Filtered By:
Specialty: Reproduction Medicine

This page shows you your search results in order of date. This is page number 16.

Order by Relevance | Date

Total 316 results found since Jan 2013.

Overexpression of chloride channel-3 is associated with the increased migration and invasion ability of ectopic endometrial cells from patients with endometriosis
STUDY QUESTION Is chloride channel-3 (ClC-3) involved in regulating the biological behavior of endometrial stromal cells (ESCs)? SUMMARY ANSWER ClC-3 promotes endometriotic cell migration and invasion. WHAT IS KNOWN ALREADY ClC-3 plays a significant role in the migration and invasion of various kinds of cells. STUDY DESIGN, SIZE, DURATION An in vitro investigation of the effect of ClC-3 on the migration and invasion of ectopic ESCs from patients with endometriosis. PARTICIPANTS/MATERIALS, SETTING, METHODS The ectopic and eutopic endometrial samples from 43 female patients with endometriosis and the endometrial samples ...
Source: Human Reproduction - April 20, 2016 Category: Reproduction Medicine Authors: Guan, Y.-t., Huang, Y.-q., Wu, J.-b., Deng, Z.-q., Wang, Y., Lai, Z.-y., Wang, H.-b., Sun, X.-x., Zhu, Y.-l., Du, M.-m., Zhu, L.-y., Chen, L.-x., Wang, L.-w. Tags: Gynaecology Source Type: research

Don´t trust an(t)ybody - Pitfalls during investigation of candidate proteins for methylmercury transport at the placental interface
While investigating placental mercury transport, we validated specificity of commercial antibodies against four candidate transporters (Large neutral amino acids transporter (LAT)1, LAT2, 4F2 cell-surface antigen heavy chain (4F2hc), and multidrug resistance-associated protein (MRP)2) by immunoblotting and small interfering RNA (siRNA)-mediated protein knockdown. An anti-4F2hc- and one anti-LAT1-antibody were specific. Another anti-LAT1-antibody reacted with LAT2. Two anti-LAT2-antibodies detected mainly albumin in placental lysates.
Source: Placenta - April 18, 2016 Category: Reproduction Medicine Authors: Isabella Ellinger, Waranya Chatuphonprasert, Martin Reiter, Agnes Voss, Jost Kemper, Elisabeth Straka, Matthias Scheinast, Harald Zeisler, Hans Salzer, Claudia Gundacker Tags: Technical note Source Type: research

Don't trust an(t)ybody - Pitfalls during investigation of candidate proteins for methylmercury transport at the placental interface
While investigating placental mercury transport, we validated specificity of commercial antibodies against four candidate transporters (Large neutral amino acids transporter (LAT)1, LAT2, 4F2 cell-surface antigen heavy chain (4F2hc), and multidrug resistance-associated protein (MRP)2) by immunoblotting and small interfering RNA (siRNA)-mediated protein knockdown. An anti-4F2hc- and one anti-LAT1-antibody were specific. Another anti-LAT1-antibody reacted with LAT2. Two anti-LAT2-antibodies detected mainly albumin in placental lysates.
Source: Placenta - April 18, 2016 Category: Reproduction Medicine Authors: Isabella Ellinger, Waranya Chatuphonprasert, Martin Reiter, Agnes Voss, Jost Kemper, Elisabeth Straka, Matthias Scheinast, Harald Zeisler, Hans Salzer, Claudia Gundacker Tags: Technical note Source Type: research

Adiponectin Inhibits Nutrient Transporters and Promotes Apoptosis in Human Villous Cytotrophoblasts: Involvement in the Control of Fetal Growth.
Abstract The placenta exchanges nutrients between the mother and the fetus, and requires a constant abundant energy supply. Adiponectin (a cytokine produced primarily by adipose tissue) controls glucose and lipid homeostasis. It is well known that maternal serum adiponectin levels are inversely related to birth weight suggesting that adiponectin has a negative effect on fetal growth. This effect appears to be related to the control of nutrient transporters in human placenta. However, the underlying molecular mechanisms have not yet been characterized. In the present work, we studied adiponectin's direct effect on ...
Source: Biology of Reproduction - March 29, 2016 Category: Reproduction Medicine Authors: Duval F, Dos Santos E, Poidatz D, Sérazin V, Gronier H, Vialard F, Dieudonné MN Tags: Biol Reprod Source Type: research

Elevated phosphatase of regenerating liver 3 (PRL-3) promotes cytoskeleton reorganization, cell migration and invasion in endometrial stromal cells from endometrioma
STUDY QUESTION Is phosphatase of regenerating liver-3 (PRL-3) associated with increased motility of endometriotic cells from endometrioma? SUMMARY ANSWER Elevated PRL-3 promotes cytoskeleton reorganization, cell migration and invasion of endometrial stromal cells (ESCs) from endometrioma. WHAT IS KNOWN ALREADY Overexpression of PRL-3 is associated with cancer cell migration, invasion and metastatic phenotype. STUDY DESIGN, SIZE, DURATION Primary human ESCs were isolated from eutopic endometrium of women without endometriosis (EuCo, n = 10), with histologically proven endometrioma (EuEM, n = 19) and from the cyst wall of...
Source: Human Reproduction - March 15, 2016 Category: Reproduction Medicine Authors: Zhan, H., Ma, J., Ruan, F., Bedaiwy, M. A., Peng, B., Wu, R., Lin, J. Tags: Gynaecology Source Type: research

Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice.
Abstract Women with endometriosis can suffer from decreased fecundity or complete infertility via abnormal oocyte function or impaired placental-uterine interactions required for normal pregnancy establishment and maintenance. Although AT-rich interactive domain 1A (SWI-like) (ARID1A) is a putative tumor suppressor in human endometrial cancers and endometriosis-associated ovarian cancers, little is known about its role in normal uterine function. To study the potential function of ARID1A in the female reproductive tract, we generated mice with a conditional knockout of Arid1a using anti-Müllerian hormone receptor...
Source: Biology of Reproduction - March 9, 2016 Category: Reproduction Medicine Authors: Wang X, Khatri S, Broaddus R, Wang Z, Hawkins SM Tags: Biol Reprod Source Type: research

RAF1 is increased in labouring myometrium and modulates inflammation-induced pro-labour mediators
In conclusion, IL1B induces the expression and secretion of pro-labour mediators through the RAF1–MAPK1–NF-B signalling pathway. TNF, on the other hand, regulates pro-labour mediators through the RAF1–NF-B signalling pathway via an MAPK1-independent mechanism.
Source: Reproduction - February 23, 2016 Category: Reproduction Medicine Authors: Lappas, M. Tags: Research Source Type: research

Role of Sirt3 in mitochondrial biogenesis and developmental competence of human in vitro matured oocytes
STUDY QUESTION Does Sirt3 dysfunction result in poor developmental outcomes for human oocytes after in vitro maturation (IVM)? SUMMARY ANSWER Inefficient Sirt3 expression induced decreased mitochondrial DNA copy number and biogenesis, and therefore impaired the developmental competence of human IVM oocytes. WHAT IS KNOWN ALREADY Cytoplasmic immaturity in IVM oocytes may lead to reduced developmental competence. Mitochondrial dysfunction results in the accumulation of free radicals and leads to DNA mutations, protein damage, telomere shortening and apoptosis. SIRT3 (in the Sirtuin protein family) has emerged as a mitochon...
Source: Human Reproduction - February 16, 2016 Category: Reproduction Medicine Authors: Zhao, H.-C., Ding, T., Ren, Y., Li, T.-J., Li, R., Fan, Y., Yan, J., Zhao, Y., Li, M., Yu, Y., Qiao, J. Tags: Reproductive biology Source Type: research

Increased Expression of Fatty Acid Binding Protein 4 in Preeclamptic Placenta and Its Relevance to Preeclampsia
The aim of this investigation was to determine the expression of fatty acid binding protein 4 (FABP4) in the placenta from women with preeclampsia and normal pregnancy, and to delineate the regulatory effects on thophoblast cell by FABP4. We determined the expression of FABP4 by real-time polymerase chain reaction (PCR) for messenger ribonucleic acid (mRNA) or enzyme-linked immunesorbent assay (ELISA) and Western blotting for protein. Small interference of ribonucleic acid (siRNA) and specific FABP4 inhibitor were used to inhibit FABP4.
Source: Placenta - January 19, 2016 Category: Reproduction Medicine Authors: Yuying Yan, Huilian Peng, Peng Wang, Hanzhi Wang, Minyue Dong Source Type: research

MCL1 is a key regulator of steroidogenesis in mouse leydig cells
This article is protected by copyright. All rights reserved
Source: Molecular Reproduction and Development - January 1, 2016 Category: Reproduction Medicine Authors: Guang‐Yu Li, Hai‐Yan Lan, Ji‐Hong Liang, Yun‐Cong Mo, Xue‐Lian Deng, Chun‐Yu Lin, Wen‐Yong Su Tags: Research Article Source Type: research

The Transcription Factor Interferon Regulatory Factor-1 (IRF1) Plays a Key Role in the Terminal Effector Pathways of Human Preterm Labor.
In conclusion, IRF1 upregulation in fetal membranes and myometrium after term labor indicates a pro-inflammatory role for IRF1 in human parturition. IRF1 is involved in TLR and cytokine mediated signaling in human myometrium. These data provide new insights into the mechanisms associated with inflammation- and infection-associated preterm birth. IRF1 inhibitors as therapeutics for the management of spontaneous preterm birth warrants further investigation. PMID: 26674566 [PubMed - as supplied by publisher]
Source: Reproductive Biology - December 16, 2015 Category: Reproduction Medicine Authors: Lim R, Tran HT, Liong S, Barker G, Lappas M Tags: Biol Reprod Source Type: research

Estradiol promotes cells invasion by activating {beta}-catenin signaling pathway in endometriosis
Endometriosis is an estrogen-dependent disease that involves the adhesion, invasion, and angiogenesis of endometrial tissues outside of the uterine cavity. We hypothesized that a link exists between estrogen and beta-catenin (β-catenin) signaling in the pathogenesis of endometriosis. Human endometrial stromal cells (HESCs) were separated from eutopic endometrial tissues that were obtained from patients with endometriosis. β-catenin expression and cells invasiveness ability were up-regulated by 17β-estradiol (E2) in an estrogen receptor (ESR)-dependent manner, whereas β-catenin siRNA abrogated this pheno...
Source: Reproduction - November 4, 2015 Category: Reproduction Medicine Authors: Xiong, W., Zhang, L., Yu, L., Xie, W., Man, Y., Xiong, Y., Liu, H., Liu, Y. Tags: Research Source Type: research

Human Placenta-Derived Multipotent Stromal Cells Involved in Placental Angiogenesis via the PDGF-BB and STAT3 Pathways.
In conclusion, endothelial cell-hPMSC interactions occur during vessel development of placenta. Endothelial cell-derived PDGF-BB recruits hPMSCs involved in vascular development via PDGFR-beta/STAT3 activation. PMID: 26353894 [PubMed - as supplied by publisher]
Source: Biology of Reproduction - September 9, 2015 Category: Reproduction Medicine Authors: Chen CY, Liu SH, Chen CY, Chen PC, Chen CP Tags: Biol Reprod Source Type: research

Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model
This study is not a clinical trial.
Source: Human Reproduction - August 19, 2015 Category: Reproduction Medicine Authors: Chen, X., Liu, J., He, B., Li, Y., Liu, S., Wu, B., Wang, S., Zhang, S., Xu, X., Wang, J. Tags: Reproductive biology Source Type: research

Evidence Supporting a Role for SMAD2/3 in Bovine Early Embryonic Development: Potential Implications for Embryotropic Actions of Follistatin.
In conclusion, the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis and that specific stimulatory actions of follistatin are not observed in the absence of SMAD2/3 signaling. PMID: 26289443 [PubMed - as supplied by publisher]
Source: Biology of Reproduction - August 19, 2015 Category: Reproduction Medicine Authors: Zhang K, Rajput SK, Lee KB, Wang D, Huang J, Folger JK, Knott JG, Zhang J, Smith GW Tags: Biol Reprod Source Type: research