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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research
Rewiring of lactate-IL-1 β auto-regulatory loop with Clock-Bmal1: A feed-forward circuit in glioma
Mol Cell Biol. 2021 Jun 14:MCB0044920. doi: 10.1128/MCB.00449-20. Online ahead of print.ABSTRACTDe-synchronized circadian rhythm in tumors is coincident with aberrant inflammation and dysregulated metabolism. As their inter-relationship in cancer etiology is largely unknown, we investigated the link between the three in glioma. Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1β was concomitant with elevated levels of core circadian regulators Clock and Bmal1. siRNA mediated knockdown of Bmal1 and Clock decreased (i) LDHA and IL-1β levels and (ii) release of lactate and pro-inflammatory cytokin...
Source: Mol Biol Cell - June 14, 2021 Category: Molecular Biology Authors: Pruthvi Gowda Kirti Lathoria Shalini Sharma Shruti Patrick Sonia B Umdor Ellora Sen Source Type: research
CDK-associated Cullin 1 promotes Cell Proliferation and inhibits Cell Apoptosis in Human Glioblastoma
CONCLUSION: CACUL1 can promote cell proliferation and suppress apoptosis of glioma cells and might serve as a potential oncogene for gliomas.PMID:34080964 | DOI:10.2174/1568009621666210602164225
Source: Current Cancer Drug Targets - June 3, 2021 Category: Cancer & Oncology Authors: Xiaohua Zhang Tianying Zhang Xiaojuan Han Zhongying Qiu Jianghong Cheng Xingchun Gao Xingchun Gou Source Type: research
Responses of porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses
Cell Signal. 2021 May 17:110047. doi: 10.1016/j.cellsig.2021.110047. Online ahead of print.ABSTRACTThe WNT (Wingless and Int-1) proteins play a role in stem cell development and cell differentiation. Mutations in the WNT proteins lead to the development of various tumours, including gastric tumours. Porcupine (PORCN) is a palmitoyltransferase and Wntless (WLS) is a chaperone protein that modify and fold the WNT proteins respectively and are involved in their proper secretion and binding to the frizzled (FZD) receptor and the lipoprotein receptor-related protein 5 or 6 (LRP5/6). We investigated how modifications of PORCN an...
Source: Cellular Signalling - May 20, 2021 Category: Cytology Authors: Rowida Mohamed Catherine Kennedy William G Willmore Source Type: research
