T-Cell-Specific Gfi-1 Knockout Mouse

Technology Bundle IDTAB-2059
T-Cell-Specific Gfi-1 Knockout MouseLinked IDE-242-2009-0Lead InventorsJinfang Zhu (NIAID)Co-InventorsWilliam Paul (NIAID)Research ProductsAnimal ModelsICsNIAIDThis is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells. It has thus-far been used to demonstrate that GFi-1 plays a critical role in enhancing Th2 cell expansion and repressing induction of Th17 and CD103+ iTreg cells.Commercial ApplicationsTool for studying T-cell proliferation and differentiation.Competitive AdvantagesCB Process - Contacted LPM for concurrence of Research Material Eval.Request More InfoLicensing Contact:Yogikala [e-mail]: 301-761-7789Intellectual PropertiesEIR ApplicationResearch Tool -- patent protection is not being pursued for this technologyPublicationsZhu J, et al.PMID">https://www.ncbi.nlm.nih.gov/pubmed/19188499'>PMID 19188499CollaborationsMaterials AvailableLicensing DesiredLicense StatusThis technology is available as a research tool under a Biological Materials License.Date PublishedMon, 01/25/2010 - 12:00Data SourcettsData Source IDTAB-2059

Source: NIH OTT Licensing Opportunities - July 16, 2021 Category: Research Authors: ott8admin Source Type: research