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Specialty: Reproduction Medicine
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Total 316 results found since Jan 2013.
HOXA10 improves endometrial receptivity by upregulating E-cadherin
In conclusion, HOXA10 can bind to the E-cadherin promoter region and directly regulate its expression, thereby improving endometrial receptivity and subsequently increasing the embryo adhesion and implantation.PMID:35044439 | DOI:10.1093/biolre/ioac007
Source: Biology of Reproduction - January 19, 2022 Category: Reproduction Medicine Authors: Yin Bi Weiyu Huang Lifang Yuan Saiqiong Chen Shengbin Liao Xiaoqian Fu Bo Liu Yihua Yang Source Type: research
The function of Nucleoporin 37 on mouse oocyte maturation and preimplantation embryo development
ConclusionsIn summary, NUP37 played an important role in mice oocyte maturation and preimplantation embryo development.
Source: Journal of Assisted Reproduction and Genetics - January 13, 2022 Category: Reproduction Medicine Source Type: research
Myostatin increases human trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 Signaling
In this study, we tested the hypothesis that myostatin increases trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 signaling. Primary and immortalized (HTR8/SVneo) trophoblast cells were used as study models. Matrigel-coated transwell invasion assays were used to study the effects of recombinant human myostatin on trophoblast cell invasion. RT-qPCR and Western blot were used to measure myostatin effects on N-cadherin mRNA and protein levels, respectively. Small inhibitor molecules as well as siRNA-mediated knockdown were used to block myostatin receptor and downstream signaling, respectively. Data were...
Source: Biology of Reproduction - January 12, 2022 Category: Reproduction Medicine Authors: Faten AbdelHafez Ahmed Christian Klausen Hua Zhu Peter C K Leung Source Type: research
Suppression of FPR2 expression inhibits inflammation in preeclampsia by improving the biological functions of trophoblast via NF- κB pathway
ConclusionSuppression of FPR2 expression alleviated the effects of inflammation induced by LPS on trophoblasts via the NF- κB signaling pathway, which provided a novel and potential strategy for the treatment of PE.
Source: Journal of Assisted Reproduction and Genetics - January 11, 2022 Category: Reproduction Medicine Source Type: research
Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells
CONCLUSIONS: Our findings provide new insight into the molecular mechanisms by which BMP2 modulates the cellular activity induced by GDF8 through the upregulated expression of their antagonist (GREM2).PMID:34838049 | DOI:10.1186/s12958-021-00854-6
Source: Reproductive Biology - November 28, 2021 Category: Reproduction Medicine Authors: Xiaoyan Luo Hsun-Ming Chang Yuyin Yi Yingpu Sun Peter C K Leung Source Type: research
Impact of growth hormone-releasing hormone (GHRH) antagonist on Decidual stromal cell growth and apoptosis in vitro
Biol Reprod. 2021 Nov 18:ioab214. doi: 10.1093/biolre/ioab214. Online ahead of print.ABSTRACTEndometrial stromal cells remodeling is critical during human pregnancy. GHRH and its functional receptor have been shown to be expressed in gynecological cancer cells and eutopic endometrial stromal cells. Recent studies have demonstrated the potential clinical uses of antagonists of GHRH as effective antitumor agents because of its directly antagonistic effect on the locally produced GHRH in gynecological tumors. However, the impact of GHRH antagonists on normal endometrial stromal cell growth remained to be elucidated. The aim o...
Source: Biology of Reproduction - November 18, 2021 Category: Reproduction Medicine Authors: Hsien-Ming Wu Liang-Hsuan Chen Andrew V Schally Hong-Yuan Huang Yung-Kuei Soong Peter C K Leung Hsin-Shih Wang Source Type: research
