Women self-reporting PCOS symptoms should not be overlooked
Sir, (Source: Human Reproduction)
Source: Human Reproduction - November 26, 2022 Category: Reproduction Medicine Source Type: research
Exploring the natural history of polycystic ovary syndrome: still a long road to traverse
I read with keen interest the systematic review byKiconcoet al. (2022) that makes a sincere effort to throw light on the understanding of the natural history of polycystic ovary syndrome (PCOS). The authors found that there was consistent evidence, though from limited studies, that the level of total testosterone and dehydroepiandrosterone sulfate declined to a greater degree and the risk of gestational diabetes was higher in women with PCOS as compared to those without it. However, the evidence was found to be conflicting or insufficient for the other outcomes which are more likely to have practical long-term implications...
Source: Human Reproduction - November 26, 2022 Category: Reproduction Medicine Source Type: research
Reply: Where are we in understanding the natural history of polycystic ovary syndrome? A systematic review of longitudinal cohort studies
Australian National Health and Medical Research (Source: Human Reproduction)
Source: Human Reproduction - November 26, 2022 Category: Reproduction Medicine Source Type: research
Ethinylestradiol in combined hormonal contraceptive has a broader effect on serum proteome compared with estradiol valerate: a randomized controlled trial
AbstractSTUDY QUESTIONDoes an estradiol-based combined oral contraceptive (COC) have a milder effect on the serum proteome than an ethinylestradiol (EE)-based COC or dienogest (DNG) only?SUMMARY ANSWERThe changes in serum proteome were multifold after the use of a synthetic EE-based COC compared to natural estrogen COC or progestin-only preparation.WHAT IS KNOWN ALREADYEE-based COCs widely affect metabolism, inflammation, hepatic protein synthesis and blood coagulation. Studies comparing serum proteomes after the use of COCs containing EE and natural estrogens are lacking.STUDY DESIGN, SIZE, DURATIONThis was a spin-off fro...
Source: Human Reproduction - November 23, 2022 Category: Reproduction Medicine Source Type: research
IL-10 is not anti-fibrotic but pro-fibrotic in endometriosis: IL-10 treatment of endometriotic stromal cells in vitro promotes myofibroblast proliferation and collagen type I protein expression
This study was supported in part by KARL STORZ SE& Co. KG (Tuttlingen, Germany). The authors have no conflict of interest to disclose. (Source: Human Reproduction)
Source: Human Reproduction - November 22, 2022 Category: Reproduction Medicine Source Type: research
Human spermatogonial stem cells and their niche in male (in)fertility: novel concepts from single-cell RNA-sequencing
AbstractThe amount of single-cell RNA-sequencing (scRNA-seq) data produced in the field of human male reproduction has steadily increased. Transcriptional profiles of thousands of testicular cells have been generated covering the human neonatal, prepubertal, pubertal and adult period as well as different types of male infertility; the latter include non-obstructive azoospermia, cryptozoospermia, Klinefelter syndrome and azoospermia factor deletions. In this review, we provide an overview of transcriptional changes in different testicular subpopulations during postnatal development and in cases of male infertility. Moreover...
Source: Human Reproduction - November 21, 2022 Category: Reproduction Medicine Source Type: research
IVF characteristics and the molecular luteal features of random start IVF cycles are not different from conventional cycles in cancer patients
AbstractSTUDY QUESTIONAre the IVF parameters and the steroidogenic luteal characteristics of random-start IVF cycles different from conventional cycles in cancer patients?SUMMARY ANSWERNo; controlled ovarian stimulation cycles randomly started at late follicular phase (LFP) and luteal phase (LP) are totally comparable to those conventional IVF cycles started at early follicular phase (EFP) in terms of the expression of the enzymes involved in cholesterol utilization and steroid hormone biosynthesis pathways, gonadotropin receptor expression and, estradiol (E2) and progesterone (P4) production in addition to the similaritie...
Source: Human Reproduction - November 11, 2022 Category: Reproduction Medicine Source Type: research
LH increases the response to FSH in granulosa-lutein cells from sub/poor-responder patients in vitro
In conclusion, FSH elicits phenotype-specific ovarian lutein cell response. Most importantly, LH addition may fill the gap between cAMP and steroid production patterns between normo- and sub/poor-responders.LIMITATIONS, REASONS FOR CAUTIONAlthough the number of experimental replicates is overall high for anin vitro study, clinical trials are required to demonstrate if the endpoints evaluated herein reflect parameters of successful ART. hGLC retrieved after ovarian stimulation may not fully reproduce the response to hormones of granulosa cells from the antral follicular stage.WIDER IMPLICATIONS of THE FINDINGSThisin vitro a...
Source: Human Reproduction - November 11, 2022 Category: Reproduction Medicine Source Type: research
Single-cell profiling reveals mechanisms of uncontrolled inflammation and glycolysis in decidual stromal cell subtypes in recurrent miscarriage
This study was supported by the Strategic Priority Research Program (No. XDB29030302), Frontier Science Key Research Project (QYZDB-SSW-SMC036), Chinese Academy of Sciences; National Key Research and Development Program of China (2021YFE0200600), National Natural Science Foundation of China (No. 31770960), Shanghai Municipal Science and Technology Major Project (No. 2019SHZDZX02, HS2021SHZX001), and Shanghai Committee of Science and Technology (17411967800). All authors report no conflict of interest. (Source: Human Reproduction)
Source: Human Reproduction - November 10, 2022 Category: Reproduction Medicine Source Type: research
IQUB deficiency causes male infertility by affecting the activity of p-ERK1/2/RSPH3
AbstractSTUDY QUESTIONCan new genetic factors responsible for male infertility be identified, especially for those characterized by asthenospermia despite normal sperm morphology?SUMMARY ANSWERWe identified the novel pathogenetic gene IQ motif and ubiquitin-like domain-containing (IQUB) as responsible for male infertility characterized by asthenospermia, involving sperm radial spoke defects.WHAT IS KNOWN ALREADYTo date, only a few genes have been found to be responsible for asthenospermia with normal sperm morphology.Iqub, encoding the IQUB protein, is highly and specifically expressed in murine testes and interacts with t...
Source: Human Reproduction - November 10, 2022 Category: Reproduction Medicine Source Type: research
The human embryonic genome is karyotypically complex, with chromosomally abnormal cells preferentially located away from the developing fetus
AbstractSTUDY QUESTIONAre chromosome abnormalities detected at Day 3 post-fertilization predominantly retained in structures of the blastocyst other than the inner cell mass (ICM), where chromosomally normal cells are preferentially retained?SUMMARY ANSWERIn human embryos, aneuploid cells are sequestered away from the ICM, partly to the trophectoderm (TE) but more significantly to the blastocoel fluid within the blastocoel cavity (Bc) and to peripheral cells (PCs) surrounding the blastocyst during Day 3 to Day 5 progression.WHAT IS KNOWN ALREADYA commonly held dogma in all diploid eukaryotes is that two gametes, each with ...
Source: Human Reproduction - November 9, 2022 Category: Reproduction Medicine Source Type: research
The effect of the menstrual cycle on the circulating microRNA pool in human plasma: a pilot study
This study was supported by the Clinique romande de r éadaptation, Sion, Switzerland. S.L. was supported by an Australian Research Council (ARC) Future Fellowship (FT10100278). D.H. was supported by an Executive Dean’s Postdoctoral Research Fellowship from Deakin University. The authors declare no competing interests. (Source: Human Reproduction)
Source: Human Reproduction - November 9, 2022 Category: Reproduction Medicine Source Type: research
Urinary phenol concentrations and fecundability and early pregnancy loss
This study is the first to use repeated pooled measures to summarize phenol exposure and the first to investigate associations with fecundability and early pregnancy loss. Within-person phenol concentration variability underscores the importance of collecting repeated samples for future studies. Exposure misclassification could contribute to differences between the findings of this study and those of other studies, all of which used one urine sample to assess phenol exposure. This study also contributes to the limited literature probing potential associations between environmental exposures and early pregnancy loss, which ...
Source: Human Reproduction - November 8, 2022 Category: Reproduction Medicine Source Type: research
Role of apoptosis and autophagy in ovarian follicle pool decline in children and women diagnosed with benign or malignant extra-ovarian conditions
This study yields a deeper understanding of regulation of the follicle pool decline, showing for the first time that both apoptosis and autophagy pathways are involved in physiological follicle depletion, the latter being crucial before puberty. Moreover, our data showed a different response to non-physiological damage according to age, with higher apoptosis rates only in premenarchal subjects with previous CHT, confirming that this pathway is activated by drugs known to induce DNA damage in oocytes, such as alkylating agents, but not by cancer itself.STUDY FUNDING/COMPETING INTEREST(S)This study was supported by grants fr...
Source: Human Reproduction - November 8, 2022 Category: Reproduction Medicine Source Type: research
Outcomes after assisted reproductive technology in women with cancer: a systematic review and meta-analysis
AbstractSTUDY QUESTIONWhat are the associations between a history of cancer and outcomes after ART?SUMMARY ANSWERCompared to women without cancer, on average, women with cancer had a lower return for embryo transfer and a lower likelihood of clinical pregnancy and live birth after ART.WHAT IS KNOWN ALREADYSmall, single-institution studies have suggested that cancer and its treatment may negatively affect ART outcomes.STUDY DESIGN, SIZE, DURATIONWe conducted a systematic review with meta-analysis of studies comparing ART outcomes between women with and without cancer. PubMed, Embase and Scopus were searched for original, En...
Source: Human Reproduction - November 7, 2022 Category: Reproduction Medicine Source Type: research
