Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal-fetal interface
CONCLUSION: Our findings highlighted the immunomodulatory roles of E2-activated SGK1 in Th2 immune responses by priming anti-inflammatory M2 macrophages at the maternal-fetal interface, resulting in a balanced immune microenvironment during pregnancy. Our results suggest new perspectives on future preventative strategies for RPL.PMID:37226177 | DOI:10.1186/s12958-023-01102-9
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Yiyun Lou Zhujing Fu Ye Tian Minhao Hu Qijing Wang Yuanyuan Zhou Ning Wang Qin Zhang Fan Jin Source Type: research
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