Filtered By:
Condition: Obesity

This page shows you your search results in order of relevance. This is page number 15.

Order by Relevance | Date

Total 449 results found since Jan 2013.

Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney.
In this study, we show that pregnane X receptor (PXR), a xenobiotic nuclear receptor, is epigenetically altered and upregulated, and may have a possible function in the diabetic kidney. PXR has been shown to play a critical role in metabolic changes in obesity and diabetes; however, its distribution and function in the kidney are unknown. In the normal kidney, PXR was selectively expressed in the proximal tubular cells with demethylation in the promoter DNA. In db/db mice, significant increases in Pxr mRNA, further demethylation of DNA, and stimulatory histone marks in the promoter were observed. Epigenetic changes are lik...
Source: Am J Physiol Renal P... - December 6, 2017 Category: Urology & Nephrology Authors: Watanabe A, Marumo T, Kawarazaki W, Nishimoto M, Ayuzawa N, Ueda K, Hirohama D, Tanaka T, Yagi S, Ota S, Nagae G, Aburatani H, Kumagai H, Fujita T Tags: Am J Physiol Renal Physiol Source Type: research

Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library.
This study is the first comprehensive analysis in discovering potential endocrine disrupters which affect the ERRα signaling pathway. PMID: 29216352 [PubMed - as supplied by publisher]
Source: Endocrinology - December 4, 2017 Category: Endocrinology Authors: Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT, Xia M Tags: Endocrinology Source Type: research

Calcium ‐sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - January 18, 2018 Category: Cytology Authors: Amanda D'Espessailles, Yuly A Mora, Cecilia Fuentes, Mariana Cifuentes Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.
CONCLUSIONS: Adipocyte Abca1 is a key regulator of adipocyte lipogenesis and lipid accretion, likely because of increased adipose tissue membrane cholesterol, resulting in decreased activation of lipogenic transcription factors PPARγ and SREBP1. PMID: 29348118 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 18, 2018 Category: Cardiology Authors: Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS Tags: Arterioscler Thromb Vasc Biol Source Type: research

High-fat-diet induces airway hyperresponsiveness partly through activating CD38 signaling pathway.
This study aimed to detect the effect of CD38 signaling pathway on the AHR of overweight/obese mice. The HFD-fed mice exhibited a significantly higher baseline airway resistance (Rn), and the increasing rates of Rn responded to increasing doses of methacholine compared with the LFD-fed mice. High-fat-diet increased CD38 expressions both in lung tissues and primary cultured ASMCs. Besides, preincubation with TNF-α led to a higher expression of CD38 protein and increased intracellular calcium in ASMC of the HFD-fed mice. Furthermore, CD38 gene knockdown through transfection of CD38 siRNA decreased the concentration of intra...
Source: International Immunopharmacology - February 1, 2018 Category: Allergy & Immunology Authors: Chong L, Zhang W, Yu G, Zhang H, Zhu L, Li H, Shao Y, Li C Tags: Int Immunopharmacol Source Type: research

Invited submission to the Diamond Jubilee Special Issue of Biochemical PharmacolLeptin induces SIRT1 expression through activation of NF-E2-related factor 2: implications for obesity-associated colon carcinogenesis.
In conclusion, leptin might play a role in colon carcinogenesis by inducing Nrf2-dependent SIRT1 overexpression. PMID: 29427626 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 7, 2018 Category: Drugs & Pharmacology Authors: Song NY, Lee YH, Na HK, Baek JH, Surh YJ Tags: Biochem Pharmacol Source Type: research

A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2.
Conclusions -We revealed that a novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via S1PR2-G12/13-RhoA signaling. Downregulation of FAM19A5 during obesity may trigger cardiometabolic diseases. PMID: 29453251 [PubMed - as supplied by publisher]
Source: Circulation - February 16, 2018 Category: Cardiology Authors: Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, Kong W Tags: Circulation Source Type: research

Hypoxia induces production of citrullinated proteins in human fibroblast ‐like synoviocytes through regulating HIF1α
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Ruohan Yu, Changhong Li, Lin Sun, Leilei Jian, Zhenzhen Ma, Jinxia Zhao, Xiangyuan Liu Tags: Regular Article Source Type: research

Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats
Conclusion: Taken together, our results suggested that enhanced CB1 receptor-mediated neurotransmissions in the RVLM may play a role in the development of obesity-induced hypertension.
Source: Journal of Hypertension - March 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research

PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes.
In this study, we created a high-fat-diet (HFD)-induced obese mouse model and examined the expression of PINK1 and Parkin in adipose tissue using western blot and real-time quantitative PCR. After we confirmed that there is an interesting difference between regular-chow-fed mice and HFD-induced obese mice in the expression of PINK1 and Parkin in vivo, we further tested the expression of PINK1 and Parkin in 3T3-L1 preadipocytes in vitro by treating cells with palmitic acid (PA) to induce metabolic stress. To better understand the role of PINK1 and Parkin in metabolic stress, 3T3-L1 preadipocytes were transfected with small ...
Source: Biochemical and Biophysical Research communications - February 28, 2018 Category: Biochemistry Authors: Cui C, Qiao J, Qing L, Wang L, He T, Wang C, Liu F, Gong L, Chen L, Hou X Tags: Biochem Biophys Res Commun Source Type: research

MiR-145 improves macrophage-mediated inflammation through targeting Arf6
ConclusionsBy means of reducing the expression of Arf6 and subsequent signal transduction via NF-kappaB, miR-145 plays a role in inhibiting the secretion of inflammatory factors and then improving the inflammatory status. MiR-145 might be one of the candidates for anti-inflammatory treatment for metabolic diseases.
Source: Endocrine - March 10, 2018 Category: Endocrinology Source Type: research

E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage
Conclusion: Here we show, for the first time, the regulation of ELF3 expression by leptin, suggesting that this transcription factor likely mediates the inflammatory responses triggered by leptin in articular chondrocytes.Cell Physiol Biochem 2018;45:2401 –2410
Source: Cellular Physiology and Biochemistry - March 16, 2018 Category: Cytology Source Type: research

1421 Topical glucosylceramide synthase inhibitor speeds wound healing in diabetic mice
Non-healing foot ulcers develop in 10-25% of type 2 diabetics. We have previously shown that reduction in ganglioside GM3 by GM3 synthase (GM3S) gene knockdown or topically applied GM3S siRNA nanoconstructs normalizes wound healing in diet-induced obese (DIO) diabetic mice. The mechanism is reversal of IGF-1 and EGF receptor resistance, leading to accelerated keratinocyte migration and normal cutaneous innervation. A small molecule inhibitor of glucosylceramide synthase (GCSI) also reduces GM3 and, given GCSI's small size, could be moved towards clinical trials of topical application should it replicate the ameliorative ef...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: I. Fogel, M.I. Guerrero-Zayas, X.Q. Wang, X. Cheng, A. Paller Tags: Tissue Regeneration and Wound Healing Source Type: research

STAT3 activation by IL-6 from adipose-derived stem cells promotes endometrial carcinoma proliferation and metastasis.
In this study, we examined the high IL-6 level in the ADSCs supernatant following treatment of endometrial cancer cell CM. Then, the activation of STAT3, a major tumourigenic IL-6 effector, was examined in endometrial cancer cells. Conditioned ADSC medium was used to stimulate endometrial cancer cell growth in vitro. Similar to IL-6, ADSC-conditioned medium significantly promoted endometrial cancer growth and invasion. Furthermore, siRNA-mediated STAT3 inhibition in endometrial cancer cells decreased the ADSC-mediated promotion of cell proliferation and invasion. In addition, a subcutaneous nude mouse model of endometrial ...
Source: Biochemical and Biophysical Research communications - April 20, 2018 Category: Biochemistry Authors: Chu Y, Wang Y, Peng W, Xu L, Liu M, Li J, Hu X, Li Y, Zuo J, Ye Y Tags: Biochem Biophys Res Commun Source Type: research

1421 Topical glucosylceramide synthase inhibitor speeds wound healing in diabetic mice
Non-healing foot ulcers develop in 10-25% of type 2 diabetics. We have previously shown that reduction in ganglioside GM3 by GM3 synthase (GM3S) gene knockdown or topically applied GM3S siRNA nanoconstructs normalizes wound healing in diet-induced obese (DIO) diabetic mice. The mechanism is reversal of IGF-1 and EGF receptor resistance, leading to accelerated keratinocyte migration and normal cutaneous innervation. A small molecule inhibitor of glucosylceramide synthase (GCSI) also reduces GM3 and, given GCSI's small size, could be moved towards clinical trials of topical application should it replicate the ameliorative ef...
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: I. Fogel, M.I. Guerrero-Zayas, X.Q. Wang, X. Cheng, A. Paller Tags: Tissue Regeneration and Wound Healing Source Type: research