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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
Effect and mechanism of action of SLP-2 on the apoptosis and autophagy of gastric cancer cells
In conclusion, SLP-2 silencing can inhibit proliferation and induce apoptosis and autophagy of gastric cancer cells, and this effect may be related to the inhibition of ANXA2/β-catenin signaling pathway.PMID:34457062 | PMC:PMC8358623 | DOI:10.3892/ol.2021.12968
Source: Oncology Letters - August 30, 2021 Category: Cancer & Oncology Authors: Shengsen Yang Yun Huang Hongyan Zhang Fang Wang Liangui Shao Xuehong Wang Source Type: research
Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer
ConclusionTMPRSS4 can be considered as a potential prognostic biomarker, especially for stage III, and a promising therapeutic target for GC.
Source: Journal of Gastrointestinal Surgery - August 11, 2021 Category: Surgery Source Type: research
LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway
ConclusionsThe present results indicate that LRRC8A functions as a mediator of and/or biomarker for GC.
Source: Gastric Cancer - August 5, 2021 Category: Gastroenterology Source Type: research
Inhibition of USP11 sensitizes gastric cancer to chemotherapy via suppressing RhoA and Ras-mediated signaling pathways
CONCLUSIONS: Our work highlights the important role of USP11 in gastric cancer and therapeutic value of inhibiting USP11 to sensitize gastric cancer to chemotherapy.PMID:34332125 | DOI:10.1016/j.clinre.2021.101779
Source: Cell Research - July 31, 2021 Category: Cytology Authors: Hongfang Liu Mei Liu Bin He Qinghuan Li Source Type: research
Targeting cPLA2 α inhibits gastric cancer and augments chemotherapy efficacy via suppressing Ras/MEK/ERK and Akt/β-catenin pathways
ConclusionsOur work demonstrates cPLA2 α inhibition as a therapeutic strategy to overcome chemo-resistance and highlights the association of cPLA2α and Ras in gastric cancer.
Source: Cancer Chemotherapy and Pharmacology - July 13, 2021 Category: Cancer & Oncology Source Type: research
The expression of the alpha1 subunit of Na+/K+-ATPase is related to tumor development and clinical outcomes in gastric cancer
ConclusionsATP1A1 appears to regulate tumor progression by altering IFN signaling, and high ATP1A1 expression levels were associated with poor postoperative survival in GC patients. The present results provide novel insights into the function of ATP1A1 as a mediator and/or biomarker of GC.
Source: Gastric Cancer - July 12, 2021 Category: Gastroenterology Source Type: research
Notch Signaling Ligand Jagged1 Enhances Macrophage-Mediated Response to Helicobacter pylori
Helicobacter pylori (H. pylori) is one of the gram-negative bacteria that mainly colonize the stomach mucosa and cause many gastrointestinal diseases, such as gastritis, peptic ulcer, and gastric cancer. Macrophages play a key role in eradicating H. pylori. Recent data have shown that Notch signaling could modulate the activation and bactericidal activities of macrophages. However, the role of Notch signaling in macrophages against H. pylori remains unclear. In the present study, in the co-culture model of macrophages with H. pylori, the inhibition of Notch signaling using γ-secretase decreased the expression of inducible...
Source: Frontiers in Microbiology - July 8, 2021 Category: Microbiology Source Type: research
KRT18 Modulates Alternative Splicing of Genes Involved in Proliferation and Apoptosis Processes in Both Gastric Cancer Cells and Clinical Samples
Keratin 18 (KRT18), one of the most abundant keratins in epithelial and endothelial cells, has been reported to be aberrantly expressed in many malignancies and extensively regarded as a biomarker and important regulator in multiple cancers, including gastric cancer (GC). But the molecular regulatory mechanisms of KRT18 in GC patients and cells are largely unknown. In the present study, we analyzed the expression level of KRT18 in 450 stomach adenocarcinoma tissue samples from TCGA database and found a significantly higher expression level in tumor tissues. We then explored the potential functions of KRT18 in AGS cells (hu...
Source: Frontiers in Genetics - July 5, 2021 Category: Genetics & Stem Cells Source Type: research
An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research
