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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
Effect of RNAi-Mediated Survivin and Hypoxia-Inducible Factor 1 α Gene Silencing on Proliferation, Invasion, Migration and Apoptosis of Gastric Cancer BGC-823 Cells
Mol Biotechnol. 2023 Jul 13. doi: 10.1007/s12033-023-00786-z. Online ahead of print.ABSTRACTIn order to investigate the effects of RNAi-mediated survivin and hypoxia-inducible factor 1α (HIF-1α) gene silencing on the proliferation and apoptosis of gastric cancer BGC-823 cells, small interfering RNAs (siRNAs) targeting survivin and HIF-1α mRNAs, respectively, as well as scrambled siRNAs (SCRs) were designed and synthesized, namely siRNA-survivin group, siRNA-HIF-1α group, and SCR group. The hypoxia-sensitive gastric cancer BGC-823 cells were identified and transfected in vitro with Hifectin II under hypoxic conditions, ...
Source: Cancer Control - July 13, 2023 Category: Cancer & Oncology Authors: Yupeng Li Yongchao Liu Mingzhu Chang Runhong Mu Jianyu Zhu Source Type: research
USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer
BMB Rep. 2023 Jul 4:5921. Online ahead of print.ABSTRACTDeubiquitinases (DUBs) are an essential component of the ubiquitin-proteasome system (UPS). They trim ubiquitin from substrate proteins, thereby preventing them from degradation, and modulate different cellular processes. Ubiquitin-specific protease 14 (USP14) is a DUB that has mainly been studied for its role in tumorigenesis in several cancers. In the present study, we found that the protein levels of USP14 were remarkably higher in gastric cancer tissues than in the adjacent normal tissues. We also demonstrated that the inhibition of USP14 activity using IU1 (an US...
Source: BMB Reports - July 4, 2023 Category: Biochemistry Authors: Mi Yea Lee Min-Jee Kim Jun-O Jin Peter Chang-Whan Lee Source Type: research
