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Cancer: Gastric (Stomach) Cancer

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Total 1410 results found since Jan 2013.

AMPK inhibits Smad3-mediated autoinduction of TGF- β1 in gastric cancer cells.
AMPK inhibits Smad3-mediated autoinduction of TGF-β1 in gastric cancer cells. J Cell Mol Med. 2021 Feb 03;: Authors: Zou J, Li C, Jiang S, Luo L, Yan X, Huang D, Luo Z Abstract We have previously shown that adenine monophosphate-activated protein kinase (AMPK) regulates transforming growth factor β (TGF-β)-triggered Smad3 phosphorylation. Here we report that AMPK inhibits TGF-β1 production. First, metformin reduced mRNA levels of TGF-β1 in gastric cancer cells, in parallel to the decrease of its protein abundance. The effects were more prominent in the cells containing LKB1, an upstream kinase of...
Source: J Cell Mol Med - February 3, 2021 Category: Molecular Biology Authors: Zou J, Li C, Jiang S, Luo L, Yan X, Huang D, Luo Z Tags: J Cell Mol Med Source Type: research

Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer.
Abstract HOXA6 gene plays a role of the oncogene in various cancers. Nonetheless, its effect on gastric cancer (GC) occurrence and development is still unclear. We analysed whether HOXA6 interacts with the PBX2 protein using the STRING database. The molecular mechanism by which HOXA6 synergizes with PBX2 in GC metastasis is not fully understood. Here, we found that the expression of HOXA6 was increased in GC tissues and cell lines. The upregulation of HOXA6 was closely associated with differentiation, lymph node metastasis, AJCC stage, TNM stage, and poor survival outcome in GC patients based on tissue microarray ...
Source: Aging - February 1, 2021 Category: Biomedical Science Authors: Lin J, Zhu H, Hong L, Tang W, Wang J, Hu H, Wu X, Chen Y, Liu G, Yang Q, Li J, Wang Y, Lin Z, Xiao Y, Dai W, Huang M, Li G, Li A, Wang J, Xiang L, Liu S Tags: Aging (Albany NY) Source Type: research

Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway
CONCLUSION: These results suggest that EHF plays a key role in cell proliferation, invasion, apoptosis, the cell cycle and EMT via the c-Met pathway. Therefore, EHF may serve as an antineoplastic target for the diagnosis and treatment of GC.PMID:33384550 | PMC:PMC7754554 | DOI:10.3748/wjg.v26.i47.7497
Source: World Journal of Gastroenterology - January 1, 2021 Category: Gastroenterology Authors: Meng-Li Gu Xin-Xin Zhou Meng-Ting Ren Ke-Da Shi Mo-Sang Yu Wen-Rui Jiao Ya-Mei Wang Wei-Xiang Zhong Feng Ji Source Type: research

Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway.
CONCLUSION: These results suggest that EHF plays a key role in cell proliferation, invasion, apoptosis, the cell cycle and EMT via the c-Met pathway. Therefore, EHF may serve as an antineoplastic target for the diagnosis and treatment of GC. PMID: 33384550 [PubMed - in process]
Source: World Journal of Gastroenterology - December 21, 2020 Category: Gastroenterology Authors: Gu ML, Zhou XX, Ren MT, Shi KD, Yu MS, Jiao WR, Wang YM, Zhong WX, Ji F Tags: World J Gastroenterol Source Type: research

Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR- γ and SOCS1 induction.
Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction. J Clin Biochem Nutr. 2020 Nov;67(3):248-256 Authors: Park JM, An JM, Han YM, Surh YJ, Hwang SJ, Kim SJ, Hahm KB Abstract The health beneficial effects of walnut plentiful of n-3 polyunsaturated fatty acid had been attributed to its anti-inflammatory and anti-oxidative properties against various clinical diseases. Since we have published Fat-1 transgenic mice overexpressing 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric pat...
Source: Journal of Clinical Biochemistry and Nutrition - December 11, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Cancers, Vol. 12, Pages 3463: DNAJA3/Tid1 Is Required for Mitochondrial DNA Maintenance and Regulates Migration and Invasion of Human Gastric Cancer Cells
Conclusions: Tid1 is required for mtDNA maintenance and regulates migration and invasion of gastric cancer cells. Tid1 deletion may be a poor prognostic factor in gastric cancers and could be further investigated for development of gastric cancer treatments.
Source: Cancers - November 20, 2020 Category: Cancer & Oncology Authors: Sheng-Fan Wang Kuo-Hung Huang Wei-Chuan Tseng Jeng-Fan Lo Anna Fen-Yau Li Wen-Liang Fang Chian-Feng Chen Tien-Shun Yeh Yuh-Lih Chang Yueh-Ching Chou Hung-Hsu Hung Hsin-Chen Lee Tags: Article Source Type: research

OSI-027 alleviates oxaliplatin chemoresistance in gastric cancer cells by suppressing P-gp induction.
Abstract Gastric cancer is one of the most common malignancies worldwide and the third leading cause of cancer-related death. In the present study, we investigated the potential activity of OSI-027, a potent and selective mammalian target of rapamycin complex 1/2 (mTOR1/2) dual inhibitor, alone or in combination with oxaliplatin against gastric cancer cells in vitro. Cell counting kit-8 assays and EdU staining were performed to examine the proliferation of cancer cells. Cell cycle and apoptosis were detected by flow cytometry. Western blot was used to detect the elements of the mTOR pathway and Pgp in gastric canc...
Source: Current Molecular Medicine - November 19, 2020 Category: Molecular Biology Authors: Xu E, Zhu H, Wang F, Miao J, Du S, Zheng C, Wang X, Li Z, Xu F, Xia X, Guan W Tags: Curr Mol Med Source Type: research

Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling.
Authors: Du J, Fu L, Hao J, Lin X, Dong Q Abstract Dysregulation of Rab11a has been implicated in the progression of several cancers. However, there have been no such studies for human gastric cancers. In the current study, we examined Rab11a protein expression and found it was upregulated in 49 of 108 gastric cancer tissues and correlated with local invasion, nodal metastasis, and advanced stage. Rab11a protein was higher in gastric cancer cell lines than normal gastric cell line. We transfected Rab11a plasmid and siRNA in both MGC803 and AGS cell lines. Rab11a overexpression increased the cell growth rate, colony...
Source: Journal of Oncology - November 14, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

MicroRNA-1297 downregulation inhibits breast cancer cell epithelial-mesenchymal transition and proliferation in a FA2H-dependent manner.
In conclusion, the present study indicated that miR-1297/FA2H might serve as a novel potential biomarker and therapeutic target for BC. PMID: 33014155 [PubMed]
Source: Oncology Letters - October 6, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

CXCR4 induces cell autophagy and maintains EBV latent infection in EBVaGC
Conclusions: Our data suggested new roles for CXCR4 in autophagy and EBV replication in EBVaGC, which further promoted cell survival and persistent latent infection. These new findings can lead to further CXCR4-based anticancer therapy.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Weiwen Wang, Yan Zhang, Wen Liu, Xiangyan Zhang, Hua Xiao, Menghe Zhao, Bing Luo Tags: Research Paper Source Type: research

Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer.
Abstract The tropomyosin-related kinase B (TrkB) receptor is a member of the neurotrophic tyrosine kinase receptors family and, together with the brain-derived neurotrophic factor (BDNF), plays an important role in the development of breast cancer, lung cancer, neuroblastoma, colorectal cancer, leukemia, cervical cancer, gallbladder cancer, gastric cancer, kidney cancer, Ewing's sarcoma, esophageal cancer, and head and neck cancer. Overexpression of these two factors has been associated with increased processes involved in carcinogenesis, such as invasion, migration, epithelial-mesenchymal transition (EMT), angiog...
Source: Cytokine - September 6, 2020 Category: Molecular Biology Authors: Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM Tags: Cytokine Source Type: research

Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway.
CONCLUSIONS: Altogether, our findings suggest that AKBA enhances GC cell sensitivity to CDDP-induced apoptosis via the p53 pathway. PMID: 32867831 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - September 2, 2020 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Keratin 18 (KRT18) induces proliferation, migration, and invasion in gastric cancer via the MAPK signaling pathway.
CONCLUSIONS: KRT18 plays a cancer-promoting role and might be a potential therapeutic target in the treatment of GC. PMID: 32860257 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - August 27, 2020 Category: Drugs & Pharmacology Authors: Wang PB, Chen Y, Ding GR, Du HW, Fan HY Tags: Clin Exp Pharmacol Physiol Source Type: research

Cancers, Vol. 12, Pages 2402: Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer
Sang Soo Kim Hypoxia-inducible factors (HIFs) induced by reduced O2 availability activate the transcription of target genes encoding proteins that play important roles in communication between cancer and stromal cells. Cancer cells were incubated under hypoxic conditions: H1299, A549 (NSCLC); Hep3B, HepG2 (HCC); HCT116, CT26 (Colon cancer); MCF-7, MDAMB231 (Breast cancer); MKN1, MKN5 (Gastric cancer); U87MG, SHSY5Y (Brain cancer); and SKOV3, SNU840 (Ovary cancer). All cells expressed HIF-1α and HIF-2α mRNA and proteins. However, cell proliferation of NSCLC, breast, gastric, and brain cancer...
Source: Cancers - August 23, 2020 Category: Cancer & Oncology Authors: Dong Hoon Shin Jeong Yeon Jo Sun Ha Kim Minyoung Choi Chungyong Han Beom K. Choi Sang Soo Kim Tags: Article Source Type: research

Phosphoproteomic analysis identifies CLK1 as a novel therapeutic target in gastric cancer
ConclusionsOur data indicates that CLK1 plays a crucial role in the regulation of splicing process in gastric cancer and that CLK1 can act as a novel therapeutic target in gastric cancer.
Source: Gastric Cancer - August 20, 2020 Category: Gastroenterology Source Type: research