Prostacyclin: A major prostaglandin in the regulation of adipose tissue development
Prostacyclin is a major prostaglandin of the arachidonate cyclooxygenase (COX) pathway. It mediates its action through a prostacyclin receptor (IP), triggers the terminal differentiation of adipocytes, and can work in both autocrine and paracrine manners. It can also induce the transformation of white adipose tissues to form thermogenic brite (brown ‐like) adipose tissues, indicating its potential to treat obesity. Prostaglandins (PGs) belong to the group lipid mediators and can act as local hormones. They contain 20 carbon atoms, including a 5 ‐carbon ring, and are biosynthesized from membrane phospholipid derived ara...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Mohammad Sharifur Rahman Tags: REVIEW ARTICLE Source Type: research

Agomelatine modulates calcium signaling through protein kinase C and phospholipase C ‐mediated mechanisms in rat sensory neurons
The obtained results of agomelatine ‐induced [Ca2+]i signals indicates that peripheral mechanisms are involved in analgesic effects of agomelatine. Agomelatine seems to possess antinociceptive properties which may be of clinical value AbstractAgomelatine, a novel antidepressant exerting its effects through melatonergic and serotonergic systems, implicated to be effective against pain including neuropathic pain but without any knowledge of mechanism of action. To explore the possible role of agomelatine on nociceptive transmission at the peripheral level, the effects of agomelatine on intracellular calcium ([Ca2+]i) signa...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Ihsan Serhatlioglu, Batuhan Bilgin, Emine Kacar, Sibel Ozcan, Sinan Canpolat, Ahmet Ayar, Haluk Kelestimur, Mete Ozcan Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

MicroRNA ‐99a‐5p suppresses breast cancer progression and cell‐cycle pathway through downregulating CDC25A
In this study, we aimed to explore the association between miR ‐99a‐5p andCDC25A in breast cancer and the regulatory mechanisms of miR ‐99a‐5p on breast cancer. The expressions of messenger RNA and microRNAs in breast cancer tissues and adjacent tissues were analyzed by the Cancer Genome Atlas microarray analysis. Quantitative real‐time polymerase chain reaction was conducted to find out the expression levels of miR‐99a‐ 5p andCDC25A. The expression levels of proteins (CDC25A, ki67, cyclin D1, p21, BAX, BCL ‐2, BCL‐XL, MMP2, and MMP9) were determined by Western blot analysis. The relationship between...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Hongzhen Qin, Wenfei Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A study of quiet eye's phenomenon in the shooting section of “laser run” of modern pentathlon
The study is the first evaluating visual behavior in the “Laser Run” section of modern pentathlon in elite athletes. The results provide insightful information about different cognitive and perceptual processes involved in Modern Pentathlon's athletes' performances at both elite and non‐elite level. AbstractThe aim of the study was to evaluate the effects of the Quiet eye (QE) phenomenon on performances during the shooting section of “Laser Run” of Modern Pentathlon, in two samples of athletes (novices and experts). The “Laser Run” consists of running and shooting activities. The study...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Andrea Chirico, Dario Fegatelli, Federica Galli, Luca Mallia, Fabio Alivernini, Susanna Cordone, Francesco Giancamilli, Stefano Pecci, Gian Marco Tosi, Antonio Giordano, Fabio Lucidi, Mina Massaro Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR ‐488‐3p in Hirschsprung's disease
In conclusion, this is the first report revealing that cir‐CCDC66 modulates DCX expression through sponging miR‐488‐3p and thus participates in the onset of HSCR. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Zechao Wen, Qiyang Shen, Hua Zhang, Yang Su, Zhongxian Zhu, Guanglin Chen, Lei Peng, Hongxing Li, Chunxia Du, Hua Xie, Xiaoqun Xu, Weibing Tang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Organ ‐on‐chip models: Implications in drug discovery and clinical applications
In this study, we review the recent advances in in vitro modeling including three‐dimensi onal (3D) organoids, 3D microfabrication, and 3D bioprinting for various organs including the heart, kidney, lung, gastrointestinal tract (intestine–gut–stomach), liver, placenta, adipose, retina, bone, and brain as well as multiorgan models. The availability of organ‐on‐chip models provides a wealth of opportunities to understand the pathogenesis of human diseases and provide a potentially better model to screen a drug, as these models utilize a dynamic 3D environment similar to the human body. Although there are li...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Rahul Mittal, Frank W. Woo, Carlo S. Castro, Madeline A. Cohen, Joana Karanxha, Jeenu Mittal, Tanya Chhibber, Vasanti M. Jhaveri Tags: REVIEW ARTICLE Source Type: research

MiRNA ‐548c‐5p downregulates inflammatory response in preeclampsia via targeting PTPRO
In this study, we first elucidate the role of miR‐548c‐5p and its underlying molecular mechanism in preeclampsia. Compared with healthy controls, miR‐548c‐5p was obviously downregulated in serum exosomes and placental mononuclear cells in patients with preeclampsia. Nonetheless, PTPRO was significantly upregulated and negatively associated with miR‐548c‐5p in placental mononuclear cells in patients with preeclampsia. PTPRO was a target of miR‐548c‐5p. PTPRO was downregulated in the miR‐548c‐5p‐overexpressed macropha ges. In addition, miR‐548c‐5p could inhibit the proliferation and activation of LP...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Zengfang Wang, Pingping Wang, Zengyan Wang, Zhihao Qin, Xia Xiu, Donghua Xu, Xiaozhen Zhang, Yingliang Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The lncRNA SCARNA2 mediates colorectal cancer chemoresistance through a conserved microRNA ‐342‐3p target sequence
AbstractLong noncoding RNAs (lncRNAs) have been implicated in numerous physiological and pathological processes, including cancer development and progression. However, the role and molecular mechanism of lncRNAs in resistance to chemotherapy of colorectal cancer (CRC) remain enigmatic. Here, we found that lncRNA small Cajal body ‐specific RNA 2 (SCARNA2) is expressed higher in CRC tissues than in adjacent normal tissues, and a robust expression of SCARNA2 is correlated with a bad prognosis of CRC patients after surgery. SCARNA2 overexpression significantly promoted chemoresistance in CRC cells, and downregulation of SCAR...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Peng ‐Fei Zhang, Jing Wu, Yin Wu, Wei Huang, Min Liu, Zhao‐Ru Dong, Bai‐Ying Xu, Yong Jin, Fei Wang, Xue‐Mei Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Potential of bacterial culture media in biofabrication of metal nanoparticles and the therapeutic potential of the as ‐synthesized nanoparticles in conjunction with artemisinin against MDA‐MB‐231 breast cancer cells
The present research endeavor explores the potential of bacterial culture media  (CM) in the biofabrication of metal nanoparticles (NPs) and, thereafter, ascertains their therapeutic potential against MDA‐MB‐231 breast cancer cells together with artemisinin. AbstractIn the recent past, various groups have proposed diverse biocompatible methods for the synthesis of metal nanoparticles (NPs). Besides culture biomass, culture supernatants (CS) are increasingly being explored for the synthesis of NPs; however, with the ever ‐increasing exploration of various CS in the biofabrication of NPs, it is equally important t...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Badrealam Farheen Khan, Hamidullah, Sonam Dwivedi, Riyuraj Konwar, Swaleha Zubair, Mohammad Owais Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Sodium –glucose cotransporter inhibitors and oxidative stress: An update
In this report we have reviewed the recent evidence of the impact that SGLT2 inhibition may have on improved oxidative stress by either amelioration of free radical generation or potentiation of cellular anti‐oxidative capacity, and its importance in preven tion of cardiovascular and diabetes complications. AbstractSodium –glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control. Recent data suggest that SGLT2 inhibitors have antioxi...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Habib Yaribeygi, Stephen L. Atkin, Alexandra E. Butler, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Benzo(a)pyrene inhibits endometrial cell apoptosis in early pregnant mice via the WNT5A pathway
In this study, we focused on the effect of BaP on endometrial cell apoptosis and the role of WNT signaling during this process. Pregnant mice were gavaged with corn o il (control group) or 0.2 mg·kg−1·day−1 BaP (treatment group) from Days 1 to 6 of pregnancy. BaP impaired endometrial function by decreasing the expression of HOXA10 and BMP2, two markers of receptivity and decidualization. WNT5A and β‐catenin were activated in the BaP group. BaP affected the expression of apoptosis‐related proteins and inhibited the apoptosis of endometrial stromal cells. In vitro, human endometrial ...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Ting Yi, Min Liu, Xueyan Li, Xueqing Liu, Yubin Ding, Junlin He, Hanting Xu, Rufei Gao, Xinyi Mu, Yanqing Geng, Yingxiong Wang, Xuemei Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Pathophysiological changes in experimental polycystic ovary syndrome in female albino rats: Using either hemin or L ‐arginine
In conclusion, either hemin or L‐arginine had protective effects against PCOS with better pa thophysiological changes with hemin. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Merhan M. Ragy, Heba A. Abdel ‐Hamid, Nisreen D.M. Toni Tags: REVIEW ARTICLE Source Type: research

Ethyl acetate and n ‐butanol fraction of Cissus quadrangularis promotes the mineralization potential of murine pre‐osteoblast cell line MC3T3‐E1 (sub‐clone 4)
The present study reports the osteoblast differentiation and mineralization potential of ethyl acetate (CQ ‐EA) and butanol (CQ‐B) extracts ofCissus quadrangularis (CQ) on mouse pre ‐osteoblast cell line MC3T3‐E1 (sub‐clone 4) with an objective to isolate an antiosteoporotic compound. We have concluded in this part of the study that the CQ‐EA treatment resulted in early differentiation and mineralization as compared with the CQ‐B treatment. These findings suggest that low concentrations of CQ‐EA and CQ‐B have proliferative and osteogenic properties. CQ‐EA, however, is more potent osteogenic than CQ‐B....
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Rabail Hassan Toor, Raazia Tasadduq, Achyut Adhikari, Muhammad Iqbal Chaudhary, Jane B. Lian, Janet L. Stein, Gary S. Stein, Abdul Rauf Shakoori Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Retraction: “Identification of Novel Biomarkers for Pancreatic Cancer Using Integrated Transcriptomics With Functional Pathways Analysis” by Zhang, X., Tong, P., Chen, J., Pei, Z., Zhang, X., Chen, W., Xu, J., and Wang, J.
The above article from theJournal of Cellular Physiology, published online on 10 March 2016 in Wiley Online Library as Early View (http://onlinelibrary.wiley.com/enhanced/doi/10.1002/jcp.25353/), has been retracted by agreement between Gary Stein, the journal's Editor ‐in‐Chief, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation at the University of Texas, MD Anderson Cancer Center, which confirmed that the article was submitted and approved for publication by Dr. Jin Wang without acknowledgement of NIH funding received or t he consent and authorship of Dr. Ann Killary and Dr. Subrata...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Tags: Retraction Source Type: research

Chronic myeloid leukemia with complex karyotypes: Prognosis and therapeutic approaches
ConclusionCML classification using different features such as Ph and ACAs can play a decisive role in the evaluation of treatment responses in patients, for example, CML patients with Ph negative and monosomy 7 develop MDS or CML patient –Y and extra copy of Ph have a good response to tyrosine kinase inhibitors, therefore, classifications according to Ph and ACAs play an important role in choosing better treatment protocols and therapeutic strategies. Karyotype analysis in CML patients with complex karyotype shows unrandom pattern so ACAs can be great clue in medical guidelines. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 14, 2018 Category: Cytology Authors: Ali Amin Asnafi, Zeinab Deris Zayeri, Saeid Shahrabi, Kazem Zibara, Tina Vosughi Tags: REVIEW ARTICLE Source Type: research

DANCR contributed to hepatocellular carcinoma malignancy via sponging miR ‐216a‐5p and modulating KLF12
In conclusion, our study indicated that DANCR might provide a new perspective for HCC treatment. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 14, 2018 Category: Cytology Authors: Jianchu Wang, Jian Pu, Ying Zhang, Tianwei Yao, Zongjiang Luo, Wenchuan Li, Guidan Xu, Juan Liu, Wujun Wei, Yibin Deng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

TGF β mediates collagen production in human CRSsNP nasal mucosa‐derived fibroblasts through Smad2/3‐dependent pathway and CTGF induction and secretion
Transforming growth factor β1 (TGF‐β1) mediates collagen expression–production through a canonical Smad2/3‐dependent pathway and connective tissue growth factor (CTGF) induction and secretion in human nasal fibroblasts. Moreover, TGF‐β1, CTGF, and collagen are highly expressed in human chronic rhinosinusitis withou t nasal polyp (CRSsNP) nasal mucosa specimens, suggesting their roles in tissue remodeling during CRSsNP progression. AbstractChronic rhinosinusitis without nasal polyp (CRSsNP) is characterized by tissue remodeling and fibrosis. Transforming growth factor ‐β (TGF‐β) is c...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Jiunn ‐Min Shieh, Yih‐Jeng Tsai, Jessie Chao‐Yun Chi, Wen‐Bin Wu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Pre ‐eclampsia onset and SPARC: A possible involvement in placenta development
In conclusion, SPARC can play a pivot al role in PE and PE–IUGR onset and it should be considered as a key molecule for future investigations in such pathologies. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Giovanni Tossetta, Sonia Fantone, Stefano R. Giannubilo, Elena Marinelli Busilacchi, Andrea Ciavattini, Mario Castellucci, Nicoletta Di Simone, Monica Mattioli ‐Belmonte, Daniela Marzioni Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction
Lifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is difficult for patients to follow in practice, and remains critical to achieve optimal glucose homeostasis. In this review, we look at what is known about the molecular pathways involved in CR ‐induced insulin sensitivity and improved insulin resistance. AbstractLifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is di...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Habib Yaribeygi, Stephen L. Atkin, Majid Ramezani, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

A genetic variant in LINGO2 contributes to the risk of gestational diabetes mellitus in a Chinese population
AbstractGenome ‐wide association studies (GWASs) showed that three single nucleotide polymorphisms (SNPs; rs10968576, rs1412239, and rs824248) in the leucine‐rich repeat and Ig domain containing 2 (LINGO2) were associated with obesity or type 2 diabetes (T2D). We aimed to determine the influence of the LINGO2 variants on the gestational diabetes mellitus (GDM) risk. Thus, we performed a case–control study including 964 GDM cases and 1,021 controls to test the associations between the three LINGO2 variants (rs10968576, rs1412239, and rs824248) and susceptibility to GDM. Logistic regression analyses show ed no sign...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Tong Su, Qingxia Ren, Yingying Lu, Wen Tai, Yuan Zhu, Zhengying Li, Juan Wen, Lingmin Hu, Le Zhang, Jiehua Ma Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO ‐1 pathway
In conclusion, our study showed that LL202 exerts an anti‐inflammatory effect by enhancing the antioxidant capacity of the Nrf2/HO‐1 pathway to macrophages. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Yuan Gao, Dongsheng Bai, Yue Zhao, Qin Zhu, Yihui Zhou, Zhiyu Li, Na Lu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Pulsed electromagnetic fields regulate osteocyte apoptosis, RANKL/OPG expression, and its control of osteoclastogenesis depending on the presence of primary cilia
This study enriches our basic knowledge for further understanding the biological behaviors of osteocytes, and is also helpful for providing a more comprehensive mechanistic understanding of the effect of electromagnetic stimulation on bone and relevant skeletal diseases (e.g., bone fractu re and osteoporosis). AbstractGrowing evidence has shown that pulsed electromagnetic fields (PEMF) can modulate bone metabolism in vivo and regulate the activities of osteoblasts and osteoclasts in vitro. Osteocytes, accounting for 95% of bone cells, act as the major mechanosensors in bone for transducing external mechanical signals and p...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Pan Wang, Chi Tang, Junjie Wu, Yuefan Yang, Zedong Yan, Xiyu Liu, Xi Shao, Mingming Zhai, Jie Gao, Shengru Liang, Erping Luo, Da Jing Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Key microRNAs in the biology of breast cancer; emerging evidence in the last decade
A large number of microRNAs (miRNAs) have been demonstrated to be implicated in breast cancer (BC) biology such as cell proliferation, migration, invasion, and metastasis by various molecular pathways and targeting that result in up ‐ or downregulation of particular involved genes. AbstractmicroRNAs (miRNAs) are a family of small noncoding RNAs that play a pivotal role in the regulation of main biological and physiological processes, including cell cycle regulation, proliferation, differentiation, apoptosis, stem cell maintenance, and organ development. Dysregulation of these tiny molecules has been related to different ...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Monireh Khordadmehr, Roya Shahbazi, Hamed Ezzati, Farinaz Jigari ‐Asl, Sanam Sadreddini, Behzad Baradaran Tags: REVIEW ARTICLE Source Type: research

Identification and characterization of circular RNAs involved in mechanical force ‐induced periodontal ligament stem cells
Circular RNAs (circRNAs) are a large class of animal RNAs with regulatory potency. Mechanical force (MF) can induce the expression changes of circRNAs in periodontal ligament stem cells (PDLSCs) which may modulate the orthodontic tooth movement process and the alveolar bone remodeling. CircRNAs may serve as miRNAs sponges by regulating one or several miRNA/miRNAs to affect the osteogenic differentiation in MF ‐induced PDLSCs AbstractCircular RNAs (circRNAs) play critical roles in signal transduction during cell proliferation, differentiation, and apoptosis in a posttranscriptional manner. Recently, circRNAs have been pro...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Hong Wang, Cheng Feng, Ye Jin, Wanye Tan, Fulan Wei Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Let ‐7g‐5p regulates mouse mammary cells differentiation and function by targeting PRKCA
In this study, to unravel the role of let‐7g‐5p, we found PRKCA (PKC‐alpha, PKC‐α) might serve as potential targets of let ‐7g‐5p by bioinformatics. Then let‐7g‐5p was knocked down by an antisense oligonucleotide in mouse primary mammary epithelial cells. As predicted,PRKCA gene expression and mammary epithelial cells growth were increased by anti ‐let‐7g‐5p regulation in vitro. By using reporter constructs, it showed that the let‐7g‐5p could direct binding with 3′‐the untranslated regions (3′‐UTR) of PRKCA mRNA. Furthermore, ectopic overexpression of let‐7g‐5p in vivo re...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Lei Tian, Ye Li, Chunmei Wang, Qingzhang Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

miR ‐150 might inhibit cell proliferation and promote cell apoptosis by targeting LMO4 in Burkitt lymphoma
This study aimed at investigating the effect of microRNA ‐150 (miR‐150) on cell proliferation of Burkitt lymphoma and its molecular mechanism. Gene expression analysis was applied to identify target genes of miR‐150 in Burkitt lymphoma cell line ST486 based on the dataset from the Gene Expression Omnibus (GEO) datasets GSE86432. miRNA mimics, inhibi tor and small interfering RNA (siRNA) were fluorescently labeled by Cy3, whereas plasmid vector was labeled by EGFP. Cells were viewed by fluorescence microscope and transfection efficiency was evaluated through fluorescent cell percentage. Quantitative real‐time polym...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Dandan Zhang, Yanshuan Wei, Jun Zhou, Guannan Wang, Lin Xiao, Jingjing Xu, Na Wei, Wencai Li, Mingzhi Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

miR ‐483 inhibits bovine myoblast cell proliferation and differentiation via IGF1/PI3K/AKT signal pathway
MicroRNA ‐483 (miR‐483) inhibits bovine myoblast cell proliferation and differentiation by targeting insulin‐like growth factor 1 (IGF1) and downregulated the expression of key proteins in the PI3K/AKT signaling pathway. These results will provide an insight target in breeding strategies appealing to c attle industry. AbstractMicroRNAs (miRNAs) have been established to regulate skeletal muscle development in mammals. However, few studies have been conducted on the regulation of proliferation and differentiation of bovine myoblast cells by miRNAs. The aim of our study was to explore the function of miR ‐483 in cell ...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Chengchuang Song, Zhaoxin Yang, Dong Dong, Jiawei Xu, Jian Wang, Hui Li, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Yun Ma, Hong Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Potentiation of paclitaxel effect by resveratrol in human breast cancer cells by counteracting the 17 β‐estradiol/estrogen receptor α/neuroglobin pathway
Res treatment does not reduce cancer cell viability by itself Res interferes with estradiol/estrogen receptor α‐induced NGB upregulation in breast cancer cells This new Res‐based mechanism potentiate cancer cell susceptibility to chemotherapeutic agent AbstractNeuroglobin (NGB), an antiapoptotic protein upregulated by 17 β‐estradiol (E2), is part of E2/estrogen receptor α (ERα) pathway pointed to preserve cancer cell survival in presence of microenvironmental stressors including chemotherapeutic drugs. Here, the possibility that resveratrol (Res), an anticancer plant polyphenol, could increase ...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Manuela Cipolletti, Emiliano Montalesi, Maria Teresa Nuzzo, Marco Fiocchetti, Paolo Ascenzi, Maria Marino Tags: RAPID COMMUNICATION Source Type: research

Serenoa repens and N ‐acetyl glucosamine/milk proteins complex differentially affect the paracrine communication between endothelial and follicle dermal papilla cells
1)Paracrine communication between endothelial and follicle dermal papilla cells. 2)Characterization of the role of natural compounds on in vutro cocultures systems. 3)mechanistic background for the potential use of natural compounds as promoters of HF vascularization. AbstractCurrent treatments for hair follicle (HF) disruption are based on 5 ‐α reductase inhibitors and prostaglandin modulators. Botanicals and nutraceutical compounds interfere with hair loss or stimulate its partial regrowth. Here, we used in vitro cocultures to investigate the activity ofSerenoa repens (SR) andN‐acetyl glucosamine +&thins...
Source: Journal of Cellular Physiology - November 12, 2018 Category: Cytology Authors: Eleonora Bassino, Franco Gasparri, Luca Munaron Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Medical Cannabis: A plurimillennial history of an evergreen
We report through the centuries evidence of its use in numerous pathologic conditions especially for its anti ‐inflammatory, antiseptic, and anticonvulsing properties that support the requirement to direct our present research efforts into the definitive understanding of its efficacy. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: S. Pisanti, M. Bifulco Tags: REVIEW ARTICLE Source Type: research

Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells
We reported previously that the δ2 isoform of Ca2+/calmodulin ‐dependent protein kinase II (CaM kinase IIδ2) was involved in GnRH‐induced ERK activation in cultured GnRH neurons (GT1–7 cells). Recently, we found that GnRH treatment of GT1–7 cells activated proline‐rich tyrosine kinase 2 (Pyk2), and Pyk2 was involved in ERK activation. In the current study, we examined the possibility that CaM kinase IIδ2 might activate Pyk2. Knockdown of CaM kinase IIδ2 and KN93, an inhibitor of CaM kinases, inhibited the GnRH‐induced activation of Pyk2. In the case of cultured gonadotroph cells ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Shiho Okitsu ‐Sakurayama, Sayomi Higa‐Nakamine, Hidetsugu Torihara, Hana Takahashi, Shigeki Higashiyama, Hideyuki Yamamoto Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Impaired DNA double ‐strand breaks repair by kinesin family member 4A inhibition renders human H1299 non‐small‐cell lung cancer cells sensitive to cisplatin
Cisplatin treatment stimulates the expression of kinesin family member 4A (KIF4A) protein in human non ‐small‐cell lung cancer (NSCLC) cells. KIF4A knockdown suppresses the formation of BRCA2 and Rad51 foci and limits the further increase in poly(ADP‐ribose) polymerase 1 activity, thereby enhancing cisplatin‐induced cell cycle arrest in S and G2/M phases and cytotoxicity in human NSCLC cells. KIF4A functions as a novel modulator of cisplatin sensitivity in human NSCLC cells via multiple mechanisms. AbstractPatients with non ‐small‐cell lung cancer (NSCLC) are routinely treated with the platinum‐based chemothe...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Qing Wan, Yong Shen, Huzi Zhao, Bei Wang, Lei Zhao, Yongchen Zhang, Xiaodong Bu, Meiling Wan, Chuanlu Shen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Prognostic value of a gene signature in clear cell renal cell carcinoma
The 3 ‐mRNA classifier proved be a useful tool for prognostic evaluation and could facilitate personalized management of ccRCC patients. AbstractRenal cancer is a  common urogenital system malignance. Novel biomarkers could provide more and more critical information on tumor features and patients’ prognosis. Here, we performed an integrated analysis on the discovery set and established a three‐gene signature to predict the prognosis for clear cell renal cell carcinoma (ccRCC). By constructing a LASSO Cox regression model, a 3‐messenger RNA (3‐mRNA) signature was identified. Based on the 3‐mRNA sig...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Liang Chen, Yongwen Luo, Gang Wang, Kaiyu Qian, Guofeng Qian, Chin ‐Lee Wu, Han C. Dan, Xinghuan Wang, Yu Xiao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Osteoblast autophagy in glucocorticoid ‐induced osteoporosis
Although the pathogenesis of glucocorticoid ‐induced osteoporosis (GIO) has been studied for decades, over the past ten years the autophagy machinery has been implicated as a novel mechanism. Autophagy in osteoblasts, osteocytes, and osteoclasts plays a critical role in the maintenance of bone homeostasis. Herein, we specifically discuss ho w osteoblast autophagy responds to glucocorticoids and its role in the development of GIO. AbstractAdministration of glucocorticoids is an effective strategy for treating many inflammatory and autoimmune diseases. However, glucocorticoid treatment can have adverse effects on bone, lea...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Lufei Wang, Bradlee L. Heckmann, Xianrui Yang, Hu Long Tags: MINI ‐REVIEW Source Type: research

Inhibition of PI3K/Akt/NF ‐κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies
Inhibition of PI3K/Akt/NF ‐κB signaling with leonurine for ameliorating the progression of osteoarthritis: in vitro and in vivo studies AbstractOsteoarthritis (OA) is characterized as the degeneration and destruction of articular cartilage. In recent decades, leonurine (LN), the main active component in medical and edible dual purpose plant Herba Leonuri, has been shown associated with potent anti ‐inflammatory effects in several diseases. In the current study, we examined the protective effects of LN in the inhibition of OA development as well as its underlying mechanism both in vitro and in vivo experiments. In...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Zhi ‐Chao Hu, Lan‐Fang Gong, Xiao‐Bin Li, Xin Fu, Jiang‐Wei Xuan, Zhen‐Hua Feng, Wen‐Fei Ni Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Fusion with mesenchymal stem cells differentially affects tumorigenic and metastatic abilities of lung cancer cells
This study will contribute to explaning the origin of lung cancer stem cells and to elucidate the role of cell fusion in cancer metastasis. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Li ‐Na Zhang, Chen‐Fei Kong, Dan Zhao, Xian‐Ling Cong, Shen‐Sen Wang, Ling Ma, Ying‐Hui Huang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Extended proliferation of chicken ‐ and Okinawa rail‐derived fibroblasts by expression of cell cycle regulators
AbstractAlthough immortalized cultured cells are useful for various functional assays or transcriptome analysis, highly efficient and reproducible immortalization methods have not been developed in avian ‐derived cells. We introduced the simian virus 40 T antigen (SV40T) and human papillomavirus(HPV) ‐E6E7 to chick and Okinawa rail (endangered species)derived fibroblast. As a result, neither theSV40T norE6E7 genes could induce avian cell immortality. Accordingly, we attempted to use a recently developed immortalization method, which involved the coexpression of mutant cyclin ‐dependent kinase 4 (CDK4), Cyclin ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Masafumi Katayama, Tohru Kiyono, Hitomi Ohmaki, Takahiro Eitsuka, Daiji Endoh, Miho Inoue ‐Murayama, Nobuyoshi Nakajima, Manabu Onuma, Tomokazu Fukuda Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A review of the anti ‐inflammatory properties of antidiabetic agents providing protective effects against vascular complications in diabetes
AbstractThe global prevalence of Type 2 diabetes mellitus and its associated complications are growing rapidly. Although the role of hyperglycemia is well recognized in the pathophysiology of diabetic complications, its exact underlying mechanisms are not fully understood. In this regard, accumulating evidence suggests that the role of inflammation appears pivotal, with studies showing that most diabetic complications are associated with an inflammatory response. Several classes of antidiabetic agents have been introduced for controlling glycemia, with evidence that these pharmacological agents may have modulatory effects ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Habib Yaribeygi, Stephen L. Atkin, Matteo Pirro, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Interleukin ‐18 and diabetic nephropathy: A review
AbstractThe inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediators such as interleukin ‐1 (IL‐1), IL‐6, IL‐18, tumor necrosis factor‐α, and macrophage chemotactic protein‐1; however, the role of IL‐18 seems to be more specific than other cytokines in the inflammatory process. IL‐18 is expressed in renal tissue and is upregulated by several stimuli including hyperglyce mia. The expression/urinary level of IL‐18 is positively correlated with the progression of diabetic nephropathy and the urinary albumin excretion rat...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Habib Yaribeygi, Stephen L. Atkin, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Inactivation of ADAMTS18 by aberrant promoter hypermethylation contribute to lung cancer progression
Our results demonstrated that the tumor suppressor gene ADAMTS18 was downregulated in lung cancer by promoter CpG methylation, and it promoted sensitivity to cisplatin via epidermal growth factor receptor/protein kinase B signaling. Our study suggests that ADAMTS18 promoter methylation is a potential epigenetic biomarker for early detection of lung cancer and warrants investigation as therapeutic target for early ‐stage lung cancer. AbstractLung cancer is the most frequently diagnosed cancer worldwide. Epigenetic regulation contributes to lung cancer pathogenesis. TheADAMTS18 tumor suppressor gene is inactivated in some ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Yan Zhang, Hongying Xu, Junhao Mu, Shuliang Guo, Lin Ye, Dairong Li, Weiyan Peng, Xiaoqian He, Tingxiu Xiang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Noncoding transcribed ultraconserved region (T ‐UCR) UC.48+ is a novel regulator of high‐fat diet induced myocardial ischemia/reperfusion injury
High ‐fat diet (HFD) is an independent risk factor for myocardial ischemia/reperfusion (MI/R) injury. Uc.48+ is a long noncoding RNA (lncRNA) from a transcribed ultraconserved region (T‐UCR) of human, mouse, and rat genomes. Here, we explored the aggravating role of uc.48+ and identified purinerg ic P2X7 receptor (P2X7R) as a downstream regulator of uc.48+ in HFD‐induced MI/R vulnerability. Targeting uc.48+ may be a novel therapeutic approach of MI/R vulnerability to HFD. AbstractIncreasing evidence has suggested high ‐fat diet (HFD) is an independent risk factor for myocardial ischemia/...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Lu Ding, Chengxin Gong, Jiani Zhao, Xingzi Liu, Tao Li, Shenqiang Rao, Shuo Wang, Yuanyuan Liu, Shanping Peng, Wen Xiao, Chaopeng Xiong, Rumeng Wang, Shangdong Liang, Hong Xu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Understanding molecular biology of codon usage in mitochondrial complex IV genes of electron transport system: Relevance to mitochondrial diseases
The mitochondrial cytochrome oxidase (CO) genes are involved in complex IV of the electron transport system (ETS), and dysfunction of CO genes leads to several diseases.  nHowever, no work has been reported on the codon usage pattern of these genes. We used bioinformatic methods to analyze the compositional properties and the codon usage pattern of the COI, COII, and COIII genes in fishes, birds, and mammals to understand the similarities and dissimilarities of cod on usage in these genes, which gave an insight into the molecular biology of these genes. AbstractThe mitochondrial cytochrome oxidase (CO) genes are invol...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Arif Uddin, Tarikul Huda Mazumder, Supriyo Chakraborty Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR ‐186‐5p and modulating NEK2
This study mainly researched the effects of circPDSS1 and its related genes in gastric cancer (GC). 2.It revealed part of a complex regulation system, circPDSS1/miR ‐186‐5p/NEK2 axis in GC, and provided a potential therapeutic target for GC treating. 3.Further research should be done to investigate the related genes in this regulation system. AbstractThe aim of this study is to investigate the regulatory mechanism of circPDSS1/miR ‐186‐5p/NEK2 axis on the viability and proliferation in gastric cancer (GC) cell line. Differentially expressed circRNAs, miRNAs, and mRNAs in GC tissues and paracarcinoma tissues were ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Yiming Ouyang, Yuejin Li, Yingguang Huang, Xing Li, Yu Zhu, Yaxin Long, Yongzhi Wang, Xiaodong Guo, Kunmei Gong Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The role of DEAD ‐box RNA helicase p68 (DDX5) in the development and treatment of breast cancer
Discussion of the precise role of p68 in cancer is complex and depends on the cellular microenvironment and interacting factors. In terms of the deregulated expression of p68 in breast cancer and the high prevalence of this cancer among women, it can be informative to review the precise function of this factor in the breast cancer. Therefore, an attempt will be made in this review to clarify the tumorigenic function of p68 in association with its targeting potential for the treatment of breast cancer. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Vida Hashemi, Ali Masjedi, Bita Hazhir ‐karzar, Asghar Tanomand, Siamak Sandoghchian Shotorbani, Mohammad Hojjat‐Farsangi, Ghasem Ghalamfarsa, Gholamreza Azizi, Enayat Anvari, Behzad Baradaran, Farhad Jadidi‐Niaragh Tags: REVIEW ARTICLE Source Type: research

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease
Parkin ‐mediated mitophagy in Drosophila heart. (a) Parkin deficiency in Drosophila heart impaired mitophagy and led to the development of dilated cardiomyopathy. (b) Simultaneous deletion of mitochondrial assembly regulatory factor and Parkin rescued cardiomyopathy (Bhandari et al.,#jcp27597-bib-0005).#jcp27597-bib-0005 AbstractMitochondria play an important role in maintaining cardiac homeostasis by supplying the major energy required for cardiac excitation –contraction coupling as well as controlling the key intracellular survival and death pathways. Healthy mitochondria generate ATP molecules through an aerobic...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Farzaneh G. Tahrir, Dianne Langford, Shohreh Amini, Taha Mohseni Ahooyi, Kamel Khalili Tags: REVIEW ARTICLE Source Type: research

Estrogen deprivation aggravates intracellular calcium dyshomeostasis in the heart of obese ‐insulin resistant rats
Estrogen deprivation had a strong impact on abnormal cardiac function through intracellular calcium regulation. Our findings showed that in obese ‐insulin resistant rats, estrogen deprivation severely aggravates cardiac dysfunction via increased impairment of calcium homeostasis. AbstractThe incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, giving evidence for the vital role of estrogen. Intracellular calcium [Ca2+]i regulation plays an important role in the maintenance of left ventricular (LV) contractile function. Although either estrogen deprivation or obesity has been ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Siripong Palee, Wanitchaya Minta, Duangkamol Mantor, Wissuta Sutham, Sasiwan Kerdphoo, Wasana Pratchayasakul, Siriporn C. Chattipakorn, Nipon Chattipakorn Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A2a adenosine receptor agonist improves endoplasmic reticulum stress in MIN6 cell line through protein kinase A/ protein kinase B/ Cyclic adenosine monophosphate response element ‐binding protein/ and Growth Arrest And DNA‐Damage‐Inducible 34/ eukaryotic Initiation Factor 2α pathways
A2a adenosine receptor activation improved endoplasmic reticulum (ER) stress in pancreatic beta cells (PBCs) and its signaling may provide new approach to control ER stress in the PBC cells. AbstractEndoplasmic reticulum (ER) stress is one of the main molecular events underlying pancreatic beta cell (PBC) failure, apoptosis, and a decrease in insulin secretion. Recent studies have highlighted the fundamental role of A2a adenosine receptor (A2aR) in potentiation of insulin secretion and proliferation of PBCs. However, possible protective effects of A2aR signaling against ER stress have not been elucidated yet. Thus, in the ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Fatemeh P. Arasi, Mohammad K. Shahrestanaki, Mahmoud Aghaei Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

MiRNAs and inflammatory bowel disease: An interesting new story
MicroRNAs (miRNAs) are a set of noncoding RNA molecules that are involved in the regulation of the gene expression. We discussed the critical roles of some miRNAs in the pathophysiology, diagnosis, and treatment of IBD. AbstractInflammatory bowel disease (IBD), as a chronic and recurrent inflammatory disorder, is caused by a dysregulated and aberrant immune response to exposed environmental factors in genetically susceptible individuals. Despite huge efforts in determining the molecular pathogenesis of IBD, an increasing worldwide incidence of IBD has been reported. MicroRNAs (miRNAs) are a set of noncoding RNA molecules t...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Soheila Moein, Mostafa Vaghari ‐Tabari, Durdi Qujeq, Maryam Majidinia, Seyed Mohammad Nabavi, Bahman Yousefi Tags: REVIEW ARTICLE Source Type: research

Effects of microRNA ‐217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4‐induced liver injury by targeting NAT2
This study aims to explore the effects of miR ‐217 targeting NAT2 on hepatocyte proliferation, apoptosis, and autophagy following carbon tetrachloride (CCL4)‐induced liver injury. Rat models of CCL4‐induced liver injury were established. Healthy Wistar rats were randomized into the normal, blank, negative control (NC), microRNA‐217 (miR ‐217) mimic, miR‐217 inhibitor, small interfering RNA (siRNA)‐N‐acetyltransferase 2 (NAT2), and miR‐217 inhibitor + siRNA‐NAT2 groups. NAT2 activity was evaluated with reversed‐phase high‐performance liquid chromatographic method. Immunohistochemis...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Cheng ‐Liang Yang, Xiao‐Li Zheng, Ke Ye, Ya‐Nan Sun, Yu‐Fei Lu, Hong Ge, Hui Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Inflammation and pericarditis: Are neutrophils actors behind the scenes?
The morbidity of acute pericarditis is increasing overtime. Apart the known impairment of the adaptive immunity, recently a large body evidence indicated the central role of the innate immune system in the pathogenesis of recurrent pericarditis, starting from similarities with autoinflammatory diseases, with the “inflammasome” playing an important role. The role of the adaptive immune system in pericarditis cannot be reduced to a black or white issue as these mechanisms often overlap and new therapeutic strategies should be investigated in this direction. AbstractThe morbidity of acute pericarditis is increasin...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Aldo Bonaventura, Fabrizio Montecucco Tags: MINI ‐REVIEW Source Type: research