Device used to close small hole in heart may protect against recurrent stroke

A device used to close a small hole in the heart may benefit certain stroke patients by providing an extra layer of protection for those facing years of ongoing stroke risk, according to the results of a large clinical trial led by UCLA researchers.“It is a major new treatment option for some people,” said Dr. Jeffrey Saver, director of theUCLA Comprehensive Stroke Center and lead author of the study. However, he added, “Using the device is going to have to be a considered clinical decision between the doctor and the patient about who’s the right person to get it.”Thefindings appear in the Sept. 14 New England Journal of Medicine.Over eight years, the RESPECT study (Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment) enrolled 980 people, ages 18 to 60, at 69study locations in the United States and Canada. All of the participants had experienced a stroke, possibly caused by a condition known as patent foramen ovale, known as a PFO, which is a hole in the heart that did not close the way it should after birth. Nearly half of the people in the study had suffered a major stroke.About 25 to 30 percent of people in the United States have a PFO, which typically causes no health problems and does not require treatment. However, this type of hole in the heart is the possible cause in about 10 percent of the 795,000 strokes that occur in the United States each year. Most strokes are caused by high blood pressure, narro...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

Related Links:

Publication date: Available online 18 June 2019Source: Journal of PhysiotherapyAuthor(s): Davide G de Sousa, Lisa A Harvey, Simone Dorsch, Bronwyn Varettas, Serena Jamieson, Abby Murphy, Sarah GiaccariAbstractQuestionDoes intensive sit-to-stand training in addition to usual care improve sit-to-stand ability in people who are unable to stand up independently after stroke?DesignA multi-centre randomised controlled trial with concealed allocation, assessor blinding and intention-to-treat analysis.ParticipantsThirty patients from two Sydney hospitals,
Source: Journal of Physiotherapy - Category: Physiotherapy Source Type: research
ConclusionAcute organophosphate poisoning treated with atropine showed a potential for inducing prothrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.
Source: Toxicology Reports - Category: Toxicology Source Type: research
Authors: Wales J, Kalia S, Moineddin R, Husain A Abstract BACKGROUND: Socioeconomic disparities in home death have been noted in the literature. Home-based palliative care increases access to home death and has been suggested as a means to decrease these disparities. AIM: Our study examines the association between socioeconomic status and other demographic factors on place of death in a population receiving home palliative care in Toronto, Canada. DESIGN: This is a retrospective chart review of patients who died between August 2013 and August 2015 when admitted to a home-based palliative care service. Multi...
Source: Journal of Palliative Care - Category: Palliative Care Tags: J Palliat Care Source Type: research
The Canadian Arctic permafrost is thawing 70 years earlier than expected, a rate shocking a group of scientists who released the findings of their long-term study this month. A research team affiliated with the University of Alaska Fairbanks observed three sites over a period of 13 years between 2003 and 2016, according to a brief of their findings. Researchers discovered that a series of unusually warm summers triggered the rapid thawing, which is occurring 150 to 240 percent above the average rate between 1979 to 2000. Bill Cable, a co-author of the study and engineer at the Alfred Wegener Institute Helmholtz Centre for ...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized climate change onetime World Source Type: news
A 71-year-old with Stanford type B aortic dissection treated with Cook Medical (Bloomington, IN) ProForm ™ stent grafts 3 years previously was referred to the nephrology outpatient clinic for asymptomatic new-onset renal impairment. Other comorbidities were chronic hepatitis B, diabetes mellitus, and hypertension. Clinic blood pressure was 152/80 mm Hg, but physical examination was otherwise unremar kable. Serum creatinine was 142 μmol/l, urine protein-to-creatinine ratio 4.07 g/g, and glomerular hematuria was present (210 red cells) without pyuria on urine microscopy.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
The role of the terminal complement pathway as the cause of atypical hemolytic uremic syndrome (aHUS) is widely recognized, but the relative contribution of the effectors C5a/C5aR1 and C5b-9 to disease pathogenesis has not been defined. Using FHR/R mice carrying a factor H mutation that causes cell surface complement alternative pathway dysregulation, Ueda documented that in FHR/R mice, C5b-9 causes renal thrombotic microangiopathy (TMA) whereas C5a/C5aR drives macrovascular thrombosis. This commentary addresses the implications and limitations of this study.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
The hypothesis that prenatal exposure to poor maternal health or nutrition is a risk factor for adult-onset disease was first proposed by the epidemiologist David Barker in 1990, based on observations in a cohort of low birth weight infants followed into adulthood. Fetal programming is now accepted as an important contributor to the development of cardiovascular disease and other adult conditions. Although the mechanisms remain unknown, it is increasingly assumed that epigenetic mechanisms play a key role in fetal programming.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research
A 59-year-old African woman was admitted with generalized weakness. The history consisted of hypertension, which was treated with lisinopril and nifedipine for many years. She denied any use of nonsteroidal anti-inflammatory drugs, herbal medications, or illicit drugs. Physical examination revealed normal vital signs, dry mucous membranes, and no evidence of lymphadenopathy, salivary gland enlargement, or rash. Laboratory evaluation revealed a serum creatinine level of 12.9 mg/dl and a blood urea nitrogen level of 149 mg/dl (baseline, 1.1 and 23 mg/dl, respectively, 3 months ago), a hemoglobin level of 8.2 g/dl, a platelet...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
Please wait while the activity loads. If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled. If loading fails, click here to try again Click on the 'Start' button to begin the mock test. After answering all questions, click on the 'Get Results' button to display your score and the explanations. There is no time limit for this mock test. Start Congratulations - you have completed DM / DNB Cardiology Entrance Mock Test 11.You scored %%SCORE%% out of %%TOTAL%%.Your performance has been rated as %%...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
Please wait while the activity loads. If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled. If loading fails, click here to try again Click on the 'Start' button to begin the mock test. After answering all questions, click on the 'Get Results' button to display your score and the explanations. There is no time limit for this mock test. Start Congratulations - you have completed DM / DNB Cardiology Entrance Mock Test 7. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rate...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
More News: Brain | Canada Health | Cardiology | Clinical Trials | Funding | Heart | Hole in the Heart | Hypertension | Learning | Lessons | Neurology | Patent Foramen Ovale | Stroke | Study | Texas University | Thrombosis | Universities & Medical Training | University of Washington | USA Health