Filtered By:
Condition: Obesity

This page shows you your search results in order of relevance. This is page number 4.

Order by Relevance | Date

Total 449 results found since Jan 2013.

Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity.
Abstract Hepatic glucose production is promoted by forkhead box O1 (FoxO1) under conditions of insulin resistance. The overactivity of cannabinoid receptor type 1 (CB1R) partly causes increased liver fat deposits and metabolic dysfunction in obese rodents by decreasing mitochondrial function. The aim of the present study was to investigate the role of FoxO1 in CB1R-mediated insulin resistance through the dysregulation of mitochondrial function in the livers of mice with high-fat diet (HFD)-induced obesity. For this purpose, male C57BL/6 mice were randomly assigned to groups and either fed a standard diet (ST...
Source: International Journal of Molecular Medicine - January 29, 2016 Category: Molecular Biology Authors: Chen CC, Lee TY, Kwok CF, Hsu YP, Shih KC, Lin YJ, Ho LT Tags: Int J Mol Med Source Type: research

The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells.
Authors: Shimada H, Satohisa S, Kohno T, Takahashi S, Hatakeyama T, Konno T, Tsujiwaki M, Saito T, Kojima T Abstract Lipolysis-stimulated lipoprotein receptor (LSR) has been identified as a novel molecular constituent of tricellular contacts that have a barrier function for the cellular sheet. LSR recruits tricellulin (TRIC), which is the first molecular component of tricellular tight junctions. Knockdown of LSR increases cell motility and invasion of certain cancer cells. However, the behavior and the roles of LSR in endometrial cancer remain unknown. In the present study, we investigated the behavior and roles of...
Source: Oncotarget - April 3, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Role of Leptin and SOCS3 in Inhibiting the Type I Interferon Response During Obesity
AbstractObesity provokes an imbalance in the immune system, including an aberrant type I interferon response during some viral infections and after TLR stimulation. SOCS3 overexpression and altered systemic leptin levels could be responsible for the reduced type I interferon production in people with obesity and, eventually, significantly increase the risk of viral infection. The aim of this study was to determine whether SOCS3- and leptin-induced tolerance are responsible for the reduced type I interferon production in people with obesity. SOCS3 overexpression in PBMCs from people with obesity was inhibited with the small...
Source: Inflammation - October 3, 2016 Category: Allergy & Immunology Source Type: research

1,25(OH)2 D3 attenuates hepatic steatosis by inducing autophagy in mice.
CONCLUSIONS: The data suggest that 1,25(OH)2 D3 may ameliorate hepatic steatosis by inducing autophagy by upregulating ATG16L1. PMID: 28145056 [PubMed - as supplied by publisher]
Source: Obesity - January 31, 2017 Category: Eating Disorders and Weight Management Authors: Li R, Guo E, Yang J, Li A, Yang Y, Liu S, Liu A, Jiang X Tags: Obesity (Silver Spring) Source Type: research

Activation of Nrf2-Antioxidant Signaling by 1,25-Dihydroxycholecalciferol Prevents Leptin-Induced Oxidative Stress and Inflammation in Human Endothelial Cells Biochemical, Molecular, and Genetic Mechanisms
Conclusion: Pretreatment with 1,25(OH)2D3 in the presence of a high concentration of leptin has a beneficial effect on HUVECs through the regulation of mediators of antioxidant activity and inflammation.
Source: Journal of Nutrition - April 3, 2017 Category: Nutrition Authors: Teixeira, T. M., da Costa, D. C., Resende, A. C., Soulage, C. O., Bezerra, F. F., Daleprane, J. B. Tags: Obesity and Metabolism Research Articles Biochemical, Molecular, and Genetic Mechanisms Source Type: research

ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype
Conclusions AT E2F1 –ASK1 molecularly defines a metabolically-detrimental obese sub-phenotype. Functionally, it may negatively affect AT endocrine function, linking AT stress to whole-body metabolic dysfunction.
Source: Molecular Metabolism - May 7, 2017 Category: Endocrinology Source Type: research

Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 α Signaling Axis
In conclusion, NHP regulates lipid metabolism in vivo and in vitro via FGF21 and AMPK/SIRT1/PGC-1 α signaling axis.Pharmacology 2017;100:115-126
Source: Pharmacology - May 29, 2017 Category: Drugs & Pharmacology Source Type: research

Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux
Publication date: Available online 23 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Sapir Bechor, Dikla Nachmias, Natalie Elia, Yulia Haim, Maayan Vatarescu, Alicia Leikin-Frenkel, Martin Gericke, Tanya Tarnovsky, Guy Las, Assaf Rudich Obesity promotes the biogenesis of adipose tissue (AT) foam cells (FC), which contribute to AT insulin resistance. Autophagy, an evolutionarily-conserved house-keeping process, was implicated in cellular lipid handling by either feeding and/or degrading lipid-droplets (LDs). We hypothesized that beyond phagocytosis of dead adipocytes,...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - June 24, 2017 Category: Lipidology Source Type: research

Type I collagen promotes primary cilia growth through down-regulating HDAC6-mediated autophagy in confluent mouse embryo fibroblast 3T3-L1 cells
In conclusion, col I promotes cilia growth through repressing the HDAC-autophagy pathway that can be involved in the interaction between primary cilia and col I.
Source: Journal of Bioscience and Bioengineering - August 17, 2017 Category: Biomedical Science Source Type: research

Small Interfering RNA Inhibition of Cannabanoid-1 Receptor (CB1R) for Treating Type 2 Diabetes
The invention pertains to the use of glucan encapsulated non-immunostimulatory small interfering RNAs (siRNAs) to treat type-2 diabetes. Endocannabinoids (EC) are lipid signaling molecules that act on the same cannabinoid receptors that recognize and mediate the effects of endo- and phytocannabanoids. EC receptor CB1R activation is implicated in the development of obesity and its metabolic consequences, including insulin resistance and type 2 diabetes. Beta-cell loss has been demonstrated in a Zucker diabetic fatty (ZDF) rat model of type-2 diabetes through CB1R-mediated activation of a macrophage-mediated inflammatory res...
Source: NIH OTT Licensing Opportunities - September 19, 2013 Category: Research Authors: ajoyprabhu3 Source Type: research

Glucagon-like peptide-1 analog prevents obesity-related glomerulopathy by inhibiting excessive autophagy in podocytes.
CONCLUSION: Excess autophagy in podocytes was induced by inhibition of Glut4 translocation to the plasma membrane and was involved in the pathology of ORG. GLP-1 restored insulin sensitivity and ameliorated renal injury by decreasing the level of autophagy. PMID: 29070572 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Guo H, Wang B, Li H, Ling L, Niu J, Gu Y Tags: Am J Physiol Renal Physiol Source Type: research

Downregulation of cathepsin G reduces the activation of CD4+ T cells in murine autoimmune diabetes.
Authors: Zou F, Lai X, Li J, Lei S, Hu L Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease due to progressive injury of islet cells mediated by T lymphocytes (T cells). Our previous studies have shown that only cathepsin G (CatG), not other proteases, is involved in the antigen presentation of proinsulin, and if the presentation is inhibited, the activation of CD4+ T cells induced by proinsulin is alleviated in T1DM patients, and CatG-specific inhibitor reduces the activation of CD4+ cells induced by proinsulin in T1DM patients. Therefore, we hypothesize that CatG may play an important role in the a...
Source: American Journal of Translational Research - December 10, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Expression of MicroRNA-448 and SIRT1 and Prognosis of Obese Type 2 Diabetic Mellitus Patients After Laparoscopic Bariatric Surgery
Conclusion: The results demonstrated that miR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery.Cell Physiol Biochem 2018;45:935 –950
Source: Cellular Physiology and Biochemistry - February 9, 2018 Category: Cytology Source Type: research

Erythropoietin alleviates hepatic Steatosis by activating SIRT1-mediated autophagy
Publication date: Available online 6 March 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Ting Hong, Zhijuan Ge, Ran Meng, Hongdong Wang, Pengzi Zhang, Sunyinyan Tang, Jing Lu, Tianwei Gu, Dalong Zhu, Yan Bi Erythropoietin (EPO), besides its stimulatory effect on erythropoiesis, is beneficial to insulin resistance and obesity. However, its role in hepatic steatosis remains unexplored. Activating autophagy seems a promising mechanism for improving fatty liver disease. The present study investigated the role of EPO in alleviating hepatic steatosis and sought to determine wh...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - March 7, 2018 Category: Lipidology Source Type: research

Erythropoietin alleviates hepatic Steatosis by activating SIRT1-mediated autophagy.
Abstract Erythropoietin (EPO), besides its stimulatory effect on erythropoiesis, is beneficial to insulin resistance and obesity. However, its role in hepatic steatosis remains unexplored. Activating autophagy seems a promising mechanism for improving fatty liver disease. The present study investigated the role of EPO in alleviating hepatic steatosis and sought to determine whether its function is mediated by the activation of autophagy. Here, we show that EPO decreased hepatic lipid content significantly in vivo and in vitro. Furthermore, EPO/EPO receptor (EPOR) signalling induced autophagy activation in hepatocy...
Source: Biochimica et Biophysica Acta - March 6, 2018 Category: Biochemistry Authors: Hong T, Ge Z, Meng R, Wang H, Zhang P, Tang S, Lu J, Gu T, Zhu D, Bi Y Tags: Biochim Biophys Acta Source Type: research