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Specialty: Reproduction Medicine
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Total 316 results found since Jan 2013.
The role of PGRMC2 in the trophoblast invasion
In conclusion, PGRMC2 plays a role in placentation by promoting cell proliferation, invasion, and angiogenesis in EVTs via activation of HIF1α signaling. We thus identified a new function of PGRMC2 and provide insights on understanding the mechanisms of trophoblast invasion.PMID:37665239 | DOI:10.1093/biolre/ioad109
Source: Reproductive Biology - September 4, 2023 Category: Reproduction Medicine Authors: Tae Yokouchi-Konishi Yongjie Liu Liping Feng Source Type: research
Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation
Biol Reprod. 2023 Sep 2:ioad108. doi: 10.1093/biolre/ioad108. Online ahead of print.ABSTRACTSpexin (SPX) is a novel neuropeptide and adipokine negatively correlated with obesity and insulin resistance. A recent study investigated expression and regulatory function of SPX in the hypothalamus and pituitary; however, the effect on ovarian function is still unknown. The aim of this study was to characterize the expression of SPX and its receptors, galanin receptors 2 and 3 (GALR2/3) in the human ovary and to study its in vitro effect on granulosa cells (GC) function. Follicular fluid (FF) and GC were obtained from normal weigh...
Source: Reproductive Biology - September 2, 2023 Category: Reproduction Medicine Authors: Patrycja Kurowska Monika Dawid Julia Oprocha Natalia Repekta Lo ïse Serra Anthony Estienne Piotr Pawlicki Ma łgorzata Kotula-Balak Fabrice Gu érif Joelle Dupont Agnieszka Rak Source Type: research
Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia
CONCLUSIONS: Placental PEG10 is reduced in patients with early-onset preeclampsia. In vitro studies suggest that hypoxia and inflammation may contribute to PEG10 downregulation. Reduced PEG10 alters canonical TGF-[Formula: see text] signalling, and thus may be involved in trophoblast dysfunction associated with this pathway.PMID:37464405 | PMC:PMC10355026 | DOI:10.1186/s12958-023-01116-3
Source: Reproductive Biology - July 18, 2023 Category: Reproduction Medicine Authors: Lydia Baird Ping Cannon Manju Kandel Tuong-Vi Nguyen Anna Nguyen Georgia Wong C íara Murphy Fiona C Brownfoot Elif Kadife Natalie J Hannan Stephen Tong Lucy A Bartho Tu'uhevaha J Kaitu'u-Lino Source Type: research
NRF2 protects against ROS-induced preterm premature rupture of membranes through regulation of mitochondria †
Biol Reprod. 2023 Jul 10:ioad075. doi: 10.1093/biolre/ioad075. Online ahead of print.ABSTRACTPreterm premature rupture of membranes (pPROM) is a major cause of preterm birth and neonatal mortality. Reactive oxygen species (ROS) have been identified as a critical factor in the development of pPROM. Mitochondria are known to be the primary source of ROS and play a vital role in maintaining cellular function. The Nuclear erythroid 2-related factor 2 (NRF2) has been demonstrated to play a crucial role in regulating mitochondrial function. However, research exploring the impact of NRF2-regulated mitochondria on pPROM is limited...
Source: Reproductive Biology - July 10, 2023 Category: Reproduction Medicine Authors: Xinyuan Zhang Xiao He Linna Wei Yang He Yunlong Li Yingxiong Wang Chunli Li Source Type: research
