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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer
BMB Rep. 2023 Jul 4:5921. Online ahead of print.ABSTRACTDeubiquitinases (DUBs) are an essential component of the ubiquitin-proteasome system (UPS). They trim ubiquitin from substrate proteins, thereby preventing them from degradation, and modulate different cellular processes. Ubiquitin-specific protease 14 (USP14) is a DUB that has mainly been studied for its role in tumorigenesis in several cancers. In the present study, we found that the protein levels of USP14 were remarkably higher in gastric cancer tissues than in the adjacent normal tissues. We also demonstrated that the inhibition of USP14 activity using IU1 (an US...
Source: BMB Reports - July 4, 2023 Category: Biochemistry Authors: Mi Yea Lee Min-Jee Kim Jun-O Jin Peter Chang-Whan Lee Source Type: research
GSE209814 Gene expression profiles in gastric cancer cells with TM4SF1-AS1 knockdown
Contributors : Hiromu Suzuki ; Hiroshi KitajimaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo clarify the function of a long noncoding RNA TM4SF1-AS1 in gastric cancer (GC), we carried out a gene expression microarray analysis using GC cell lines HSC45 transfected with a siRNA targeting TM4SF1-AS1 or a control siRNA. Gene ontology analysis revealed that genes associated with interferon signaling and immune response were significantly enriched among downregulated genes.
Source: GEO: Gene Expression Omnibus - July 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
ASAP β‑Glucan-Mediated Oral Codelivery of 5FU and Bcl2 siRNA Attenuates Stomach Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.3c03528
Source: ACS Applied Materials and Interfaces - June 23, 2023 Category: Materials Science Authors: Humayra Afrin, Stephanie Vargas Esquivel, Raj Kumar, Md Ikhtiar Zahid, Ikhtiar Zahid, Beu Oporeza, Md Fashiar Rahman, Thomas Boland, and Md Nurunnabi Source Type: research
Targeting Nanog expression increased Cisplatin chemosensitivity and inhibited cell migration in Gastric cancer cells
Exp Cell Res. 2023 Jun 12:113681. doi: 10.1016/j.yexcr.2023.113681. Online ahead of print.ABSTRACTRegardless of significant advances in cancer treatment, gastric cancer (GC) incidence rate is increasing worldwide. As one of the main transcription factors participating in stemness, Nanog plays a pivotal role in various aspects of tumorigenesis, metastasis, and chemosensitivity. Given that, the current research intended to evaluate the potential effects of Nanog suppression on the GC cell cisplatin chemosensitivity and in vitro tumorigenesis. First, bioinformatics analysis was performed to evaluate the effect of Nanog expres...
Source: Experimental Cell Research - June 14, 2023 Category: Cytology Authors: Parisa Vasefifar Souzan Najafi Rouhollah Motafakkerazad Mohammad Amini Sahar Safaei Basira Najafzadeh Hajar Alemohammad Mahdi Jafarlou Behzad Baradaran Source Type: research
Linc-ROR Regulates < em > POU5F1 < /em > and < em > SOX2 < /em > by Competitively Binding miR-145-5p to Affect the Proliferation and Migration of Gastric Cancer Cells
In this study, in situ hybridization revealed that long intergenic non-protein coding RNA-regulator of reprogramming (linc-ROR) was highly expressed in gastric cancer cells and was mainly cytoplasmic-positive. Cell counting kit-8 (CCK-8), plate colony formation, wound healing, and Transwell assay revealed that linc-ROR knockdown impedes the growth, proliferation, and migration of gastric cancer cells, while linc-ROR overexpression promoted gastric cancer cell growth, migration, and colony formation ability. Combined with previous studies, the molecular mechanism axis of linc-ROR/miR-145-5-5p/POU5F1/SOX2 was verified. The e...
Source: Cell Transplantation - June 12, 2023 Category: Cytology Authors: Xiuchong Yu Xinyi Ma Yangtao Jia Xinxin Wu Zhilong Yan Source Type: research
SIRT1 mediated gastric cancer progression under glucose deprivation through the FoxO1-Rab7-autophagy axis
ConclusionThe SIRT1-FoxO1-Rab7 pathway is crucial for the autophagy and malignant biological behaviors of GC cells under GD conditions, which could be a new target for the treatment of GC.
Source: Frontiers in Oncology - May 24, 2023 Category: Cancer & Oncology Source Type: research
Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis
In conclusion, our results suggest that URI is involved in the cisplatin-induced DNA damage response via the ATM/CHK2 pathway, and silencing URI can increase cisplatin-induced DNA damage and enhance drug sensitivity in gastric cancer cells.PMID:37034221 | PMC:PMC10077030
Source: Cell Research - April 10, 2023 Category: Cytology Authors: Huiqin Bian Yu Gu Chen Chen Jinnan Chen Fei Zhang Zhonghai Xu Qian Wang Rui Mi Xuan Wu Yaojuan Lu Qiping Zheng Junxia Gu Source Type: research
Cancers, Vol. 15, Pages 834: Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis
Johannes F. Fahrmann
The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is frequently activated in various cancer types. Aberrant activation of NRF2 in cancer is attributed to gain-of-function mutations in the NRF2-encoding gene NFE2L2 or a loss of function of its suppressor, Kelch-like ECH-associated protein 1 (KEAP1). NRF2 activation exerts pro-tumoral effects in part by altering cancer cell metabolism. Previously, we reported a novel mechanism of NRF2 tumoral immune suppression through the selective upregulation of the tryptophan-metabolizing enzyme kynureninase (KYNU) in lung adenocarcinoma. In the cu...
Source: Cancers - January 29, 2023 Category: Cancer & Oncology Authors: Ricardo A. Le ón-Letelier Ali H. Abdel Sater Yihui Chen Soyoung Park Ranran Wu Ehsan Irajizad Jennifer B. Dennison Hiroyuki Katayama Jody V. Vykoukal Samir Hanash Edwin J. Ostrin Johannes F. Fahrmann Tags: Article Source Type: research
Suppression of galectin-4 attenuates peritoneal metastasis of poorly differentiated gastric cancer cells
ConclusionsWe clarified the role of galectin-4 in the development of peritoneal dissemination of poorly differentiated gastric cancer cells. Our data highlight the diagnostic and therapeutic potential of galectin-4 in the peritoneal dissemination of gastric cancer.
Source: Gastric Cancer - January 25, 2023 Category: Gastroenterology Source Type: research
