Human and Improved Murine Monoclonal Antibodies Against CD22
Technology Bundle IDNCI-E-080-2008
Human and Improved Murine Monoclonal Antibodies Against CD22ApplicationsTherapeuticsLead InventorsIra Pastan (NCI, CCR, LMB)Co-InventorsDimiter Dimitrov (NCI, CCR, NP)Xiaodong Xiao (NCI, CCR, NP)Development StatusPre-clinical (in vivo)CD22 is a common cell surface glycoprotein expressed in B-cells and present in B-cell lymphomas; e.g., hairy cell leukemia (HCL), non-Hodgkins lymphoma (NHL), chronic lymphoblastic leukemia (CLL), and other cancers. It is therefore a target for cancer immunotherapy. Conjugation of anti-CD22 monoclonal antibodies with toxins or drugs has shown promise in cli...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Adriamycin-Resistant Ovarian Tumor Cell Line, NCI/ADR-RES
Technology Bundle IDNCI-E-115-2021
Adriamycin-Resistant Ovarian Tumor Cell Line, NCI/ADR-RESApplicationsResearch MaterialsCo-InventorsKenneth Cowan (NCI)Development StatusPre-clinical (in vivo)ICsNCICancer cells may acquire drug resistance after prolonged chemotherapy. In many cases, cancer cells develop resistance to several drugs with distinct structures and modes of action. This multi-drug resistance phenomenon increases the complexity of cancer treatment.Researchers at the National Cancer Institute (NCI) have derived an Adriamycin-resistant cell line, NCI/ADR-RES, from human ovarian cancer cells. The parental cell lin...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Polymer-Cast Inserts for Cell Histology and Microscopy
Technology Bundle IDNCI-E-196-2018
Polymer-Cast Inserts for Cell Histology and MicroscopyApplicationsResearch MaterialsCo-InventorsRalph Parchment (NCI)Thu Nguyen ()Development StatusPrototypeICsNCIThree-dimensional (3D) cell cultures systems are important for studying cell biology because they providein vivo-like microenvironments more physiologically relevant than two-dimensional (2D) culture systems. In 3D culture systems, cells are grown in culture matrixes and turn into spheroids and organoids later processed for downstream analysis by microscopy and histology techniques. The processing of 3D cultures for analysis by...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
An Anti-Viral Polypeptide: Griffithsin
Technology Bundle IDNCI-E-106-2003
An Anti-Viral Polypeptide: GriffithsinApplicationsTherapeuticsLead InventorsBarry OKeefe (NCI)Co-InventorsJames McMahon ()Toshiyuki Mori (NCI)Development StatusDiscovery (Lead Identification)ICsNCIVirus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated neutralization by the host ’s immune system and as a preventive and therapeutic antiviral strategy. Plant-derived carbohydrate-binding proteins (lectins) have emerged as a new class of antiviral biologic...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Development and Characterization of the SLC46A3 Knockout Mouse Line
Technology Bundle IDNCI-E-152-2021
Development and Characterization of the SLC46A3 Knockout Mouse LineApplicationsResearch MaterialsLead InventorsFrank Gonzalez (NCI)Co-InventorsJung-Hwan Kim ()Sun Yim ()Development StatusPre-clinical (in vivo)ICsNCINonalcoholic fatty liver disease is caused by several factors including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. TCDD causes lipid accumulation in humans by inducing the Solute Carrier Family 46 Member 3 (SLC46A3) gene expression. To effectively study TCDD-mediated lipid accumulation, research tools such as SLC46A3 knockout cells and animal mod...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Biological/Research Material for HIV Vaccine Research
Technology Bundle IDTAB-2023
Biological/Research Material for HIV Vaccine ResearchLinked IDE-258-2009-0Lead InventorsBernard Moss (NIAID)Co-InventorsLinda Wyatt (NIAID)Development StatusFully developed. Material has been used extensively in research.Therapeutic AreasInfectious DiseaseICsNIAIDOffered for licensing is a recombinant attenuated vaccinia virus, MVA, that expresses SIV 239gagpol. The materials can be used for research purposes and in particular in the area of HIV/AIDS vaccines.
Plasmid insertion vector pJH-4, containing the foreign gene SIV 239 GagPol controlled by vaccinia early/late promoter, inserts into de...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
A Target for the Development of Diagnostics and Therapeutics for Abnormal Hematopoiesis
Technology Bundle IDTAB-2024
A Target for the Development of Diagnostics and Therapeutics for Abnormal HematopoiesisApplicationsTherapeuticsLinked IDE-255-2007-0Lead InventorsPerry Blackshear (NIEHS)Co-InventorsDeborah Stumpo (NIEHS)Development StatusDiscovery stageICsNIEHSThe zinc finger protein ZFP36L2 has been shown by the inventors to play an essential role in hematopoiesis, a process that is dysregulated in hematological cancers, anemia, and other conditions. Thus, ZFP36L2 has promise for use in a diagnostic test to detect abnormal hematopoiesis, or as a target for the development of therapeutics to treat abnormal he...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune Responses
Technology Bundle IDTAB-2041
RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune ResponsesApplicationsResearch MaterialsLinked IDE-222-2009-0Lead InventorsAnton Jetten (NIEHS)ICsNIEHSThe retinoid-related orphan receptor gamma (RORgamma) is a member of the nuclear receptor superfamily. NIH investigators used homologous recombination in embryonic stem cells to generate mice in which the RORgamma gene was disrupted. RORgamma deficient mice lack peripheral and mesenteric lymph nodes and Peyer's patches indicating that ROR expression is indispensable for lymph node organogenesis...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Device and Method for Direct Measurement of Isotopes of Expired Gases: Application in Research of Metabolism and Metabolic Disorders, and in Medical Screening and Diagnostics
Technology Bundle IDTAB-2046
Device and Method for Direct Measurement of Isotopes of Expired Gases: Application in Research of Metabolism and Metabolic Disorders, and in Medical Screening and DiagnosticsApplicationsResearch MaterialsMedical DevicesLinked IDE-099-2009-0Lead InventorsCharles Venditti (NHGRI)Co-InventorsRandy Chandler (NHGRI)Development StatusPrototypeICsNHGRIThe technology offered for licensing and for further development concerns a novel device for intervallic collection of expired gas from subjects and subsequent measurement of the isotopic content of such expired gases. The device is specifically designe...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Vaccines Against Malarial Diseases
Technology Bundle IDTAB-2047
Vaccines Against Malarial DiseasesLinked IDE-052-2004-0Lead InventorsDavid Narum (EntreMed, Inc.)Development StatusProof of concept demonstrated.Therapeutic AreasInfectious DiseaseThe invention offered for licensing is in the field of use of vaccines for malaria. The invention provides gene sequences encoding an erythrocyte binding protein of a malaria pathogen for the expression of the erythrocyte binding protein. The codon composition of the synthetic gene sequences approximates the mammalian codon composition. The synthetic gene sequences are useful for incorporation into DNA vaccine vector...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Device for Selective Partitioning of Frozen Cellular Products
Technology Bundle IDTAB-2049
Device for Selective Partitioning of Frozen Cellular ProductsLinked IDE-173-2009-0Lead InventorsRichard Childs (NHLBI)Co-InventorsSumithira Vasu (CC)Development StagesPrototypeDevelopment StatusPrototypeICsNHLBICCCryopreservation using liquid nitrogen frozen polyvinyl bags allows for storing cellular materials for extended periods while maintaining their activity and viability. Such bags are commonly used in the clinic to store blood products including blood cells, plasma, hematopoietic stem cells, umbilical cord blood for future uses including transplantation. These materials, typically obtai...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Non-Contact Total Emission Detection Methods for Multiphoton Microscopy: Improved Image Fidelity and Biological Sample Analysis
Technology Bundle IDTAB-2053
Non-Contact Total Emission Detection Methods for Multiphoton Microscopy: Improved Image Fidelity and Biological Sample AnalysisLinked IDE-236-2009-0Co-InventorsJay Knutson (NHLBI)Development StagesPrototypeDevelopment StatusIn vitro data availablePrototypeICsNHLBIThe technology offered for licensing and for further development is in the field of multiphoton microscopy (MPM). More specifically, the invention pertains to optical designs that can enhance and extend the capabilities of MPM in spectral imaging of biological samples. The unique design of the light collection and the detection optics...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Mutations of the ERBB4 Gene in Melanoma
Technology Bundle IDTAB-2055
Mutations of the ERBB4 Gene in MelanomaApplicationsDiagnosticsLinked IDE-272-2008-0Lead InventorsYardena Samuels (NHGRI)Development StatusThe technology is currently in the pre-clinical stage of development.Therapeutic AreasOncologyICsNHGRICutaneous malignant melanoma is the most common fatal skin cancer, and the incidence of this disease increases each year. The average survival time for patients diagnosed with malignant melanoma is less than ten months. Consequently, it is important to identify and understand genetic alterations leading to malignant melanoma so that new treatments strategies...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
T-Cell-Specific Gfi-1 Knockout Mouse
Technology Bundle IDTAB-2059
T-Cell-Specific Gfi-1 Knockout MouseLinked IDE-242-2009-0Lead InventorsJinfang Zhu (NIAID)Co-InventorsWilliam Paul (NIAID)Research ProductsAnimal ModelsICsNIAIDThis is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells. It has thus-far been used to demonstrate that GFi-1 plays a critical role in enhancin...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
Signal-to-Noise Enhancement in Imaging Applications Using a Time-Series of Images
Technology Bundle IDTAB-2060
Signal-to-Noise Enhancement in Imaging Applications Using a Time-Series of ImagesApplicationsDiagnosticsLinked IDE-292-2009-0Lead InventorsHan Wen (NHLBI)Co-InventorsVinay Pai (NHLBI)Development StatusProof of concept has been demonstrated. Data is available.Need to acquire further data to establish clinical utility of the method and to further optimize the protocol.ICsNHLBIThe invention offered for licensing relates to the field of imaging and specifically to the field of medical imaging. The apparatus and method of the invention provide for noise reduction in imaging applications that use a ...
Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research
