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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
Overexpression of DAPK1-mediated inhibition of IKKbeta/CSN5/PD-L1 axis enhances natural killer cell killing ability and inhibits tumor immune evasion in gastric cancer
Cell Immunol. 2021 Dec 10;372:104469. doi: 10.1016/j.cellimm.2021.104469. Online ahead of print.ABSTRACTGastric cancer (GC) originates from the stomach and is a prevalent human malignancy. Dysfunction of death associated protein kinase 1 (DAPK1) has been identified as a major regulator involved in the development and progression of GC. However, there's limited data regarding the regulatory mechanism of GC. Herein, we investigated role of DAPK1 in natural killer (NK) cell killing ability and immune evasion of GC cells and mediated pathway. Samples from GC-related gene expression profile and clinical samples from 67 patients...
Source: Cellular Immunology - February 3, 2022 Category: Allergy & Immunology Authors: Zhiyuan Guo Cheng Zhou Linsen Zhou Zhiqiang Wang Xinguo Zhu Xiangming Mu Source Type: research
The Antitumor Effect of TPD52L2 Silencing on Oxaliplatin-Resistant Gastric Carcinoma Is Related to Endoplasmic Reticulum Stress < em > In Vitro < /em >
Evid Based Complement Alternat Med. 2022 Jan 18;2022:4451178. doi: 10.1155/2022/4451178. eCollection 2022.ABSTRACTTumor protein D52-like 2 or simply TPD52L2 belongs to the TPD52 family which has been implicated in a variety of human carcinomas. However, the TPD52L2 function in the gastric carcinoma oxaliplatin (OXA) resistance remains elusive. The main objective of this study is to evaluate the TPD52L2 effect in OXA-resistant gastric carcinoma cells in vitro. Oxaliplatin-resistant gastric carcinoma cells were generated in MGC-803 and SGC-7901 cells. siRNA-mediated knockdown of TPD52L2 was investigated in OXA-resistant MGC-...
Source: Evidence-based Complementary and Alternative Medicine - January 28, 2022 Category: Complementary Medicine Authors: Yu Zhang Dejun Yang Ziran Wei Xin Zhang Zunqi Hu Hongbing Fu Jiapeng Xu Weijun Wang Source Type: research
Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes
BMB Rep. 2022 Jan 10:5446. Online ahead of print.ABSTRACTIncreased mRNA levels of cancer upregulated gene (CUG)2 have been detected in many different tumor tissues using Affymetrix microarray. Oncogenic capability of the CUG2 gene has been further reported. However, the mechanism by which CUG2 overexpression promotes cancer stem cell (CSC)-like phenotypes remains unknown. With recent studies showing that pyruvate kinase muscle 2 (PKM2) is overexpressed in clinical tissues from gastric, lung, and cervical cancer patients, we hypothesized that PKM2 might play an important role in CSC-like phenotypes caused by CUG2 overexpres...
Source: BMB Reports - January 10, 2022 Category: Biochemistry Authors: Natpaphan Yawut Sirichat Kaowinn Il-Rae Cho Phatcharaphon Budluang Seonghye Kim Suhkmann Kim So Eun Youn Sang Seok Koh Young-Hwa Chung Source Type: research
