Automatic System and Method for Tissue Sectioning, Staining, and Scanning
Computer and imaging technologies led to the development of digital pathology and the capture and storage of pathological specimens as digitally formatted images. The use of artificial intelligence (AI) in digital pathology, such as in three-dimensional (3D) reconstruction, requires analyses of high volumes of data. This results in increased demands for processing and acquisition of digital images of pathology samples. Increased usage cannot be met by the time-consuming, manual, and laborious methods currently used. Therefore, there is a need for automation of techniques used in processing of pathology samples and acquisit...
Source: NIH OTT Licensing Opportunities - September 14, 2022 Category: Research Authors: ott8admin Tags: Non-Medical Devices Licensing Desired NCI Source Type: research
Test Abstract
A test description (Source: NIH OTT Licensing Opportunities)
Source: NIH OTT Licensing Opportunities - September 10, 2022 Category: Research Authors: ott8admin Tags: Research Materials Licensing Desired Source Type: research
Bacteriophage Based-Vaccine System
Vaccines have become one of the most important tools in the fight against cancers and infectious diseases. However, some vaccines have shown limitations due to their high cost and low immune responses. To overcome these limitations, bacteriophages were proposed for the development of more cost-effective, immunogenic vaccines. Phages have shown a strong ability to activate innate and adaptive immune systems. The genome of these viral particles can be engineered, and their surface proteins can be exploited for antigen display.Researchers at National Cancer Institute (NCI) developed an engineered bacteriophage lambda ( ) v...
Source: NIH OTT Licensing Opportunities - August 18, 2022 Category: Research Authors: ott8admin Tags: Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
Neoantigen T Cell Therapy with Neoantigen Vaccination as a Combination Immunotherapy Against Cancer
Adoptive cell therapy (ACT) is a breakthrough form of cancer immunotherapy that utilizes autologous, antitumor T cells to attack tumors through recognition of tumor-specific mutations, or neoantigens. A major hurdle in the development of ACT is the exhausted phenotype exhibited by many neoantigen-specific T cells, which limits their efficacy and prevents a sustained immune response.
Researchers at the National Cancer Institute (NCI) have developed a combination immunotherapy to rescue the function of exhausted, neoantigen-specific T cells and, thus, enhance ACT. The method involves concurrent administration of neoantig...
Source: NIH OTT Licensing Opportunities - August 18, 2022 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
T-cell Receptor Targeting Human Papillomavirus-16 E6 Oncoprotein
Human papillomavirus (HPV) is a group of human viruses known to cause various malignancies. Of the group, HPV-16 is the most prevalent strain – an estimated 90% of adults have been exposed. HPV-16 is also the strain most commonly associated with malignancy, causing the vast majority of cervical, anal, vaginal, vulvar, and penile cancers. Currently, HPV-positive malignancies non-responsive to surgery or radiation are incurable and poorly palliated by existing systemic therapies. Thus, an alternative therapeutic approach for HPV-positive malignancies is needed. Researchers at the National Cancer Institute (NCI) develope...
Source: NIH OTT Licensing Opportunities - July 10, 2022 Category: Research Authors: ott8admin Source Type: research
T-cell Receptor Targeting Human Papillomavirus-16 E7 Oncoprotein
Human papillomavirus (HPV) is a group of human viruses known to cause various malignancies. Of the group, HPV-16 is the most prevalent strain – an estimated 90% of adults have been exposed. HPV-16 is also the strain most commonly associated with malignancy, causing the vast majority of cervical, anal, vaginal, vulvar, and penile cancers. Currently, HPV-positive malignancies non-responsive to surgery or radiation are incurable and poorly palliated by existing systemic therapies. Thus, an alternative therapeutic approach for HPV-positive malignancies is needed. Researchers at the National Cancer Institute (NCI) developed ...
Source: NIH OTT Licensing Opportunities - July 9, 2022 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
Novel Human Immunogenic Epitopes of the Human Endogenous Retrovirus ERVMER34-1
Human endogenous retroviruses (HERV) are an ongoing area of research for targeted cancer therapy. HERVs are relics of ancient retroviral infection of the germ line which occurred early in primate evolution. They make up about 8% of the human genome. It is now known that HERV RNAs and/or proteins are overexpressed in a range of human tumors compared to normal tissues – despite most HERV components being nonfunctional due to epigenetic control or deactivating mutations,. Cancer patients have T cells reactive with specific HERV peptides. Human T cells generated in vitro by employing specific HERV peptides were observed to ...
Source: NIH OTT Licensing Opportunities - July 8, 2022 Category: Research Authors: ott8admin Tags: Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
T-cell Receptors Targeting Human Papillomavirus Oncoproteins
Human papillomavirus (HPV) is a group of human viruses known to cause various malignancies. Of the group, HPV-16 is the most prevalent strain – an estimated 90% of adults have been exposed. HPV-16 is also the strain most commonly associated with malignancy, causing the vast majority of cervical, anal, vaginal, vulvar, and penile cancers. Currently, HPV-positive malignancies non-responsive to surgery or radiation are incurable and poorly palliated by existing systemic therapies. Thus, an alternative therapeutic approach for HPV-positive malignancies is needed. Researchers at the National Cancer Institute (NCI) develope...
Source: NIH OTT Licensing Opportunities - July 8, 2022 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NCI Source Type: research
PIM-Targeted PROTACs
Proviral Integration for the Moloney murine leukemia virus (PIM) kinases are overexpressed in many solid cancers – including prostate, breast, colon, endometrial, gastric and pancreatic. High of PIM1 expression is predictive of poor survival in multiple cancer types. While several selective pan-PIM inhibitors were developed and tested in clinical trials, all ultimately increased PIM1-3 protein levels and dev eloped intrinsic resistance. Researchers at the National Institutes of Health (NIH) developed multiple PIM kinase-targeting proteolysis-targeting chimeras (PROTACs) that lead to PIM1 degradation in a prostate cancer...
Source: NIH OTT Licensing Opportunities - July 8, 2022 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NHLBI Source Type: research
La Protein as a Novel Regulator of Osteoclastogenesis
Millions of patients in the United States are afflicted by a host of bone diseases caused by osteoclast (specialized calls arising from the macrophage/monocyte lineage) dysfunction. Diseases include Paget ’s disease, osteoporosis, fibrous dysplasia and osteolytic bone metastasis. The current standard of care for these diseases uses broad-spectrum therapies that either coat the skeletal system or inhibit osteoclast development in an effort to modulate osteoclastogenesis. New therapies are needed tha t specifically target osteoclast fusion – allowing patients to forgo the off-target side effects caused by existing, broad...
Source: NIH OTT Licensing Opportunities - July 8, 2022 Category: Research Authors: ott8admin Tags: Therapeutics Licensing Desired & Collaboration Desired Collaboration Sought NICHD Source Type: research
IgG4 Hinge Containing Nanobody-based CARs Targeting GPC3 for Treating Liver Cancer
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Globally, HCC is the sixth most prevalent cancer and third leading cause of cancer-related morbidity. Standard treatment for HCC is not suitable for a large proportion of liver cancer patients. Part of this is because less than a quarter of HCC patients are surgical candidates for curative-intent treatment. As a result, alternative treatments are needed. Chimeric antigen receptor (CAR) T cell therapy is a promising alternative approach selectively targets targeting tumors via tumor-specific antigens. However, to date, no effective CAR T cell therapy ex...
Source: NIH OTT Licensing Opportunities - July 7, 2022 Category: Research Authors: ott8admin Source Type: research
Mouse Lines with Fluorescently Labelled Membrane Proteins Regulating Cellular Motility and Membrane Trafficking
Cell motility and membrane trafficking play important roles in regulating cell division, cell migration, cell death and autophagy. Impairment of these processes can result in enhanced cell proliferation and survival and increased migration and invasion leading to cancer. Several proteins involved in cell motility and membrane trafficking have been shown to be dysregulated in various cancers. There is therefore a need for development of animal models for studying the roles of these proteins in cancer and their responses to drug treatment in vivo.
Researchers at the National Cancer Institute (NCI) have developed mouse lines...
Source: NIH OTT Licensing Opportunities - May 10, 2022 Category: Research Authors: ott8admin Source Type: research
Time Efficient Multi-Pulsed Field Gradient (mPFG) MRI Without Concomitant Gradient Field Artifacts
Measuring and mapping nervous tissue microstructure noninvasively is a long sought-after goal in neuroscience. Clinically, several neuropathologies such as cancer and stroke, are associated with changes in tissue microstructure. Diffusion tensor imaging (DTI), which models diffusion anisotropy, is an ideal imaging modality to elucidate these changes. However, DTI provides a mean diffusion tensor averaged over the entire MRI voxel. This has limitations when applied to heterogeneous neural tissue. Although some of these could be overcome by increased spatial resolution, this comes at the cost of reduced signal-to-noise ratio...
Source: NIH OTT Licensing Opportunities - May 10, 2022 Category: Research Authors: ott8admin Source Type: research
Use of Repurposed Compounds for the Treatment of Alzheimer ’s Disease
There are no effective treatments for Alzheimer ’s disease (AD), a progressive brain disease that slowly destroys a person’s memory, cognitive skills and ability to carry out the simplest tasks. AD affects more than 5 million individuals in the United States and ranks as the sixth leading cause of death. The ε4 allele of the apolipoprotein-E (APOE) gene is the strongest genetic risk factor for sporadic or late-onset AD. Heterozygous carriers of the ε4 allele are at three-to-four times greater risk; homozygous carriers are at ten times greater risk. In fact, APOE ε4 carriers accumulate AD neuropathology early in adul...
Source: NIH OTT Licensing Opportunities - May 10, 2022 Category: Research Authors: ott8admin Source Type: research
Enhanced Antigen Reactivity of Immune Cells Expressing a Mutant Non-Signaling CD3 Zeta Chain
Immunotherapy is a cutting-edge new category of treatment that aims to harness and, in some cases, modify the patient ’s own immune cells to improve their ability to cure diseases. It can be an effective approach for a variety of conditions, ranging from cancer to inflammatory diseases. However, a number of obstacles to the overall success of immunotherapy still exist. For example, reactivity against a target antigen can be attenuated or the lifespan of the “modified” immune cells can be too short. In cancer, some tumor cells could express antigen with very low reactivity, thus remaining undetected by “classica...
Source: NIH OTT Licensing Opportunities - May 10, 2022 Category: Research Authors: ott8admin Source Type: research
