes and Sex.
Abstract Diabetes increases the risk and severity of cognitive impairment, especially after ischemic stroke. Pathological remodeling of the cerebrovasculature has been postulated to contribute to poor neuronal repair and worsened cognitive deficits in diabetes. However, little is known about the effect of diabetes on the vascularization of hippocampus, a domain critical to memory and learning. Therefore we had two aims for this study: 1) to determine the impact of diabetes on hippocampal neurovascular remodeling and the resulting cognitive impairment after stroke using two models with varying disease severity, and...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 17, 2018 Category: Physiology Authors: Ward R, Valenzuela JP, Li W, Dong G, Fagan SC, Ergul A Tags: Am J Physiol Heart Circ Physiol Source Type: research

Prediction of Hemorrhagic Transformation Severity in Acute Stroke From Source Perfusion MRI
Conclusion: The key contribution of our framework formalize HT prediction as a machine learning problem. Specifically, the model learns to extract imaging markers of HT directly from source PWI images rather than from pre-established metrics. Significance: Predictions visualized in terms of spatial likelihood of HT in various territories of the brain were evaluated against follow-up gradient recalled echo and provide novel insights for neurointerventionalists prior to endovascular therapy.
Source: IEEE Transactions on Biomedical Engineering - August 21, 2018 Category: Biomedical Engineering Source Type: research

Ultrasound imaging gauges muscle tightness after stroke
Ultrasound strain imaging can be an effective tool for assessing poststroke...Read more on AuntMinnie.comRelated Reading: MRI links lifestyle factors to stroke, dementia risk 5 risk factors help predict brain hemorrhage on CT AI algorithm can triage head CT exams for urgent review Ultrasound elastography helps identify invasive breast cancer AIUM: Can deep learning classify liver fibrosis on US?
Source: AuntMinnie.com Headlines - August 22, 2018 Category: Radiology Source Type: news

Automatic Segmentation of Acute Ischemic Stroke From DWI Using 3-D Fully Convolutional DenseNets
Acute ischemic stroke is recognized as a common cerebral vascular disease in aging people. Accurate diagnosis and timely treatment can effectively improve the blood supply of the ischemic area and reduce the risk of disability or even death. Understanding the location and size of infarcts plays a critical role in the diagnosis decision. However, manual localization and quantification of stroke lesions are laborious and time-consuming. In this paper, we propose a novel automatic method to segment acute ischemic stroke from diffusion weighted images (DWIs) using deep 3-D convolutional neural networks (CNNs). Our method can e...
Source: IEE Transactions on Medical Imaging - August 31, 2018 Category: Biomedical Engineering Source Type: research