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Is YouTube and Stroke a Bad Liaison? (P5.141)
CONCLUSIONS: YouTube provides a good and reliable source to learn the signs and symptoms of stroke but it features insufficient information about the use of IV-rtPA, risk factors, and prevention. Study Supported by: NONEDisclosure: Dr. Gupta has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Jacob has nothing to disclose. Dr. Hinduja has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Gupta, H., Patel, R., Jacob, S., Hinduja, A. Tags: Cerebrovascular Disease and Interventional Neurology: Clinical Research Tools, Methods, and Innovations Source Type: research
The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (S53.005)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Sleep Source Type: research
A study on the natural history of scanning behaviour in patients with visual field defects after stroke
DiscussionThe longitudinal comparison of patients who do and do not learn compensatory scanning techniques may reveal important prognostic markers of natural recovery. Importantly, it may also help to determine the most effective treatment window for visual rehabilitation.
Source: BMC Neurology - April 24, 2015 Category: Neurology Authors: Tobias LoetscherCelia ChenSophie WignallAndreas BullingSabrina HoppeOwen ChurchesNicole ThomasMichael NichollsAndrew Lee Source Type: research
Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke
Publication date: Available online 18 April 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): D. Walker-Batson , J. Mehta , P. Smith , M. Johnson Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine su...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 28, 2015 Category: Psychiatry Source Type: research
Stress-induced cardiomyopathy accompanied by heat stroke
We describe a case with high body temperature and coma, who also presented with wide QRS tachycardia and shock. He was initially treated for heat stroke and wide QRS tachycardia. Serial electrocardiographic change and echocardiographic findings suggested this was complicated with stress-induced cardiomyopathy. This case demonstrates the importance of recognizing that serious myocardial damage can result from heat stroke. <Learning objective: Heat stroke can cause multiple organ failure and the presentation of circulatory failure in heat stroke may be the sign of myocardial dysfunction. To distinguish acute coronary ...
Source: Journal of Cardiology Cases - May 2, 2015 Category: Cardiology Source Type: research
Stroke unit Nurse Managers' views of individual and organizational factors liable to influence evidence‐based practice: A survey
This study investigated Nurse Managers of New South Wales, Australia, stroke units (n = 19) in their views on: leadership ability (measured by the Leadership Practices Inventory), organizational learning (measured by the Organizational Learning Survey), attitudes and beliefs towards evidence‐based practice (EBP) and readiness for change. Overall Nurse Managers reported high‐level leadership skills and a culture of learning. Nurse Managers' attitude towards EBP was positive, although nursing colleague's attitudes were perceived as less positive. Nurse Managers agreed that implementing evidence in practice places add...
Source: International Journal of Nursing Practice - April 1, 2015 Category: Nursing Authors: Peta Drury, Elizabeth McInnes, Jennifer Hardy, Simeon Dale, Sandy Middleton Tags: Research Paper Source Type: research
Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spacial learning and memory in mouse middle cerebral artery occlusion model
IntroductionGrowing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of the most appropriate for stroke treatment. However, previous experimental data could not reach to an agreement on the efficacy of ADSC transplantation for treating stroke in vivo as well as its mechanism which hinders their further clinical translational application. Methods: To explore their in vivo mechanism of hADSC administration on neurological injury, hADSC were labeled with EGFP expressing FG12 len...
Source: BioMed Central - May 8, 2015 Category: Journals (General) Authors: Fei ZhouShane GaoLin WangChenxi SunLu ChenPing YuanHaiyang ZhaoYi YiYing QinZhiqiang DongLimei CaoHaiyan RenLiang ZhuQiang LiBing LuAibin LiangGuotong XuHongwen ZhuZhengliang GaoJie MaJun XuXu Chen Source Type: research
Analysis of correlation between white matter changes and functional responses in thalamic stroke: a DTI & EEG study
Abstract Diffusion tensor imaging (DTI) allows in vivo structural brain mapping and detection of microstructural disruption of white matter (WM). One of the commonly used parameters for grading the anisotropic diffusivity in WM is fractional anisotropy (FA). FA value helps to quantify the directionality of the local tract bundle. Therefore, FA images are being used in voxelwise statistical analyses (VSA). The present study used Tract-Based Spatial Statistics (TBSS) of FA images across subjects, and computes the mean skeleton map to detect voxelwise knowledge of the tracts yielding to groupwise comparison. The skel...
Source: Brain Imaging and Behavior - May 10, 2015 Category: Neurology Source Type: research
Efficacy of virtual reality-based intervention on balance and mobility disorders post-stroke: a scoping review
Rehabilitation interventions involving virtual reality (VR) technology have been developed for the promotion of functional independence post stroke. A scoping review was performed to examine the efficacy of VR-based interventions on balance and mobility disorders post stroke. Twenty-four articles in the English language examining VR game-based interventions and outcomes directed at balance and mobility disorders were included. Various VR systems (customized and commercially available) were used as rehabilitation tools. Outcome measures included laboratory and clinical measures of balance and gait. Outcome measures of dynam...
Source: Journal of NeuroEngineering and Rehabilitation - May 10, 2015 Category: Rehabilitation Authors: Anuja DarekarBradford McFadyenAnouk LamontagneJoyce Fung Source Type: research
Key components of external facilitation in an acute stroke quality improvement collaborative in the Veterans Health Administration
Conclusions: This study shows that external facilitation involves core elements related to communication, relationship building, methods training, monitoring performance over time, and facilitating team-based problem solving. Importantly, this work demonstrates the fluid nature of external facilitation over time, as teams learn, grow, change, and experience changing contexts.
Source: Implementation Science - May 14, 2015 Category: Health Management Authors: Balmatee BidassieLinda WilliamsHeather Woodward-HaggMarianne MatthiasTeresa Damush Source Type: research
Supporting the Women in our Lives: Stroke Prevention
May is Stroke Awareness Month and May 10-16th is National Women's Health Week, making this the perfect time to talk about the special challenges women face related to stroke and how women can reduce their risk and protect their health. Being the mid-Atlantic Regional Health Administrator might make stroke prevention my professional duty, but it's my role as a father, husband, and son to so many special women that makes it my personal responsibility. It's alarming to think that every 4 minutes someone in the United States dies of a stroke -- most of them women. Stroke -- which is sometimes called a brain attack -- happens...
Source: Healthy Living - The Huffington Post - May 18, 2015 Category: Consumer Health News Source Type: news
Abstract 207: The Stroke Prevention Clinic, Extending Care Past The Stroke Center Session Title: Poster Session II
Conclusion: Implementation of the Stroke Prevention Clinic increased follow up completion within 90 days of discharge.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Johnson, B., Bojang, B., Butler, J., Urrutia, V. C. Tags: Session Title: Poster Session II Source Type: research
A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice
Publication date: Available online 30 May 2015 Source:Life Sciences Author(s): Richard D. Ronca , Alyssa M. Myers , Doina Ganea , Ronald F. Tuma , Ellen A. Walker , Sara Jane Ward Aims We have recently demonstrated that treatment with a cannabinoid CB2 agonist was protective in a mouse middle cerebral artery occlusion model of cerebral ischemia/reperfusion injury. The present study aimed to determine whether these protective effects of CB2 agonism would extend to a mouse photoinjury model of permanent ischemia and determine associated alterations in cognition and infarct size. Main Methods Mice received three injections...
Source: Life Sciences - May 31, 2015 Category: Biology Source Type: research
Interprofessional learning on a stroke unit
This article outlines the development of a practice‐based interprofessional learning initiative on a stroke unit. The World Health Organization has advocated that future health care professionals should be ‘collaborative practice ready’ MethodsA half‐day seminar was developed by King's College London in conjunction with an interprofessional clinical team from the Stroke Unit at St Thomas' Hospital. Students were assigned discipline‐specific supervisors who allocated them to care for a patient within the confines of their usual professional role. They were asked to present the patient to a mixed‐discipline grou...
Source: The Clinical Teacher - June 5, 2015 Category: Universities & Medical Training Authors: Jayne Frisby, Zehra Mehdi, Jonathan Birns Tags: Original Article Source Type: research
Subclinical cerebrovascular disease inversely associates with learning ability: The NOMAS
Conclusions: White matter hyperintensities, a marker of cerebral small vessel disease, may have an impact on learning slope. This suggests that verbal learning performance can be incorporated into neuropsychological measures for vascular cognitive impairment and that cerebrovascular disease discovered on imaging affects the ability to learn new information.
Source: Neurology - June 8, 2015 Category: Neurology Authors: Glazer, H., Dong, C., Yoshita, M., Rundek, T., Elkind, M. S. V., Sacco, R. L., DeCarli, C., Stern, Y., Wright, C. B. Tags: All Cerebrovascular disease/Stroke, Cognitive aging, Assessment of cognitive disorders/dementia ARTICLE Source Type: research
Using swing resistance and assistance to improve gait symmetry in individuals post-stroke.
Abstract A major characteristic of hemiplegic gait observed in individuals post-stroke is spatial and temporal asymmetry, which may increase energy expenditure and the risk of falls. The purpose of this study was to examine the effects of swing resistance/assistance applied to the affected leg on gait symmetry in individuals post-stroke. We recruited 10 subjects with chronic stroke who demonstrated a shorter step length with their affected leg in comparison to the non-affected leg during walking. They participated in two test sessions for swing resistance and swing assistance, respectively. During the adaptation p...
Source: Human Movement Science - June 8, 2015 Category: Neurology Authors: Yen SC, Schmit BD, Wu M Tags: Hum Mov Sci Source Type: research
Provision of safe and specialized stroke care using an inter-professional learning approach: A novel stroke service improvement
Introduction: The King Abdulaziz Medical City (KAMC) in Riyadh has reconfigured stroke services by creating a novel stroke model whereby all suspected stroke patients are admitted directly to the high dependency stroke unit (HSDU) in order to provide specialized multidisciplinary care to all stroke patients. Before the launch of this new stroke model, training for all nurses is imperative to ensure they will deliver safe and specialized care.
Source: Journal of Infection and Public Health - June 19, 2015 Category: Global & Universal Authors: Elmer Catangui, Jeanette Malan, Anne Morrow Source Type: research
A Mirror Therapy-Based Action Observation Protocol to Improve Motor Learning After Stroke
Conclusion. The present study showed that a mirror therapy–based AO protocol contributes to motor learning after stroke.
Source: Neurorehabilitation and Neural Repair - June 25, 2015 Category: Neurology Authors: Harmsen, W. J., Bussmann, J. B. J., Selles, R. W., Hurkmans, H. L. P., Ribbers, G. M. Tags: Clinical Research Articles Source Type: research
Key protein may affect risk of stroke
Studies on mice reveal that a special protein in the brain's tiniest blood vessels may affect the risk of stroke. Scientists are learning how the blood-brain barrier develops and what makes the capillaries in the brain different from small blood vessels in other organs.
Source: ScienceDaily Headlines - June 26, 2015 Category: Science Source Type: news
Thrombolysis in acute stroke: ongoing challenges based on a tertiary hospital audit and comparisons with other Australian studies.
Conclusion The proportion of eligible stroke patients who receive tPA in a timely manner remains less than ideal at our centre. More accurate patient selection and reductions in treatment delays serve as targets for quality improvement efforts that have broad applicability.What is known about the topic? Stroke unit care and tPA thrombolysis are two proven strategies to improve outcome in patients with ischaemic stroke. Although the stroke unit is gaining momentum of growth in Australia (especially in Queensland), little improvement has been achieved in thrombolysis rate and timeliness of treatment delivery, and little is k...
Source: Australian Health Review - June 29, 2015 Category: Hospital Management Authors: Lau AH, Hall G, Scott IA, Williams M Tags: Aust Health Rev Source Type: research
Simulation Improves Nurses’ Adherence With Stroke Quality Measures
This article reviews the impact simulation training had on nurses’ adherence to stroke quality measures.
Source: Journal for Nurses in Professional Development - July 1, 2015 Category: Nursing Tags: Articles Source Type: research
Cognitive state following mild stroke: A matter of hippocampal mean diffusivity
This article is protected by copyright. All rights reserved.
Source: Hippocampus - July 27, 2015 Category: Neurology Authors: Efrat Kliper, Einor Ben Assayag, Amos D. Korczyn, Eitan Auriel, Ludmila Shopin, Hen Hallevi, Shani Shenhar‐Tsarfaty, Anat Mike, Moran Artzi, Ilana Klovatch, Natan M. Bornstein, Dafna Ben Bashat Tags: Research Article Source Type: research
E-033 variety of clot types and their implication on technique during endovascular stroke therapy
ConclusionOur data indicate that thrombectomy with a stent-retriever and balloon guide system provides the best opportunity for good outcomes. Because of the risks of shearing off part or all of a clot when aspirating an oversized thrombus into an intermediate catheter and further retrieving against the flow in the internal carotid, our strategy is to use intermediate catheters in conjunction with a balloon guide whenever possible to achieve flow-arrest. We did not have a large enough sample size to draw conclusions about the impact of technique on the number of passes. Further evaluation of how to optimize techniques in d...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Andersson, T. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research
A Review on Carotid Ultrasound Atherosclerotic Tissue Characterization and Stroke Risk Stratification in Machine Learning Framework
Abstract Cardiovascular diseases (including stroke and heart attack) are identified as the leading cause of death in today’s world. However, very little is understood about the arterial mechanics of plaque buildup, arterial fibrous cap rupture, and the role of abnormalities of the vasa vasorum. Recently, ultrasonic echogenicity characteristics and morphological characterization of carotid plaque types have been shown to have clinical utility in classification of stroke risks. Furthermore, this characterization supports aggressive and intensive medical therapy as well as procedures, including endarterectomy and ...
Source: Current Atherosclerosis Reports - August 2, 2015 Category: Cardiology Source Type: research
Identifying Neuroimaging Markers of Motor Disability in Acute Stroke by Machine Learning Techniques
In conclusion, multivariate fMRI analyses offer the potential to serve as markers for endophenotypes of functional impairment.
Source: Cerebral Cortex - August 14, 2015 Category: Neurology Authors: Rehme, A. K., Volz, L. J., Feis, D.- L., Bomilcar-Focke, I., Liebig, T., Eickhoff, S. B., Fink, G. R., Grefkes, C. Tags: Articles Source Type: research
Could be the Predominantly-Used Hemibody Related to the Weight Bearing Distribution Modified by the Chronic Hemiparesis After Stroke?
Since the first Broca publications issued from 1970s, lateralized functions in the human brain have urged the researchers to postulate hypothesis based in the right-left asymmetries and, according to some theories, the lateralization of the voluntary motor control could represent a solution to avoid redundant process optimizing space and time. Supported by this idea, the clinicians and researchers tend to concept that the chronic hemiplegic stroke patients learn to use predominantly the non-affected hemibody after stroke in which is more convenient to execute their daily life activities, modifying their natural preference in some cases.
Source: Medical Hypotheses - August 17, 2015 Category: Biomedical Science Authors: Anderson Castro Mundim, Clarissa Cardoso dos Santos Couto Paz, Emerson Fachin-Martins Source Type: research
015: the effectiveness of collaborative and cooperative method in increasing cadre ability for stroke campaign
Conclusion Collaborative and cooperative method can increase cadre's knowledge and self efficacy of stroke effectively than one way traffic method.
Source: BMJ Open - August 24, 2015 Category: Journals (General) Authors: Hariyanti, T. W., Prabandari, Y. S., Wiyoto, H. M. Tags: Open access Global Forum on Research and Innovation for Health 2015 Source Type: research
Transcranial Stimulation Aids Motor Learning After StrokeTranscranial Stimulation Aids Motor Learning After Stroke
Transcranial direct current stimulation (tDCS) helps patients' motor learning after stroke, new research suggests. Reuters Health Information
Source: Medscape Medical News Headlines - September 15, 2015 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Robotic therapy for chronic stroke: general recovery of impairment or improved task-specific skill?
There is a great need to develop new approaches for rehabilitation of the upper limb after stroke. Robotic therapy is a promising form of neurorehabilitation that can be delivered in higher doses than conventional therapy. Here we sought to determine whether the reported effects of robotic therapy, which have been based on clinical measures of impairment and function, are accompanied by improved motor control. Patients with chronic hemiparesis were trained for 3 wk, 3 days a week, with titrated assistive robotic therapy in two and three dimensions. Motor control improvements (i.e., skill) in both arms were assessed with a ...
Source: Journal of Neurophysiology - September 18, 2015 Category: Neurology Authors: Kitago, T., Goldsmith, J., Harran, M., Kane, L., Berard, J., Huang, S., Ryan, S. L., Mazzoni, P., Krakauer, J. W., Huang, V. S. Tags: Control Of Movement Source Type: research
The use of a planar and simple robotic device to investigate how chronic stroke patients learn a movement
Introduction: The ability of chronic stroke patients to learn a new movement is not well known in literature yet. A way to investigate motor outcome after rehabilitation is to use robotic devices that allow the objective and repeatable assessment of the acquired movement.
Source: Gait and Posture - September 1, 2015 Category: Orthopaedics Authors: G. Lamola, C. Fanciullacci, F. Bertolucci, A. Panarese, S. Micera, B. Rossi, C. Chisari Tags: O13 Source Type: research
First‐time stroke survivors and caregivers’ perceptions of being engaged in rehabilitation
ConclusionThe findings of this study challenge service providers to realize a true partnership with stroke survivors and caregivers by working with them as one team that is led by nurses. Making the necessary changes requires mutual effort at both the systemic and individual levels with rehabilitation nurse‐led coordination of rehabilitation programmes.
Source: Journal of Advanced Nursing - September 25, 2015 Category: Nursing Authors: Langduo Chen, Lily Dongxia Xiao, Anita De Bellis Tags: Original Research: Empirical Research – Qualitative Source Type: research
Predicting discharge mortality after acute ischemic stroke using balanced data.
Authors: Ho KC, Speier W, El-Saden S, Liebeskind DS, Saver JL, Bui AA, Arnold CW Abstract Several models have been developed to predict stroke outcomes (e.g., stroke mortality, patient dependence, etc.) in recent decades. However, there is little discussion regarding the problem of between-class imbalance in stroke datasets, which leads to prediction bias and decreased performance. In this paper, we demonstrate the use of the Synthetic Minority Over-sampling Technique to overcome such problems. We also compare state of the art machine learning methods and construct a six-variable support vector machine (SVM) model ...
Source: AMIA Annual Symposium Proceedings - September 25, 2015 Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research
Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): study protocol for a randomized controlled trial
This study is a double-blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke.Methods/DesignSixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex and sham stimulation. Each group will receive transcranial direct current stimulation at an intensity of 2 mA for 20 minutes daily for 10 consecutive days. Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go-no ...
Source: Trials - September 29, 2015 Category: Journals (General) Authors: Suellen AndradeBernardino Fernández-CalvoPaulo BoggioEliane de OliveiraLilze GomesJosé Pinheiro JúniorRafaela RodriguesNatália de AlmeidaGioconda MoreiraNelson Alves Source Type: research
A Multifaceted Approach to the Enhancement of Motor Recovery After Stroke
Despite aggressive conventional therapy, lasting hemiplegia persists in a large percentage of stroke survivors. This project critically reviewed the rationale behind targeting motor recovery at multiple sites along the motor learning network by combining robotic therapy with pharmacotherapy and virtual reality-based reward learning for stroke survivors.
Source: Archives of Physical Medicine and Rehabilitation - October 1, 2015 Category: Rehabilitation Authors: Duc Tran, Marta Pajaro, Jean Francois Daneault, Jaime G. Gallegos, Mary Alexis Iaccarino, Felipe Fregni, Ross Zafonte Tags: Systematic/meta-analytic review poster Source Type: research
Motor Imagery Training on Muscle Strength and Gait Performance in Ambulant Stroke Subjects: A Randomized Clinical Trial
50%-65% of stroke survivors have residual motor deficits; principal among them is hemi paretic gait that limits mobility, increases the risk of falls and promoting sedentary life style. Increased strength in the lower extremity muscles has been shown to be associated with improvements in walking performance. Recently Motor Imagery training (MIT) are enhancing motor learning, neural reorganization and cortical activation in stroke patients. However, efficacy MIT involving lower extremity mobility tasks are limited in stroke rehabilitation.
Source: Archives of Physical Medicine and Rehabilitation - October 1, 2015 Category: Rehabilitation Authors: Vijaya Kumar Tags: Research poster Source Type: research
The presence of a single-nucleotide polymorphism in the BDNF gene affects the rate of locomotor adaptation after stroke.
Abstract Induction of neural plasticity through motor learning has been demonstrated in animals and humans. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of growth factors, is thought to play an integral role in modulation of central nervous system plasticity during learning and motor skill recovery. Thirty percent of humans possess a single-nucleotide polymorphism on the BDNF gene (Val66Met), which has been linked to decreased activity-dependent release of BDNF. Presence of the polymorphism has been associated with altered cortical activation, short-term plasticity and altered skil...
Source: Experimental Brain Research - October 20, 2015 Category: Neuroscience Authors: Helm EE, Tyrell CM, Pohlig RT, Brady LD, Reisman DS Tags: Exp Brain Res Source Type: research
Machine Learning For Identifying Potentially Undiagnosed Post-Stroke Spasticity Patients In United Kingdom
Spasticity is one of the well-recognized complications of stroke which may give rise to pain and limit patients’ ability to perform daily activities. The predisposing factors and direct effects of post-stroke spasticity (PSS) also involve high management costs in terms of healthcare resources and case-control designs are required for establishing such differences. In ‘The Health Improvement Network’ (THIN) database, such a study was difficult to provide reliable estimates since the prevalence of post-stroke spasticity was found to be substantially below the most conservative previously reported estimates.
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: A Cox, M Raluy-Callado, M Wang, A Bakheit, AP Moor, J Dinet Source Type: research
Discovery could lead to better recovery after stroke
UCLA researchers have identified a molecule that, after a stroke, signals brain tissue to form new connections to compensate for the damage and initiate repairs to the brain. The finding could eventually lead to a new treatment to promote brain repair and functional recovery in people who have suffered a stroke, which is the leading cause of serious long-term disability in adults. The five-year study, performed in an animal model, was the first to identify growth differentiation factor 10, or GDF10, a molecule that previously had no known role in the adult brain, said Dr. S. Thomas Carmichael, the study’s senior author ...
Source: UCLA Newsroom: Health Sciences - October 26, 2015 Category: Universities & Medical Training Source Type: news
How to Learn the Warning Signs of a Stroke F.A.S.T
What if singing a song or rapping lyrics could give someone the power to spot stroke signs and take action? And what if sharing that song could spread power all around the world? Would you use it to save lives? Imagine the impact it could have. Well the American Heart Association/American Stroke Association (AHA/ASA) has partnered with me and David Augustine, aka Dee-1, a former teacher and now an up and coming hip hop artist, to do just that -- spread the word about stroke warning signs through music. Our version of the song includes a music video that will bring life to the letters F.A.S.T.! Although we had plenty of...
Source: Healthy Living - The Huffington Post - October 27, 2015 Category: Consumer Health News Source Type: news
Severe paraneoplastic hypoglycemia secondary to a gastrointestinal stromal tumour masquerading as a stroke.
We report the case of a 70-year-old previously healthy female who presented acutely to the Accident and Emergency department with left-sided vasomotor symptoms including reduced muscle tone, weakness upon walking and slurred speech. Physical examination confirmed hemiparesis with VIIth nerve palsy and profound hepatomegaly. A random glucose was low at 1.7 mmol/l, which upon correction resolved her symptoms. In hindsight, the patient recalled having had similar episodes periodically over the past 3 months to which she did not give much attention. While hospitalized, she continued having episodes of symptomatic hypoglycaem...
Source: Diabetes Metab - November 7, 2015 Category: Endocrinology Authors: Dimitriadis GK, Gopalakrishnan K, Rao R, Grammatopoulos DK, Randeva HS, Weickert MO, Murthy N Tags: Endocrinol Diabetes Metab Case Rep Source Type: research
Spontaneous white matter lesion in brain of stroke-prone renovascular hypertensive rats: a study from MRI, pathology and behavior
This study aimed to investigate the WML in RHRSP from MRI, pathology and behavior. RHRSP model was established by two-kidney, two-clipmethod and kept for 20 weeks. WML was decteted by magnetic resonance imaging (MRI) and loyez staining. Cognition was tested by morris water maze (MWM). Vascular changes were observed by HE staining on brain and carotid sections. Ultrastucture of blood brain barrier (BBB) were observed by transmission electron microscope. Immunofluorescence was used to detect albumin leakage and cell proliferation. T2-weighted MRI scans of RHRSP displayed diffuse, confluent white-matter hyperintensities. Pat...
Source: Metabolic Brain Disease - November 11, 2015 Category: Neurology Source Type: research
Study on the behavioral changes of a post-stroke depression rat model.
In conclusion, rats with PSD exhibited a significantly reduced memory capacity and altered behavior. The changes in the PSD rats were more severe than those in the rats in the stroke group. PMID: 26170928 [PubMed - as supplied by publisher]
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research
Development of clinical practice guidelines for urinary continence care of adult stroke survivors in acute and rehabilitation settings.
This study developed evidence-based clinical practice guidelines for the urinary continence care of adult stroke survivors in acute and rehabilitation settings. The research team conducted a comprehensive review of the literature on urinary continence interventions and outcomes. The team then developed a set of recommendations outlined in the resulting clinical practice guidelines titled Clinical Practice Guidelines (CPGs) for the Urinary Continence Care of Stroke Survivors in Acute and Rehabilitation Settings. The evaluation of the CPGs consisted of a two-part assessment and pilot implementation. An expert panel of 25 loc...
Source: Canadian Journal of Neuroscience Nursing - November 18, 2015 Category: Nursing Tags: Can J Neurosci Nurs Source Type: research
Pilot evaluation of the family informal caregiver stroke self-management program.
CONCLUSIONS: The pilot evaluation of the program validated the content of the FICSS program and indicated recommendations for improvement. PMID: 24180208 [PubMed - indexed for MEDLINE]
Source: Canadian Journal of Neuroscience Nursing - November 18, 2015 Category: Nursing Tags: Can J Neurosci Nurs Source Type: research
Intra-arterial treatment in acute ischaemic stroke: what we learn from the MR CLEAN trial.
Authors: Sekhar A PMID: 25874830 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - November 30, 2015 Category: Journals (General) Tags: J R Coll Physicians Edinb Source Type: research
Development of an educational program for staffs of emergency medical service to improve their awareness of stroke within 3 hours of symptom onset: a pilot study.
CONCLUSION: The educational program increased knowledge about stroke and improved the accuracy of triage by dedicated EMS providers. Further investigation is needed to determine the effectiveness of similar educational programs for non-dedicated EMS responders. PMID: 23479240 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
Impaired implicit learning and feedback processing after stroke
Publication date: 9 February 2016 Source:Neuroscience, Volume 314 Author(s): J.M. Lam, C. Globas, J.A. Hosp, H.-O. Karnath, T. Wächter, A.R. Luft The ability to learn is assumed to support successful recovery and rehabilitation therapy after stroke. Hence, learning impairments may reduce the recovery potential. Here, the hypothesis is tested that stroke survivors have deficits in feedback-driven implicit learning. Stroke survivors (n =30) and healthy age-matched control subjects (n =21) learned a probabilistic classification task with brain activation measured using functional magnetic resonance imaging in a subse...
Source: Neuroscience - December 18, 2015 Category: Neuroscience Source Type: research
Dyad Training Protocol on Learning of Bimanual Cup Stacking in Individuals with Stroke: Effects of Observation Duration.
CONCLUSION: For individuals with chronic stroke, compared with the 1-minute observation alternating with physical practice, the 6-minute duration resulted in greater persistent learning. Moreover the 6-minute duration greatly enhanced the planning of bimanual cup stacking. PMID: 26387420 [PubMed - indexed for MEDLINE]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - December 20, 2015 Category: Journals (General) Tags: J Med Assoc Thai Source Type: research
Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults—The Reasons for Geographic and Racial Differences in Stroke Study
ConclusionHigher levels of objectively measured MVPA%, rather than LPA% or ST%, were associated with lower prevalence of cognitive impairment and better performance in memory and executive function in aging people. The amount of MVPA associated with lower prevalence of cognitive impairment is consistent with meeting PA guidelines.
Source: Journal of the American Geriatrics Society - December 22, 2015 Category: Geriatrics Authors: Wenfei Zhu, Virginia J. Howard, Virginia G. Wadley, Brent Hutto, Steven N. Blair, John E. Vena, Natalie Colabianchi, David Rhodes, Steven P. Hooker Tags: Clinical Investigations Source Type: research
Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we e...
Source: eLife - January 6, 2016 Category: Biomedical Science Authors: Pielecka-Fortuna, J., Kalogeraki, E., Fortuna, M. G., Löwel, S., Sengpiel, F. Tags: Neuroscience Source Type: research