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Specialty: Reproduction Medicine
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Total 316 results found since Jan 2013.
The IL6/sIL-6R α trans-signaling increases PGE2 production in human granulosa cells
In conclusion, IL6 trans-signaling upregulates the expression of PTGS2 and increases the production of PGE2 via the JAK2/STAT3/SOCS3 signaling pathway in hGL cells. Our findings provide insights into the molecular mechanisms by which IL6 trans-signaling may potentially modulate the event of ovulation in human ovaries.PMID:34198336 | DOI:10.1093/biolre/ioab128
Source: Biology of Reproduction - July 1, 2021 Category: Reproduction Medicine Authors: Sai-Jiao Li Hsun-Ming Chang Jiamin Xie Jeremy H Wang Jing Yang Peter C K Leung Source Type: research
Downregulation of decidual SKP2 is associated with human recurrent miscarriage
CONCLUSIONS: Our study indicates a functional role of SKP2 in RM: downregulation of SKP2 in RM leads to impaired decidualization and downregulation of GLUT1 and consequently predisposes individuals to RM.PMID:34116705 | DOI:10.1186/s12958-021-00775-4
Source: Reproductive Biology - June 12, 2021 Category: Reproduction Medicine Authors: Shijian Lv Mei Liu Lizhen Xu Cong Zhang Source Type: research
Thrombin impairs the angiogenic activity of extravillous trophoblast cells via monocyte chemotactic protein-1 (MCP-1): A possible link with preeclampsia
In conclusion, we propose that thrombin-controlled MCP-1 secretion may play an essential role in normal placental development and successful pregnancy maintenance. Improper thrombin production and MCP-1 secretion during pregnancy might cause inadequate vascular formation and transformation of spiral arteries, which may contribute to pregnancy disorders, such as preeclampsia.PMID:34058707 | DOI:10.1016/j.repbio.2021.100516
Source: Reproductive Biology - May 31, 2021 Category: Reproduction Medicine Authors: Daniela Br ünnert Vijay Kumar Vibha Kaushik Jens Ehrhardt Kirti Raj Chahar Phulwanti Kumari Sharma Marek Zygmunt Pankaj Goyal Source Type: research
Spastin interacts with CRMP5 to promote spindle organization in mouse oocytes by severing microtubules
Zygote. 2021 May 26:1-12. doi: 10.1017/S0967199421000344. Online ahead of print.ABSTRACTMicrotubule-severing protein (MTSP) is critical for the survival of both mitotic and postmitotic cells. However, the study of MTSP during meiosis of mammalian oocytes has not been reported. We found that spastin, a member of the MTSP family, was highly expressed in oocytes and aggregated in spindle microtubules. After knocking down spastin by specific siRNA, the spindle microtubule density of meiotic oocytes decreased significantly. When the oocytes were cultured in vitro, the oocytes lacking spastin showed an obvious maturation disorde...
Source: Zygote - May 26, 2021 Category: Reproduction Medicine Authors: Zhen Jin Hua-Feng Shou Jin-Wei Liu Shan-Shan Jiang Yan Shen Wei-Ye Cheng Lei-Lei Gao Source Type: research
Functional roles of the chromatin remodeler SMARCA5 in mouse and bovine preimplantation embryos
Biol Reprod. 2021 Apr 23:ioab081. doi: 10.1093/biolre/ioab081. Online ahead of print.ABSTRACTUpon fertilization, extensive chromatin reprogramming occurs during preimplantation development. Growing evidence reveals species-dependent regulations of this process in mammals. ATP-dependent chromatin remodeling factor SMARCA5 (also known as SNF2H) is required for peri-implantation development in mice. However, the specific functional role of SMARCA5 in preimplantation development and if it is conserved among species remain unclear. Herein, comparative analysis of public RNA-seq datasets reveals that SMARCA5 is universally expre...
Source: Biology of Reproduction - April 26, 2021 Category: Reproduction Medicine Authors: Yan Shi Panpan Zhao Yanna Dang Shuang Li Lei Luo Bingjie Hu Shaohua Wang Huanan Wang Kun Zhang Source Type: research
