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Condition: Obesity

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Total 449 results found since Jan 2013.

Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitus.
CONCLUSION: NLRP3 and NLRP1 inflammasomes signaling pathways were associated with the development and progression of T1DM, which response as protective factors in the early stage of T1DM. PMID: 28783585 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 4, 2017 Category: Drugs & Pharmacology Authors: Liu H, Xu R, Kong Q, Liu J, Yu Z, Zhao C Tags: Biomed Pharmacother Source Type: research

Apelin protects against liver X receptor-mediated steatosis through AMPK and PPAR α in human and mouse hepatocytes.
Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes. Cell Signal. 2017 Aug 15;39:84-94 Authors: Huang J, Kang S, Park SJ, Im DS Abstract Non-alcoholic fatty liver disease is the most commonly occurring chronic liver disease, and hepatic steatosis, a condition defined as extensive lipid accumulation in hepatocytes, is associated with liver dysfunction and metabolic diseases, such as, obesity and type II diabetes. Apelin is an adipokine that acts on a G protein-coupled receptor named APJ, and has been established to play pivotal roles in var...
Source: Cellular Signalling - August 15, 2017 Category: Cytology Authors: Huang J, Kang S, Park SJ, Im DS Tags: Cell Signal Source Type: research

Adipochemokines induced by ultraviolet irradiation contribute to impaired fat metabolism in subcutaneous fat cells.
CONCLUSIONS: These UV-induced adipochemokines may be implicated in the reduction of lipogenesis in SC fat, leading to impairment of fat homeostasis and associated comorbidities such as obesity. This article is protected by copyright. All rights reserved. PMID: 28845522 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - August 27, 2017 Category: Dermatology Authors: Kim EJ, Kim YK, Kim S, Kim JE, Tian YD, Doh EJ, Lee DH, Chung JH Tags: Br J Dermatol Source Type: research

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
In conclusion, these studies provide evidence that within the hypothalamic nuclei, leptin-glutamate signaling regulates the sympathetic activation. This may contribute to the sympathoexcitation commonly observed in obesity-related T2D. PMID: 28845307 [PubMed - in process]
Source: Neural Plasticity - August 30, 2017 Category: Neurology Authors: Zheng H, Liu X, Li Y, Patel KP Tags: Neural Plast Source Type: research

Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy
Conclusion: Endothelial dysfunction in ZDF rats is partially attributable to excessive autophagy. TSG improves endothelial function and exerts hypotensive effectsvia regulation of endothelial autophagy.Cell Physiol Biochem 2017;43:293 –307
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice
Conclusion These findings suggest that CB1R expressed in KCs plays a critical role in obesity-related hepatic insulin resistance via a pro-inflammatory mechanism.
Source: Molecular Metabolism - September 2, 2017 Category: Endocrinology Source Type: research

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling
Lymphatic vessels constitute a specialized vasculature that is involved in development, cancer, obesity, and immune regulation. The migration of lymphatic endothelial cells (LECs) is critical for vessel growth (lymphangiogenesis) and vessel remodeling, processes that modify the lymphatic network in response to developmental or pathological demands. Using the publicly accessible results of our genome-wide siRNA screen, we characterized the migratome of primary human LECs and identified individual genes and signaling pathways that regulate LEC migration. We compared our data set with mRNA differential expression data from en...
Source: Signal Transduction Knowledge Environment - October 3, 2017 Category: Science Authors: Williams, S. P., Odell, A. F., Karnezis, T., Farnsworth, R. H., Gould, C. M., Li, J., Paquet-Fifield, S., Harris, N. C., Walter, A., Gregory, J. L., Lamont, S. F., Liu, R., Takano, E. A., Nowell, C. J., Bower, N. I., Resnick, D., Smyth, G. K., Coultas, L. Tags: STKE Research Articles Source Type: news

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling.
er SA Abstract Lymphatic vessels constitute a specialized vasculature that is involved in development, cancer, obesity, and immune regulation. The migration of lymphatic endothelial cells (LECs) is critical for vessel growth (lymphangiogenesis) and vessel remodeling, processes that modify the lymphatic network in response to developmental or pathological demands. Using the publicly accessible results of our genome-wide siRNA screen, we characterized the migratome of primary human LECs and identified individual genes and signaling pathways that regulate LEC migration. We compared our data set with mRNA differential...
Source: Science Signaling - October 3, 2017 Category: Biomedical Science Authors: Williams SP, Odell AF, Karnezis T, Farnsworth RH, Gould CM, Li J, Paquet-Fifield S, Harris NC, Walter A, Gregory JL, Lamont SF, Liu R, Takano EA, Nowell CJ, Bower NI, Resnick D, Smyth GK, Coultas L, Hogan BM, Fox SB, Mueller SN, Simpson KJ, Achen MG, Stac Tags: Sci Signal Source Type: research

Pro ‐inflammatory M1 Macrophage enhances metastatic potential of ovarian cancer cells through NF‐κB activation
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - October 12, 2017 Category: Molecular Biology Authors: Untack Cho, Boyun Kim, Soochi Kim, Youngjin Han, Yong Sang Song Tags: RESEARCH ARTICLE Source Type: research

“Epigenetic control of early neurodegenerative events in Diabetic Retinopathy by the histone deacetylase SIRT6”
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - October 19, 2017 Category: Neuroscience Authors: Mar ía A. Zorrilla‐Zubilete, Ada Yeste, Francisco J. Quintana, Debra Toiber, Raul Mostoslavsky, Dafne M. Silberman Tags: Original Article Source Type: research

Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells.
Authors: Mahbouli S, Der Vartanian A, Ortega S, Rougé S, Vasson MP, Rossary A Abstract NADPH oxidase (NOX) complexes (a family of seven isoforms) drive cellular ROS production in patho-logical processes such as cancer. NOX-driven ROS production is involved in cell mechanisms from signalling to oxidative stress. Leptin, an adipokine overexpressed in obese patients, has been investigated in studies on breast carcinogenesis, but its effects on oxidative stress remain largely unexplored, especially in breast cancer. The study used three human mammary epithelial cell models presenting different neoplastic status (healt...
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways.
In conclusion, the FFAR1 promoted airway smooth muscle cell proliferation and p70S6K phosphorylation through MEK/ERK and PI3K/Akt signaling pathways. PMID: 29097424 [PubMed - as supplied by publisher]
Source: Am J Physiol Lung Ce... - November 2, 2017 Category: Respiratory Medicine Authors: Matoba A, Matsuyama N, Shibata S, Masaki E, Emala CW, Mizuta K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.
Conclusions: Reduced SLC19A1 expression in human adipocytes induces DNA hypermethylation resulting in increased expression of specific pro-inflammatory genes including CCL2. This constitutes an epigenetic mechanism that may link dysfunctional adipocytes to WAT inflammation and IR. PMID: 29121255 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - November 7, 2017 Category: Endocrinology Authors: Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, Gracia A, Toft S, Dahlman-Wright K, Hedén P, Dahlman I, Wheelock CE, Arner P, Mejhert N, Gao H, Rydén M Tags: J Clin Endocrinol Metab Source Type: research

Microvascular Adaptations to Exercise: Protective Effect of PGC-1 Alpha.
CONCLUSIONS: These findings suggest that the microvascular adaptations to exercise training, and the exercise-induced protection against acute vascular stress in overweight/obese subjects, are mediated by PGC-1α. PMID: 29140431 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - November 11, 2017 Category: Cardiology Authors: Kadlec AO, Barnes C, Durand MJ, Gutterman DD Tags: Am J Hypertens Source Type: research

Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6
Abstract Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes. Moreover, glucose‐induced neuron and glial cell damage may occur shortly after the onset of diabetes which makes the disease hard to diagnose at early stages. SIRT6, a NAD‐dependent sirtuin deacylase, modulates aging, energy metabolism, and neurodegeneration. In previous studies we showed that SIRT6 deficiency causes major retinal transmission d...
Source: Journal of Neurochemistry - November 21, 2017 Category: Neuroscience Authors: Mar ía A. Zorrilla‐Zubilete, Ada Yeste, Francisco J. Quintana, Debra Toiber, Raul Mostoslavsky, Dafne M. Silberman Tags: Original Article Source Type: research