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Specialty: Reproduction Medicine

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Total 316 results found since Jan 2013.

Cortactin knockdown results in disruption of basal TBCs and alters turnover of Sertoli cell ESs in R. norvegicus
Biol Reprod. 2021 Aug 23:ioab161. doi: 10.1093/biolre/ioab161. Online ahead of print.ABSTRACTHere we explore the prediction that long-term knockdown of cortactin (CTTN), a component of tubulobulbar complexes (TBCs), disrupts TBCs in Sertoli cells and alters the turnover of basal ectoplasmic specializations (ESs). In rats, intratesticular injections of siRNA targeting CTTN (siCTTN) in one testis and non-targeting siRNA (siControl) in the contralateral testis were done on days 0, 2, 4, 6, and 8. The experiment was terminated on day 9 and testes were analyzed by either Western Blotting, or by stimulated emission depletion (ST...
Source: Biology of Reproduction - August 24, 2021 Category: Reproduction Medicine Authors: Prunveer Palia Arlo Adams Aarati Sriram A Wayne Vogl Source Type: research

Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells
This study explored the molecular mechanism underlying the effects of dexamethasone (DEX, 1µM) on glucose transporters (GLUT) in JEG-3 human placental choriocarcinoma cells. JEG-3 cells were treated with DEX, an expression plasmid encoding human glucocorticoid receptor α (GRα), pcDNA3.1-GRα, GRα short interference (si) RNA, LY294002, xanthine oxidase (XO)/hypoxanthine (HX), rapamycin, insulin-like growth factor (IGF) 1, N-acetylcysteine (NAC) or phosphatidic acid (PA), and cell proliferation, apoptosis, mitochondrial membrane potential (MMP), human chorionic gonadotrophin (hCG) content, human placental lactogen (hPL) ...
Source: Reproduction, Fertility, and Development - August 16, 2021 Category: Reproduction Medicine Authors: Xin Zhan Yiran Xie Liping Sun Qi Si Hongkai Shang Source Type: research

O-145 Green Tea catechins EGCG and pro-drug of EGCG (Pro-EGCG) inhibit endometriosis through targeting molecules regulating macrophages and B cells
This study shows that macrophage and B cell could be potential therapeutic targets for treatment of endometriosis, which opens up new horizon for the novel immunotherapy for endometriosis.Trial registration numberNA
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

P-556 Pre-selected for an award: NAT10-mediated N4-acetylcytidine in RNA regulates mouse oocyte maturation in vitro
This study was performed in vitro. The role of NAT10-mediated ac4C in vivo remains to be elucidated. Also, limited by current techniques, ac4C modification in oocytes cannot be detected. Our exploration of regulated genes and ac4C binding proteins were performed in somatic cell lines.Wider implications of the findingsPost-transcriptional modulation is crucial in oocyte maturation. Our study using in-vitro systems for mouse oocyte identified NAT10-mediated ac4C as an important regulator in IVM. It provided a new insight into the epigenetic mechanisms of IVM, which may lead to improvement of clinical IVM systems.Trial regist...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

P –556 NAT10-mediated N4-acetylcytidine in RNA regulates mouse oocyte maturation in vitro
This study was performed in vitro. The role of NAT10-mediated ac4C in vivo remains to be elucidated. Also, limited by current techniques, ac4C modification in oocytes cannot be detected. Our exploration of regulated genes and ac4C binding proteins were performed in somatic cell lines.Wider implications of the findings: Post-transcriptional modulation is crucial in oocyte maturation. Our study using in-vitro systems for mouse oocyte identified NAT10-mediated ac4C as an important regulator in IVM. It provided a new insight into the epigenetic mechanisms of IVM, which may lead to improvement of clinical IVM systems.Trial regi...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

Overexpressed MPS-1 contributes to endometrioma development through the NF- κB signaling pathway
CONCLUSION: MPS-1 can regulate EcESCs proliferation, motility, invasion, apoptosis, and cell cycle via the NF-κB signaling pathway in endometrioma. This may contribute to the formation or development of endometriotic foci. This study suggests the potential role of MPS-1 in the pathogenesis of endometriosis and enabled further research into the use of MPS-1 in the clinical diagnosis of endometrioma.PMID:34266426 | PMC:PMC8281640 | DOI:10.1186/s12958-021-00796-z
Source: Reproductive Biology - July 16, 2021 Category: Reproduction Medicine Authors: Yang Liu Junyan Ma Liqi Zhang Jun Lin Xiaohua Liu Source Type: research

The IL6/sIL-6R α trans-signaling increases PGE2 production in human granulosa cells
In conclusion, IL6 trans-signaling upregulates the expression of PTGS2 and increases the production of PGE2 via the JAK2/STAT3/SOCS3 signaling pathway in hGL cells. Our findings provide insights into the molecular mechanisms by which IL6 trans-signaling may potentially modulate the event of ovulation in human ovaries.PMID:34198336 | DOI:10.1093/biolre/ioab128
Source: Reproductive Biology - July 1, 2021 Category: Reproduction Medicine Authors: Sai-Jiao Li Hsun-Ming Chang Jiamin Xie Jeremy H Wang Jing Yang Peter C K Leung Source Type: research