Wild-type IDH2 contributes to Epstein-Barr virus -dependent metabolic alterations and tumorigenesis
ConclusionsOur results demonstrate EBV-LMP1/c-Myc/IDH2WT signaling axis is critical for EBV-dependent metabolic changes and tumorigenesis, which may provide new insights into EBV-related cancer diagnosis and therapy.Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 19, 2020 Category: Endocrinology Source Type: research

PPARγ and PPARα synergize to induce robust browning of white fat in vivo
ConclusionsPPARγ and PPARα synergize to induce robust browning of white fat in vivo, via PPARγ activation in adipose, and PPARα-mediated increase in FGF21.Graphical abstractDual PPARα/γ activation is superior to selective PPARγ activation at inducing browning of white fat in vivo: via PPARγ action in the adipose and a PPARα-mediated action in the liver resulting in increased circulating fibroblast growth factor 21 (FGF21). (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 19, 2020 Category: Endocrinology Source Type: research

Adipose TBX1 Regulates β-Adrenergic Sensitivity in Subcutaneous Adipose Tissue and Thermogenic Capacity In Vivo
Conclusions: Adipose expression of TBX1 is necessary, but not sufficient, to defend body temperature during cold via proper UCP1 expression. Adipose TBX1 expression was also required for proper insulin signaling in subcutaneous adipose as well as maintaining β-adrenergic sensitivity but overexpression of TBX1 was not sufficient to induce adipocyte beiging or prevent diet induced obesity. TBX1 expression is enriched in adipose stem cells in which it has contrasting effects on adipogenesis in mouse versus human cells. Collectively, these data demonstrate the importance of adipose TBX1 in the regulation of beige adipocyt...
Source: Molecular Metabolism - February 19, 2020 Category: Endocrinology Source Type: research

ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids
ConclusionOur data provide proof-of-concept for the controlled manipulation of specific endocrine lineages with small molecules, whilst also shedding new light on human EEC differentiation and its similarity to the mouse. Given their diverse roles, understanding endocrine lineage plasticity and its control could have multiple therapeutic implications.Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 18, 2020 Category: Endocrinology Source Type: research

Irisin: Still chasing shadows
ConclusionOur data represent an explicit warning against measuring circulating irisin using available methods. Measuring irisin is akin to chasing shadows. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 16, 2020 Category: Endocrinology Source Type: research

Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice
ConclusionsOur study provides fundamental insights on the molecular mechanisms underlying POMC neuron malprogramming in obesogenic contexts.Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 16, 2020 Category: Endocrinology Source Type: research

De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry
ConclusionsWe developed the SPACiAL workflow to provide immunohistochemistry-guided in situ metabolomics on intact tissue sections. Diminishing the workload by automated recognition of histological and functional features, the pipeline allows comprehensive analyses of metabolic heterogeneity. The multimodality of immunohistochemical staining and extensive molecular information from imaging mass spectrometry has the advantage of increasing both the efficiency and precision for spatially resolved analyses of specific cell types. The SPACiAL method is a stepping stone for the objective analysis of high-throughput, multi-omics...
Source: Molecular Metabolism - February 15, 2020 Category: Endocrinology Source Type: research

Two genomes one cell: mitochondrial-nuclear coordination via epigenetic pathways
Publication date: Available online 15 February 2020Source: Molecular MetabolismAuthor(s): Meike Wiese, Andrew J. BannisterAbstractBackgroundVirtually all eucharyotic cells contain spatially distinct genomes; a single nuclear genome that harbours the vast majority of genes and much smaller genomes found in mitochondria present at thousands of copies per cell. In order to generate a coordinated gene response to various environmental cues, the genomes must communicate with each another. Much of this bi-directional crosstalk relies upon epigenetic processes, which include DNA, RNA and histone modification pathways. Crucially, ...
Source: Molecular Metabolism - February 15, 2020 Category: Endocrinology Source Type: research

A non-proliferative role of pyrimidine metabolism in cancer
ConclusionIn leukemic cells the pyrimidine catabolism induces terminal differentiation towards monocytic lineage to check the aberrant cell proliferation whereas in some solid tumors (such as triple negative breast cancer and hepatocellular carcinoma) catalytic degradation of pyrimidines maintains the mesenchymal-like state driven by epithelial to mesenchymal transition (EMT). This review further broadens this concept to understand the effect of PyM on metastasis and, ultimately, delivers a rationale to investigate the involvement of the pyrimidine molecules as oncometabolites. Overall, understanding the non-proliferative ...
Source: Molecular Metabolism - February 15, 2020 Category: Endocrinology Source Type: research

Beta Cell Identity Changes with Mild Hyperglycemia: Implications for Function, Growth, and Vulnerability
ConclusionsThese findings suggest that mild glucose elevations in the early stages of diabetes lead to phenotypic changes that adversely affect beta cell function, growth, and vulnerability. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 15, 2020 Category: Endocrinology Source Type: research

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation
ConclusionsA majority of acyl-CoA species are annotated to mitochondrial metabolic processes. Since acyl-CoAs are not known to be directly transported across mitochondrial membranes, they must be synthesized outside of mitochondria and potentially within the nucleus to participate in chromatin regulation. Thus, subcellular metabolic compartmentalization likely plays a key role in the regulation of histone acylation. Metabolite tracing in combination with targeting of relevant enzymes and transporters will help to elucidate the metabolic pathways that connect acyl-CoA metabolism to chromatin modification. The specific funct...
Source: Molecular Metabolism - February 15, 2020 Category: Endocrinology Source Type: research

Capturing functional epigenomes for insight into metabolic diseases
Publication date: Available online 14 February 2020Source: Molecular MetabolismAuthor(s): Fiona Allum, Elin GrundbergAbstractBackgroundMetabolic diseases such as obesity are known to be driven by both environmental and genetic factors. Although genome-wide association studies of common variants and their impact in complex traits have provided some biological insight into disease etiology, identified genetic variants have been found to contribute only a small proportion to disease heritability and to map mainly to non-coding regions of the genome. In order to link variants to function, association studies of cellular traits...
Source: Molecular Metabolism - February 15, 2020 Category: Endocrinology Source Type: research

Metabolic transcriptional memory
Publication date: Available online 12 February 2020Source: Molecular MetabolismAuthor(s): Poonam BhedaAbstractBackgroundOrganisms can be primed by metabolic exposures to continue expressing response genes even once the metabolite is no longer available, and can affect the speed and magnitude of responsive gene expression during subsequent exposures. This “metabolic transcriptional memory” can have a profound impact on the survivability of organisms in fluctuating environments.Scope of reviewHere I present several examples of metabolic transcriptional memory in the microbial world and discuss what is known so fa...
Source: Molecular Metabolism - February 13, 2020 Category: Endocrinology Source Type: research

The taming of PARP1 and its impact on NAD+ metabolism
ConclusionsThe presence of macroH2A1.1, particularly in differentiated cells, raises the threshold for the activation of PARP1 with consequences for DNA repair, gene transcription and NAD+ homeostasis. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 13, 2020 Category: Endocrinology Source Type: research

Interaction between metabolism and chromatin in plant models
ConclusionsDue to conservation of chromatin modifying mechanisms, mammals and plants share a common dependence on metabolic intermediates that serve as cofactors for chromatin modifications. In addition, plant specific non-CG methylation pathways are particularly sensitive to changes in folate-mediated one-carbon metabolism. Finally, reactive oxygen and nitrogen species may fine-tune epigenetic processes and involve similar signaling mechanisms involved in environmental stress responses in plants as well as in animals. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 13, 2020 Category: Endocrinology Source Type: research

Testing the carbohydrate insulin model in mice: erroneous critique does not alter previous conclusion
Publication date: Available online 12 February 2020Source: Molecular MetabolismAuthor(s): J.R. Speakman, S. Hu, J. Togo (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 13, 2020 Category: Endocrinology Source Type: research

Testing the Carbohydrate-Insulin Model in Mice: The Importance of Distinguishing Primary Hyperinsulinemia from Insulin Resistance and Metabolic Dysfunction
Publication date: Available online 12 February 2020Source: Molecular MetabolismAuthor(s): David S. Ludwig, Cara B. Ebbeling, Benjamin T. Bikman, James D. Johnson (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 13, 2020 Category: Endocrinology Source Type: research

Klf6 protects β-cells against insulin resistance-induced dedifferentiation
ConclusionOur study identifies a new transcription factor that protects β-cells against dedifferentiation, and which may be targeted to prevent diabetes development. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 7, 2020 Category: Endocrinology Source Type: research

Hypothalamic POMC Deficiency Increases Circulating Adiponectin Despite Obesity
ConclusionIn summary, we provide the first evidence that despite obesity, the ArcPomc-/- mouse model has high circulating adiponectin levels, which revealed that increased fat mass is not necessarily correlated with hypoadiponectinemia. Our investigation also uncovered a previously unknown physiological pathway connecting POMC neurons via the sympathetic nervous system to circulating adiponectin, thereby shedding light on the biological regulation of adiponectin. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 7, 2020 Category: Endocrinology Source Type: research

Metabolic Dysfunction in Polycystic Ovary Syndrome: Pathogenic Role of Androgen Excess and Potential Therapeutic Strategies
Publication date: Available online 5 February 2020Source: Molecular MetabolismAuthor(s): Miguel A. Sanchez-Garrido, Manuel Tena-SempereAbstractBackgroundPolycystic ovary syndrome (PCOS) is the most common endocrinopathy among women at reproductive age. While its cardinal manifestations include hyperandrogenism, oligo/anovulation and/or polycystic ovarian morphology, PCOS women often display also notable metabolic comorbidities. An array of pathogenic mechanisms have been implicated in the etiology of this heterogeneous endocrine disorder; hyperandrogenism at various developmental periods being proposed as major driver for ...
Source: Molecular Metabolism - February 6, 2020 Category: Endocrinology Source Type: research

Impact Of Global Ptp1b Deficiency On The Gut Barrier Permeability During Nash In Mice
ConclusionAltogether our results have unraveled a potential role of PTP1B in the gut-liver axis during NASH, likely mediated by increased sensitivity to GLPs, with potential therapeutic value.Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 6, 2020 Category: Endocrinology Source Type: research

Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation
ConclusionWe identified iRhom2 as a key regulator that promotes obesity-associated metabolic disorders. Loss of iRhom2 from macrophages in adipose tissues may indirectly restrain inflammation and insulin resistance via blocking crosslinks between macrophages and adipocytes. Hence, iRhom2 may be a therapeutic target for obesity-induced metabolic dysfunction.Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 5, 2020 Category: Endocrinology Source Type: research

Melanocortin Regulation of Histaminergic Neurons via Perifornical Lateral Hypothalamic Melanocortin 4 Receptors
ConclusionsThese experiments identify a functional interaction between the melanocortin and histaminergic systems, and suggest that HDC neurons act naturally to restrain the anorexigenic effect of melanocortin system activation. These findings may have implications for the control of arousal and metabolic homeostasis, especially in the context of obesity where both processes are subjected to alterations. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 5, 2020 Category: Endocrinology Source Type: research

Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure
ConclusionsThe findings highlight a pathway linking FoxO1 to mitochondrial dysfunction that can mediate β-cell failure. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 5, 2020 Category: Endocrinology Source Type: research

Editorial Board, cover figure description and credits
Publication date: February 2020Source: Molecular Metabolism, Volume 32Author(s): (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 4, 2020 Category: Endocrinology Source Type: research

MBOAT7-Driven Phosphatidylinositol Remodeling Promotes the Progression of Clear Cell Renal Carcinoma
ConclusionsOur work highlights the accumulation of AA-PI in ccRCC and demonstrates a novel way to decrease the AA-PI pool in ccRCC by limiting MBOAT7. Our data reveal that metastatic ccRCC is associated with altered AA-PI metabolism, and identify MBOAT7 as a novel target in advanced ccRCC. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 4, 2020 Category: Endocrinology Source Type: research

Irisin – still chasing shadows
ConclusionOur data represent an explicit warning against relying on measurements of circulating irisin with available methods. Measuring irisin is still like chasing shadows. (Source: Molecular Metabolism)
Source: Molecular Metabolism - February 1, 2020 Category: Endocrinology Source Type: research

Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity
ConclusionOur data suggest that extrahepatic targeting of T39 by ASOs in adipose tissue macrophages produced an off-target type 1 IFN response, leading to activation of lipolysis, browning of WAT and weight loss. While our findings suggest that ASOs may induce off-target type 1 IFN response more commonly than previously appreciated, they also suggest that therapeutic induction of type 1 IFN selectively in ATMs could potentially represent a novel approach to the treatment of obesity. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 31, 2020 Category: Endocrinology Source Type: research

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight
ConclusionsAltogether, our results demonstrate that PRDM12 plays an essential role in the early establishment of hypothalamic melanocortin neuron identity and the maintenance of high expression levels of Pomc. Its absence in adult mice significantly impairs Pomc expression and leads to increased food intake, adiposity, and obesity. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 29, 2020 Category: Endocrinology Source Type: research

Mechanisms of insulin resistance related to white, beige, and brown adipocytes
Publication date: Available online 7 January 2020Source: Molecular MetabolismAuthor(s): Michael P. CzechAbstractBackgroundThe diminished glucose lowering effect of insulin in obesity, called “insulin resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious maladies. Many publications on this topic have suggested numerous hypotheses on the molecular and cellular disruptions that contribute to the syndrome. However, significant uncertainty remains on the mechanisms of its initiation and long-term maintenance.Scope of reviewTo simplify insulin resistance analysis, this review focuses...
Source: Molecular Metabolism - January 28, 2020 Category: Endocrinology Source Type: research

Genome-wide association study of adipocyte lipolysis in the GENetics of Adipocyte Lipolysis (GENiAL) cohort
ConclusionsIn conclusion, we identified a genetic regulator of spontaneous lipolysis, and provide evidence for HIF3A as a novel key regulator of lipolysis in subcutaneous adipoctyes as the mechanism through which the locus is influencing adipose tissue biology. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 26, 2020 Category: Endocrinology Source Type: research

Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation
ConclusionWe identify iRhom2 as a key regulator that promotes obesity-associated metabolic disorders. Loss of iRhom2 from macrophages in adipose tissues may indirectly restrain inflammation and insulin resistance via blocking crosslink between macrophages and adipocytes. Hence, iRhom2 may be a therapeutic target for obesity-induced metabolic dysfunction.Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 22, 2020 Category: Endocrinology Source Type: research

Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism
ConclusionsLepRb sequences between residues 921 and 960 mediate the STAT3 and LepRb phosphorylation-independent second signal that contributes to the control of energy balance and metabolism by leptin/LepRb. In addition to confirming the inhibitory role of the region (residues 961–1013) containing Tyr985, we also identified the region containing residues 1013–1053 (which contains no Tyr residues) as a second potential mediator of LepRb inhibition. Thus, the intracellular domain of LepRb mediates multiple Tyr-independent signals. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 18, 2020 Category: Endocrinology Source Type: research

Chromatin dynamics and histone modifications in intestinal microbiota-host crosstalk
Publication date: Available online 27 December 2019Source: Molecular MetabolismAuthor(s): Rachel Fellows, Patrick Varga-WeiszAbstractBackgroundThe microbiota in the human gut is an important component of normal physiology that has co-evolved from the earliest multicellular organisms. Therefore, it is unsurprising that there is intimate crosstalk between the microbial world in the gut and the host. Genome regulation through microbiota-host interactions not only affects the host's immunity, but also metabolic health and resilience against cancer. Chromatin dynamics of the host epithelium involving histone modifications and o...
Source: Molecular Metabolism - January 14, 2020 Category: Endocrinology Source Type: research

Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
ConclusionsThe direct adverse effect of glucocorticoid in human beta cell function is mediated via important beta cell proteins and components of the GC signaling pathway in an intricate interplay with GAS5 lincRNA, a potentially novel therapeutic target to counter GC-mediated beta cell dysfunction. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 12, 2020 Category: Endocrinology Source Type: research

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and the control of food intake, adiposity and body weight
ConclusionsAltogether, our results demonstrate that PRDM12 plays an essential role in the early establishment of hypothalamic melanocortin neuron identity and the maintenance of high expression levels of Pomc. Its absence in adult mice greatly impairs Pomc expression and leads to increased food intake, adiposity and obesity. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 12, 2020 Category: Endocrinology Source Type: research

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
ConclusionsPGC-1α variants have distinct, yet complementary roles in hepatic responses to metabolism and inflammation and we identify PGC-1α4 as an important mitigator of apoptosis.Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 12, 2020 Category: Endocrinology Source Type: research

A neural basis for octanoic acid regulation of energy balance
ConclusionsThe MCFA octanoic acid is a centrally signalling nutrient that targets POMC neurons via distinct direct and indirect signal transduction pathways to instigate changes in energy status. These results could explain the beneficial health effects that accompany MCFA consumption. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 9, 2020 Category: Endocrinology Source Type: research

Regulation of hepatic glutamine metabolism by miR-122
ConclusionsCollectively, these results show that miR-122 modulates Gln metabolism both in vitro and in vivo, implicating therapeutic potential of miR-122 in HCCs that exhibit relatively high GLS levels. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 9, 2020 Category: Endocrinology Source Type: research

Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures
ConclusionsCollectively, we identify the islet cell type of action across genetic signals of T2D predisposition and provide higher-resolution mechanistic insights into genetically encoded risk pathways. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 9, 2020 Category: Endocrinology Source Type: research

Analysing central metabolism in ultra-high resolution: At the crossroads of carbon and nitrogen
ConclusionWith the technological advances in mass spectrometry that allow for the analysis of the metabolome in high resolution, the application of stable isotope resolved metabolomics has become an important technique in the investigation of biological processes. The literature in the area of isotope labelling is dominated by 13C tracer studies. Metabolic pathways have to be considered as complex interconnected networks and should be investigated as such. Moving forward to simultaneous tracing of different stable isotopes will help elucidate the interplay between carbon and nitrogen flow and the dynamics of de novo nucleo...
Source: Molecular Metabolism - January 7, 2020 Category: Endocrinology Source Type: research

Editorial Board, cover figure description and credits
Publication date: January 2020Source: Molecular Metabolism, Volume 31Author(s): (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 7, 2020 Category: Endocrinology Source Type: research

Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes
ConclusionsOur data reveals that exendin-4 stimulates hepatic ABCA1 expression and reduces lipid accumulation by the CaMKK/CaMKIV/PREB pathway, suggesting that ABCA1 and PREB might be the therapeutic targets in fatty liver disease.Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 7, 2020 Category: Endocrinology Source Type: research

Mechanisms of insulin resistance related to white, beige and brown adipocytes
ConclusionsAdipocyte heterogeneity is required to mediate the multiple pathways that control systemic glucose tolerance. White adipocytes specialize in sequestering triglyceride away from liver, muscle and other tissues to limit toxicity. In contrast, brown/beige adipocytes are very active in directly taking up glucose in response to β adrenergic signaling and insulin and enhancing energy expenditure. Nonetheless, white, beige and brown adipocytes all share the common feature of secreting factors and perhaps exosomes that act on distant tissues to control glucose homeostasis. Obesity exerts deleterious effects on each...
Source: Molecular Metabolism - January 7, 2020 Category: Endocrinology Source Type: research

Identification of Leptin Receptor Sequences Crucial for the STAT3-Independent Control of Metabolism
ConclusionsLepRb sequences between residues 921 and 960 mediate the STAT3 and LepRb phosphorylation-independent second signal that contributes to the control of energy balance and metabolism by leptin/LepRb. In addition to confirming the inhibitory role of the region (residues 961-1013) containing Tyr985, we also identified the region containing residues 1013-1053 (which contains no Tyr residues) as a second potential mediator of LepRb inhibition. Thus, the intracellular domain of LepRb mediates multiple Tyr-independent signals. (Source: Molecular Metabolism)
Source: Molecular Metabolism - January 4, 2020 Category: Endocrinology Source Type: research

Glucocorticoid induces human beta cell dysfunction and involves the riborepressor GAS5 lincRNA
ConclusionsThe direct adverse effect of glucocorticoid in human beta cell function is mediated via important beta cell proteins and components of the GC-signaling pathway in an intricate interplay with the GAS5 lincRNA, a potentially novel therapeutic target to counter GC-mediated beta cell dysfunction. (Source: Molecular Metabolism)
Source: Molecular Metabolism - December 28, 2019 Category: Endocrinology Source Type: research

Chromatin dynamics and histone modifications in the intestinal microbiota-host crosstalk
ConclusionsHost-microbiome interactions are important evolutionary drivers and are, thus, expected to be hardwired into and mould the epigenetic machinery in multicellular organisms. Microbial derived short chain fatty acids (SCFA) emerge as a dominant determinant in microbiome-host interaction and the inhibition of histone deacetylases (HDACs) by SCFA is a key mechanism in this process. The discovery of alternative histone acylations, such as crotonylation, in addition to the canonical histone acetylation reveals a new layer of complexity in this crosstalk. (Source: Molecular Metabolism)
Source: Molecular Metabolism - December 28, 2019 Category: Endocrinology Source Type: research

Early life lessons: the lasting effects of germline epigenetic information on organismal development
Publication date: Available online 27 December 2019Source: Molecular MetabolismAuthor(s): Carolina Galan, Marina Krykbaeva, Oliver J. RandoAbstractBackgroundAn organism’s metabolic phenotype is primarily affected by its genotype, its lifestyle, and the nutritional composition of its food supply. In addition, it is now clear from studies in many different species that ancestral environments can also modulate metabolism in at least one to two generations of offspring.Scope of reviewWe limit ourselves here to paternal effects in mammals, primarily focusing on studies performed in inbred rodent models. Although hundreds ...
Source: Molecular Metabolism - December 28, 2019 Category: Endocrinology Source Type: research

Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation
ConclusionsCollectively, these results suggest that ERα function is superfluous in protecting against HFD-induced skeletal muscle metabolic derangements after postnatal development is complete. (Source: Molecular Metabolism)
Source: Molecular Metabolism - December 24, 2019 Category: Endocrinology Source Type: research

Continuous glucose monitoring reveals glycemic variability and hypoglycemia after vertical sleeve gastrectomy in rats
ConclusionsRat bariatric surgery duplicates many features of human post bariatric surgery hypoglycemia including postprandial hypoglycemia and glycemic variability, while blockade of GLP-1 receptor signaling prevents the hypoglycemia but the variability. (Source: Molecular Metabolism)
Source: Molecular Metabolism - December 24, 2019 Category: Endocrinology Source Type: research