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Specialty: Reproduction Medicine
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Total 316 results found since Jan 2013.
Aquaporin 9 regulates Leydig cell steroidogenesis in diabetes
Syst Biol Reprod Med. 2022 Mar 30:1-14. doi: 10.1080/19396368.2022.2033350. Online ahead of print.ABSTRACTDiabetes mellitus induced hyperglycemia increases oxidative stress, which contributes to impairment of male reproductive function. Aquaporins (AQPs) belong to a transmembrane protein superfamily containing 13 isoforms (AQP0-12), differentially expressed in various organs, and play a pivotal role in male reproductive function. In the current study, we investigated the relationship between AQPs and testicular steroidogenesis under hyperglycemia in vivo and in vitro. The effect of high glucose on the role of AQPs in Leydi...
Source: Systems Biology in Reproductive Medicine - March 30, 2022 Category: Reproduction Medicine Authors: Arun Kannan Lezy Flora Mariajoseph-Antony Antojenifer Panneerselvam Chithra Loganathan Diwakar Kiduva Jothiraman Kumarasamy Anbarasu Chidambaram Prahalathan Source Type: research
Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells
CONCLUSIONS: This study increases the understanding of the biological function of GDF-11 and provides important insights into the regulation of ovarian steroidogenesis.PMID:35183204 | DOI:10.1186/s12958-022-00912-7
Source: Reproductive Biology - February 20, 2022 Category: Reproduction Medicine Authors: Qiongqiong Jia Boqun Liu Xuan Dang Yanjie Guo Xiaoyu Han Tinglin Song Jung-Chien Cheng Lanlan Fang Source Type: research
Protective role of Cytoglobin and Neuroglobin against the Lipopolysaccharide (LPS)-induced inflammation in Leydig cells ex vivo
Reprod Biol. 2022 Feb 1;22(1):100595. doi: 10.1016/j.repbio.2021.100595. Online ahead of print.ABSTRACTLeydig cells are responsible for testosterone production in male testis upon stimulation by luteinizing hormone. Inflammation and oxidative stress related Leydig cell dysfunction is one of the major causes of male infertility. Cytoglobin (CYGB) and Neuroglobin (NGB) are two globin family member proteins which protect cells against oxidative stress. In the current study, we established a Lipopolysaccharide (LPS)-induced inflammation model in TM3 Leydig cell culture to study the function of CYGB and NGB proteins under infla...
Source: Reproductive Biology - February 5, 2022 Category: Reproduction Medicine Authors: Derya Sa ğraç Selinay Şenkal Taha Bartu Hayal Selami Demirci Hatice Burcu Şişli Ayla Bur çin Asutay Ay şegül Doğan Source Type: research
TGF- β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway
CONCLUSIONS: By illustrating the potential physiological role of TGF-β1 in the regulation of kisspeptin expression, our results may serve to improve current strategies used to treat placental diseases.PMID:35101033 | DOI:10.1186/s12958-022-00902-9
Source: Reproductive Biology - February 1, 2022 Category: Reproduction Medicine Authors: Lanlan Fang Yang Yan Yibo Gao Ze Wu Zhen Wang Sizhu Yang Jung-Chien Cheng Ying-Pu Sun Source Type: research
The Interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells
Biol Reprod. 2022 Jan 29:ioac020. doi: 10.1093/biolre/ioac020. Online ahead of print.ABSTRACTAs a critical paracrine regulator of multiple reproductive functions, the cytokine interleukin-6 (IL-6) is expressed in human granulosa cells and can be detected in follicular fluid. At present, the functional role of IL-6 in the regulation of ovarian steroidogenesis is controversial. Moreover, the detailed molecular mechanisms by which IL-6 regulates the production of progesterone in human granulosa cells remain to be elucidated. In the present study, we used primary and immortalized human granulosa-lutein (hGL) cells to investiga...
Source: Biology of Reproduction - January 31, 2022 Category: Reproduction Medicine Authors: Sai-Jiao Li Hsun-Ming Chang Jeremy H Wang Jing Yang Peter C K Leung Source Type: research
Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis
CONCLUSIONS: The testicular zinc transporter ZIP12 expression levels especially in spermatogonia and spermatozoa are higher than in other tissues. ZIP12 may play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis which help counteract declines in male fertility.PMID:35065654 | PMC:PMC8783530 | DOI:10.1186/s12958-022-00893-7
Source: Reproductive Biology - January 23, 2022 Category: Reproduction Medicine Authors: Xinye Zhu Chengxuan Yu Wangshu Wu Lei Shi Chenyi Jiang Li Wang Zhide Ding Yue Liu Source Type: research
HOXA10 improves endometrial receptivity by upregulating E-cadherin
In conclusion, HOXA10 can bind to the E-cadherin promoter region and directly regulate its expression, thereby improving endometrial receptivity and subsequently increasing the embryo adhesion and implantation.PMID:35044439 | DOI:10.1093/biolre/ioac007
Source: Reproductive Biology - January 19, 2022 Category: Reproduction Medicine Authors: Yin Bi Weiyu Huang Lifang Yuan Saiqiong Chen Shengbin Liao Xiaoqian Fu Bo Liu Yihua Yang Source Type: research
