Filtered By:
Specialty: Reproduction Medicine
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 316 results found since Jan 2013.
Associations between isoflavone exposure and reproductive damage in adult males: evidence from human and model system studies
This study was designed to investigate whether isoflavone exposure during adulthood could have deleterious impacts on male reproductive health by the cross-sectional study, animal experiments, and in vitro tests. In the cross-sectional study, we observed that urinary isoflavones were not significantly associated with semen quality including sperm concentrations, sperm count, progressive motility, and total motility, respectively (All P-value for trend>0.05). However, negative associations were found between plasma testosterone and urinary Ī£isoflavones, genistein, glycitein, and dihydrodaidzein (all P-value for trend &l...
Source: Biology of Reproduction - August 10, 2022 Category: Reproduction Medicine Authors: Wang Yang Jiuyang Deng Jianfang Gao Huan Yang Qing Chen Zhou Niya Xi Ling Guowei Zhang Peng Zou Lei Sun Linping Huang Jinyi Liu Jia Cao Lin Ao Source Type: research
Diverse actions of sirtuin-1 on ovulatory genes and cell death pathways in human granulosa cells
CONCLUSIONS: These findings reveal that in hGLCs, SIRT1 enhances the expression of ovulatory and angiogenic genes while eventually advancing cell death pathways. Interestingly, these seemingly contradictory events may have occurred in a cAMP-dependent manner.PMID:35840944 | DOI:10.1186/s12958-022-00970-x
Source: Reproductive Biology - July 15, 2022 Category: Reproduction Medicine Authors: Jackson Sapuleni Magdalena Szymanska Rina Meidan Source Type: research
SET improved oocyte maturation by serine/threonine protein phosphatase 2A and inhibited oocyte apoptosis in mouse oocytes
Reprod Biol. 2022 Jun 18;22(3):100668. doi: 10.1016/j.repbio.2022.100668. Online ahead of print.ABSTRACTSET is a multifunctional protein involved in a variety of molecular processes such as cell apoptosis and cell-cycle regulation. In ovaries SET is predominantly expressed in theca cells and oocytes. In polycystic ovary syndrome (PCOS) patients the expression of SET was increased than healthy people. The current study was designed to determine whether SET plays a role in oocyte maturation and apoptosis, which may provide clues for the underlying pathological mechanism of follicular development in PCOS patients. Oocytes at ...
Source: Reproductive Biology - June 21, 2022 Category: Reproduction Medicine Authors: Lingling Gao Siying Wang Jianbo Xu Dan Lu Yugui Cui Source Type: research
Activin a promotes hyaluronan production and upregulates versican expression in human granulosa cells via the ALK4-SMAD2/3-SMAD4 signaling pathway
Biol Reprod. 2022 Apr 9:ioac070. doi: 10.1093/biolre/ioac070. Online ahead of print.ABSTRACTHyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 (HAS2) is the major enzyme for the synthesis of hyaluronan in humans. Versican cross-links the hyaluronan-rich matrix to cumulus cells and is critical for successful ovulation. Activin A is a critical intrafollicular regulator of ovarian function. Although activin A has been shown to promote cumulus matrix expansion in mice, the functional role of activin A in the regulation of cumulus expansion in the human ovary remains to be elucidated....
Source: Biology of Reproduction - April 11, 2022 Category: Reproduction Medicine Authors: Shen Tian Han Zhang Hsun-Ming Chang Christian Klausen He-Feng Huang Min Jin Peter C K Leung Source Type: research
Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells
CONCLUSIONS: Our findings provide new insight into the molecular mechanism by which BMP2 promotes the production of hyaluronan in human granulosa cells.PMID:35395768 | DOI:10.1186/s12958-022-00937-y
Source: Reproductive Biology - April 9, 2022 Category: Reproduction Medicine Authors: Hsun-Ming Chang Long Bai Yi-Min Zhu Peter C K Leung Source Type: research
NDRG1 is expressed in human granulosa cells: An implicative role of NDRG1 in the ovary
CONCLUSIONS: These results indicate that ovarian NDRG1 may play important roles in follicular development, especially in the early luteinization of pre-ovulatory follicles.PMID:35386369 | PMC:PMC8967294 | DOI:10.1002/rmb2.12437
Source: Reproductive Biology - April 7, 2022 Category: Reproduction Medicine Authors: Akemi Nishigaki Hiroaki Tsubokura Mitsuaki Ishida Yoshiko Hashimoto Aya Yoshida Yoji Hisamatsu Tomoko Tsuzuki-Nakao Hiromi Murata Hidetaka Okada Source Type: research
Aquaporin 9 regulates Leydig cell steroidogenesis in diabetes
Syst Biol Reprod Med. 2022 Mar 30:1-14. doi: 10.1080/19396368.2022.2033350. Online ahead of print.ABSTRACTDiabetes mellitus induced hyperglycemia increases oxidative stress, which contributes to impairment of male reproductive function. Aquaporins (AQPs) belong to a transmembrane protein superfamily containing 13 isoforms (AQP0-12), differentially expressed in various organs, and play a pivotal role in male reproductive function. In the current study, we investigated the relationship between AQPs and testicular steroidogenesis under hyperglycemia in vivo and in vitro. The effect of high glucose on the role of AQPs in Leydi...
Source: Systems Biology in Reproductive Medicine - March 30, 2022 Category: Reproduction Medicine Authors: Arun Kannan Lezy Flora Mariajoseph-Antony Antojenifer Panneerselvam Chithra Loganathan Diwakar Kiduva Jothiraman Kumarasamy Anbarasu Chidambaram Prahalathan Source Type: research
