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Specialty: Reproduction Medicine

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Total 316 results found since Jan 2013.

Functional roles of the chromatin remodeler SMARCA5 in mouse and bovine preimplantation embryos
Biol Reprod. 2021 Apr 23:ioab081. doi: 10.1093/biolre/ioab081. Online ahead of print.ABSTRACTUpon fertilization, extensive chromatin reprogramming occurs during preimplantation development. Growing evidence reveals species-dependent regulations of this process in mammals. ATP-dependent chromatin remodeling factor SMARCA5 (also known as SNF2H) is required for peri-implantation development in mice. However, the specific functional role of SMARCA5 in preimplantation development and if it is conserved among species remain unclear. Herein, comparative analysis of public RNA-seq datasets reveals that SMARCA5 is universally expre...
Source: Biology of Reproduction - April 26, 2021 Category: Reproduction Medicine Authors: Yan Shi Panpan Zhao Yanna Dang Shuang Li Lei Luo Bingjie Hu Shaohua Wang Huanan Wang Kun Zhang Source Type: research

The regulatory role of miR-20a in bovine cumulus cells and its contribution to oocyte maturation
Zygote. 2021 Apr 23:1-10. doi: 10.1017/S0967199420000933. Online ahead of print.ABSTRACTDynamic changes in microRNAs in oocyte and cumulus cells before and after maturation may explain the spatiotemporal post-transcriptional gene regulation within bovine follicular cells during the oocyte maturation process. miR-20a has been previously shown to regulate proliferation and differentiation as well as progesterone levels in cultured bovine granulosa cells. In the present study, we aimed to demonstrate the function of miR-20a during the bovine oocyte maturation process. Maturation of cumulus-oocyte complexes (COCs) was performe...
Source: Zygote - April 23, 2021 Category: Reproduction Medicine Authors: Eryk Andreas Hari Om Pandey Michael Hoelker Dessie Salilew-Wondim Samuel Gebremedhn Karl Schellander Dawit Tesfaye Source Type: research

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
This study was mainly conducted in primary human endometrial stromal cells. Therefore, the function of FPNin vivo need to be further investigated.WIDER IMPLICATIONS OF THE FINDINGSOur findings reveal that erastin may serve as a potential therapeutic treatment for endometriosis.STUDY FUNDING/COMPETING INTEREST(S)This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. The authors declare no conflict of interest.
Source: Human Reproduction - December 30, 2020 Category: Reproduction Medicine Source Type: research

EZH2 is essential for spindle assembly regulation and chromosomal integrity during porcine oocyte meiotic maturation †.
EZH2 is essential for spindle assembly regulation and chromosomal integrity during porcine oocyte meiotic maturation†. Biol Reprod. 2020 Nov 27;: Authors: Cai Q, Wen K, Ma M, Chen W, Mo D, He Z, Chen Y, Cong P Abstract Enhancer of zeste homolog 2 (EZH2) has been extensively investigated to participate in diverse biological processes, including carcinogenesis, the cell cycle, X-chromosome inactivation and early embryonic development. However, the functions of this protein during mammalian oocyte meiotic maturation remain largely unexplored. Here, combined with RNA-Seq, we provided evidence that EZH2 ...
Source: Biology of Reproduction - November 27, 2020 Category: Reproduction Medicine Authors: Cai Q, Wen K, Ma M, Chen W, Mo D, He Z, Chen Y, Cong P Tags: Biol Reprod Source Type: research

The SARS-CoV-2 receptor, Angiotensin converting enzyme 2 (ACE2) is required for human endometrial stromal cell decidualization.
Abstract The coronavirus disease 2019 (COVID-19) first appeared in December 2019 and rapidly spread throughout the world. The SARS-CoV-2 virus enters the host cells by binding to the angiotensin-converting enzyme (ACE2). Although much of the focus is on respiratory symptoms, recent reports suggest that SARS-CoV-2 can cause pregnancy complications such as pre-term birth and miscarriages; and women with COVID-19 had maternal vascular malperfusion and decidual arteriopathy in their placentas. Here, we report that ACE2 protein is expressed in both endometrial epithelial and stromal cells in the proliferative phase of ...
Source: Biology of Reproduction - November 18, 2020 Category: Reproduction Medicine Authors: Chadchan SB, Popli P, Maurya VK, Kommagani R Tags: Biol Reprod Source Type: research

Sirtuin-1 Inhibits Endothelin-2 Expression in Human Granulosa-Lutein Cells via HIF1A and Epigenetic Modifications †.
Sirtuin-1 Inhibits Endothelin-2 Expression in Human Granulosa-Lutein Cells via HIF1A and Epigenetic Modifications†. Biol Reprod. 2020 Oct 28;: Authors: Szymanska M, Manthe S, Shrestha K, Girsh E, Harlev A, Kisliouk T, Meidan R Abstract Endothelin-2 (EDN2) expression in granulosa cells was previously shown to be highly dependent on the hypoxic mediator, HIF1A. Here we investigated whether sirtuin-1 (SIRT1), by deacetylating HIF1A and class III histones, modulates EDN2 in human granulosa-lutein cells (hGLCs). We found that HIF1A was markedly suppressed in the presence of resveratrol or a specific SIRT...
Source: Biology of Reproduction - October 28, 2020 Category: Reproduction Medicine Authors: Szymanska M, Manthe S, Shrestha K, Girsh E, Harlev A, Kisliouk T, Meidan R Tags: Biol Reprod Source Type: research

Osteoprotegerin interacts with syndecan-1 to promote human endometrial stromal decidualization by decreasing Akt phosphorylation
In this study, based on a number of approaches, it was demonstrated that OPG mediated the repression of Akt that occurs during human stromal cell decidualization, however, the molecular link between OPG and Akt signaling was not determined, and still requires further exploration.WIDER IMPLICATIONS OF THE FINDINGSOPG is required for decidualization, and a decrease in OPG levels is associated with RPL. These findings provide a new candidate molecule for the diagnosis and potential treatment of RPL.STUDY FUNDING/COMPETING INTEREST(S)This work was supported in part by the National Natural Science Foundation of China U1605223 (...
Source: Human Reproduction - October 13, 2020 Category: Reproduction Medicine Source Type: research

The role of ORC4 in enucleation of Murine Erythroleukemia (MEL) cells is similar to that in oocyte polar body extrusion.
Abstract The Origin Replication Complex subunit 4 (ORC4) is one in six subunits of the Origin Replication Complexes (ORCs) which is essential for initiating licensing at DNA replication origins and recruiting adaptor molecules necessary for various cellular processes. Previously, we reported that ORC4 also plays a vital role in polar body extrusion (PBE) during oogenesis in which half the chromosomes are extruded from the oocyte. We hypothesized that ORC4 might play a broader role in chromatin elimination. We tested its role in enucleation during the development of erythrocytes. Murine erythroleukemia (MEL) cells ...
Source: Systems Biology in Reproductive Medicine - September 23, 2020 Category: Reproduction Medicine Authors: Nguyen H, Ung A, Ward WS Tags: Syst Biol Reprod Med Source Type: research