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Specialty: Reproduction Medicine
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Total 316 results found since Jan 2013.
Impact of growth hormone-releasing hormone (GHRH) antagonist on Decidual stromal cell growth and apoptosis in vitro
Biol Reprod. 2021 Nov 18:ioab214. doi: 10.1093/biolre/ioab214. Online ahead of print.ABSTRACTEndometrial stromal cells remodeling is critical during human pregnancy. GHRH and its functional receptor have been shown to be expressed in gynecological cancer cells and eutopic endometrial stromal cells. Recent studies have demonstrated the potential clinical uses of antagonists of GHRH as effective antitumor agents because of its directly antagonistic effect on the locally produced GHRH in gynecological tumors. However, the impact of GHRH antagonists on normal endometrial stromal cell growth remained to be elucidated. The aim o...
Source: Biology of Reproduction - November 18, 2021 Category: Reproduction Medicine Authors: Hsien-Ming Wu Liang-Hsuan Chen Andrew V Schally Hong-Yuan Huang Yung-Kuei Soong Peter C K Leung Hsin-Shih Wang Source Type: research
Differential expression of estrogen receptor subtypes in ovarian high-grade serous carcinoma and clear cell carcinoma
CONCLUSIONS: High GPER-1 expression is an independent prognostic factor for PFS in HGSC patients, and GPER-1 may play a role in HGSC cell proliferation.PMID:34646075 | PMC:PMC8499597 | DOI:10.1002/rmb2.12402
Source: Reproductive Biology - October 14, 2021 Category: Reproduction Medicine Authors: Daiken Osaku Tetsuro Oishi Naoshi Kawamura Yuki Iida Hiroaki Komatsu Akiko Kudoh Jun Chikumi Shinya Sato Tasuku Harada Source Type: research
The balance between cell survival and death in the placenta: Do neurotrophins have a role?
Syst Biol Reprod Med. 2021 Oct 6:1-10. doi: 10.1080/19396368.2021.1980132. Online ahead of print.ABSTRACTNeurotrophins (NT) are a closely related family of growth factors, which regulate the nervous system's development, maintenance, and function. Although NTs have been well studied in neuronal cells, they are also expressed in the placenta. Despite their suggested role in regulating fetoplacental development, their precise functional significance in the placenta remains elusive. NT activate two different classes of receptors. These include the Trk, tropomyosin-related kinase family of high-affinity tropomyosin-related kin...
Source: Reproductive Biology - October 7, 2021 Category: Reproduction Medicine Authors: Prachi Pathare-Ingawale Preeti Chavan-Gautam Source Type: research
Knockdown of Dnmt1 and Dnmt3a gene expression disrupts preimplantation embryo development through global DNA methylation
ConclusionPrecisely aligned expression of Dnmt genes is highly essential for the fate of an embryo in the early developmental period. Our data indicates that further analysis is mandatory to designate the specific targets of these methylation/demethylation processes in mouse and human preimplantation embryos.
Source: Journal of Assisted Reproduction and Genetics - September 17, 2021 Category: Reproduction Medicine Source Type: research
