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Specialty: Reproduction Medicine

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Total 316 results found since Jan 2013.

ORP9 Knockdown Delays the Maturation of Junction Related Endocytic Structures in the Testis and Leads to Impaired Sperm Release †.
ORP9 Knockdown Delays the Maturation of Junction Related Endocytic Structures in the Testis and Leads to Impaired Sperm Release†. Biol Reprod. 2020 Sep 09;: Authors: Adams A, Vogl W Abstract The release of late spermatids from the seminiferous epithelium requires the internalization of intercellular junctions by Sertoli cell specific structures called 'tubulobulbar complexes' (TBCs). These large, endocytic devices likely evolved from classic clathrin-mediated endocytosis machinery (CME), but have several important morphological differences to CME vesicles. Most notable among these differences is tha...
Source: Biology of Reproduction - September 8, 2020 Category: Reproduction Medicine Authors: Adams A, Vogl W Tags: Biol Reprod Source Type: research

miR-4463 regulates aromatase expression and activity for 17 β-estradiol synthesis in response to follicle-stimulating hormone.
Conclusion: In this study, we identified differentially expressed miRNAs related to FSH responsiveness. In particular, upregulation of miR-4463 expression by FSHR deficiency in human granulosa cells impaired 17β-estradiol synthesis by targeting CYP19A1 and ESR1. Therefore, our data might provide novel candidates for molecular biomarkers for use in research into poor responders. PMID: 32854459 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Reproductive Medicine - August 30, 2020 Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research

Embryonic MTHFR contributes to blastocyst development
ConclusionThe results indicate that embryonic MTHFR is indispensable for normal blastocyst development. The findings provide insight into the debatable roles of MTHFR in fertility and may be applicable for the improvement of care for early embryos via modulation of surrounding folate-related nutritional conditions in vitro and/or in utero, depending on the parental and embryonicMTHFR genotype.
Source: Journal of Assisted Reproduction and Genetics - August 6, 2020 Category: Reproduction Medicine Source Type: research

Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity.
CONCLUSION: Together, our data revealed that CDH6 was dysregulated in the endometrium from women with infertility and altered Ishikawa cell adhesive capacity. Our study supports a role for CDH6 in regulating endometrial adhesion and implantation. PMID: 32600462 [PubMed - in process]
Source: Reproductive Biology - June 28, 2020 Category: Reproduction Medicine Authors: Zhou W, Santos L, Dimitriadis E Tags: Reprod Biol Endocrinol Source Type: research

Spatiotemporal expression of aquaporin 9 is critical for the antral growth of mouse ovarian follicles ††.
Spatiotemporal expression of aquaporin 9 is critical for the antral growth of mouse ovarian follicles††. Biol Reprod. 2020 Jun 24;: Authors: Lee SE, Kang HK, Ryou C, Cheon YP Abstract Although a few aquaporins (AQPs) expressed in granulosa cells have been postulated to mediate fluid passage into the antrum, the specific expression of AQPs in different follicle cell types and stages and their roles have not been evaluated extensively. The spatiotemporal expression of aquaporin (Aqp) 7, 8, and 9 and the functional roles of Aqp9 in antral growth and ovulation were examined using a superovulation mode...
Source: Biology of Reproduction - June 23, 2020 Category: Reproduction Medicine Authors: Lee SE, Kang HK, Ryou C, Cheon YP Tags: Biol Reprod Source Type: research

Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus †.
In this study, we employed PGR knockout mice (PRKO) and steroid receptor coactivator-1 knockout mice (SRC-1-/-) to profile the expression of Il13ra2 in the murine endometrium and determine the role of these transcriptional regulators in the hormone-responsiveness of Il13ra2 expression. Furthermore, we utilized a well-established decidualization-inducing steroidogenic cocktail and a siRNA-based knockdown of IL13RA2 to determine the importance of IL13RA2 in the decidualization of primary human endometrial stromal cells. Our findings demonstrate that Il13ra2 is expressed in the sub-epithelial stroma of the murine endometrium ...
Source: Biology of Reproduction - June 18, 2020 Category: Reproduction Medicine Authors: Marquardt RM, Lee K, Kim TH, Lee B, DeMayo FJ, Jeong JW Tags: Biol Reprod Source Type: research

Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development
ConclusionsThese results suggest that mouseNlrp9b, as a maternal effect gene, could contribute to mouse preimplantation embryo development. It remains to investigate whether NLRP9 have a crucial role in human preimplantation embryo and infertility.
Source: Journal of Assisted Reproduction and Genetics - May 11, 2020 Category: Reproduction Medicine Source Type: research

hCG improves luteal function and promotes progesterone output through the activation of JNK pathway in the luteal granulosa cells of the stimulated IVF cycles.
Abstract Human chorionic gonadotropin (hCG) is a luteotropic hormone that promotes the survival and steroidogenic activity of corpus luteum by acting through LH receptors expressed on luteinized theca and granulosa cells. Therefore, it is used to support luteal phase in IVF cycles in order to improve clinical pregnancy rates and prevent miscarriage. However, the molecular mechanism underlying this action of hCG is not well-characterized. To address this question we designed an in vitro translational research study on the luteal granulosa cells (GCs) obtained from 58 IVF patients. hCG treatment at different concent...
Source: Reproductive Biology - March 11, 2020 Category: Reproduction Medicine Authors: Bildik G, Akin N, Esmaeilian Y, Hela F, Yakin K, Onder T, Urman B, Oktem O Tags: Biol Reprod Source Type: research

Role of vaspin in porcine ovary: effect on signaling pathways and steroid synthesis via GRP78 receptor and protein kinase A.
Abstract Vaspin, visceral adipose tissue-derived serine protease inhibitor, is involved in the development of obesity, insulin resistance, inflammation and energy metabolism. Our previous study showed vaspin expression and its regulation in the ovary; however, the role of this adipokine in ovarian cells has never been studied. Here, we studied in vitro the effect of vaspin on various kinase signaling pathways: mitogen-activated kinase (MAP3/1), serine/threonine kinase (AKT), signal transducer and activator of transcription 3 (STAT3) protein kinase AMP (PRKAA1), protein kinase A (PKA) and on expression of nuclear f...
Source: Biology of Reproduction - March 8, 2020 Category: Reproduction Medicine Authors: Kurowska P, Mlyczyńska E, Dawid M, Dupont J, Rak A Tags: Biol Reprod Source Type: research

Fibrinogen alpha chain is up-regulated and affects the pathogenesis of endometriosis
ConclusionsHigh FGA expression in endometriosis was closely related to disease severity and affected cell adhesion, migration and invasion, which might play an important role in the pathogenesis of endometriosis.
Source: Reproductive BioMedicine Online - December 12, 2019 Category: Reproduction Medicine Source Type: research

Reduced expression of PD-L1 in autoimmune thyroiditis attenuate trophoblast invasion through ERK/MMP pathway.
CONCLUSION: AIT inhibits ERK/MMP-2 and MMP-9 pathways through PD-L1 reduction, attenuates embryonic trophoblast invasion and ultimalely induces miscarriage ultimately. PMID: 31656199 [PubMed - in process]
Source: Reproductive Biology - October 26, 2019 Category: Reproduction Medicine Authors: Chen M, Gilbert N, Liu H Tags: Reprod Biol Endocrinol Source Type: research

CTHRC1 Overexpression Promotes Ectopic Endometrial Stromal Cell Proliferation, Migration and Invasion via Activation of Wnt/β-catenin Pathway
ConclusionsThese findings suggest that CTHRC1 may be partly responsible for the development and progression of endometriosis by increasing EESC proliferation, migration and invasion via Wnt/β-catenin pathway, and thus serves as a diagnostic and therapeutic target for endometriosis.
Source: Reproductive BioMedicine Online - October 10, 2019 Category: Reproduction Medicine Source Type: research

The distribution and expression of vascular endothelial growth factor A (VEGFA) during follicular development and atresia in the pig.
This study investigated the distribution and expression of VEGFA during porcine follicular development and atresia. Pig ovaries were obtained, individual medium-sized (3-5mm in diameter) antral follicles were separated and classified into healthy, early atretic or progressively atretic groups. Immunobiology and quantitative techniques were used to investigate the varied follicular distribution of VEGFA at both the morphological and molecular level. The results indicated that VEGFA protein expression peaked in tertiary follicles, mostly distributed in the thecal and inner granulosa layers, during follicular development whil...
Source: Reproduction, Fertility, and Development - September 23, 2019 Category: Reproduction Medicine Authors: Gao X, Zhang J, Pan Z, Li Q, Liu H Tags: Reprod Fertil Dev Source Type: research

Fibrinogen alpha chain is upregulated and affects the pathogenesis of endometriosis
ConclusionsHigh expression of FGA in EM was closely related to disease severity and affected cell adhesion, migration, and invasion, which might play an important role in the pathogenesis of EM.
Source: Reproductive BioMedicine Online - August 21, 2019 Category: Reproduction Medicine Source Type: research

FoxO transcription factors 1 regulate mouse preimplantation embryo development
ConclusionsThese results suggest that FOXO transcription factors could contribute to mouse preimplantation embryo development, and it remains to investigate whether they have crucial roles in human preimplantation embryo and infertility.
Source: Journal of Assisted Reproduction and Genetics - August 7, 2019 Category: Reproduction Medicine Source Type: research