On-demand HIV Pre-exposure Prophylaxis
According to World Health Organization statistics, 1.7 million people became newly infected with HIV in 2019. Daily PrEP (pre-exposure prophylaxis) with the combination of emtricitabine (FTC) and tenofovir (TAF) or tenofovir disoproxil fumarate (TDF) is highly effective in preventing HIV infection. However, many people can find it challenging to adhere to a daily pill schedule and thus, may not fully benefit from PrEP. CDC researchers developed a new method with the potential to prevent HIV infection by administering a clinical drug regimen n only one or two doses prior to anticipated HIV exposure. This method includes co...
Source: NIH OTT Licensing Opportunities - September 14, 2021 Category: Research Authors: ott8admin Tags: Collaboration Sought CDC Source Type: research

Cross Species Single Domain Antibodies Targeting PD-L1 for Treating Solid Tumors
Programed Death-Ligand 1 (PD-L1, also known as B7-H1 or CD274) is a cell surface protein that binds to Programmed Cell Death Protein 1 (PD-1, also known as CD279). An imbalance in PD-1/PD-L1 activity contributes to cancer immune escape.   PD-1 is expressed on the surface of antigen-stimulated T cells. The interaction between PD-L1 and PD-1 negatively regulates T cell-mediated immune responses. It has been suggested that disrupting the PD-L1/PD-1 signaling pathway can be used to treat cancers. The aberrant expression of PD-L1 on mu ltiple tumor types supports this suggestion. As a result, PD-L1 represents a strong targ...
Source: NIH OTT Licensing Opportunities - September 10, 2021 Category: Research Authors: ott8admin Tags: Therapeutics Collaboration Sought NCI Source Type: research

Tempol as a Therapeutic to Treat Covid-19 Via Inhibition of Viral Replication
Despite several partially effective prophylactic vaccines for SARS-CoV-2 exist, patients worldwide still succumb to COVID-19. New therapeutics to treat this disease are still needed.   Upon host invasion, a critical step in the pathogenesis of COVID-19 is intracellular replication of SARS-CoV-2 before viral particles invade nearby healthy cells. This triggers an extreme inflammatory response that may lead to acute respiratory distress syndrome (ARDS) or transmission to another host. Therefore, therapeutics that can successfully curb the replication of SARS-CoV-2 are imperative. Within host cells, the replication ...
Source: NIH OTT Licensing Opportunities - September 10, 2021 Category: Research Authors: ott8admin Tags: Therapeutics Collaboration Sought NICHD NCI Source Type: research

Personalized Tumor Vaccine and Use Thereof for Cancer Immunotherapy
Immune checkpoint inhibitors (ICIs) vastly improved the outcome of various advanced cancers; however, many are less likely to respond to single-agent ICI. Tumors with low T-cell infiltration are "immunologically cold" and less likely to respond to single-agent ICI therapy. This diminished response is presumably due to the lack of neoantigens necessary to activate an adaptive immune response. On the other hand, an "immunologically hot" tumor with high T-cell infiltration has an active anti-tumor immune response following ICI treatment. Therefore, converting immunologically “cold: tumors to "ho...
Source: NIH OTT Licensing Opportunities - September 10, 2021 Category: Research Authors: ott8admin Tags: Therapeutics Collaboration Sought NICHD NCI Source Type: research

IgG4 Hinge Containing Chimeric Antigen Receptors Targeting Glypican-1 For Treating Solid Tumors
Pancreatic cancer is the fourth most common cause of cancer deaths in the U.S. The overall 5-year survival rate is 8.5%. Glypican-1 (GPC1) is a cell surface heparan sulfate proteoglycan protein overexpressed in pancreatic cancer. Due to preferential expression, GPC1 represents a potential candidate for targeted therapy for pancreatic cancer and other GPC1-expressing cancers, such as prostate.Researchers at National Cancer Institute (NCI) developed novel Chimeric Antigen Receptors (CARs) specific for GPC1 that include short Immunoglobulin subclass 4 (IgG4) hinge sequences between the extracellular antigen recognition domain...
Source: NIH OTT Licensing Opportunities - September 10, 2021 Category: Research Authors: ott8admin Tags: Therapeutics Collaboration Sought NCI Source Type: research

Novel Human Insulin C α-Peptide as an Antagonist for Islet and Brain Amyloidosis
Over 32 million Americans are living with Diabetes and newly diagnosed cases of type 1 and type 2 diabetes is increasing. A defining feature of type 2 diabetes mellitus (T2DM) is the accumulation of islet amyloid polypeptide (IAPP) fibrils in pancreatic islets. Such accumulations form amyloid plaques, referred to as islet amyloidosis. Mounting evidence suggests that islet amyloidosis plays a causative role in the development and progression of ß-cell dysfunction in T2DM. Currently, approved therapies for T2DM modulate the production of or sensitivity to insulin, but do not specifically target islet amyloidosis. Thus,...
Source: NIH OTT Licensing Opportunities - September 10, 2021 Category: Research Authors: ott8admin Tags: Therapeutics Collaboration Sought NIA Source Type: research

A Murine Model of Inflammation Based on Chronic Expression of Interferon-Gamma
An autoimmune disease is characterized by a malfunctioning healthy immune system mistakenly attacking healthy cells, tissues, and organs. These chronic diseases likely result from interactions between genetic and environmental factors. Gender, race, and ethnicity characteristics have been linked to the development of an autoimmune disease. Autoimmune diseases affect approximately 8% of the population, 78% of whom are women. Importantly, autoimmunity is known to have a genetic basis and tends to cluster in families.The cytokine Interferon gamma (IFN γ) is critical for innate and adaptive immune responses. Aberrant exp...
Source: NIH OTT Licensing Opportunities - September 10, 2021 Category: Research Authors: ott8admin Tags: Research Materials Collaboration Sought NCI Source Type: research

Novel Method of Fat Suppression in Steady State Free Precession (SSFP) Based Magnetic Resonance Imaging (MRI)
Technology IDE-237-2003-0 Novel Method of Fat Suppression in Steady State Free Precession (SSFP) Based Magnetic Resonance Imaging (MRI)Linked IDTAB-923InventorsDaniel Herzka (NHLBI)Elliot Mcveigh (NHLBI)John Derbyshire (NHLBI)Lead InventorsJohn Derbyshire (NHLBI)Co-InventorsDaniel Herzka (NHLBI)Elliot Mcveigh (NHLBI)ApplicationsResearch MaterialsDiagnosticsICsNHLBIAvailable for licensing is a technique for improving magnetic resonance imaging (MRI) that employs steady state free precession (SSFP). One such technique, fast imaging with steady-state free precession (FISP), is a well established and is a fast MR imaging meth...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRI
Technology IDE-240-1998-0 Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRILinked IDTAB-925InventorsAnthony Aletras ()Kathleen Ward ()Robert Balaban (NHLBI)Lead InventorsRobert Balaban (NHLBI)Co-InventorsAnthony Aletras ()Kathleen Ward ()ApplicationsResearch MaterialsDiagnosticsICsNHLBIAvailable for licensing is an MRI image improving system wherein at least one contrast agent is administered to a subject in amounts effective to perform chemical exchange dependent saturation transfer (CEDST) MRI analysis.Examples of contrast agents suitable for administration as exogenous contrast a...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

Haplotypes of Human Bitter Taste Receptor Genes
Technology IDE-222-2003-1 Haplotypes of Human Bitter Taste Receptor GenesLinked IDTAB-946InventorsDennis Drayna (NIDCD)Un-kyung Kim (NIDCD)Lead InventorsDennis Drayna (NIDCD)Co-InventorsUn-kyung Kim (NIDCD)ApplicationsTherapeuticsResearch MaterialsDiagnosticsICsNIDCDBitter taste has evolved in mammals as a crucial, important warning signal against ingestion of poisonous or toxic compounds. However, many beneficial compounds are also bitter, and taste masking of bitter tasting pharmaceutical compounds is a billion dollar industry. The diversity of compounds that elicit bitter-taste sensations is very large and more than tw...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

Peptides With Laminin Activity
Technology IDE-521-1986-3 Peptides With Laminin ActivityLinked IDTAB-95InventorsFrank Robey (NIDCR)George Martin (NIDCR)Hynda Kleinman (NIDCR)Jeannette Graf ()Makoto Sasaki ()Yoshihiko Yamada (NIDCR)Yukihide Iwamoto ()Lead InventorsYoshihiko Yamada (NIDCR)Co-InventorsFrank Robey (NIDCR)George Martin (NIDCR)Hynda Kleinman (NIDCR)Jeannette Graf ()Makoto Sasaki ()Yukihide Iwamoto ()Development StagesPre-clinical (in vivo)ICsNIDCRCommercial Applicationscancer therapeuticresearch reagentPeptides with laminin activity, including YIGSR, are claimed. These peptides block angiogenesis, alter the formation of capillary structures b...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

Laminin A Peptides
Technology IDE-246-1988-0 Laminin A PeptidesLinked IDTAB-96InventorsGeorge Martin (NIDCR)Hynda Kleinman (NIDCR)Makoto Sasaki (NIDCR)Yoshihiko Yamada (NIDCR)Lead InventorsYoshihiko Yamada (NIDCR)Co-InventorsGeorge Martin (NIDCR)Hynda Kleinman (NIDCR)Makoto Sasaki (NIDCR)ApplicationsTherapeuticsResearch MaterialsDiagnosticsTherapeutic AreasOncologyICsNIDCRCommercial Applicationsadhesion agentcancer therapeuticresearch reagentThis invention relates to peptides and derivatives thereof having laminin-like activity, as well as a pharmaceutical composition of the peptide. The peptides claimed include Serine-Isoleucine-Lysine-Val...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

Probe To Identify Enteroinvasive E. coli And Shigella Species
Technology IDE-034-1989-0 Probe To Identify Enteroinvasive E. coli And Shigella SpeciesLinked IDTAB-97InventorsJames Jagow ()Keith Lampel ()Lead InventorsKeith Lampel ()Co-InventorsJames Jagow ()ApplicationsDiagnosticsTherapeutic AreasInfectious DiseaseStandard means for detecting pathogenic organisms in food or clinical specimens rely on animals or large DNA fragments, such as the 17 kb EcoRI fragment of Boileau. These methods are expensive, time-consuming, difficult to use, and have not been able to distinguish between nonvirulent enteroinvasive E. coli and Shigella. This invention describes DNA probes for enteroinvasiv...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

Anti-Vaccinia Monoclonal Antibody
Technology IDE-123-2004-0 Anti-Vaccinia Monoclonal AntibodyLinked IDTAB-978InventorsJack Bennink (NIAID)Jonathan (Jon) Yewdell (NIAID)Josephine Cox (NIAID)Lead InventorsJonathan (Jon) Yewdell (NIAID)Co-InventorsJack Bennink (NIAID)Josephine Cox (NIAID)ApplicationsResearch MaterialsTherapeutic AreasInfectious DiseaseICsNIAIDThe current technology describes a monoclonal antibody that reacts with a vaccinia virus protein abundantly expressed under an early viral promoter after infection of cells. The antibody is useful for quantitating vaccinia virus infected cells and for studying the function of the protein to which it bin...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine Recipients
Technology IDE-259-2004-2 HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine RecipientsLinked IDTAB-985InventorsHana Golding (FDA)Surender Khurana (FDA)Lead InventorsHana Golding (FDA)Co-InventorsSurender Khurana (FDA)ApplicationsDiagnosticsTherapeutic AreasInfectious DiseaseICsFDACommercial ApplicationsVaccine efficacy studies; Detection of early seroconversion in vaccine recipientsDistinguishing between healthy vaccine recipients and natural HIV infectionBlood bank screeningAvailable for licensing and commercial distribution is a serological test specifically designed to distinguish between antibodies gener...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine Recipients
Technology IDE-259-2004-3 HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine RecipientsLinked IDTAB-985InventorsHana Golding (FDA)Surender Khurana (FDA)Lead InventorsHana Golding (FDA)Co-InventorsSurender Khurana (FDA)ApplicationsDiagnosticsTherapeutic AreasInfectious DiseaseICsFDACommercial ApplicationsVaccine efficacy studies; Detection of early seroconversion in vaccine recipientsDistinguishing between healthy vaccine recipients and natural HIV infectionBlood bank screeningAvailable for licensing and commercial distribution is a serological test specifically designed to distinguish between antibodies gener...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

Transcytosis of Adeno-Associated Viruses
Technology IDE-298-2004-0 Transcytosis of Adeno-Associated VirusesLinked IDTAB-995InventorsGiovanni Di Pasquale (NIDCR)John Chiorini (NIDCR)Lead InventorsJohn Chiorini (NIDCR)Co-InventorsGiovanni Di Pasquale (NIDCR)ICsNIDCRThe invention relates to a method for delivering nucleic acids to a variety of cells including those of the gut, kidney, lung and central nervous system. The underlying cells of such organs are covered by a barrier of endothelial or epithelial cells which can limit the transfer of nucleic acids, or other potentially therapeutic agents, to the underlying target cells. To overcome this limitation, the met...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Source Type: research

Novel Method of Fat Suppression in Steady State Free Precession (SSFP) Based Magnetic Resonance Imaging (MRI)
Available for licensing is a technique for improving magnetic resonance imaging (MRI) that employs steady state free precession (SSFP). One such technique, fast imaging with steady-state free precession (FISP), is a well established and is a fast MR imaging method commonly used to evaluate cardiovascular anatomy and function. FISP provides high signal to noise ratio (SNR) images with excellent contrast between blood and the myocardium. However, these images are often contaminated with high signal from fatty tissue resulting in image artifacts. Conventional methods of fat signal suppression in FISP are often inefficient and...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Research Materials Diagnostics Licensing Desired NHLBI Source Type: research

Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRI
Available for licensing is an MRI image improving system wherein at least one contrast agent is administered to a subject in amounts effective to perform chemical exchange dependent saturation transfer (CEDST) MRI analysis. Examples of contrast agents suitable for administration as exogenous contrast agents include at least one functional group bearing a proton capable of chemical exchange. Examples of these functional groups include, without limitation, amides, amines, and carboxyl, hydroxyl, and sulfhydryl groups. The contrast agent can be administered as a solid, as a dispersion or solution, such as an aqueous composi...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Research Materials Diagnostics Licensing Desired NHLBI Source Type: research

Haplotypes of Human Bitter Taste Receptor Genes
Bitter taste has evolved in mammals as a crucial, important warning signal against ingestion of poisonous or toxic compounds. However, many beneficial compounds are also bitter, and taste masking of bitter tasting pharmaceutical compounds is a billion dollar industry. The diversity of compounds that elicit bitter-taste sensations is very large and more than two dozen members of the T2R bitter taste receptor family have been identified. Individuals are now known to be genetically predisposed to respond or not to respond to the bitter taste of a number of substances. For example, large individual differences in the perceptio...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Therapeutics Research Materials Diagnostics Licensing Desired NIDCD Source Type: research

Peptides With Laminin Activity
Peptides with laminin activity, including YIGSR, are claimed. These peptides block angiogenesis, alter the formation of capillary structures by endothelial cells, prevent the formation of excess blood vessels in tissue and inhibit in vivo tumor cell colonization of tissues. These peptides can be used, among other things, to inhibit metastasis.Inventors: Frank Robey (NIDCR) George Martin (NIDCR) Hynda Kleinman (NIDCR) Jeannette Graf () Makoto Sasaki (NIDCR) Yoshihiko Yamada (NIDCR) Yukihide Iwamoto ()Commercial Advantages:cancer therapeuticresearch reagentCompetitive Advantages:encourage cell ...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Licensing Desired Pre-clinical (in vivo) NIDCR Source Type: research

Laminin A Peptides
This invention relates to peptides and derivatives thereof having laminin-like activity, as well as a pharmaceutical composition of the peptide. The peptides claimed include Serine-Isoleucine-Lysine-Valine-Alanine-Valine (SIKVAV). Methods for promoting increased adhesion and migration of epithelial cells is also disclosed. The peptides have wide usage in research, nerve regeneration and cancer treatment. For example, this invention may be useful as an adhesion and regeneration agent for nerve guides and as an adhesion agent for vascular prosthesis.Inventors: Hynda Kleinman (NIDCR)Commercial Advantages:adhesion agent...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Research Materials Licensing Desired NIDCR Oncology Source Type: research

Probe To Identify Enteroinvasive E. coli And Shigella Species
Standard means for detecting pathogenic organisms in food or clinical specimens rely on animals or large DNA fragments, such as the 17 kb EcoRI fragment of Boileau. These methods are expensive, time-consuming, difficult to use, and have not been able to distinguish between nonvirulent enteroinvasive E. coli and Shigella. This invention describes DNA probes for enteroinvasive E. coli and Shigella species, including the sequence of the 2.5 kb fragment (SmaII and Falkow's) on which the probe is based. The probe is more reliable, more sensitive, and less expensive than methods now in use.Inventors: James Jagow () Ke...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Diagnostics Licensing Desired Infectious Disease Source Type: research

Anti-Vaccinia Monoclonal Antibody
The current technology describes a monoclonal antibody that reacts with a vaccinia virus protein abundantly expressed under an early viral promoter after infection of cells. The antibody is useful for quantitating vaccinia virus infected cells and for studying the function of the protein to which it binds, which is known to be a double stranded RNA binding protein involved in resistance of the virus to interferons. This antibody is available for licensing through a biological materials license agreement.Inventors: Jonathan (Jon) Yewdell (NIAID) (Source: NIH OTT Licensing Opportunities)
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Research Materials Licensing Desired NIAID Infectious Disease Source Type: research

HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine Recipients
Available for licensing and commercial distribution is a serological test specifically designed to distinguish between antibodies generated in HIV vaccine recipients and those generated in a natural HIV infection. The method is useful in HIV vaccine development and clinical studies as it can readily detect early breakthrough infections in seroconverted vaccine recipients, thus providing the information required to determine vaccine efficacy. The test kit includes diagnostic peptide fragments derived from human immunodeficiency virus-1 (HIV-1). The peptide epitopes are primarily derived from the GAG-p6 and gp41 genes. These...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Diagnostics Licensing Desired FDA Infectious Disease Source Type: research

Transcytosis of Adeno-Associated Viruses
The invention relates to a method for delivering nucleic acids to a variety of cells including those of the gut, kidney, lung and central nervous system. The underlying cells of such organs are covered by a barrier of endothelial or epithelial cells which can limit the transfer of nucleic acids, or other potentially therapeutic agents, to the underlying target cells. To overcome this limitation, the method employs certain members of the parvovirus family to transcytose the barrier cells. During transcytosis, the virus passes through these barrier cells and can infect cells of the underlying layer. Therefore, this method co...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Licensing Desired & Collaboration Desired Collaboration Sought NIDCR Source Type: research

Multimeric Protein Toxins to Target Cells Having Multiple Identifying Characteristics
This technology relates to multimeric bacterial protein toxins which can be used to specifically target cells. Specifically, this is a modified recombinant anthrax toxin protective antigen (PrAg) that has been modified in several ways. First, the PrAg can be activated both by a metalloproteinase (MMP) and by urokinase plasminogen activator (uPA). Second, the native PrAg lethal factor (LF) binding site has been modified so that only a modified PrAg comprising two different monomers can bind anthrax LF. When administered with an effector component, the recombinant anthrax toxins are toxic only to cells expressing both a MMP ...
Source: NIH OTT Licensing Opportunities - July 21, 2021 Category: Research Authors: ott8admin Tags: Therapeutics Collaboration Sought NIDCR NIAID Oncology Immunology Source Type: research

Synergistic Use of Exo VII Inhibitors And Quinolone Antibiotics For Treating Bacterial Infection
Technology Bundle IDNCI-E-171-2020 Synergistic Use of Exo VII Inhibitors And Quinolone Antibiotics For Treating Bacterial InfectionApplicationsTherapeuticsLead InventorsShar-yin Huang (NCI)Yves Pommier (NCI)Co-InventorsBrianna Mitchell (NCI)Development StatusPre-clinical (in vivo)ICsNCITopoisomerase poisons, such as quinolone antibiotics, are widely used as anticancer drugs and antibiotics. Quinolone antibiotics act by trapping prokaryotic type IIA topoisomerases (DNA gyrase and TOPO IV), resulting in irreversible topoisomerase cleavage complexes. However, current U.S. Food and Drug Administration (FDA) guidance reserves ...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Human Synovial Sarcoma Cell Line A2243
Technology Bundle IDNCI-E-160-2005 Human Synovial Sarcoma Cell Line A2243ApplicationsResearch MaterialsCo-InventorsNelson Ellmore ()Stuart Aaronson ()Development StatusDiscovery (Lead Identification)Synovial sarcoma is a cancer affecting mesenchymal cells in connective tissues. This rare cancer is typically linked to genetic abnormalities or exposure to radiation. Metastatic growth throughout the body can occur primarily through blood circulation. More than 90% of synovial sarcomas show a characteristic t(X;18)(p11;q11) translocation involving the SYT and SSX genes. The resulting SYT-SSX abnormal fusion protein causes mis...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

T-cell Phenotypes Associated with Clinical Response to Adoptive Immunotherapy
Technology Bundle IDNCI-E-167-2019 T-cell Phenotypes Associated with Clinical Response to Adoptive ImmunotherapyApplicationsTherapeuticsLead InventorsSteven Rosenberg (NCI)Co-InventorsFrank Lowery (NCI)Gregoire Altan-Bonnet (NCI)Paul Robbins (NCI)Sri Krishna (NCI)Development StatusBasic (Target Identification)ICsNCIAdoptive T-cell therapy (ACT) utilizes tumor-reactive T cells to induce disease remission. While ACT has been used effectively to treat metastatic melanoma and certain epithelial cancers, most patients do not respond to treatment. Although the mechanisms underlying this variable response to therapy are not full...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Immunogens for Use in a High Efficacy HIV Vaccine
Technology Bundle IDNCI-E-160-2018 Immunogens for Use in a High Efficacy HIV VaccineLead InventorsGenoveffa Franchini (NCI)Co-InventorsGiacomo Gorini (NCI)Isabela Castro (NCI)Massimiliano Bissa (NCI)Timothy Cardozo (New York University)Development StatusPre-clinical (in vivo)ICsNCIHuman immunodeficiency virus (HIV) infections remain a pandemic, most prevalent in Africa and the Americas. Anti-retroviral treatments have been effective in preventing spread of the virus and active outbreaks of acquired immune deficiency syndrome (AIDS). However, the development and deployment of an effective vaccine would provide long-lasting...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Chimeric Antigen Receptors to CD22 for Treating Hematological Cancers
Technology Bundle IDNCI-E-291-2012 Chimeric Antigen Receptors to CD22 for Treating Hematological CancersApplicationsTherapeuticsLead InventorsIra Pastan (NCI)Co-InventorsCrystal Mackall (NCI)Dimiter Dimitrov (NCI)Rimas Orentas (NCI)Development StatusClinicalICsNCIChimeric antigen receptors (CARs) are hybrid proteins consisting of an antibody binding fragment fused to protein signaling domains that cause T-cells which express the CAR to become cytotoxic.   Once activated, these cytotoxic T-cells can selectively eliminate the cells which they recognize via the antibody binding fragment of the CAR.  Thus, by engine...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Human and Improved Murine Monoclonal Antibodies Against CD22
Technology Bundle IDNCI-E-080-2008 Human and Improved Murine Monoclonal Antibodies Against CD22ApplicationsTherapeuticsLead InventorsIra Pastan (NCI, CCR, LMB)Co-InventorsDimiter Dimitrov (NCI, CCR, NP)Xiaodong Xiao (NCI, CCR, NP)Development StatusPre-clinical (in vivo)CD22 is a common cell surface glycoprotein expressed in B-cells and present in B-cell lymphomas; e.g., hairy cell leukemia (HCL), non-Hodgkins lymphoma (NHL), chronic lymphoblastic leukemia (CLL), and other cancers. It is therefore a target for cancer immunotherapy. Conjugation of anti-CD22 monoclonal antibodies with toxins or drugs has shown promise in cli...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Adriamycin-Resistant Ovarian Tumor Cell Line, NCI/ADR-RES
Technology Bundle IDNCI-E-115-2021 Adriamycin-Resistant Ovarian Tumor Cell Line, NCI/ADR-RESApplicationsResearch MaterialsCo-InventorsKenneth Cowan (NCI)Development StatusPre-clinical (in vivo)ICsNCICancer cells may acquire drug resistance after prolonged chemotherapy. In many cases, cancer cells develop resistance to several drugs with distinct structures and modes of action. This multi-drug resistance phenomenon increases the complexity of cancer treatment.Researchers at the National Cancer Institute (NCI) have derived an Adriamycin-resistant cell line, NCI/ADR-RES, from human ovarian cancer cells. The parental cell lin...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Polymer-Cast Inserts for Cell Histology and Microscopy
Technology Bundle IDNCI-E-196-2018 Polymer-Cast Inserts for Cell Histology and MicroscopyApplicationsResearch MaterialsCo-InventorsRalph Parchment (NCI)Thu Nguyen ()Development StatusPrototypeICsNCIThree-dimensional (3D) cell cultures systems are important for studying cell biology because they providein vivo-like microenvironments more physiologically relevant than two-dimensional (2D) culture systems. In 3D culture systems, cells are grown in culture matrixes and turn into spheroids and organoids later processed for downstream analysis by microscopy and histology techniques. The processing of 3D cultures for analysis by...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

An Anti-Viral Polypeptide: Griffithsin
Technology Bundle IDNCI-E-106-2003 An Anti-Viral Polypeptide: GriffithsinApplicationsTherapeuticsLead InventorsBarry OKeefe (NCI)Co-InventorsJames McMahon ()Toshiyuki Mori (NCI)Development StatusDiscovery (Lead Identification)ICsNCIVirus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated neutralization by the host ’s immune system and as a preventive and therapeutic antiviral strategy. Plant-derived carbohydrate-binding proteins (lectins) have emerged as a new class of antiviral biol...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Development and Characterization of the SLC46A3 Knockout Mouse Line
Technology Bundle IDNCI-E-152-2021 Development and Characterization of the SLC46A3 Knockout Mouse LineApplicationsResearch MaterialsLead InventorsFrank Gonzalez (NCI)Co-InventorsJung-Hwan Kim ()Sun Yim ()Development StatusPre-clinical (in vivo)ICsNCINonalcoholic fatty liver disease is caused by several factors including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. TCDD causes lipid accumulation in humans by inducing the Solute Carrier Family 46 Member 3 (SLC46A3) gene expression. To effectively study TCDD-mediated lipid accumulation, research tools such as SLC46A3 knockout cells and animal mod...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Biological/Research Material for HIV Vaccine Research
Technology Bundle IDTAB-2023 Biological/Research Material for HIV Vaccine ResearchLinked IDE-258-2009-0Lead InventorsBernard Moss (NIAID)Co-InventorsLinda Wyatt (NIAID)Development StatusFully developed. Material has been used extensively in research.Therapeutic AreasInfectious DiseaseICsNIAIDOffered for licensing is a recombinant attenuated vaccinia virus, MVA, that expresses SIV 239gagpol. The materials can be used for research purposes and in particular in the area of HIV/AIDS vaccines. Plasmid insertion vector pJH-4, containing the foreign gene SIV 239 GagPol controlled by vaccinia early/late promoter, inserts into de...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

A Target for the Development of Diagnostics and Therapeutics for Abnormal Hematopoiesis
Technology Bundle IDTAB-2024 A Target for the Development of Diagnostics and Therapeutics for Abnormal HematopoiesisApplicationsTherapeuticsLinked IDE-255-2007-0Lead InventorsPerry Blackshear (NIEHS)Co-InventorsDeborah Stumpo (NIEHS)Development StatusDiscovery stageICsNIEHSThe zinc finger protein ZFP36L2 has been shown by the inventors to play an essential role in hematopoiesis, a process that is dysregulated in hematological cancers, anemia, and other conditions. Thus, ZFP36L2 has promise for use in a diagnostic test to detect abnormal hematopoiesis, or as a target for the development of therapeutics to treat abnormal he...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune Responses
Technology Bundle IDTAB-2041 RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune ResponsesApplicationsResearch MaterialsLinked IDE-222-2009-0Lead InventorsAnton Jetten (NIEHS)ICsNIEHSThe retinoid-related orphan receptor gamma (RORgamma) is a member of the nuclear receptor superfamily. NIH investigators used homologous recombination in embryonic stem cells to generate mice in which the RORgamma gene was disrupted. RORgamma deficient mice lack peripheral and mesenteric lymph nodes and Peyer's patches indicating that ROR expression is indispensable for lymph node organogenesis...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Device and Method for Direct Measurement of Isotopes of Expired Gases: Application in Research of Metabolism and Metabolic Disorders, and in Medical Screening and Diagnostics
Technology Bundle IDTAB-2046 Device and Method for Direct Measurement of Isotopes of Expired Gases: Application in Research of Metabolism and Metabolic Disorders, and in Medical Screening and DiagnosticsApplicationsResearch MaterialsMedical DevicesLinked IDE-099-2009-0Lead InventorsCharles Venditti (NHGRI)Co-InventorsRandy Chandler (NHGRI)Development StatusPrototypeICsNHGRIThe technology offered for licensing and for further development concerns a novel device for intervallic collection of expired gas from subjects and subsequent measurement of the isotopic content of such expired gases. The device is specifically designe...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Vaccines Against Malarial Diseases
Technology Bundle IDTAB-2047 Vaccines Against Malarial DiseasesLinked IDE-052-2004-0Lead InventorsDavid Narum (EntreMed, Inc.)Development StatusProof of concept demonstrated.Therapeutic AreasInfectious DiseaseThe invention offered for licensing is in the field of use of vaccines for malaria. The invention provides gene sequences encoding an erythrocyte binding protein of a malaria pathogen for the expression of the erythrocyte binding protein. The codon composition of the synthetic gene sequences approximates the mammalian codon composition. The synthetic gene sequences are useful for incorporation into DNA vaccine vector...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Device for Selective Partitioning of Frozen Cellular Products
Technology Bundle IDTAB-2049 Device for Selective Partitioning of Frozen Cellular ProductsLinked IDE-173-2009-0Lead InventorsRichard Childs (NHLBI)Co-InventorsSumithira Vasu (CC)Development StagesPrototypeDevelopment StatusPrototypeICsNHLBICCCryopreservation using liquid nitrogen frozen polyvinyl bags allows for storing cellular materials for extended periods while maintaining their activity and viability. Such bags are commonly used in the clinic to store blood products including blood cells, plasma, hematopoietic stem cells, umbilical cord blood for future uses including transplantation. These materials, typically obtai...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Non-Contact Total Emission Detection Methods for Multiphoton Microscopy: Improved Image Fidelity and Biological Sample Analysis
Technology Bundle IDTAB-2053 Non-Contact Total Emission Detection Methods for Multiphoton Microscopy: Improved Image Fidelity and Biological Sample AnalysisLinked IDE-236-2009-0Co-InventorsJay Knutson (NHLBI)Development StagesPrototypeDevelopment StatusIn vitro data availablePrototypeICsNHLBIThe technology offered for licensing and for further development is in the field of multiphoton microscopy (MPM). More specifically, the invention pertains to optical designs that can enhance and extend the capabilities of MPM in spectral imaging of biological samples. The unique design of the light collection and the detection optics...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Mutations of the ERBB4 Gene in Melanoma
Technology Bundle IDTAB-2055 Mutations of the ERBB4 Gene in MelanomaApplicationsDiagnosticsLinked IDE-272-2008-0Lead InventorsYardena Samuels (NHGRI)Development StatusThe technology is currently in the pre-clinical stage of development.Therapeutic AreasOncologyICsNHGRICutaneous malignant melanoma is the most common fatal skin cancer, and the incidence of this disease increases each year. The average survival time for patients diagnosed with malignant melanoma is less than ten months. Consequently, it is important to identify and understand genetic alterations leading to malignant melanoma so that new treatments strategies...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

T-Cell-Specific Gfi-1 Knockout Mouse
Technology Bundle IDTAB-2059 T-Cell-Specific Gfi-1 Knockout MouseLinked IDE-242-2009-0Lead InventorsJinfang Zhu (NIAID)Co-InventorsWilliam Paul (NIAID)Research ProductsAnimal ModelsICsNIAIDThis is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells. It has thus-far been used to demonstrate that GFi-1 plays a critical role in enhancin...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Signal-to-Noise Enhancement in Imaging Applications Using a Time-Series of Images
Technology Bundle IDTAB-2060 Signal-to-Noise Enhancement in Imaging Applications Using a Time-Series of ImagesApplicationsDiagnosticsLinked IDE-292-2009-0Lead InventorsHan Wen (NHLBI)Co-InventorsVinay Pai (NHLBI)Development StatusProof of concept has been demonstrated. Data is available.Need to acquire further data to establish clinical utility of the method and to further optimize the protocol.ICsNHLBIThe invention offered for licensing relates to the field of imaging and specifically to the field of medical imaging. The apparatus and method of the invention provide for noise reduction in imaging applications that use a ...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research

Novel Method of Fat Suppression in Steady State Free Precession (SSFP) Based Magnetic Resonance Imaging (MRI)
Technology Bundle IDE-237-2003-0 Novel Method of Fat Suppression in Steady State Free Precession (SSFP) Based Magnetic Resonance Imaging (MRI)ApplicationsResearch MaterialsDiagnosticsLinked IDTAB-923Lead InventorsJohn Derbyshire (NHLBI)Co-InventorsDaniel Herzka (NHLBI)Elliot Mcveigh (NHLBI)ICsNHLBIAvailable for licensing is a technique for improving magnetic resonance imaging (MRI) that employs steady state free precession (SSFP). One such technique, fast imaging with steady-state free precession (FISP), is a well established and is a fast MR imaging method commonly used to evaluate cardiovascular anatomy and function. FI...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research

Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRI
Technology Bundle IDE-240-1998-0 Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRIApplicationsResearch MaterialsDiagnosticsLinked IDTAB-925Lead InventorsRobert Balaban (NHLBI)Co-InventorsAnthony Aletras ()Kathleen Ward ()ICsNHLBIAvailable for licensing is an MRI image improving system wherein at least one contrast agent is administered to a subject in amounts effective to perform chemical exchange dependent saturation transfer (CEDST) MRI analysis.Examples of contrast agents suitable for administration as exogenous contrast agents include at least one functional group bearing a prot...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research

Haplotypes of Human Bitter Taste Receptor Genes
Technology Bundle IDE-222-2003-1 Haplotypes of Human Bitter Taste Receptor GenesApplicationsTherapeuticsResearch MaterialsDiagnosticsLinked IDTAB-946Lead InventorsDennis Drayna (NIDCD)Co-InventorsUn-kyung Kim (NIDCD)ICsNIDCDBitter taste has evolved in mammals as a crucial, important warning signal against ingestion of poisonous or toxic compounds. However, many beneficial compounds are also bitter, and taste masking of bitter tasting pharmaceutical compounds is a billion dollar industry. The diversity of compounds that elicit bitter-taste sensations is very large and more than two dozen members of the T2R bitter taste rec...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research