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Specialty: Reproduction Medicine
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Total 316 results found since Jan 2013.
USP7 prevents recurrent spontaneous abortion by targeting EZH2 to regulate trophoblast proliferation, apoptosis, migration and invasion through the Wnt/ β-catenin pathway†
In this study, we analyzed the expression of USP7 in villous tissues obtained from RSA patients and healthy controls, and then GNE-6776 (a USP7-specific inhibitor) and USP7 siRNA were used in a trophoblast cell line, HTR-8/SVneo, to further assess the effect of USP7 on the biological function of trophoblasts. Our results provide convincing evidence that USP7 is downregulated in the placental villous tissues of RSA patients. USP7 was found to have a crucial role in the proliferation, apoptosis, migration, invasion and epithelial-mesenchymal transition (EMT) process of trophoblast cells. Further experiments revealed that USP...
Source: Reproductive Biology - May 30, 2023 Category: Reproduction Medicine Authors: Mengqi Zhou Yue Gao Shujuan Wu Jiao Chen Jinli Ding Yaqin Wang Jing Yang Source Type: research
Effect of peroxiredoxin 1 on the regulation of trophoblast function by affecting autophagy and oxidative stress in preeclampsia
ConclusionPRDX1 regulated trophoblast function through the PTEN/AKT signaling pathway to affect cell autophagy and ROS level, which provided a potential target for the treatment of PE.
Source: Journal of Assisted Reproduction and Genetics - May 25, 2023 Category: Reproduction Medicine Source Type: research
Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal-fetal interface
CONCLUSION: Our findings highlighted the immunomodulatory roles of E2-activated SGK1 in Th2 immune responses by priming anti-inflammatory M2 macrophages at the maternal-fetal interface, resulting in a balanced immune microenvironment during pregnancy. Our results suggest new perspectives on future preventative strategies for RPL.PMID:37226177 | DOI:10.1186/s12958-023-01102-9
Source: Reproductive Biology - May 24, 2023 Category: Reproduction Medicine Authors: Yiyun Lou Zhujing Fu Ye Tian Minhao Hu Qijing Wang Yuanyuan Zhou Ning Wang Qin Zhang Fan Jin Source Type: research
< em > Pum3 < /em > is dispensable for mouse oocyte maturation and embryo development < em > in vitro < /em >
Zygote. 2023 May 17:1-7. doi: 10.1017/S0967199423000205. Online ahead of print.ABSTRACTPumilio3 (Pum3), an evolutionarily distant homologue of the classical RNA-binding protein PUF (PUMILIO and FBF) family member, is also involved in the process of RNA metabolism through post-transcriptional regulation. However, the functions of Pum3 in mouse oocyte maturation and preimplantation embryonic development have not been elucidated. By comparing RNA levels in different tissues, we found that Pum3 was widely expressed in multiple tissues, but moderately predominant in the ovary. Histochemical staining suggested that the PUM3 prot...
Source: Zygote - May 17, 2023 Category: Reproduction Medicine Authors: TingTing Zhao Wei Huang Kaibo Lin Source Type: research
Supplementing culture medium with the weak acid, 5,5-dimethyl-2,4-oxazolidinedione (DMO) limits the development of aneuploid mouse embryos through a Trp53-dependent mechanism
ConclusionThese studies suggest that the development of morphologically normal aneuploid-enriched mouse blastocysts can be inhibited by adding low amounts of DMO to the culture media, which results in elevated levels ofTrp53 mRNA that suppressesOct-4 andCdx2 expression.
Source: Journal of Assisted Reproduction and Genetics - April 14, 2023 Category: Reproduction Medicine Source Type: research
circPLOD2 knockdown suppresses endometriosis progression via the miR-216a-5p/ZEB1 axis
In conclusion, circPLOD2 promotes the proliferation, migration, and invasion of EC-ESCs and inhibits their apoptosis by targeting miR-216a-5p. These findings indicate potential therapeutic targets for endometriosis.PMID:37023661 | DOI:10.1016/j.repbio.2023.100758
Source: Reproductive Biology - April 6, 2023 Category: Reproduction Medicine Authors: Ganping Lai Dan Bu Maolin Chen Hongfang Liu Lei Dong Source Type: research
Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway
ConclusionsThe decline of INHBB in HESCs suppressed ADCY1-induced cAMP production and cAMP-mediated signalling, which attenuated decidualization in RIF patients, indicating that INHBB is an essential component in the decidualization process.
Source: Journal of Assisted Reproduction and Genetics - March 13, 2023 Category: Reproduction Medicine Source Type: research
