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Condition: Obesity
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Total 449 results found since Jan 2013.
Role of FAM57B in Adipocyte Differentiation Lipids
This report identifies a novel gene encoding Fam57b (family with sequence similarity 57, member B) as a novel peroxisome proliferator-activated receptor γ (PPARγ)-responsive transmembrane gene that is related to obesity. The gene was identified based on an integrated bioinformatics analysis of the following three expression profiling data sets: adipocyte differentiation of mouse stromal cells (ST2 cells), adipose tissues from obesity mice, and siRNA-mediated knockdown of Pparγ using ST2 cells. Fam57b consists of three variants expressed from different promoters and contains a Tram-Lag1-CLN8 domain that is related to cer...
Source: Journal of Biological Chemistry - February 15, 2013 Category: Chemistry Authors: Yamashita-Sugahara, Y., Tokuzawa, Y., Nakachi, Y., Kanesaki-Yatsuka, Y., Matsumoto, M., Mizuno, Y., Okazaki, Y. Tags: Cell Biology Source Type: research
Slit2 Exerts Anti‐Inflammatory Actions in Human Placenta and is Decreased with Maternal Obesity
ConclusionThe anti‐inflammatory effects of Slit2 in human placenta is a novel finding, and suggests that inflammatory mediators, which are increased with obesity, downregulates Slit2 to enhance placental inflammation. Given the central role of pro‐inflammatory cytokines in placental nutrient transport, our findings suggest Slit2 may play a role in fetal growth and development.
Source: American Journal of Reproductive Immunology - October 20, 2014 Category: Allergy & Immunology Authors: Ratana Lim, Martha Lappas Tags: Original Article Source Type: research
Role of PTEN in TNFα Induced Insulin Resistance.
DISCUSSION: The PTEN increase due to TNFα treatment was reversible by both PTEN siRNA knockdown and VO-OHpic treatment. Thus, PTEN is identified as a potential new therapeutic target for reducing IR in Type 2 DM.
PMID: 25918024 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - April 24, 2015 Category: Biochemistry Authors: Bulger DA, Conley J, Conner SH, Majumdar G, Solomon SS Tags: Biochem Biophys Res Commun Source Type: research
Oestrogen exerts anti-inflammation via p38 MAPK/NF-κB cascade in adipocytes
Conclusions E2 inhibits LPS-stimulated MCP-1 in adipocytes. This effect is related to the inhibition of p38 MAPK/NF-κB cascade, and ERα appears to be the dominant ER subtype in these events.
Source: Obesity Research and Clinical Practice - March 21, 2016 Category: Eating Disorders and Weight Management Source Type: research
Oestrogen exerts anti-inflammation via p38 MAPK/NF- κB cascade in adipocytes
Conclusions E2 inhibits LPS-stimulated MCP-1 in adipocytes. This effect is related to the inhibition of p38 MAPK/NF-κB cascade, and ERα appears to be the dominant ER subtype in these events.
Source: Obesity Research and Clinical Practice - November 10, 2016 Category: Eating Disorders and Weight Management Source Type: research
Zinc rescues obesity ‐induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress‐activated BCL10/CARD9/p38 MAPK pathway
In this study, we investigated the mechanisms by which zinc inactivates p38 MAPK to prevent ORCH.
Mice (4‐week old) were fed either high fat diet (HFD, 60% kcal fat) or normal diet (ND, 10% kcal fat) containing variable amounts of zinc (deficiency, normal and supplement) for 3 and 6 months. P38 MAPK siRNA and the p38 MAPK inhibitor SB203580 were used to suppress p38 MAPK activity in vitro and in vivo, respectively. HFD activated p38 MAPK and increased expression of B‐cell lymphoma/CLL 10 (BCL10) and caspase recruitment domain family member 9 (CARD9). These responses were enhanced by zinc deficiency and attenuated by zi...
Source: Journal of Cellular and Molecular Medicine - February 2, 2017 Category: Molecular Biology Authors: Shudong Wang, Junlian Gu, Zheng Xu, Zhiguo Zhang, Tao Bai, Jianxiang Xu, Jun Cai, Gregory Barnes, Qiu ‐Ju Liu, Jonathan H. Freedman, Yonggang Wang, Quan Liu, Yang Zheng, Lu Cai Tags: Original Article Source Type: research
Zinc rescues obesity-induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress-activated BCL10/CARD9/p38 MAPK pathway.
In this study, we investigated the mechanisms by which zinc inactivates p38 MAPK to prevent ORCH. Mice (4-week old) were fed either high fat diet (HFD, 60% kcal fat) or normal diet (ND, 10% kcal fat) containing variable amounts of zinc (deficiency, normal and supplement) for 3 and 6 months. P38 MAPK siRNA and the p38 MAPK inhibitor SB203580 were used to suppress p38 MAPK activity in vitro and in vivo, respectively. HFD activated p38 MAPK and increased expression of B-cell lymphoma/CLL 10 (BCL10) and caspase recruitment domain family member 9 (CARD9). These responses were enhanced by zinc deficiency and attenuated by zinc s...
Source: J Cell Mol Med - February 2, 2017 Category: Molecular Biology Authors: Wang S, Gu J, Xu Z, Zhang Z, Bai T, Xu J, Cai J, Barnes G, Liu QJ, Freedman JH, Wang Y, Liu Q, Zheng Y, Cai L Tags: J Cell Mol Med Source Type: research
Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle
In conclusion, we elucidated that ER stress induced by palmitate could increase the expression of HPS in hepatocytes and further contribute to the development of insulin resistance in skeletal muscle via EGFR/JNK-mediated pathway. Taken together, we suggest that HPS could be a therapeutic target for obesity-linked insulin resistance. Graphical abstract
Source: Molecular and Cellular Endocrinology - October 28, 2017 Category: Endocrinology Source Type: research
Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway.
CONCLUSIONS: Resveratrol prevented high-fat diet-induced muscle atrophy in aged rats by reversing mitochondrial dysfunction and oxidative stress, which was partially mediated by the PKA/LKB1/AMPK pathway. These findings indicate that resveratrol might have potential uses for the prevention and treatment of sarcopenic obesity.
PMID: 30988232 [PubMed - as supplied by publisher]
Source: Aging - April 14, 2019 Category: Biomedical Science Authors: Huang Y, Zhu X, Chen K, Lang H, Zhang Y, Hou P, Ran L, Zhou M, Zheng J, Yi L, Mi M, Zhang Q Tags: Aging (Albany NY) Source Type: research
A Novel Regulator of Preadipocyte Differentiation, Transcription Factor TCF21, Functions Partially Through Promoting LPL Expression
Discussion
Excessive fat deposition in chickens can result in many undesirable consequences within the poultry industry, including reduced feeding efficiency (Zhou et al., 2006) and decreased reproductive performance (Walzem and Chen, 2014). Thus, broiler breeders urgently require a more thorough understanding of the molecular mechanism governing chicken adipogenesis. We previously found that broilers from lean and fat lines exhibit clear differences in reproductive performance (Zhang et al., 2018). In addition, TCF21 was found to be related to testis growth and development in these broilers (Zhang et al., 2017). In mice ...
Source: Frontiers in Physiology - April 22, 2019 Category: Physiology Source Type: research
Estrogen-independent role of ER α in ovarian cancer progression induced by leptin/Ob-Rb axis.
In conclusion, our findings demonstrated that ERα, but not ERβ, is involved in leptin-induced ovarian cancer in an E2-independent manner, providing new evidence for cancer progression in obesity-associated ovarian cancer.
PMID: 31077012 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - May 9, 2019 Category: Biochemistry Authors: Ghasemi A, Saeidi J, Mohtashami M, Hashemy SI Tags: Mol Cell Biochem Source Type: research
Programmed Epigenetic DNA Methylation-Mediated Reduced Neuroprogenitor Cell Proliferation and Differentiation in Small-for-Gestational-Age Offspring
Publication date: Available online 31 May 2019Source: NeuroscienceAuthor(s): Mina Desai, Guang Han, Tie Li, Michael G. RossAbstractSmall-for-gestational age (SGA) human newborns have an increased risk of hyperphagia and obesity, as well as a spectrum of neurologic and neurobehavioral abnormalities. We have shown that the SGA hypothalamic (appetite regulatory site) neuroprogenitor cells (NPCs) exhibit reduced proliferation and neuronal differentiation. DNA methylation (DNA methyltransferase; DNMT1) regulates neurogenesis by maintaining NPC proliferation and suppressing premature differentiation. Once differentiation ensues,...
Source: Neuroscience - June 1, 2019 Category: Neuroscience Source Type: research
Eicosapentaenoic acid suppresses palmitate-induced cytokine production by modulating long-chain acyl-CoA synthetase 1 expression in human THP-1 macrophages
Conclusion: The suppressive effects of EPA on palmitate-induced cytokine production may be mediated by the suppression of ACSL1 expression, at least partly. This anti-inflammatory effect of EPA may contribute to suppression of chronic inflammation caused by macrophages in atherosclerotic plaques.Highlights: ► EPA markedly suppressed palmitate-induced inflammation in THP-1 macrophages. ► EPA weakly suppressed LPS-induced inflammation in THP-1 macrophages. ► Palmitate up-regulated expression of long-chain acyl-CoA synthetase 1 (ACSL1). ► The inhibitor and siRNA for ACSL1 suppressed palmitate-induced inflammation. ►...
Source: Atherosclerosis - February 21, 2013 Category: Cardiology Authors: Masanori Nakakuki, Hiroyuki Kawano, Tatsuto Notsu, Kazunori Imada Tags: Metabolism: Lipids, Lipoprotein, Carbohydrates, Homocysteine, Cholesterol Source Type: research
The anti-adipogenic effects of (-)epigallocatechin gallate are dependent on the WNT/β-catenin pathway
In this study, we determined that the up-regulation of the WNT/β-catenin pathway is the anti-adipogenic mechanisms of EGCG in 3T3-L1 cells. EGCG treatment down-regulates the expression of major genes involved in the adipogenesis pathway including peroxisome proliferator-activated receptor (PPAR)γ, CCAAT/enhancer binding protein (C/EBP)α, fatty acid binding protein (FABP)4 and fatty acid synthase (FASN), while up-regulating the nuclear level of β-catenin. Knockdown of β-catenin using small interfering (si) RNA attenuated the inhibitory effects of EGCG on intracellular lipid accumulation. β-catenin siRNA transfection a...
Source: The Journal of Nutritional Biochemistry - January 14, 2013 Category: Biochemistry Authors: Haeyong Lee, Sungmin Bae, Yoosik Yoon Tags: Research Articles Source Type: research
Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation.
Conclusion:DML effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders.
PMID: 23852084 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - July 15, 2013 Category: Drugs & Pharmacology Authors: Zhou R, Lin ZH, Jiang CS, Gong JX, Chen LL, Guo YW, Shen X Tags: Acta Pharmacol Sin Source Type: research
