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Specialty: Reproduction Medicine
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Total 316 results found since Jan 2013.
Sialyl Lewis X mediates interleukin-1 beta induced trophoblast adhesion to endometrial cells during human embryo implantation
Biol Reprod. 2023 Jan 16:ioad007. doi: 10.1093/biolre/ioad007. Online ahead of print.ABSTRACTCell surface carbohydrate antigens sialyl Lewis X (sLeX) and Lewis Y (LeY) are paramount glycoconjugates and are abundantly expressed in the receptive endometrium. Furthermore, among the important biological functions of both antigens is their role in leukocytes adhesion and extravasation. Interleukin-1 beta (IL-1β) is involved in the process of human embryo implantation and placenta development. Here we used an in vitro model to investigate whether sLeX and LeY are playing a role in the embryo implantation process mediated by IL-...
Source: Biology of Reproduction - January 17, 2023 Category: Reproduction Medicine Authors: Zhi Ma Mirjana Kessler Anca Chelariu-Raicu Markus Sperandio Sven Mahner Udo Jeschke Viktoria von Sch önfeldt Source Type: research
TGF- β1 induces type I collagen deposition in granulosa cells via the AKT/GSK-3β signaling pathway-mediated MMP1 down-regulation
This study aimed to investigate the molecular mechanisms through which TGF-β1 regulates MMP1 expression and type I collagen deposition in GCs. Our results show that TGF-β1 upregulates COL1A1 expressions and downregulates MMP1 expression. Inhibition approaches, including pharmacological inhibitors such as p38 inhibitor (SB203580), ERK1/2 inhibitor (U0126), AKT inhibitor (LY294002), and GSK-3β inhibitor (LiCl), as well as knockdown using siRNA specific to these genes, were used. Our results suggest that TGF-β1 decreases MMP1 production via an ALK5-mediated AKT/GSK-3β-dependent signaling pathway, and a decrease in MMP1 l...
Source: Reproductive Biology - October 29, 2022 Category: Reproduction Medicine Authors: Jie Shen Zeping Wang Weimin Zhao Yanfeng Fu Bixia Li Jinhua Cheng Yanfei Deng Saijiao Li Hui Li Source Type: research
HIF-1 α is Essential for the Augmentation of Myometrial Contractility during Labor
In this study, transcriptomes revealed that hypoxia-inducible factor (HIF)-1α was up-regulated in laboring myometrial biopsies, while blockade of HIF-1α decreased the contractility of the myometrium and myocytes in vitro via siRNA and the inhibitor, 2-methoxyestradiol. Chromatin immunoprecipitation sequencing revealed that HIF-1α directly binds to the genome of contraction-associated proteins: the promoter of GJA1 and PTGS2, and the intron of OXTR. Silencing the HIF-1α reduced the expression of PTGS2, GJA1, and OXTR. Furthermore, blockade of GJA1 or PTGS2 led to a significant decrease in myometrial contractions in the ...
Source: Reproductive Biology - September 12, 2022 Category: Reproduction Medicine Authors: Bolun Wen Zheng Zheng Lele Wang Xueya Qian Xiaodi Wang Yunshan Chen Junjie Bao Yanmin Jiang J I Kaiyuan Huishu Liu Source Type: research
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway
CONCLUSIONS: These findings suggest that SIRT1 pathway plays essential roles in the pleiotropic actions of melatonin on Leydig cells and in the prevention of hyperglycaemia-induced steroidogenic dysfunction. The stimulatory action of melatonin on SIRT1 pathway is related to oxidative stress and its antioxidant property. Our data provide new evidence for the relationship of melatonin and SIRT1 pathway in the context of hyperglycaemia, and melatonin as a combination therapy may be useful to combat DM-related complications, especially male reproductive system injury.PMID:35962432 | DOI:10.1186/s12958-022-00991-6
Source: Reproductive Biology - August 12, 2022 Category: Reproduction Medicine Authors: Ping Wang Shoubing Zhang Shuai Lin Zhengmei Lv Source Type: research
