Novel Method of Fat Suppression in Steady State Free Precession (SSFP) Based Magnetic Resonance Imaging (MRI)
Technology Bundle IDE-237-2003-0
Novel Method of Fat Suppression in Steady State Free Precession (SSFP) Based Magnetic Resonance Imaging (MRI)ApplicationsResearch MaterialsDiagnosticsLinked IDTAB-923Lead InventorsJohn Derbyshire (NHLBI)Co-InventorsDaniel Herzka (NHLBI)Elliot Mcveigh (NHLBI)ICsNHLBIAvailable for licensing is a technique for improving magnetic resonance imaging (MRI) that employs steady state free precession (SSFP). One such technique, fast imaging with steady-state free precession (FISP), is a well established and is a fast MR imaging method commonly used to evaluate cardiovascular anatomy and function. FI...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRI
Technology Bundle IDE-240-1998-0
Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRIApplicationsResearch MaterialsDiagnosticsLinked IDTAB-925Lead InventorsRobert Balaban (NHLBI)Co-InventorsAnthony Aletras ()Kathleen Ward ()ICsNHLBIAvailable for licensing is an MRI image improving system wherein at least one contrast agent is administered to a subject in amounts effective to perform chemical exchange dependent saturation transfer (CEDST) MRI analysis.Examples of contrast agents suitable for administration as exogenous contrast agents include at least one functional group bearing a prot...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
Haplotypes of Human Bitter Taste Receptor Genes
Technology Bundle IDE-222-2003-1
Haplotypes of Human Bitter Taste Receptor GenesApplicationsTherapeuticsResearch MaterialsDiagnosticsLinked IDTAB-946Lead InventorsDennis Drayna (NIDCD)Co-InventorsUn-kyung Kim (NIDCD)ICsNIDCDBitter taste has evolved in mammals as a crucial, important warning signal against ingestion of poisonous or toxic compounds. However, many beneficial compounds are also bitter, and taste masking of bitter tasting pharmaceutical compounds is a billion dollar industry. The diversity of compounds that elicit bitter-taste sensations is very large and more than two dozen members of the T2R bitter taste rec...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
Peptides With Laminin Activity
Technology Bundle IDE-521-1986-3
Peptides With Laminin ActivityLinked IDTAB-95Lead InventorsYoshihiko Yamada (NIDCR)Co-InventorsFrank Robey (NIDCR)George Martin (NIDCR)Hynda Kleinman (NIDCR)Jeannette Graf ()Makoto Sasaki ()Yukihide Iwamoto ()Development StagesPre-clinical (in vivo)ICsNIDCRPeptides with laminin activity, including YIGSR, are claimed. These peptides block angiogenesis, alter the formation of capillary structures by endothelial cells, prevent the formation of excess blood vessels in tissue and inhibit in vivo tumor cell colonization of tissues. These peptides can be used, among other things, to inhibit metas...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
Laminin A Peptides
Technology Bundle IDE-246-1988-0
Laminin A PeptidesApplicationsTherapeuticsResearch MaterialsDiagnosticsLinked IDTAB-96Lead InventorsYoshihiko Yamada (NIDCR)Co-InventorsGeorge Martin (NIDCR)Hynda Kleinman (NIDCR)Makoto Sasaki (NIDCR)Therapeutic AreasOncologyICsNIDCRThis invention relates to peptides and derivatives thereof having laminin-like activity, as well as a pharmaceutical composition of the peptide. The peptides claimed include Serine-Isoleucine-Lysine-Valine-Alanine-Valine (SIKVAV). Methods for promoting increased adhesion and migration of epithelial cells is also disclosed. The peptides have wide usage in resear...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
Probe To Identify Enteroinvasive E. coli And Shigella Species
Technology Bundle IDE-034-1989-0
Probe To Identify Enteroinvasive E. coli And Shigella SpeciesApplicationsDiagnosticsLinked IDTAB-97Lead InventorsKeith Lampel ()Co-InventorsJames Jagow ()Therapeutic AreasInfectious DiseaseStandard means for detecting pathogenic organisms in food or clinical specimens rely on animals or large DNA fragments, such as the 17 kb EcoRI fragment of Boileau. These methods are expensive, time-consuming, difficult to use, and have not been able to distinguish between nonvirulent enteroinvasive E. coli and Shigella. This invention describes DNA probes for enteroinvasive E. coli and Shigella species,...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
Anti-Vaccinia Monoclonal Antibody
Technology Bundle IDE-123-2004-0
Anti-Vaccinia Monoclonal AntibodyApplicationsResearch MaterialsLinked IDTAB-978Lead InventorsJonathan (Jon) Yewdell (NIAID)Co-InventorsJack Bennink (NIAID)Josephine Cox (NIAID)Therapeutic AreasInfectious DiseaseICsNIAIDThe current technology describes a monoclonal antibody that reacts with a vaccinia virus protein abundantly expressed under an early viral promoter after infection of cells. The antibody is useful for quantitating vaccinia virus infected cells and for studying the function of the protein to which it binds, which is known to be a double stranded RNA binding protein involved i...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine Recipients
Technology Bundle IDE-259-2004-2
HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine RecipientsApplicationsDiagnosticsLinked IDTAB-985Lead InventorsHana Golding (FDA)Co-InventorsSurender Khurana (FDA)Therapeutic AreasInfectious DiseaseICsFDAAvailable for licensing and commercial distribution is a serological test specifically designed to distinguish between antibodies generated in HIV vaccine recipients and those generated in a natural HIV infection. The method is useful in HIV vaccine development and clinical studies as it can readily detect early breakthrough infections in seroconverted vaccine recipients, t...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine Recipients
Technology Bundle IDE-259-2004-3
HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine RecipientsApplicationsDiagnosticsLinked IDTAB-985Lead InventorsHana Golding (FDA)Co-InventorsSurender Khurana (FDA)Therapeutic AreasInfectious DiseaseICsFDAAvailable for licensing and commercial distribution is a serological test specifically designed to distinguish between antibodies generated in HIV vaccine recipients and those generated in a natural HIV infection. The method is useful in HIV vaccine development and clinical studies as it can readily detect early breakthrough infections in seroconverted vaccine recipients, t...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
Transcytosis of Adeno-Associated Viruses
Technology Bundle IDE-298-2004-0
Transcytosis of Adeno-Associated VirusesLinked IDTAB-995Lead InventorsJohn Chiorini (NIDCR)Co-InventorsGiovanni Di Pasquale (NIDCR)ICsNIDCRThe invention relates to a method for delivering nucleic acids to a variety of cells including those of the gut, kidney, lung and central nervous system. The underlying cells of such organs are covered by a barrier of endothelial or epithelial cells which can limit the transfer of nucleic acids, or other potentially therapeutic agents, to the underlying target cells. To overcome this limitation, the method employs certain members of the parvovirus famil...
Source: NIH OTT Licensing Opportunities - July 1, 2021 Category: Research Authors: ott8admin Source Type: research
A Mobile Health Platform
Researchers at theNational Institute on Drug Abusedeveloped a mobile health technology to monitor and predict a user ’s psychological status and to deliver an automated intervention when needed. The technology uses smartphones to monitor the user’s location and ask questions about psychological status throughout the day. Continuously-collected ambulatory psychological data are fused with data on location a nd responses to questions. The mobile data are combined with geospatial risk maps to quantify exposure to risk and predict a future psychological state. The predictions are used to warn the user when he or ...
Source: NIH OTT Licensing Opportunities - June 5, 2021 Category: Research Authors: ott-admin Source Type: research
89Zr-Oxine Complex for In Vivo PET Imaging of Labelled Cells and Associated Methods
This technology from theNCI Molecular Imaging Program relates to a Zirconium-89 (89Zr)-oxine complex for cell labeling, tracking of labeled cells by whole-body positron emission tomography/computed tomography (PET/CT) imaging, and associated methods. A long half-life of 89Zr (78.4 hours), high sensitivity of PET, and absence of background signal in the recipient enable tracking cells over a week using low levels of labeling radioactivity without causing cellular toxicity.The 89Zr-oxine complex is synthesized quickly by mixing components at room temperature and produces high yields. Cell labeling is achieved by a short, roo...
Source: NIH OTT Licensing Opportunities - June 5, 2021 Category: Research Authors: ott-admin Source Type: research
3D Image Rendering Software for Biological Tissues
Available for commercial development is software that provides automatic visualization of features inside biological image volumes in 3D. The software provides a simple and interactive visualization for the exploration of biological datasets through dataset-specific transfer functions and direct volume rendering. The method employs a K-Means++ clustering algorithm to classify a two-dimensional histogram created from the input volume. The classification process utilizes spatial and data properties from the volume. Then using properties derived from the classified clusters, the software automatically generates color and opac...
Source: NIH OTT Licensing Opportunities - June 5, 2021 Category: Research Authors: ott-admin Source Type: research
A Mobile Health Platform
Researchers at the National Institute on Drug Abuse developed a mobile health technology to monitor and predict a user ’s psychological status and to deliver an automated intervention when needed. The technology uses smartphones to monitor the user’s location and ask questions about psychological status throughout the day. Continuously-collected ambulatory psychological data are fused with data on location and r esponses to questions. The mobile data are combined with geospatial risk maps to quantify exposure to risk and predict a future psychological state. The predictions are used to warn the user when he or she is a...
Source: NIH OTT Licensing Opportunities - June 5, 2021 Category: Research Authors: ott-admin Source Type: research
3D Image Rendering Software for Biological Tissues
Available for commercial development is software that provides automatic visualization of features inside biological image volumes in 3D. The software provides a simple and interactive visualization for the exploration of biological datasets through dataset-specific transfer functions and direct volume rendering. The method employs a K-Means++ clustering algorithm to classify a two-dimensional histogram created from the input volume. The classification process utilizes spatial and data properties from the volume. Then using properties derived from the classified clusters, the software automatically generates color and opac...
Source: NIH OTT Licensing Opportunities - June 5, 2021 Category: Research Authors: ott-admin Source Type: research
