Synthesis and Characterization of Bismuth Beads for Trans Arterial Chemo Embolization Under Computed Tomography (CT) Guidance
Existing microsphere technologies are used as therapy for certain cancers. The therapy is by way of occlusion, when the microspheres are delivered into blood vessels that feed a tumor. The physical dimensions of the microspheres occlude the blood supply and thus, killing the tumor. Some microspheres have also been modified to bind protein, elute drugs, and reduce inflammatory reactions as part of the therapy. However, one technical short-coming of existing microsphere technology is a limited capability to be visualized in real-time. The inability to visualize embolic microspheres during treatment and post treatment could l...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

AngleNav: Micro-Electro-Mechanical Systems (MEMs) Trackers to Facilitate Computed Topography (CT)-Guided Needle Puncture
Conventional free-hand needle puncture procedures for biopsy and other procedures, often rely on unguided manual movements to guide a needle to its destination. Freehand procedures risk missing the tumor, or accidental injury, such as puncturing a vital organ. Needle guidance systems may improve accuracy and reduce risks but available guidance technologies are cumbersome and expensive and may carry other risks. For example, Computed Topography (CT)-guided fluoroscopy for needle guidance may be used, but fluoroscopy requires expensive bulky equipment and exposes patients to increased radiation. The high costs, cumbersome er...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Drug Repurposing to Treat Merkel Cell Carcinoma (MCC)
Merkel Cell Carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin.   It is most commonly found on areas of the skin with higher ultraviolet (UV) exposure, and in Caucasian patients of advanced age.  Interestingly, approximately 80% of MCC tumors are caused by integration of the Merkel cell polyomavirus (MCPyV) into the host genome (VP-MCC).  The remaining 20% ar e virus negative (VN-MCC) and caused by somatic mutations induced by UV exposure.  Current therapeutic strategies include surgical resection and radiotherapy for localized, and chemotherapy for metastatic, disease. Howev...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Topical Sodium Nitrate Ointment for Sickle Cell Disease
Chronic leg ulcers are a debilitating vasculopathic complication for some patients with sickle cell disease (SCD). Prevalence of leg ulcers varies based on age and geographic location; about 5-10% of all SCD patients may suffer leg ulcers. These leg ulcers are painful, result in infections, hospitalization, disability, and negatively impact the patient ’s social and psychological wellbeing on an ongoing basis. Until recently, patients with SCD only had one drug treatment option: hydroxyurea, which was approved by the Food and Drug Administration (FDA) in 1998 in adults and in 2017, in children age 2 and older.  ...
Source: NIH OTT Licensing Opportunities - August 15, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Category Discovery via Looped Deep Pseudo-Task Optimization Using a Large Scale Radiology Image Database
With the advent of large-scale medical databases, thousands of medical images have become available for research and clinical studies. However, with so many images, there are almost no descriptions or annotations associated with each image. Recognizing what is in each image requires highly specialized skills and time.  Generating semantic labels for large-scale radiology image datasets creates a bottleneck in training the deep convolutional neural network (CNN) for image recognition needed for developing Computer Aided Detection (CAD) systems. Natural language processing (NLP) in radiology reports presents many challe...
Source: NIH OTT Licensing Opportunities - August 15, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Methods for Producing Stem Cell-Like Memory T Cells for Use in T Cell-Based Immunotherapies
T cells currently employed for T cell-based immunotherapies are often senescent, terminally differentiated cells with poor proliferative and survival capacity. Recently, however, scientists at the National Cancer Institute (NCI) identified and characterized a new human memory T cell population with stem cell-like properties. Since these T cells have limited quantities in vivo, the scientists have developed methods by which high numbers of these cells can be generated ex vivo for use in T cell-based immunotherapies. Specifically, this invention describes a method for generating the stem cell-like memory T cells by stimulati...
Source: NIH OTT Licensing Opportunities - August 15, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

A Dendritic Cell Vaccine to Immunize Cancer Patients Against Mutated Neoantigens Expressed by the Autologous Cancer
Vaccines against non-viral cancers target mainly differentiation antigens, cancer testis antigens, and overexpressed antigens.   One common feature to these antigens is their presence in central immunological tolerance. Using these vaccines, T cells underwent depletion of high avidity clones directed against such antigens. This depletion can cause the loss of T cells bearing high affinity T cell receptors (TCRs) for their cognate antigens which have superior cytotoxic capacity, longer persistence in the tumor microenvironment, and decreased susceptibility to immune suppression.The Surgery Branch of the National Cancer...
Source: NIH OTT Licensing Opportunities - August 15, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Machine Learning and/or Neural Networks to Validate Stem Cells and Their Derivatives for Use in Cell Therapy, Drug Delivery, and Diagnostics
Many biological and clinical procedures require functional validation of a desired cell type. Current techniques to validate rely on various assays and methods, such as staining with dyes, antibodies, and nucleic acid probes, to assess stem cell health, death, proliferation, and functionality. These techniques potentially destroy stem cells and risk contaminating cells and cultures by exposing them to the environment; they are low-throughput and difficult to scale-up. Therefore, there is a significant need for potentially less invasive, scalable, higher throughput methods of validation, while maintaining quality and accura...
Source: NIH OTT Licensing Opportunities - August 14, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Method for Reproducible Differentiation of Clinical Grade Retinal Pigment Epithelium Cells
The retinal pigment epithelium (RPE) is a cell monolayer with specialized functions crucial to maintaining the metabolic environment and chemistry of the sub-retinal and choroidal layers in the eye. Damage or disease causing RPE cell loss leads to progressive photoreceptor damage and impaired vision. Loss of RPE is observed in many of the most prevalent cases of vision loss, including age related macular degeneration (AMD) and Best disease. Retinal degenerative diseases linked to loss of RPE result in a substantial economic, social, and healthcare burden for individuals and governments worldwide.Currently, no Food and Drug...
Source: NIH OTT Licensing Opportunities - August 14, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

A Triple Combination HIV Microbicide
The HIV-positive population continues to rise despite a worldwide decline in the rates of infection caused by human immunodeficiency virus (HIV).   The HIV virus continues to spread due to a lack of effective vaccines and pre-exposure prophylaxis methods, even though the availability and effectiveness of antiretroviral therapy has helped reduce acquired immunodeficiency syndrome (AIDS)-related deaths. Researchers at the National Cancer Institute (NCI), in collaboration with researchers at the University of Lleida, developed a triple combination microbicide for the prevention of HIV and other sexually transmitted ...
Source: NIH OTT Licensing Opportunities - August 14, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Nucleic Acid Nanoparticles (NANP) and Methods of Using Same for Controlled Immunomodulation
The technology is directed to compositions and methods of designing nucleic acid nanoparticles (NANPs) composed entirely of DNA, RNA, or DNA and RNA to achieve desirable immunostimulation and decrease undesirable effects on the immune system by changing the composition of the NANP. Benefits of the invention include the desirable activation of the immune system by these particles to increase the efficacy of vaccines and immunotherapies.In contrast, the NANPs with minimal to no recognition by the host's immune cells serve as an effective tool for the delivery of therapeutic payloads (small molecules and therapeutic oligonucl...
Source: NIH OTT Licensing Opportunities - August 14, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Argon to Improve Bioanalyte Stability in Fixed Tissue Specimens
The degradation of archival surgical and biospecimen limits the utility of many biomarkers that may have prognostic or predictive significance in guiding a patient ’s therapy. Previous methods at preventing the degradation of RNA and proteins in formalin fixed, paraffin embedded (FFPE) tissue blocks& slides have no protective benefit.  Researchers at the National Institutes of Health (NIH) and American Air Liquide have demonstrated that dissolved reactive gasses entrapped in the fixative and solutions used in tissue preparation contribute to this degradation. Removal of these reactive gasses, and replacement...
Source: NIH OTT Licensing Opportunities - August 3, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

New Chimeric Antigen Receptor (CAR) Format for Developing Improved Adoptive Cell Therapies
Adoptive cell therapy (ACT) is an attractive new therapeutic approach for treating various cancers. ACT has recently demonstrated a high degree of efficacy when treating patients with hematological malignancies. However, to date, no effective Chimeric Antigen Receptors (CAR) T cell therapy exists for solid tumors. Researchers in the National Cancer Institute (NCI) Laboratory of Molecular Biology (LMB) have created a new CAR format that is available for licensing and further co-development. This new format uses a specific promoter and signal peptide in a specific order allowing for increased efficiency of CAR T therapy. Th...
Source: NIH OTT Licensing Opportunities - August 3, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Anti-CD33 Chimeric Antigen Receptors for Treatment of Human Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML) is an aggressive malignancy that is treated using intensive cytotoxic chemotherapeutic regimens. There are limited alternative therapeutic options once the disease becomes refractory to chemotherapeutic treatment. CD33 is expressed on the surface of the vast majority of AML blasts and cells in chronic myeloid leukemia-blast crisis (CML-BC) – and is a well-validated immunotherapeutic target.  CD33 is also aberrantly expressed on a subset of T cell acute lymphoblastic leukemias (ALLs). Normal tissue expression is restricted to normal myeloid cells. Treatment of pre-B cell ALL and lymph...
Source: NIH OTT Licensing Opportunities - August 2, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Dual Specific Anti-CD22 Anti-CD19 Chimeric Antigen Receptors
Chimeric antigen receptors (CARs) combine an antibody-based binding domain (and single chain fragment variable region, scFv) with T cell receptor signaling domains (CD3 zeta with a costimulatory domain, typically CD28 or 41BB). When T cells express CARs, they are activated in a major histocompatibility complex- (MHC-) independent manner to kill tumor cells expressing the target to which the scFv binds.   CAR T cells targeting the B cell antigen CD19 have resulted in remissions in 60-80% of patients with pre-B cell precursor acute lymphoblastic leukemia (BCP-ALL). However, not all patients respond, and relapses occur i...
Source: NIH OTT Licensing Opportunities - August 2, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Enhanced Immunogenicity Against HIV-1 Using a DNA-prime Poxvirus Vaccination
Researchers at the National Cancer Institute (NCI) have developed a method of stimulating an immune response in humans at risk for infection by, or already infected with, an Human Immunodeficiency Virus (HIV)-1 retrovirus. This method utilizes deoxyribonucleic acid (DNA) vaccines to stimulate CD8+ T cell immune responses. The DNA vaccine encodes antigens known to be effective against retroviruses, such as HIV-1gag, gp120, nefCTL, and proCTL. The same antigens are also expressed by the pox virus vaccine, which elicits an increased immune response when combined with the DNA vaccine. The pox virus expands T and B cells activa...
Source: NIH OTT Licensing Opportunities - August 1, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Renal Selective Unsaturated Englerin Analogues
Englerin A, a natural product, has shown growth-inhibiting activity against renal cancer cell lines. The compound is an agonist of protein kinase C (PCK) theta, which results in cell cytotoxicity, insulin inhibition, and selective activation of viral replication in T cells.   Englerin A derivatives are promising treatment strategies for any diseases associated with PKC theta and/or ion channel proteins.Researchers at the National Cancer Institute have developed a series of Englerin A analogs for the treatment of renal cancer. The new derivatives are less toxic than the parent compound and have shown effective inhibiti...
Source: NIH OTT Licensing Opportunities - August 1, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Improved HIV Vaccines Through Ras Activation
Researchers at the National Cancer Institute (NCI) have developed a new method of improving the efficacy of vaccines in patients with human immunodeficiency virus (HIV) by activating Ras. This method can be used to develop more efficacious vaccine compositions by activating Ras before, during, or after vaccination. Additionally, the researchers discovered that modulation of the Ras pathways could be a predictive biomarker of protection against HIV. This novel method has been shown to effectively stimulate the Ras pathway and to improve vaccine protection from Simian Immunodeficiency Virus (SIV), a HIV animal model, in chim...
Source: NIH OTT Licensing Opportunities - August 1, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Monitoring Public Water Supply for a Variety of Pathogens
The simultaneous concentration and recovery of microbes in drinking water is important for responding to potential water-related events such as pathogen contamination or bioterrorism and could be a cost-effective technique for routine monitoring of drinking water quality. Scientists at the CDC have combined two techniques, ultrafiltration (UF) and insulator-based dielectrophoresis (iDEP) in series, to achieve significant concentration of microbes and pathogens for analysis. UF can concentrate a water sample ≥200X, depending on turbidity; if a secondary concentration step is applied, then a ≥25,000X can be achieved. R...
Source: NIH OTT Licensing Opportunities - July 31, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Conformational Restriction of Cyanine Fluorophores in Far-Red and Near-IR Range
Small molecule fluorescent probes are important tools in diagnostic medicine. Existing far-red and near-IR cyanine fluorophores (e.g. Cy5, Alexa 647, Cy7, ICG) are active in the far-red and near-range, but these agents suffer from modest quantum yields (brightness) which limit wide utility. It has been reported that the limited brightness of these fluorophores is due to an excited-state C-C rotation pathway.The invention is directed to a new class of conformationally restricted cyanines that exhibit significantly improved quantum yield (3-4-fold increase in fluorescence quantum yield). These compounds are active in the lon...
Source: NIH OTT Licensing Opportunities - July 27, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Fusion Proteins as HIV-1 Entry Inhibitors
Soluble forms of human CD4 (sCD4) inhibit HIV-1 entry into immune cells.   Different forms of sCD4 and their fusion proteins have been extensively studied as promising HIV-1 inhibitors – including in animal models and clinical trials.  However, they have not been successful in human studies due to their transient efficacy.  sCD4 is also known to interact with class II major histocompatibility complex (MHCII) and, at low concentrations, could enhance HIV-1 infectivity. NCI researchers previously described a novel bispecific multivalent fusion protein called 4Dm2m which contains a single human CD4 d...
Source: NIH OTT Licensing Opportunities - July 27, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Targeted RNA/DNA Nanoparticles with Single Stranded RNA Toeholds
The development of RNA-based nanostructures and their use in a variety of applications, including RNA interference (RNAi) and drug delivery, represents an emerging field of science, technology, and biomedicine.   RNA is a dynamic material because of its natural functionalities, its ability to fold into complex small structures, and its capacity to self-assemble.  Taking advantage of these characteristic, NCI Researchers have improved upon their existing invention of multi-functional RNA/DNA nanoparticles by adding a RNA toehold instead of a DNA toehold.   In in vitro studies, they have shown that the nanopa...
Source: NIH OTT Licensing Opportunities - July 27, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Scytovirin Domain 1 Related Polypeptides
Despite therapeutic advances, human immunodeficiency virus (HIV) is still a pervasive disease, with approximately 37 million people infected worldwide. Peptides have become popular therapeutic agents, as these proteins offer structural diversity for many different diseases. Several peptides were commercially developed as HIV therapeutics, demonstrating the high potential for peptides in treating HIV.  Researchers at the National Cancer Institute developed a novel small polypeptide, known as SD1, for use as an HIV therapeutic. SD1 is derived from scytovirin, a potent anti-HIV protein isolated from the cyanobacterium Sc...
Source: NIH OTT Licensing Opportunities - July 27, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Methods and Compositions for Treating Genetically Linked Diseases of the Eye
X-linked retinoschisis (XLRS) is an inherited, monogenetic ocular disease caused by mutations in the retinoschisin (RS1) gene, resulting in the development of cystic cavities throughout the retina and leading to juvenile macular degeneration. Approximately 1:15,000 males in the US are affected, classifying the condition as an orphan indication.  The National Eye Institute (NEI) has developed a tissue-specific gene therapy approach based upon adeno-associated virus (AAV) mediated delivery of the full coding sequence for human retinoschisin to retinal cells under the control of a retinoschisin promoter.   Delivery ...
Source: NIH OTT Licensing Opportunities - July 27, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Inhibition of CD300f Function on Dendritic Cells Promotes Tumor Destruction
Cancer immunotherapy aims to enhance the ability of a patient ’s own immune response to destroy tumors. The magnitude of the immune response is determined by the balance between immune activating signals and negative inhibitory signals. Checkpoint receptors are negative regulators that normally deliver inhibitory signals which limit immune activation. Bloc kade of immune checkpoints represents an effective strategy to enhance the immune response against cancer cells.NIAID researchers have discovered that blocking CD300f function in dendritic cells markedly enhances their ability to phagocytose and process apoptotic t...
Source: NIH OTT Licensing Opportunities - July 23, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Methods and Compositions for Treating Lysosomal Storage Diseases
Recombinant AAV serotype 6 (rAAV6) is used to deliver the human lysosomal alpha-mannosidase (LAMAN) (MAN2B) cDNA sequence to the choroid plexus epithelia. This approach is designed to replace the missing lysosomal enzyme, LAMAN in the brain and thereby avert lethal neurodegenerative processes that follow from defects in lysosomal storage and metabolism. Preclinical experiments in a mouse model have demonstrated restoration of LAMAN to normal or near-normal levels globally throughout the brain, after specific and selective transduction of choroid plexus. Additional preclinical development, including large animal testing and...
Source: NIH OTT Licensing Opportunities - July 20, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Interleukin 24 (IL-24) to treat inflammatory diseases
Proinflammatory T-helper 17 cells (Th17) play important roles in host immune defense against infection, but uncontrolled activation of these cells, known as the Th17 response, may cause autoimmune and autoinflammatory diseases (uveitis, multiple sclerosis, rheumatoid arthritis, and Crohn ’s disease) through the effects of Th17 lineage cytokines (such as, IL-17F, IL-22 and GM-CSF). Importantly, IL-17A (a proinflammatory cytokine) represses other Th17 lineage cytokines by upregulating the regulatory cytokine IL-24. Loss of this regulatory pathway due to IL-17A neutralization, and co nsequent upregulation of the other T...
Source: NIH OTT Licensing Opportunities - July 19, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

3D Image Rendering Softwarefor Biological Tissues
Available for commercial development is software that provides automatic visualization of features inside biological image volumes in 3D. The software provides a simple and interactive visualization for the exploration of biological datasets through dataset-specific transfer functions and direct volume rendering. The method employs a K-Means++ clustering algorithm to classify a two-dimensional histogram created from the input volume. The classification process utilizes spatial and data properties from the volume. Then using properties derived from the classified clusters, the software automatically generates color and opac...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Improved Production of Prenylated Protein in Insect Cells
KRAS and other Ras-family enzymes are an important component of over 30% of human cancers, however, no effective therapeutics targeting Ras or Ras-driven cancers are currently available.   The production of Ras proteinsin vitro is required for the identification and characterization of Ras targeting drugs.   An important step in producing the Ras protein involves prenylation of the C-terminus of the protein via farnesyltransferase, a modification that does not occur in prokaryotic organisms.  Previous attempts to generate properly processed Ras in eukaryotic cells has produced only low levels of pro tein whi...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Device for selectively removing cells from a biological sample
A variety of techniques have been used to isolate specific cells or cell populations from a histological sample under direct microscopic visualization.   Techniques that involve manual or micro-manipulation devices to isolate individual cells based upon visible characteristics and/or immunological staining are labor intensive and can require an extended amount of time.  TheNational Institute for Childhood Health and Diseases (NICHD) has invented a device and a method to automatically identify cells reacting with light sensitive immunoreagent (s) (e.g., antibodies labeled with a light sensitive tag).   The d...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Therapeutic antibody-drug conjugates targeting CD56-positive cancers
The glycoprotein CD56, also known as a neural cell adhesion molecule (NCAM), plays an important role in normal physiological functions.   It is expressed in low levels in normal cells such as neurons, glia, skeletal muscle and natural killer cells. It is highly expressed on a variety of cancerous cells including those of neuroblastoma, small-cell lung cancer, and multiple myeloma.  In neuroblastoma, patients undergo a very aggress ive standard of care regimen that results in a high mortality rate.  Many neuroblastomas have increased expression of CD56, which represents a possible therapeutic target for these...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Human Antibody for Deploying CH2-Based Therapeutics
The National Cancer Institute seeks parties to license fully human antibodies for CH2-based research materials.Recently, isolated immunoglobulin constant CH2 domains were proposed as scaffolds for construction of libraries containing diverse binders that could confer some effector functions.  As a fragment in all IgGs, which are at high concentrations in blood, CH2-based therapeutics are likely to be well tolerated in therapeutic concentrations. CH2 binders can also be engineered to be selective so as to retain some of the effector functions that are possessed only by IgGs and not by o ther scaffolds.NCI scientists di...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

High-throughput Assay to Identify New Cancer Drugs
 The National Cancer Institute seeks parties interested in collaborative research to evaluate or commercialize a diagnostic tool that can identify new drugs that increase chromosome instability.  Although chromosomal instability is generally thought of as a driver of tumor growth, a threshold leve l exists where CIN becomes a barrier to tumor growth and therefore can be exploited therapeutically.Most human malignant solid tumors have been shown to contain chromosomal abnormalities.   Chromosomal instability (CIN) is the continuous formation of novel chromosome mutations at a higher rate than that of normal c...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Transgenic Mouse Model of Human Basal Triple Negative Breast Cancer
The NCI Laboratory of Cancer Biology and Genetics seeks parties interested in collaborative research to further develop this mouse model of triple-negative breast cancer (TNBC) to study cancer biology and for preclinical testing.   As a Research Tool, patent protection is not being pursued for this technology. Basal triple-negative breast cancer (TNBC) is a common form of human breast cancer for which there are no specific, targeted therapies, unlike hormone-responsive or Her2+ breast cancers. TNBC has a much worse prognosis than hormone receptor + cancer and is disproportionately high in the African-American populati...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics
The promise of RNA interference based therapeutics is made evident by the recent surge of biotechnological drug companies that pursue such therapies and their progression into human clinical trials. The present invention discloses novel RNA   and RNA/DNA nanoparticles including  multiple siRNAs, RNA aptamers, fluorescent dyes, and proteins. These RNA nanoparticles are useful for various nanotechnological applications. This technology has a higher detection sensitivity and higher silencing efficiencies of targeted genes than conventio nal siRNAs.  This technology has significant therapeutic potential against ...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Fully-human Monoclonal Antibodies Against Human EphrinB2 and EphB4
Ephrin receptor tyrosine kinases and their ephrin ligands have been implicated in cancer pathogenesis. Ephrin receptors and ligands affect tumor growth, invasiveness, angiogenesis, and metastasis. Ephrin signaling activities in cancer are complex and are only now beginning to be uncovered. Researchers at the National Cancer Institute-Frederick, NIH developed a set of five fully-human monoclonal antibodies against human Ephrin-B2 and Ephrin type-B receptor 4 ( " EphB4 " ). The antibodies were identified by screening a naive human antibody phage display library against Ephrin-B2 and EphB4. These human monoclonal an...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Treatment of Prostate Cancer using Anti-androgen Small Molecules
Castrate-resistant prostate cancer (CRPC) is characterized by androgen-independent cancer cells that have adapted to the depletion of hormones and continue to grow. Abnormal androgen receptor signaling is known to drive advanced castrate-resistant prostate cancer. The small molecule compounds of this invention are antiandrogens that target androgen receptor signaling in both androgen-independent and androgen-sensitive androgen receptor activity, and androgen receptors that are resistant to the current antiandrogens available.   Unlike the currently available antiandrogens, the new small molecules induce androgen recep...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Dual-Function Protein ATIA for Diagnostics and Therapeutics of Glioblastoma
Investigators at the NCI Laboratory of Immune Cell Biology  discovered an Anti-TNF Induced Apoptosis (ATIA) protein, which protects cells against apoptosis.  ATIA is highly expressed in glioblastoma and astrocytomas and its inhibition results in increased cell sensitivity to TNF-related apoptosis-inducing ligand induced cell death.  Hence, ATIA assays ma y enable clinicians to effectively stratify patients for appropriate treatment.  ATIA exists in a soluble form that can be detected in culture medium of ATIA expressing cells indicating it could be used to develop a non-invasive, blood based diagnostic ...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Diagnostics and Therapeutics for Adrenocortical Carcinomas
The National Cancer Institute'sEndocrine Oncology Branch seeks parties to co-develop diagnostic that target altered human miRNA expression such as miRNA-483 and miRNA 100 to accurately predict if a patient's adrenal cortex tumor is benign or malignant.Adrenocortical carcinomas (ACC) are rare but aggressive cancers and typically have a poor prognosis.   Currently, there are limited options for molecular diagnosis to distinguish malignant tumors from benign tumors of this type.  As a result there are few treatment strategies for ACC. This technology describes that altered human miRNA expression such as miRNA-483 an...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

PARP Inhibitor and NO-Donor Dual Prodrugs as Anticancer Agents
Poly-ADP ribose polymerase-1 (PARP-1) is a critical enzyme involved in DNA repair.   The inhibition of PARP has emerged as a promising strategy in cancer therapy.  Numerous PARP inhibitors have been developed and advanced into clinical trials, both for use as single agents in specific patient populations and as combination therapies with various chemotherapeutics.  The inductio n of strand break damage to DNA, as has been demonstrated in cancer cells treated with O2-arylated diazeniumdiolates, coupled with inhibition of DNA repair by PARP inhibitors, represents a novel rationale for effective combination the...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Co-Transcriptional Assembly of Modified RNA Nanoparticles
The National Cancer Institute seeks parties interested in  collaborative research to co-develop a method to generate RNA molecules suitable for nanoparticle and biomedical applications.The development of nanoparticles as a method of drug delivery is paving the way for precise targeted therapy making it a more attractive and effective method for treating cancer. However, the current methods of designing RNA nanoparticles are limited by three factors: 1) the cost and size limitations associated with chemical synthesis of RNA; 2) the complexity of RNA nanoparticle production; and 3) low retention time of RNA nanoparticle...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Immunocompetent Mouse Model for Tracking Cancer Progression
The National Cancer Institute seeks interested parties to co-develop transgenic mice having immunocompetent rat growth hormone-firefly Luciferase-enhanced green fluorescent protein.The technology is a transgenic mouse model tolerized to firefly Luciferase (ffLuc)- and enhanced green fluorescent protein (eGFP)-labeled tissue whilst maintaining normal immune function. Luc and eGFP are the most frequently used bioimaging markers to track cancer progression in pre-clinical mouse models. As these markers are immunogenic, their reporter activity becomes diminished over time and so their use has largely been limited to immunodefi...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Synergistic Combination Agent for Cancer Therapy
Work by theNanotechnology Characterization Laboratory (NCL), a joint initiative of NCI, NIST, and the FDA, has led to the discovery of a novel combination chemotherapy. This combination is shown to have synergistic effects on cytotoxicity to cancer cells in vitro, and to cause a substantial decrease in tumor growth in preclinical tumor models in vivo. Combination therapy using these agents may enhance the response rate of different cancers to these drugs and may significantly reduce side effects by permitting a lower therapeutic dose to be administered. SAIC Frederick'' s Nanotechnology Characterization   Laboratory&n...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

BODIPY-FL Nilotinib (Tasigna) for Use in Cancer Research
The National Cancer Institute'' s Laboratory of Cell Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize bodipy conjugated tyrosine kinase inhibitors that are currently used in the clinic for the treatment of CML or gastric cancers. We are also interested in evaluating third generation tyrosine kinase inhibitor derivatives as modulators of ABC drug transporters to improve the efficiency of chemotherapy in animal (mouse) model system. In addition, we can identify possible pharmacokinetic interactions of the novel kinase inhi...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Software for Automated Generation of Density Maps
The   National Cancer Institute (NCI) is seeking parties interested in licensing software for the automated determination of macromolecular structures using cryo-electron microscopy. The technology available  is computer software for the automated generation of density maps of macromolecular structures from a series of 2D digital micrographs of frozen hydrated specimens collected using an electron microscope equipped with an ultra-cooled computerized stage.  A series of images of biological specimens collected at different tilt angles relative to the electron beam are aligned to compensate for mechanical err...
Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Antibodies for Rabies Post-exposure Prophylaxis or Antiviral Therapy of Clinical Rabies
Lyssaviruses are single-stranded RNA viruses that cause rabies and rabies-like diseases in mammals. According to the World Health Organization, human rabies caused by the classical rabies virus continues to be almost 100% fatal once clinical symptoms of rabies appear, with no specific treatment available anywhere in the world.CDC researchers have identified lyssavirus-specific antibodies for the treatment and prevention of rabies in humans post-exposure. They have also developed a method using a na ïve antibody phage display library to identify phage clones that bind recombinant rabies virus or cells from multiple lys...
Source: NIH OTT Licensing Opportunities - July 11, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Real-time PCR Detection of Streptococcus pneumoniae with High Sensitivity and Specificity
Streptococcus pneumoniae em> is the leading cause of community-acquired pneumonia and is also a frequent cause of bloodstream, brain and spinal cord, ear, and sinus infections. According to 2015 CDC data, an estimated 900,000 Americans get pneumococcal pneumonia each year and approximately 5-7% die from it annually. Accurate diagnosis and early treatment are important for improving patient outcomes.Pneumonia is typically diagnosed by clinical examination, chest X-rays, and culture of patient blood and secretions. X-rays cannot identify the pathogen; blood cultures take several days to grow with limited reliability; and ...
Source: NIH OTT Licensing Opportunities - July 10, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Transperineal Ultrasound-Guided Prostate Biopsy
Prostate cancer is the most common male cancer in the United States, and the third most common worldwide. Prostate biopsies are often performed to confirm a cancer diagnosis and examine suspect tissue. Prostate biopsies are most often performed under transrectal ultrasound imaging (TRUS) guidance. TRUS images in real-time, at relatively low cost, and shows both prostate and boundaries. However, major problems with TRUS imaging are poor spatial resolution and low sensitivity for cancer detection. Fusion of TRUS images with preoperative images such as Magnetic Resonance (MR) or CAT may improve accuracy and resolution. But, t...
Source: NIH OTT Licensing Opportunities - July 9, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Microosmometer for the Study of a Wide Range of Biological, Macromolecular, Polymeric, Gel, or Other Samples
Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have discovered a new microosmometer that allows for the quantification of minor changes in the swelling properties of different materials (including tissue specimens) using microgram amounts of sample. Varying the vapor pressure in the environmental chamber of the device induces controlled changes in the osmotic pressure of the specimen on the surface of a flat quartz crystal microbalance. Variation in the swelling degree is measured with high sensitivity and reliability by monitoring the change in resonance frequenc...
Source: NIH OTT Licensing Opportunities - July 9, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Adjustable Barricade Safety Rail System and Roof Bracket Assembly to Prevent Worker Falls
Falls are the leading cause of death in construction. In 2016, there were 370 fatal falls out of 991 construction fatalities (Bureau of Labor Statistics, Census of Fatal Occupational Injuries data). These deaths are preventable. According to the Occupational Safety and Health Administration, employers must set up the workplace to prevent employees from falling from overhead platforms, elevated work stations, or into holes in the floor and walls. For a roofing job, employers should consider all potential fall hazards, such as holes, skylights, and leading edges, then plan and select fall protection suitable for the proposed...
Source: NIH OTT Licensing Opportunities - July 5, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research